{"id":"https://openalex.org/W2912488496","doi":null,"title":"Optical Imaging Strategies for High-Content Studies of Development","display_name":"Optical Imaging Strategies for High-Content Studies of Development","publication_year":2018,"publication_date":"2018-11-01","ids":{"openalex":"https://openalex.org/W2912488496","mag":"2912488496"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/91538","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/91538","pdf_url":"https://utoronto.scholaris.ca/bitstreams/b6c37077-96db-436e-8538-631d8ab36ad3/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/b6c37077-96db-436e-8538-631d8ab36ad3/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045290622","display_name":"Aaron Au","orcid":"https://orcid.org/0000-0001-5717-048X","observed_orcids":["https://orcid.org/0000-0001-5717-048X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Aaron Au","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5045290622"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.6987000107765198,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.6987000107765198,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.19900000095367432,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.0364999994635582,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-content-imaging","display_name":"high-content imaging","score":0.8930000066757202},{"id":"https://openalex.org/keywords/high-throughput-microscopy","display_name":"high-throughput imaging","score":0.7730000019073486},{"id":"https://openalex.org/keywords/developmental-biology","display_name":"developmental biology","score":0.8029999732971191},{"id":"https://openalex.org/keywords/automated-imaging","display_name":"automated imaging","score":0.5989999771118164},{"id":"https://openalex.org/keywords/light-sheet-microscopy","display_name":"light-sheet microscopy","score":0.9620000123977661},{"id":"https://openalex.org/keywords/optical-coherence-tomography","display_name":"optical coherence tomography","score":0.9860000014305115},{"id":"https://openalex.org/keywords/image-processing-pipeline","display_name":"image processing pipeline","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C2778152352","wikidata":"https://www.wikidata.org/wiki/Q5165061","display_name":"Content (measure theory)","level":2,"score":0.4133670926094055},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.34148019552230835},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3053120970726013},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10315343737602234},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/91538","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/91538","pdf_url":"https://utoronto.scholaris.ca/bitstreams/b6c37077-96db-436e-8538-631d8ab36ad3/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2912488496","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/91538/3/Au_Aaron_K_201811_MAS_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/91538","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/91538","pdf_url":"https://utoronto.scholaris.ca/bitstreams/b6c37077-96db-436e-8538-631d8ab36ad3/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2912488496.pdf","grobid_xml":"https://content.openalex.org/works/W2912488496.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W628695023","https://openalex.org/W862235781","https://openalex.org/W1156765303","https://openalex.org/W1540070193","https://openalex.org/W1545446478","https://openalex.org/W1675556122","https://openalex.org/W1823866444","https://openalex.org/W1967581724","https://openalex.org/W1980882212","https://openalex.org/W2001695176","https://openalex.org/W2011487080","https://openalex.org/W2017894089","https://openalex.org/W2032893178","https://openalex.org/W2038416597","https://openalex.org/W2049784603","https://openalex.org/W2053270078","https://openalex.org/W2056942342","https://openalex.org/W2057132085","https://openalex.org/W2094727035","https://openalex.org/W2095442369","https://openalex.org/W2103782445","https://openalex.org/W2120447670","https://openalex.org/W2133872553","https://openalex.org/W2156472837","https://openalex.org/W2158706178","https://openalex.org/W2245458847","https://openalex.org/W2270609213","https://openalex.org/W2326707709","https://openalex.org/W2331982492","https://openalex.org/W2410523792","https://openalex.org/W2537731554","https://openalex.org/W2581082771","https://openalex.org/W2741799782","https://openalex.org/W2751207373","https://openalex.org/W2754090274","https://openalex.org/W2781744457","https://openalex.org/W2800969268","https://openalex.org/W2887379385","https://openalex.org/W2950695830","https://openalex.org/W4237173899"],"related_works":["https://openalex.org/W1981398520","https://openalex.org/W2577724645","https://openalex.org/W2323541887","https://openalex.org/W4386401812","https://openalex.org/W2767168727","https://openalex.org/W2797664654","https://openalex.org/W2803302343","https://openalex.org/W177277048","https://openalex.org/W2512518637","https://openalex.org/W2149817032"],"abstract_inverted_index":{"The":[0,91],"advent":[1],"of":[2,10,25,40,64,71,74,78,88,101,125],"automated":[3,60,106,116],"microscopy":[4,34],"has":[5],"brought":[6],"forth":[7],"the":[8,72,86,97],"field":[9],"high-throughput":[11,107],"microscopy.":[12],"High":[13,32],"throughput":[14,62,76],"screens":[15,47],"have":[16],"become":[17],"a":[18,109],"commonly":[19],"used":[20,36],"approach":[21],"to":[22],"obtain":[23],"streams":[24],"quantitative":[26],"information":[27],"from":[28],"complex":[29],"biological":[30],"systems.":[31],"content":[33],"is":[35],"in":[37],"many":[38,56],"fields":[39],"biology,":[41],"such":[42],"as":[43],"drug":[44],"discovery,":[45],"genomic":[46],"and":[48,85,99,114],"recently":[49],"developmental":[50,65],"studies.":[51],"Despite":[52],"this,":[53],"there":[54],"remains":[55],"challenges":[57,73],"that":[58],"prohibit":[59],"high":[61,75],"imaging":[63,77,89],"processes.":[66],"This":[67],"thesis":[68],"discusses":[69],"some":[70],"development,":[79],"how":[80],"they":[81],"could":[82],"be":[83],"addressed":[84],"merits":[87],"platforms.":[90],"work":[92],"presented":[93],"here":[94],"focuses":[95],"on":[96],"design":[98],"application":[100],"custom":[102],"optical":[103,117],"solutions:":[104],"an":[105,115],"imager,":[108],"high-content":[110],"light":[111],"sheet":[112],"microscope,":[113],"coherence":[118],"tomography":[119],"image":[120],"processing":[121],"pipeline,":[122],"for":[123],"studies":[124],"development.":[126]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2019-02-21T00:00:00"}