{"id":"https://openalex.org/W2912444292","doi":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b148","title":"Abstract B148: Microvilli enable efficient T-cell antigen search and ligand detection","display_name":"Abstract B148: Microvilli enable efficient T-cell antigen search and ligand detection","publication_year":2019,"publication_date":"2019-02-01","ids":{"openalex":"https://openalex.org/W2912444292","doi":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b148","mag":"2912444292"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6074.cricimteatiaacr18-b148","doi":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b148","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b148","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082529820","display_name":"En Cai","orcid":"https://orcid.org/0000-0002-8212-8387","observed_orcids":["https://orcid.org/0000-0002-8212-8387"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"En Cai","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kyle Marchuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle Marchuk","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065269258","display_name":"Casey Beppler","orcid":"https://orcid.org/0000-0001-9241-2413","observed_orcids":["https://orcid.org/0000-0001-9241-2413"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Casey Beppler","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018179968","display_name":"Matthew F. Krummel","orcid":"https://orcid.org/0000-0001-7915-3533","observed_orcids":["https://orcid.org/0000-0001-7915-3533"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Krummel","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"2_Supplement","first_page":"B148","last_page":"B148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-antigen-recognition","display_name":"T cell antigen recognition","score":0.843999981880188},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.7919999957084656},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.906000018119812},{"id":"https://openalex.org/keywords/anomalous-diffusion","display_name":"anomalous diffusion","score":0.7770000100135803},{"id":"https://openalex.org/keywords/ligand-detection","display_name":"ligand detection","score":0.7570000290870667},{"id":"https://openalex.org/keywords/t-cell-apc-interaction","display_name":"T cell-APC interaction","score":0.6430000066757202},{"id":"https://openalex.org/keywords/membrane-apposition","display_name":"membrane apposition","score":0.5910000205039978},{"id":"https://openalex.org/keywords/lattice-light-sheet-microscopy","display_name":"lattice light-sheet microscopy","score":0.8799999952316284}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6378129720687866},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.5468449592590332},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5136744379997253},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4685894846916199},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.4491455852985382},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44329890608787537},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.43418997526168823},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4219907224178314},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35869303345680237},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35021302103996277},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15952184796333313},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.15317681431770325},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11326318979263306}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2326-6074.cricimteatiaacr18-b148","doi":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b148","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b148","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2793415556","https://openalex.org/W7056032017","https://openalex.org/W4297984421","https://openalex.org/W2522267165","https://openalex.org/W4214705640","https://openalex.org/W4367281452","https://openalex.org/W4289261651","https://openalex.org/W7203912224","https://openalex.org/W4281735069","https://openalex.org/W2011066310"],"abstract_inverted_index":{"Abstract":[0],"During":[1,193],"antigen":[2,26,97,278],"detection,":[3],"T-cells":[4,54,88,147,239],"survey":[5,107],"the":[6,85,108,138,210,227,252,287],"surface":[7,86,211,245],"of":[8,87,110,127,133,178,212,286],"antigen-presenting":[9],"cells":[10,91,214],"(APCs),":[11],"which":[12,130,225,257],"may":[13],"display":[14],"mainly":[15],"nonstimulatory":[16],"peptide-loaded":[17],"major":[18],"histocompatibility":[19],"complexes":[20],"(pMHCs)":[21],"and":[22,44,73,92,95,137,216,233,280],"only":[23],"rare":[24],"cognate":[25],"in":[27,124,246,262],"a":[28,39,175],"process":[29,255],"involving":[30],"close":[31],"(nanometer-scale)":[32],"membrane":[33,168,218],"apposition.":[34],"Thus,":[35],"T-cell":[36,104,119,198,223,232,277],"must":[37],"solve":[38],"classic":[40],"trade-off":[41],"between":[42,231],"speed":[43],"sensitivity.":[45],"It":[46],"has":[47,65],"long":[48],"been":[49,66],"supposed":[50],"that":[51,101,143],"microvilli":[52,83,102,171,179,199],"on":[53,84,103,145,151,158,166,209],"act":[55],"as":[56],"sensory":[57],"organs":[58],"to":[59,80,191,221,240],"enable":[60,275],"search,":[61],"but":[62,174],"their":[63],"strategy":[64],"unknown.":[67],"We":[68,99,141],"used":[69],"lattice":[70],"light-sheet":[71],"microscopy":[72,79],"quantum":[74],"dot-enabled":[75],"synaptic":[76],"contact":[77],"mapping":[78],"show":[81],"how":[82],"search":[89,254,279],"opposing":[90,111],"surfaces":[93,105,112],"before":[94],"during":[96],"recognition.":[98],"uncovered":[100],"dynamically":[106],"majority":[109],"within":[113],"one":[114],"minute":[115],"through":[116],"anomalous":[117],"diffusion.":[118],"receptor":[120],"(TCR)":[121],"recognition":[122],"resulted":[123],"selective":[125],"stabilization":[126],"receptor-occupied":[128],"protrusions,":[129],"was":[131],"independent":[132],"tyrosine":[134],"kinase":[135],"signaling":[136],"actin":[139],"cytoskeleton.":[140],"revealed":[142],"TCRs":[144,155,162],"activated":[146],"were":[148,156,172,180],"nonuniformly":[149],"distributed":[150],"cell":[152],"membrane:":[153],"some":[154],"concentrated":[157],"microvilli,":[159,224],"while":[160],"other":[161],"formed":[163,205],"high-density":[164,187],"patches":[165,188],"flatter":[167],"regions.":[169],"Many":[170],"TCR-occupied,":[173],"small":[176],"population":[177],"found":[181],"not":[182],"occupied":[183],"by":[184,206],"TCRs.":[185],"TCR":[186],"moved":[189],"relative":[190],"microvilli.":[192],"T-cell-APC":[194],"interaction,":[195],"we":[196],"observed":[197],"projected":[200],"deep":[201],"into":[202,296],"3D":[203],"pockets":[204],"veil":[207],"structures":[208],"dendritic":[213],"(DC),":[215],"DC":[217],"also":[219],"conformed":[220],"accommodate":[222],"increased":[226],"effective":[228],"close-contact":[229],"area":[230],"APC.":[234],"Such":[235],"scanning":[236],"pattern":[237],"enabled":[238],"efficiently":[241],"scan":[242],"more":[243],"APC":[244],"given":[247],"time.":[248],"This":[249],"work":[250],"defines":[251],"efficienT-cellular":[253],"against":[256],"ligand":[258,281],"detection":[259,282],"takes":[260],"place":[261],"T-cells.":[263],"Citation":[264],"Format:":[265],"En":[266],"Cai,":[267],"Kyle":[268],"Marchuk,":[269],"Casey":[270],"Beppler,":[271],"Matthew":[272],"Krummel.":[273],"Microvilli":[274],"efficient":[276],"[abstract].":[283],"In:":[284],"Proceedings":[285],"Fourth":[288],"CRI-CIMT-EATI-AACR":[289],"International":[290],"Cancer":[291,308],"Immunotherapy":[292],"Conference:":[293],"Translating":[294],"Science":[295],"Survival;":[297],"Sept":[298],"30-Oct":[299],"3,":[300],"2018;":[301],"New":[302],"York,":[303],"NY.":[304],"Philadelphia":[305],"(PA):":[306],"AACR;":[307],"Immunol":[309],"Res":[310],"2019;7(2":[311],"Suppl):Abstract":[312],"nr":[313],"B148.":[314]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2019-02-21T00:00:00"}