{"id":"https://openalex.org/W2912308296","doi":"https://doi.org/10.1159/000496019","title":"Highly Aggressive and Radiation-Resistant, \u201cAtypical\u201d and Silent Pituitary Corticotrophic Carcinoma: A Case Report and Review of the Literature","display_name":"Highly Aggressive and Radiation-Resistant, \u201cAtypical\u201d and Silent Pituitary Corticotrophic Carcinoma: A Case Report and Review of the Literature","publication_year":2019,"publication_date":"2019-02-08","ids":{"openalex":"https://openalex.org/W2912308296","doi":"https://doi.org/10.1159/000496019","mag":"2912308296","pmid":"https://pubmed.ncbi.nlm.nih.gov/31043952","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6477470"},"language":"en","primary_location":{"id":"doi:10.1159/000496019","doi":"https://doi.org/10.1159/000496019","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000496019","pdf_url":null,"source":{"id":"https://openalex.org/S62365728","display_name":"Case Reports in Oncology","issn_l":"1662-6575","issn":["1662-6575"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","norway-1","poland-40","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Case Reports in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1159/000496019","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058920402","display_name":"Laura E. Flores","orcid":"https://orcid.org/0000-0002-7861-5713","observed_orcids":["https://orcid.org/0000-0002-7861-5713"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Flores","raw_affiliation_strings":["College of Allied Health Professionals, University of Nebraska Medical Center, Omaha, Nebraska, USA","College of Allied Health Professionals, University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Allied Health Professionals, University of Nebraska Medical Center, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"College of Allied Health Professionals, University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058086823","display_name":"Richard L. Sleightholm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Sleightholm","raw_affiliation_strings":["Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska, USA","Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055721473","display_name":"Beth K. Neilsen","orcid":"https://orcid.org/0000-0002-4859-6486","observed_orcids":["https://orcid.org/0000-0002-4859-6486"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth Neilsen","raw_affiliation_strings":["Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska, USA","Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006831359","display_name":"Michael J. Baine","orcid":"https://orcid.org/0000-0002-1163-7539","observed_orcids":["https://orcid.org/0000-0002-1163-7539"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Baine","raw_affiliation_strings":["Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska, USA","Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036017161","display_name":"Andjela Drincic","orcid":"https://orcid.org/0000-0001-8365-7662","observed_orcids":["https://orcid.org/0000-0001-8365-7662"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andjela Drincic","raw_affiliation_strings":["Division of Endocrinology, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA","Division of Endocrinology, Department of Medicine, University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053903108","display_name":"William Thorell","orcid":"https://orcid.org/0000-0003-1489-8205","observed_orcids":["https://orcid.org/0000-0003-1489-8205"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Thorell","raw_affiliation_strings":["Division of Neurosurgery, Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA","Division of Neurosurgery, Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025601929","display_name":"Nicole Shonka","orcid":"https://orcid.org/0000-0002-8182-3409","observed_orcids":["https://orcid.org/0000-0002-8182-3409"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Shonka","raw_affiliation_strings":["Division of Oncology/Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA","Division of Oncology/Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology/Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Division of Oncology/Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016187749","display_name":"David Oupick\u00fd","orcid":"https://orcid.org/0000-0003-4710-861X","observed_orcids":["https://orcid.org/0000-0003-4710-861X"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Oupicky","raw_affiliation_strings":["Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA","Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073669300","display_name":"Chi Zhang","orcid":"https://orcid.org/0000-0001-8367-1149","observed_orcids":["https://orcid.org/0000-0001-8367-1149"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chi Zhang","raw_affiliation_strings":["Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska, USA","Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073669300"],"corresponding_institution_ids":["https://openalex.org/I59130452"],"apc_list":{"value":1170,"currency":"USD","value_usd":1170},"apc_paid":{"value":1170,"currency":"USD","value_usd":1170},"fwci":0.6084,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.70316587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"12","issue":"1","first_page":"139","last_page":"146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.7260000109672546},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cushing-disease","display_name":"Cushing's disease","score":0.7799999713897705},{"id":"https://openalex.org/keywords/psychosis","display_name":"psychosis","score":0.6010000109672546},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.800000011920929},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/radiofrequency-ablation","display_name":"radiofrequency ablation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/stereotactic-body-radiation-therapy","display_name":"stereotactic body radiotherapy","score":0.9610000252723694},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8330000042915344},{"id":"https://openalex.org/keywords/mitotic-rate","display_name":"mitotic activity","score":0.6240000128746033},{"id":"https://openalex.org/keywords/locally-invasive-tumor","display_name":"locally invasive tumor","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9050684571266174},{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.7735733985900879},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5615252256393433},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.5462484359741211},{"id":"https://openalex.org/C2781449511","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary tumors","level":2,"score":0.5169445872306824},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43393343687057495},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4285281300544739},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3679451644420624}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1159/000496019","doi":"https://doi.org/10.1159/000496019","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000496019","pdf_url":null,"source":{"id":"https://openalex.org/S62365728","display_name":"Case Reports in Oncology","issn_l":"1662-6575","issn":["1662-6575"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","norway-1","poland-40","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Case Reports in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5476682","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6477470","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6477470","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6477470","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Case Rep Oncol","raw_type":"Text"},{"id":"pmid:31043952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31043952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Case reports in oncology","raw_type":"Case Reports"},{"id":"pmh:oai:doaj.org/article:2eebe8c273114bbda4b3da371866a9d7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2eebe8c273114bbda4b3da371866a9d7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Case Reports in Oncology, Vol 12, Iss 1, Pp 139-146 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1159/000496019","doi":"https://doi.org/10.1159/000496019","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000496019","pdf_url":null,"source":{"id":"https://openalex.org/S62365728","display_name":"Case Reports in Oncology","issn_l":"1662-6575","issn":["1662-6575"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","norway-1","poland-40","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Case Reports in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[{"id":"https://openalex.org/G2938025278","display_name":"Discovering Vulnerabilities in Ras-driven Cancers","funder_award_id":"F30CA203397","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W11220192","https://openalex.org/W627244622","https://openalex.org/W1531919129","https://openalex.org/W1532764056","https://openalex.org/W1607070363","https://openalex.org/W1976005085","https://openalex.org/W1981171396","https://openalex.org/W1981498768","https://openalex.org/W1982756072","https://openalex.org/W1985766420","https://openalex.org/W1990181362","https://openalex.org/W1991062165","https://openalex.org/W1993860678","https://openalex.org/W2002852108","https://openalex.org/W2014360334","https://openalex.org/W2016950386","https://openalex.org/W2026870745","https://openalex.org/W2033680813","https://openalex.org/W2039899387","https://openalex.org/W2050079330","https://openalex.org/W2052506678","https://openalex.org/W2058254927","https://openalex.org/W2062019831","https://openalex.org/W2088975177","https://openalex.org/W2100396774","https://openalex.org/W2119847613","https://openalex.org/W2123761756","https://openalex.org/W2127400392","https://openalex.org/W2131388016","https://openalex.org/W2148304836","https://openalex.org/W2166094499","https://openalex.org/W2171238446","https://openalex.org/W2404553822","https://openalex.org/W2468085889","https://openalex.org/W2511071682","https://openalex.org/W2562164006","https://openalex.org/W2623245238","https://openalex.org/W2755312700","https://openalex.org/W2766825024","https://openalex.org/W2802161257"],"related_works":["https://openalex.org/W6987205689","https://openalex.org/W4200274498","https://openalex.org/W1584253498","https://openalex.org/W4293161980","https://openalex.org/W4393056116","https://openalex.org/W4281846341","https://openalex.org/W2901797773","https://openalex.org/W2004031828","https://openalex.org/W4285793767","https://openalex.org/W2034080468"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pituitary":[1],"tumors":[2,16],"typically":[3],"remain":[4],"silent":[5,192],"unless":[6],"interaction":[7],"with":[8,52,72,78,146,165,211],"nearby":[9],"structures":[10],"occurs.":[11],"Rare":[12],"subsets":[13],"of":[14,81,86,117,127,183,189,213,221,241,249],"pituitary":[15,64,76,185,251],"display":[17],"aggressive":[18,63,250],"phenotypes:":[19],"highly":[20],"mitotic,":[21],"locally":[22,91],"invasive,":[23],"metastatic,":[24],"chemotherapy":[25],"and":[26,32,41,55,90,95,136,141,149,194,216,229],"radiation":[27,152,236],"resistant,":[28],"etc.":[29],"Disease":[30],"progression":[31],"response":[33],"to":[34,132,223,235],"therapy":[35],"is":[36,46,179],"ill-defined":[37],"in":[38,62,158,161,246],"these":[39],"subtypes,":[40],"their":[42],"true":[43],"prognostic":[44,53],"potential":[45],"debated.":[47],"Thus,":[48,238],"identifying":[49,125],"tumor":[50],"characteristics":[51,188],"value":[54],"efficacious":[56],"treatment":[57,156,225,248],"options":[58],"remains":[59],"a":[60,73,122,159,180,184],"challenge":[61],"tumors.":[65,252],"CASE":[66],"PRESENTATION:":[67],"A":[68],"45-year-old":[69],"female":[70],"presented":[71],"nonfunctioning":[74],"corticotropic":[75,193],"macroadenoma":[77,196],"biomarkers":[79],"suggestive":[80],"an":[82,115],"\"atypical\"":[83,195],"subtype:":[84],"Ki-67":[85],"8-12%,":[87],"increased":[88],"mitosis,":[89],"invasive.":[92],"Despite":[93],"resections":[94],"radiation,":[96],"growth":[97],"continued,":[98],"eventually":[99],"affecting":[100],"her":[101,133,137,162,166,224,227],"vision.":[102],"Although":[103,198],"histologically":[104],"ACTH":[105,163,200],"positive,":[106],"the":[107,205,219,239,247],"patient":[108],"remained":[109],"clinically":[110,191,203],"asymptomatic.":[111],"Twelve":[112],"months":[113,172],"later,":[114],"episode":[116],"Cushing's":[118,214],"disease-induced":[119],"psychosis":[120],"prompted":[121],"PET-CT":[123],"scan,":[124],"sites":[126,231],"metastasis.":[128],"Temozolomide":[129],"was":[130],"added":[131],"medical":[134],"regimen,":[135],"metastatic":[138,230],"liver":[139],"lesions":[140],"boney":[142],"metastases":[143],"were":[144],"treated":[145],"radiofrequency":[147],"ablation":[148],"stereotactic":[150],"body":[151],"therapy,":[153],"respectively.":[154],"Systemic":[155],"resulted":[157],"drop":[160],"levels,":[164],"most":[167],"recent":[168],"scans/labs":[169],"at":[170],"12":[171],"following":[173],"RFA":[174],"suggesting":[175],"remission.":[176],"CONCLUSIONS:":[177],"This":[178],"unique":[181],"presentation":[182],"tumor,":[186],"displaying":[187],"both":[190],"subtypes.":[197],"initially":[199],"positive":[201],"while":[202],"silent,":[204],"patient's":[206],"disease":[207,215],"ultimately":[208],"recurred":[209],"metastatically":[210],"manifestations":[212],"psychosis.":[217],"With":[218],"addition":[220,240],"temozolomide":[222,242],"plan,":[226],"primary":[228],"have":[232],"responded":[233],"favorably":[234],"therapy.":[237],"may":[243],"be":[244],"beneficial":[245]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-02-21T00:00:00"}