{"id":"https://openalex.org/W2912304271","doi":"https://doi.org/10.1158/1538-7445.pedca17-a22","title":"Abstract A22: Identification of gene expression differences between primary pediatric tumors and their PDX models","display_name":"Abstract A22: Identification of gene expression differences between primary pediatric tumors and their PDX models","publication_year":2018,"publication_date":"2018-10-01","ids":{"openalex":"https://openalex.org/W2912304271","doi":"https://doi.org/10.1158/1538-7445.pedca17-a22","mag":"2912304271"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.pedca17-a22","doi":"https://doi.org/10.1158/1538-7445.pedca17-a22","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.pedca17-a22","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067945000","display_name":"Jacob Pfeil","orcid":"https://orcid.org/0000-0002-8773-8520","observed_orcids":["https://orcid.org/0000-0002-8773-8520"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob J. Pfeil","raw_affiliation_strings":["1UCSC, Santa Cruz, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCSC, Santa Cruz, CA,","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021539098","display_name":"Alex Gia Lee","orcid":"https://orcid.org/0000-0003-0107-5920","observed_orcids":["https://orcid.org/0000-0003-0107-5920","https://orcid.org/0000-0002-4583-0740"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex G. Lee","raw_affiliation_strings":["2UCSF, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2UCSF, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056872209","display_name":"Leanne C. Sayles","orcid":"https://orcid.org/0000-0003-3963-6412","observed_orcids":["https://orcid.org/0000-0003-3963-6412"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leanne C. Sayles","raw_affiliation_strings":["2UCSF, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2UCSF, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038999588","display_name":"Ellen Towle Kephart","orcid":"https://orcid.org/0000-0002-3117-4439","observed_orcids":["https://orcid.org/0000-0002-3117-4439"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen T. Kephart","raw_affiliation_strings":["1UCSC, Santa Cruz, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCSC, Santa Cruz, CA,","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030798059","display_name":"Holly C. Beale","orcid":"https://orcid.org/0000-0003-4091-538X","observed_orcids":["https://orcid.org/0000-0003-4091-538X"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly C. Beale","raw_affiliation_strings":["1UCSC, Santa Cruz, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCSC, Santa Cruz, CA,","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004644133","display_name":"Lauren Sanders","orcid":"https://orcid.org/0000-0001-9393-0861","observed_orcids":["https://orcid.org/0000-0001-9393-0861"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren M. Sanders","raw_affiliation_strings":["1UCSC, Santa Cruz, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCSC, Santa Cruz, CA,","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109267874","display_name":"Olena Morozova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olena Morozova","raw_affiliation_strings":["2UCSF, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2UCSF, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057187122","display_name":"Sofie R. Salama","orcid":"https://orcid.org/0000-0001-6999-7193","observed_orcids":["https://orcid.org/0000-0001-6999-7193"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sofie R. Salama","raw_affiliation_strings":["1UCSC, Santa Cruz, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCSC, Santa Cruz, CA,","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026362990","display_name":"Alejandro Sweet-Cordero","orcid":"https://orcid.org/0000-0002-9787-9351","observed_orcids":["https://orcid.org/0000-0002-9787-9351"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandro Sweet-Cordero","raw_affiliation_strings":["2UCSF, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2UCSF, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090849321","display_name":"David H. Haussler","orcid":"https://orcid.org/0000-0003-1533-4575","observed_orcids":["https://orcid.org/0000-0003-1533-4575"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Haussler","raw_affiliation_strings":["1UCSC, Santa Cruz, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCSC, Santa Cruz, CA,","institution_ids":["https://openalex.org/I185103710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"19_Supplement","first_page":"A22","last_page":"A22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.4796999990940094,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.4796999990940094,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.22300000488758087,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.12269999831914902,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-cancer","display_name":"childhood cancer","score":0.8019999861717224},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9779999852180481},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8399999737739563},{"id":"https://openalex.org/keywords/drug-response-prediction","display_name":"drug response prediction","score":0.6830000281333923},{"id":"https://openalex.org/keywords/tnf-signaling","display_name":"TNF signaling","score":0.878000020980835},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.7002245783805847},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.680001437664032},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5837628245353699},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5444582104682922},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.509888768196106},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4849972426891327},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47753942012786865},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4226163327693939},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3880147933959961},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37998437881469727},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22736376523971558},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2265116572380066}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.pedca17-a22","doi":"https://doi.org/10.1158/1538-7445.pedca17-a22","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.pedca17-a22","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2986723641","https://openalex.org/W3070475142","https://openalex.org/W3047600203","https://openalex.org/W317780140","https://openalex.org/W7095931631","https://openalex.org/W7100005891","https://openalex.org/W2808943109","https://openalex.org/W2891097641","https://openalex.org/W2566243764","https://openalex.org/W2134030033"],"abstract_inverted_index":{"Abstract":[0],"Molecularly":[1],"targeted":[2,21,61,114],"therapies":[3,22,62],"inhibit":[4],"specific":[5,132],"cancer":[6,44,65,80,93,133,168,258],"pathways":[7,45],"and":[8,35,142,162,176,181,198,239,259,308],"have":[9,38],"fewer":[10],"harmful":[11],"side":[12],"effects":[13],"than":[14],"cytotoxic":[15],"chemotherapies;":[16],"however,":[17],"the":[18,86,125,234,249,316,327],"development":[19],"of":[20,30,78,88,124,131,227,236,256,300,315],"for":[23,63,91,101,110,243,264],"childhood":[24,36,64],"cancers":[25,37],"has":[26],"lagged":[27],"behind":[28],"that":[29,74,153],"adult":[31,34],"cancers.":[32],"Although":[33],"different":[39],"molecular":[40],"mechanisms,":[41],"similar":[42,167],"druggable":[43],"may":[46,232],"be":[47,241],"activated.":[48],"We":[49,67,135,170],"propose":[50],"using":[51,245],"gene":[52,71,81,98,138,215,253,301],"expression":[53,72,82,99,139,174,216,254,302],"analysis":[54,117,175,210],"to":[55,58,112,326],"identify":[56],"opportunities":[57],"reposition":[59],"FDA-approved":[60],"patients.":[66],"developed":[68],"an":[69],"N-of-1":[70],"approach":[73,90],"leverages":[75],"a":[76,166,223,261],"compendium":[77],"~11,000":[79],"profiles.":[83],"To":[84],"evaluate":[85],"utility":[87],"this":[89,246],"identifying":[92,219],"driver":[94],"pathways,":[95],"we":[96,151],"analyzed":[97],"data":[100],"9":[102,126],"patient-derived":[103],"xenograft":[104],"(PDX)":[105],"tumors.":[106,187,229],"PDXs":[107,127],"were":[108,190,204],"tested":[109],"sensitivity":[111,121],"selected":[113],"therapies.":[115],"Our":[116],"correctly":[118],"predicted":[119],"drug":[120],"in":[122,185,206,214],"8":[123],"based":[128],"on":[129],"overexpression":[130],"pathways.":[134],"also":[136,171,218],"compared":[137],"between":[140,304],"PDX":[141,154,186,228,237,250,310],"matched":[143,159],"primary":[144,160,305],"tumor":[145,161],"samples":[146,164],"(n=7).":[147],"Using":[148],"TumorMap":[149],"analysis,":[150],"found":[152,177],"tumors":[155,307],"cluster":[156],"with":[157,165,192],"their":[158,309],"other":[163],"diagnosis.":[169],"ran":[172],"differential":[173],"260":[178],"overexpressed":[179],"genes":[180,184,189,203],"630":[182],"underexpressed":[183],"Underexpressed":[188],"associated":[191],"immune":[193],"functions,":[194],"extracellular":[195],"matrix":[196],"proteins,":[197],"growth":[199],"factor":[200],"signaling.":[201,208],"Overexpressed":[202],"involved":[205],"TNF-\u03b1;":[207,220],"This":[209],"confirmed":[211],"expected":[212],"changes":[213],"while":[217],"signaling":[221],"as":[222],"potential":[224],"biologic":[225],"artifact":[226],"These":[230],"features":[231,255],"influence":[233],"results":[235],"experiments":[238],"should":[240],"accounted":[242],"when":[244],"model.":[247],"Overall,":[248],"model":[251],"recapitulates":[252],"pediatric":[257,306],"is":[260],"powerful":[262],"tool":[263],"evaluating":[265],"novel":[266],"precision":[267],"medicine":[268],"approaches.":[269],"Citation":[270],"Format:":[271],"Jacob":[272],"J.":[273],"Pfeil,":[274],"Alex":[275],"G.":[276],"Lee,":[277],"Leanne":[278],"C.":[279,285],"Sayles,":[280],"Ellen":[281],"T.":[282],"Kephart,":[283],"Holly":[284],"Beale,":[286],"Lauren":[287],"M.":[288],"Sanders,":[289],"Olena":[290],"Morozova,":[291],"Sofie":[292],"R.":[293],"Salama,":[294],"Alejandro":[295],"Sweet-Cordero,":[296],"David":[297],"Haussler.":[298],"Identification":[299],"differences":[303],"models":[311],"[abstract].":[312],"In:":[313],"Proceedings":[314],"AACR":[317],"Special":[318],"Conference:":[319],"Pediatric":[320],"Cancer":[321,337],"Research:":[322],"From":[323],"Basic":[324],"Science":[325],"Clinic;":[328],"2017":[329],"Dec":[330],"3-6;":[331],"Atlanta,":[332],"Georgia.":[333],"Philadelphia":[334],"(PA):":[335],"AACR;":[336],"Res":[338],"2018;78(19":[339],"Suppl):Abstract":[340],"nr":[341],"A22.":[342]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2019-02-21T00:00:00"}
