{"id":"https://openalex.org/W2912490652","doi":"https://doi.org/10.3389/fimmu.2019.00102","title":"Non-canonical Inflammasome-Mediated IL-1\u03b2 Production by Primary Endometrial Epithelial and Stromal Fibroblast Cells Is NLRP3 and Caspase-4 Dependent","display_name":"Non-canonical Inflammasome-Mediated IL-1\u03b2 Production by Primary Endometrial Epithelial and Stromal Fibroblast Cells Is NLRP3 and Caspase-4 Dependent","publication_year":2019,"publication_date":"2019-02-05","ids":{"openalex":"https://openalex.org/W2912490652","doi":"https://doi.org/10.3389/fimmu.2019.00102","mag":"2912490652","pmid":"https://pubmed.ncbi.nlm.nih.gov/30804935","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6371858"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2019.00102","doi":"https://doi.org/10.3389/fimmu.2019.00102","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.00102","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.00102/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.00102/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Paul Kelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Paul Kelly","raw_affiliation_strings":["Animal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre, Grange, Ireland","Comparative Immunology Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre, Grange, Ireland","institution_ids":[]},{"raw_affiliation_string":"Comparative Immunology Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002853430","display_name":"Kieran G. Meade","orcid":"https://orcid.org/0000-0002-3051-8586","observed_orcids":["https://orcid.org/0000-0002-3051-8586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kieran G. Meade","raw_affiliation_strings":["Animal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre, Grange, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre, Grange, Ireland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091548602","display_name":"Cliona O\u2019Farrelly","orcid":"https://orcid.org/0000-0002-0616-2874","observed_orcids":["https://orcid.org/0000-0002-0616-2874"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Cliona O'Farrelly","raw_affiliation_strings":["Comparative Immunology Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland","School of Medicine, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comparative Immunology Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"School of Medicine, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091548602"],"corresponding_institution_ids":["https://openalex.org/I205274468"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.9045,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.86360758,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"102","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-endometritis","display_name":"bovine endometritis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9380000233650208},{"id":"https://openalex.org/keywords/caspase-4","display_name":"caspase-4","score":0.9610000252723694},{"id":"https://openalex.org/keywords/il-1beta-production","display_name":"IL-1\u03b2 production","score":0.8149999976158142},{"id":"https://openalex.org/keywords/endometrial-epithelial-cells","display_name":"endometrial epithelial cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/endometrial-stromal-fibroblasts","display_name":"endometrial stromal fibroblasts","score":0.9610000252723694},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.7369999885559082},{"id":"https://openalex.org/keywords/gasdermin-d","display_name":"gasdermin D","score":0.7850000262260437},{"id":"https://openalex.org/keywords/nek7","display_name":"NEK7","score":0.746999979019165},{"id":"https://openalex.org/keywords/asc","display_name":"ASC","score":0.5299999713897705},{"id":"https://openalex.org/keywords/nigericin","display_name":"nigericin","score":0.7580000162124634},{"id":"https://openalex.org/keywords/lipopolysaccharide-stimulation","display_name":"lipopolysaccharide stimulation","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.8814793825149536},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.683163583278656},{"id":"https://openalex.org/C2775846227","wikidata":"https://www.wikidata.org/wiki/Q1340774","display_name":"Endometritis","level":3,"score":0.6340128183364868},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5888127088546753},{"id":"https://openalex.org/C2779742232","wikidata":"https://www.wikidata.org/wiki/Q839508","display_name":"Endometrium","level":2,"score":0.4933275282382965},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.49084311723709106},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43497103452682495},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4221707582473755},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.4180457592010498},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3947153389453888},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3629661202430725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3400953412055969},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3306366503238678},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.31604161858558655},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2731684446334839},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2411520779132843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2220543622970581},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.18183740973472595},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002418","descriptor_name":"Cattle Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002418","descriptor_name":"Cattle Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004716","descriptor_name":"Endometritis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004716","descriptor_name":"Endometritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004717","descriptor_name":"Endometrium","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009550","descriptor_name":"Nigericin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053471","descriptor_name":"Caspases, Initiator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.3389/fimmu.2019.00102","doi":"https://doi.org/10.3389/fimmu.2019.00102","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.00102","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.00102/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5377929","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6371858","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30804935","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30804935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6371858","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6371858/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:t-stor.teagasc.ie:11019/2114","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11019/2114","pdf_url":null,"source":{"id":"https://openalex.org/S4306402356","display_name":"T-St\u00f3r (Teagasc)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I141766778","host_organization_name":"Teagasc - The Irish Agriculture and Food Development Authority","host_organization_lineage":["https://openalex.org/I141766778"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:http://www.rian.ie/170854/","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2262/89548","pdf_url":"http://hdl.handle.net/2262/89548","source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kelly, P. and Meade, K.G. and O'Farrelly, C., Non-canonical inflammasome-mediated IL-1\u00ce\u00b2 production by primary endometrial epithelial and stromal fibroblast cells is NLRP3 and caspase-4 dependent, Frontiers in Immunology, 10, 2019, 1--","raw_type":"Journal article"},{"id":"pmh:http://www.rian.ie/189092/","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11019/2114","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Other"},{"id":"pmh:oai:doaj.org/article:27773ecd392e42df8592f167443a5a25","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/27773ecd392e42df8592f167443a5a25","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 10 (2019)","raw_type":"article"},{"id":"pmh:oai:tara.tcd.ie:2262/89548","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2262/89548","pdf_url":null,"source":{"id":"https://openalex.org/S4306400387","display_name":"Trinity's Access to Research Output (TARA) (Trinity College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205274468","host_organization_name":"Trinity College Dublin","host_organization_lineage":["https://openalex.org/I205274468"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2019.00102","doi":"https://doi.org/10.3389/fimmu.2019.00102","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.00102","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.00102/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1647558924","display_name":null,"funder_award_id":"13\u2013S\u2013472","funder_id":"https://openalex.org/F4320320831","funder_display_name":"Department of Agriculture, Food and the Marine, Ireland"}],"funders":[{"id":"https://openalex.org/F4320320831","display_name":"Department of Agriculture, Food and the Marine, Ireland","ror":"https://ror.org/008gjgb19"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2912490652.pdf","grobid_xml":"https://content.openalex.org/works/W2912490652.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W18528202","https://openalex.org/W1529674879","https://openalex.org/W1535884210","https://openalex.org/W1546424182","https://openalex.org/W1577577364","https://openalex.org/W1618627661","https://openalex.org/W1873207210","https://openalex.org/W1958466825","https://openalex.org/W1964977785","https://openalex.org/W1967342482","https://openalex.org/W1970837608","https://openalex.org/W1979242324","https://openalex.org/W1984841263","https://openalex.org/W1986243847","https://openalex.org/W2001979726","https://openalex.org/W2008261126","https://openalex.org/W2012270515","https://openalex.org/W2040776765","https://openalex.org/W2051658957","https://openalex.org/W2056220051","https://openalex.org/W2061380679","https://openalex.org/W2081257577","https://openalex.org/W2082992629","https://openalex.org/W2106286901","https://openalex.org/W2108511142","https://openalex.org/W2134753271","https://openalex.org/W2138579860","https://openalex.org/W2140637559","https://openalex.org/W2147071024","https://openalex.org/W2151843453","https://openalex.org/W2159002913","https://openalex.org/W2160470106","https://openalex.org/W2166442806","https://openalex.org/W2167186849","https://openalex.org/W2170382285","https://openalex.org/W2288100440","https://openalex.org/W2317391245","https://openalex.org/W2741457362","https://openalex.org/W2755294599","https://openalex.org/W2767239260","https://openalex.org/W2791033272","https://openalex.org/W2883027987","https://openalex.org/W2898209387","https://openalex.org/W4211217520","https://openalex.org/W6600757741"],"related_works":["https://openalex.org/W2922451745","https://openalex.org/W2801916980","https://openalex.org/W3137994919","https://openalex.org/W2134753271","https://openalex.org/W2133664604","https://openalex.org/W4200621826","https://openalex.org/W3194273234","https://openalex.org/W2075185675","https://openalex.org/W4404420615","https://openalex.org/W4310702112"],"abstract_inverted_index":{"Inflammation":[0],"of":[1,39,51,130,149,158,164,207,240,287,300,310,322],"the":[2,18,40,45,114,142,183,205,222,285,292,308,314,320],"postpartum":[3],"uterus":[4,46],"is":[5,47,264],"a":[6,48,172],"normal":[7],"physiological":[8],"event,":[9],"crucial":[10],"for":[11,297,307,319],"tissue":[12,58],"involution":[13],"and":[14,64,77,90,118,137,141,171,192,211,225,275,302,316],"repair.":[15],"However,":[16],"in":[17,28,44,54,101,204,230,236,247,261,278,291,313,317],"bovine,":[19],"some":[20],"cows":[21,70,78],"fail":[22],"to":[23,105,232],"resolve":[24],"this":[25],"inflammation,":[26],"resulting":[27],"endometritis,":[29],"which":[30],"compromises":[31],"fertility.":[32],"Here":[33],"we":[34],"hypothesize":[35],"that":[36,71,79,103,258],"inflammasome-mediated":[37],"cleavage":[38],"inflammatory":[41,311],"cytokine":[42],"IL-1\u03b2":[43,84,95,175,216,255],"key":[49],"driver":[50],"pathological":[52],"inflammation":[53,301],"endometritic":[55],"cows.":[56],"Endometrial":[57,201],"samples":[59],"were":[60,98,154,194],"obtained":[61],"at":[62,74,108],"7":[63],"21":[65,75,109],"days":[66],"post-partum":[67],"(DPP)":[68],"from":[69],"developed":[72],"endometritis":[73,107],"DPP":[76,110],"remained":[80],"healthy":[81],"throughout":[82],"involution.":[83],"was":[85,245],"measured":[86],"by":[87,113,196],"qPCR,":[88],"ELISA":[89],"immunohistochemistry.":[91],"Seven":[92],"DPP,":[93],"endometrial":[94,132,197,249,262,280],"protein":[96,176,180],"levels":[97,148],"significantly":[99],"higher":[100],"animals":[102],"proceeded":[104],"develop":[106],"with":[111,139,178],"production":[112],"epithelium":[115],"(both":[116],"luminal":[117],"glandular),":[119],"underlying":[120],"stromal":[121,135],"fibroblasts":[122,136],"as":[123,125],"well":[124],"infiltrating":[126],"immune":[127],"cells.":[128,250],"Stimulation":[129],"primary":[131],"epithelial":[133,166],"cells,":[134],"PBMCs":[138],"LPS":[140,162],"inflammasome":[143,187,224,233,259,282,288],"activator":[144],"nigericin":[145],"induced":[146,168],"high":[147],"IL-1\u03b2.":[150,159],"Stromal":[151],"fibroblast":[152],"cells":[153,167,198,263],"particularly":[155],"potent":[156],"producers":[157],"Furthermore,":[160],"basolateral":[161],"stimulation":[163,203],"polarized":[165],"IL1B":[169],"mRNA":[170],"previously":[173],"undescribed":[174],"isoform,":[177],"preferential":[179],"secretion":[181],"into":[182],"apical":[184],"compartment.":[185],"Key":[186],"components":[188],"(NLRP3,":[189],"NEK7,":[190],"ASC":[191],"Gasdermin-D)":[193],"expressed":[195],"following":[199],"stimulation.":[200],"cell":[202,281],"presence":[206],"NLRP3":[208,223],"receptor":[209],"(MCC950)":[210],"pan-caspase":[212],"(Z-VAD-FMK)":[213],"inhibitors":[214],"blocked":[215],"production,":[217,256],"demonstrating":[218],"its":[219],"dependence":[220],"on":[221,226],"caspase":[227],"activity.":[228],"Interestingly,":[229],"contrast":[231],"pathways":[234],"detected":[235,246],"other":[237],"species,":[238],"expression":[239],"caspase-4":[241,265],"but":[242,266],"not":[243,267],"caspase-1":[244,268],"bovine":[248,279,293,315,323],"Caspase-4":[251],"specific":[252],"siRNA":[253],"prevented":[254],"confirming":[257],"activation":[260,289],"dependent.":[269],"This":[270],"study":[271],"has":[272,294],"identified":[273],"species-":[274],"tissue-specific":[276],"differences":[277],"assembly.":[283],"Identifying":[284],"mechanisms":[286],"operating":[290],"critical":[295],"relevance":[296],"our":[298],"understanding":[299],"suggests":[303],"new":[304],"therapeutic":[305],"targets":[306],"resolution":[309],"pathologies":[312],"particular":[318],"prevention":[321],"endometritis.":[324]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-02-21T00:00:00"}
