{"id":"https://openalex.org/W2912377312","doi":"https://doi.org/10.4236/jbm.2019.72007","title":"Triple Effect of Doxorubicin, 5-Fluorouracil, Propranolol on Cell Survival on MCF-7 Breast Cancer Cell Line","display_name":"Triple Effect of Doxorubicin, 5-Fluorouracil, Propranolol on Cell Survival on MCF-7 Breast Cancer Cell Line","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2912377312","doi":"https://doi.org/10.4236/jbm.2019.72007","mag":"2912377312"},"language":"en","primary_location":{"id":"doi:10.4236/jbm.2019.72007","doi":"https://doi.org/10.4236/jbm.2019.72007","is_oa":true,"landing_page_url":"https://doi.org/10.4236/jbm.2019.72007","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=90494","source":{"id":"https://openalex.org/S2764372278","display_name":"Journal of Biosciences and Medicines","issn_l":"2327-5081","issn":["2327-5081","2327-509X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biosciences and Medicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=90494","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028982308","display_name":"Onur Ero\u011flu","orcid":"https://orcid.org/0000-0002-3451-8540","observed_orcids":["https://orcid.org/0000-0002-3451-8540"]},"institutions":[{"id":"https://openalex.org/I169255954","display_name":"Bilecik \u015eeyh Edebali \u00dcniversitesi","ror":"https://ror.org/00dzfx204","country_code":"TR","type":"education","lineage":["https://openalex.org/I169255954"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Onur Eroglu","raw_affiliation_strings":["Biotechnology Research and Application Center, Bilecik Seyh Edebali University, Bilecik, Turkey","Department of Molecular Biology and Genetics, Faculty of Science and Letters, Bilecik Seyh Edebali University, Bilecik, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research and Application Center, Bilecik Seyh Edebali University, Bilecik, Turkey","institution_ids":["https://openalex.org/I169255954"]},{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Science and Letters, Bilecik Seyh Edebali University, Bilecik, Turkey","institution_ids":["https://openalex.org/I169255954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068496681","display_name":"Hacer Kaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169255954","display_name":"Bilecik \u015eeyh Edebali \u00dcniversitesi","ror":"https://ror.org/00dzfx204","country_code":"TR","type":"education","lineage":["https://openalex.org/I169255954"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hacer Kaya","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Faculty of Science and Letters, Bilecik Seyh Edebali University, Bilecik, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Science and Letters, Bilecik Seyh Edebali University, Bilecik, Turkey","institution_ids":["https://openalex.org/I169255954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102921439","display_name":"Esin G\u00fcvenir \u00c7elik","orcid":"https://orcid.org/0000-0002-3368-9700","observed_orcids":["https://orcid.org/0000-0002-3368-9700"]},"institutions":[{"id":"https://openalex.org/I169255954","display_name":"Bilecik \u015eeyh Edebali \u00dcniversitesi","ror":"https://ror.org/00dzfx204","country_code":"TR","type":"education","lineage":["https://openalex.org/I169255954"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Esin Guvenir Celik","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Faculty of Science and Letters, Bilecik Seyh Edebali University, Bilecik, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Science and Letters, Bilecik Seyh Edebali University, Bilecik, Turkey","institution_ids":["https://openalex.org/I169255954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071499398","display_name":"Merve Celen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169255954","display_name":"Bilecik \u015eeyh Edebali \u00dcniversitesi","ror":"https://ror.org/00dzfx204","country_code":"TR","type":"education","lineage":["https://openalex.org/I169255954"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Merve Celen","raw_affiliation_strings":["Vocational School of Medical Services, Program of Medical Laboratory Techniques, Bilecik Seyh Edebali University, Bilecik, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vocational School of Medical Services, Program of Medical Laboratory Techniques, Bilecik Seyh Edebali University, Bilecik, Turkey","institution_ids":["https://openalex.org/I169255954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080555750","display_name":"Elif Korkut","orcid":"https://orcid.org/0000-0002-4778-3781","observed_orcids":["https://orcid.org/0000-0002-4778-3781"]},"institutions":[{"id":"https://openalex.org/I188740104","display_name":"Ba\u015fkent University","ror":"https://ror.org/02v9bqx10","country_code":"TR","type":"education","lineage":["https://openalex.org/I188740104"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Elif Korkut","raw_affiliation_strings":["Department of Medical Genetics, Faculty of Medicine, Ba\u015fkent University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, Faculty of Medicine, Ba\u015fkent University, Ankara, Turkey","institution_ids":["https://openalex.org/I188740104"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5092426647","display_name":"Nagihan N\u0130ZAM","orcid":"https://orcid.org/0000-0002-7296-5050","observed_orcids":["https://orcid.org/0000-0002-7296-5050"]},"institutions":[{"id":"https://openalex.org/I169255954","display_name":"Bilecik \u015eeyh Edebali \u00dcniversitesi","ror":"https://ror.org/00dzfx204","country_code":"TR","type":"education","lineage":["https://openalex.org/I169255954"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nagihan Nizam","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Faculty of Science and Letters, Bilecik Seyh Edebali University, Bilecik, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Science and Letters, Bilecik Seyh Edebali University, Bilecik, Turkey","institution_ids":["https://openalex.org/I169255954"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028982308"],"corresponding_institution_ids":["https://openalex.org/I169255954"],"apc_list":null,"apc_paid":null,"fwci":0.3011,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.44397518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"07","issue":"02","first_page":"74","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6929000020027161,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6929000020027161,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":1.0},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":1.0},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6940000057220459},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.5830000042915344},{"id":"https://openalex.org/keywords/ic50","display_name":"IC50","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7929999828338623},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.6380000114440918},{"id":"https://openalex.org/keywords/wild-type-p53","display_name":"wild-type p53","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.8614412546157837},{"id":"https://openalex.org/C109541995","wikidata":"https://www.wikidata.org/wiki/Q1881253","display_name":"MCF-7","level":5,"score":0.7901387214660645},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.741073489189148},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.6450437307357788},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5753426551818848},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.5488137602806091},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5471285581588745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49883270263671875},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.3709830641746521},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3544664680957794},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3343183696269989},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2845315635204315},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2763518989086151},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2751390337944031},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1978609561920166},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.1032244861125946},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08350026607513428}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4236/jbm.2019.72007","doi":"https://doi.org/10.4236/jbm.2019.72007","is_oa":true,"landing_page_url":"https://doi.org/10.4236/jbm.2019.72007","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=90494","source":{"id":"https://openalex.org/S2764372278","display_name":"Journal of Biosciences and Medicines","issn_l":"2327-5081","issn":["2327-5081","2327-509X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biosciences and Medicines","raw_type":"journal-article"},{"id":"pmh:oai:acikkaynak.bilecik.edu.tr:11552/9579","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11552/9579","pdf_url":"https://acikkaynak.bilecik.edu.tr/bitstreams/6317b917-7aae-489b-9769-1bba8f6911ff/download","source":{"id":"https://openalex.org/S7407055253","display_name":"Bilecik \u015eeyh Edebali University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.4236/jbm.2019.72007","doi":"https://doi.org/10.4236/jbm.2019.72007","is_oa":true,"landing_page_url":"https://doi.org/10.4236/jbm.2019.72007","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=90494","source":{"id":"https://openalex.org/S2764372278","display_name":"Journal of Biosciences and Medicines","issn_l":"2327-5081","issn":["2327-5081","2327-509X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biosciences and Medicines","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2912377312.pdf","grobid_xml":"https://content.openalex.org/works/W2912377312.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1509291382","https://openalex.org/W1543790510","https://openalex.org/W1882271490","https://openalex.org/W1977622321","https://openalex.org/W1984328540","https://openalex.org/W1997385587","https://openalex.org/W2018652769","https://openalex.org/W2062941476","https://openalex.org/W2068577449","https://openalex.org/W2068694673","https://openalex.org/W2082976830","https://openalex.org/W2086034451","https://openalex.org/W2090077875","https://openalex.org/W2091458141","https://openalex.org/W2103885797","https://openalex.org/W2107567947","https://openalex.org/W2108155748","https://openalex.org/W2114865501","https://openalex.org/W2121258392","https://openalex.org/W2151356556","https://openalex.org/W2161761604","https://openalex.org/W2169054045","https://openalex.org/W2171892107","https://openalex.org/W2317055602","https://openalex.org/W2530867754","https://openalex.org/W2586749137","https://openalex.org/W2756562465","https://openalex.org/W4210673819","https://openalex.org/W4235030271"],"related_works":["https://openalex.org/W7217007984","https://openalex.org/W2957011528","https://openalex.org/W2383924397","https://openalex.org/W7203897756","https://openalex.org/W2082976830","https://openalex.org/W2114865501","https://openalex.org/W3144787325","https://openalex.org/W2105339861","https://openalex.org/W4306362565","https://openalex.org/W4389180988"],"abstract_inverted_index":{"Purpose:":[0],"Investigating":[1],"the":[2,38,85,132,187,193,198,209],"triple":[3],"effect":[4],"of":[5,30,33,87,104,211],"doxorubicin,":[6,34,60,88,105,212],"5-fluorouracil,":[7,35,64,89,106],"propranolol":[8,36,68,91,146,215],"on":[9,37,192],"MCF-7":[10,39,133,194],"(ER+,":[11],"WTp53)":[12],"breast":[13],"cancer":[14],"cell":[15,40,134,141,195],"line":[16,41,196],"with":[17,127,179],"MTT":[18,44,54],"test":[19],"and":[20,45,69,90,107,145,214],"survival":[21,46],"analysis.":[22],"Materials/Methods:":[23],"In":[24,131],"order":[25],"to":[26,129,157,163,181,207],"determine":[27],"effective":[28,96],"dosages":[29],"a":[31,218],"combination":[32,93,166,191,216],"by":[42,53],"using":[43],"analysis":[47],"technique.":[48],"Result:":[49],"IC50":[50],"values":[51],"acquired":[52],"tests":[55],"are":[56,79,111],"0.01":[57,138],"mg/ml":[58,62,66,71],"for":[59,63,67,197],"6":[61],"30":[65,174],"0.2/1/30":[70],"(with":[72],"previous":[73],"respect)":[74],"if":[75,109],"all":[76],"three":[77,188],"agents":[78],"combined.":[80],"It":[81],"is":[82,94,160,204],"found":[83],"that":[84],"use":[86],"in":[92,122,153,155,165,190,201],"much":[95],"than":[97],"their":[98],"single":[99],"application.":[100],"Discussion:":[101],"Moderate":[102],"concentrations":[103],"propranolol,":[108],"they":[110],"applied":[112,186],"individually,":[113],"showed":[114,176],"high":[115],"toxicity.":[116],"When":[117],"we":[118],"used":[119],"these":[120],"drugs":[121,189],"combination;":[123],"toxic":[124],"effects":[125,152,178],"lessened":[126],"respect":[128,180],"monotherapy.":[130],"line,":[135],"doxorubicin":[136],"(IC50:":[137,147,168,173],"\u03bcM)":[139,149,175],"increases":[140],"death":[142],"rates":[143],"significantly":[144],"3":[148],"has":[150],"minimum":[151],"monotherapy":[154],"contrast":[156],"others.":[158],"Propranolol":[159],"only":[161],"superior":[162],"itself":[164],"therapy":[167,220],"4":[169],"\u03bcM).":[170],"However":[171],"5-fluorouracil":[172,213],"antagonistic":[177],"other":[182],"drugs.":[183],"Additionally,":[184],"having":[185],"first":[199],"time":[200],"literature,":[202],"it":[203],"highly":[205],"possible":[206],"assess":[208],"application":[210],"as":[217],"novel":[219],"option.":[221]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-02-21T00:00:00"}