{"id":"https://openalex.org/W2912246453","doi":"https://doi.org/10.1002/cam4.2006","title":"Recognition of HER2 expression in hepatocellular carcinoma and its significance in postoperative tumor recurrence","display_name":"Recognition of HER2 expression in hepatocellular carcinoma and its significance in postoperative tumor recurrence","publication_year":2019,"publication_date":"2019-02-04","ids":{"openalex":"https://openalex.org/W2912246453","doi":"https://doi.org/10.1002/cam4.2006","mag":"2912246453","pmid":"https://pubmed.ncbi.nlm.nih.gov/30714677","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6434216"},"language":"en","primary_location":{"id":"doi:10.1002/cam4.2006","doi":"https://doi.org/10.1002/cam4.2006","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.2006","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.2006","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2912246453"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.2006","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076009573","display_name":"Jihua Shi","orcid":"https://orcid.org/0000-0002-9267-7523","observed_orcids":["https://orcid.org/0000-0002-9267-7523"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN","NO"],"is_corresponding":false,"raw_author_name":"Ji\u2010Hua Shi","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, Henan Key Laboratory of Digestive Organ transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China","Department of Transplantation Medicine, Institute of Surgical Research, Oslo University Hospital, Oslo, Norway"],"raw_orcid":"https://orcid.org/0000-0002-9267-7523","affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, Henan Key Laboratory of Digestive Organ transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Department of Transplantation Medicine, Institute of Surgical Research, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wen\u2010Zhi Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen\u2010Zhi Guo","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, Henan Key Laboratory of Digestive Organ transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, Henan Key Laboratory of Digestive Organ transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100343815","display_name":"Yang Jin","orcid":"https://orcid.org/0000-0002-7996-048X","observed_orcids":["https://orcid.org/0000-0002-7996-048X","https://orcid.org/0000-0003-1671-8343"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Yang Jin","raw_affiliation_strings":["Department of Biosciences, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102868682","display_name":"Huapeng Zhang","orcid":"https://orcid.org/0000-0002-8729-6523","observed_orcids":["https://orcid.org/0000-0002-8729-6523"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua-Peng Zhang","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, Henan Key Laboratory of Digestive Organ transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, Henan Key Laboratory of Digestive Organ transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chun Pang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun Pang","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, Henan Key Laboratory of Digestive Organ transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, Henan Key Laboratory of Digestive Organ transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100742387","display_name":"Jie Li","orcid":"https://orcid.org/0000-0002-2540-7494","observed_orcids":["https://orcid.org/0000-0002-2540-7494"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Li","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, Henan Key Laboratory of Digestive Organ transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, Henan Key Laboratory of Digestive Organ transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086349004","display_name":"P\u00e5l\u2010Dag Line","orcid":"https://orcid.org/0000-0002-5884-9336","observed_orcids":["https://orcid.org/0000-0002-5884-9336"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"P\u00e5l\u2010Dag Line","raw_affiliation_strings":["Department of Transplantation Medicine, Institute of Surgical Research, Oslo University Hospital, Oslo, Norway","Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplantation Medicine, Institute of Surgical Research, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085203241","display_name":"Shuijun Zhang","orcid":"https://orcid.org/0000-0003-4893-4331","observed_orcids":["https://orcid.org/0000-0003-4893-4331"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shui\u2010Jun Zhang","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, Henan Key Laboratory of Digestive Organ transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, Henan Key Laboratory of Digestive Organ transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5085203241","https://openalex.org/A5086349004"],"corresponding_institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I184942183","https://openalex.org/I38877650","https://openalex.org/I4210156804"],"apc_list":{"value":2750,"currency":"USD","value_usd":2750},"apc_paid":{"value":2750,"currency":"USD","value_usd":2750},"fwci":3.0329,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.93045916,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"8","issue":"3","first_page":"1269","last_page":"1278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.12319999933242798,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.875},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/postoperative-tumor-recurrence","display_name":"postoperative tumor recurrence","score":0.7250000238418579},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.906000018119812},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9520000219345093},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9160000085830688},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.8289999961853027},{"id":"https://openalex.org/keywords/smad3","display_name":"Smad3","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.6499999761581421},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9729999899864197},{"id":"https://openalex.org/keywords/her2-targeted-therapy","display_name":"HER2-targeted therapy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.8619130849838257},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6647339463233948},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.6020554304122925},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5952064990997314},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.5925556421279907},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5898730158805847},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.572329044342041},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.571783185005188},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5309284329414368},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4109411835670471},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33008497953414917},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3233479857444763},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2979710102081299},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2829221487045288},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.27261853218078613},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2183821201324463},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.11723041534423828},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07118025422096252},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011184","descriptor_name":"Postoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051900","descriptor_name":"Smad3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1002/cam4.2006","doi":"https://doi.org/10.1002/cam4.2006","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.2006","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.2006","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5436392","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6434216","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30714677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30714677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6434216","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6434216/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9149469d93454e9bb91cfb44ebc3c6b5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9149469d93454e9bb91cfb44ebc3c6b5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Medicine, Vol 8, Iss 3, Pp 1269-1278 (2019)","raw_type":"article"},{"id":"pmh:oai:www.duo.uio.no:10852/74298","doi":null,"is_oa":true,"landing_page_url":"http://urn.nb.no/URN:NBN:no-77391","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2045-7634","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/cam4.2006","doi":"https://doi.org/10.1002/cam4.2006","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.2006","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.2006","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335774","display_name":"Key Technologies Research and Development Program","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2912246453.pdf","grobid_xml":"https://content.openalex.org/works/W2912246453.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W59117797","https://openalex.org/W155652442","https://openalex.org/W1491220176","https://openalex.org/W1757407923","https://openalex.org/W1971837077","https://openalex.org/W1973701648","https://openalex.org/W1976203623","https://openalex.org/W1980523883","https://openalex.org/W1993472217","https://openalex.org/W1993871753","https://openalex.org/W1994974515","https://openalex.org/W2015143670","https://openalex.org/W2016586043","https://openalex.org/W2040108549","https://openalex.org/W2041331415","https://openalex.org/W2056579307","https://openalex.org/W2056846662","https://openalex.org/W2095156669","https://openalex.org/W2105912300","https://openalex.org/W2110094917","https://openalex.org/W2123206362","https://openalex.org/W2132611552","https://openalex.org/W2141393790","https://openalex.org/W2147172608","https://openalex.org/W2179507467","https://openalex.org/W2213661638","https://openalex.org/W2417723070","https://openalex.org/W2471860058","https://openalex.org/W2560499218","https://openalex.org/W2607237735","https://openalex.org/W2751640563","https://openalex.org/W2765091286","https://openalex.org/W2806608984"],"related_works":["https://openalex.org/W4319348114","https://openalex.org/W7122561296","https://openalex.org/W2315929299","https://openalex.org/W2008865737","https://openalex.org/W7162645916","https://openalex.org/W2015143670","https://openalex.org/W4362593680","https://openalex.org/W4403652580","https://openalex.org/W2387835089","https://openalex.org/W2001364602"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"ERBB2":[2,106],"oncogene":[3],"hypothesis":[4],"is":[5,221,234,244],"challenged":[6],"in":[7,44,111,119,132,171,194],"hepatocellular":[8],"carcinoma":[9],"(HCC)":[10],"with":[11,123,147,158,184,223],"the":[12,159,172,229,248],"conflicting":[13],"evidences":[14],"of":[15,55,76,149,164,178,211,215,232],"human":[16],"epidermal":[17],"growth":[18,251],"factor":[19],"receptor":[20],"2":[21],"(HER2)":[22],"overexpression.":[23],"HER2":[24,43,128,181,207,218,233],"could":[25],"be":[26],"a":[27,31,124],"new":[28],"target":[29],"as":[30,36,38],"treatment":[32,243],"option":[33],"for":[34],"HCC":[35,45,56,62,92,112,122,140],"well":[37],"tumor":[39,143,196,224,250],"recurrence":[40],"after":[41],"surgery.":[42],"biology":[46],"needs":[47],"further":[48],"explorations.":[49],"METHODS:":[50],"Clinical":[51],"and":[52,65,69,79,87,98,114,137,142,152,187,198,213,226,240],"mRNA":[53,107],"data":[54],"patients":[57],"were":[58,71,103],"obtained":[59],"from":[60],"TCGA":[61],"cohort,":[63],"GSE89377":[64],"GSE115018.":[66],"Western":[67],"Blotting":[68],"immunohistochemistry":[70],"employed":[72],"to":[73,175,246],"test":[74],"expression":[75,116,148,182,219],"HER2,":[77,150],"E-cadherin,":[78,151],"Vimentin.":[80,189],"In":[81],"HepG2,":[82,134],"JM1,":[83],"HER2-transfected":[84],"McA":[85],"cells,":[86,91,136,180],"TGF-\u03b2":[88],"cocultured":[89],"JM1":[90,135,179],"biology,":[93],"including":[94],"cell":[95],"survival,":[96],"proliferation,":[97],"epithelial-to-mesenchymal":[99],"transition":[100],"(EMT)":[101],"phenotypes":[102],"evaluated.":[104],"RESULTS:":[105],"amplification":[108],"was":[109,117,130,145],"found":[110,235],"datasets,":[113],"its":[115],"downregulated":[118,185],"high":[120,160],"grade":[121],"worse":[125],"overall":[126,227],"survival.":[127],"overexpression":[129],"identified":[131],"H4IIE,":[133],"82%":[138],"(14/17)":[139],"samples,":[141],"stage":[144,225],"correlated":[146],"Vimentin":[153],"(P":[154,168,200],"<":[155,169,201],"0.05).":[156,202],"Trastuzumab":[157,190],"concentrations":[161],"suppressed":[162],"proliferation":[163],"HER2-positive":[165],"hepatoma":[166],"cells":[167],"0.05);":[170],"coculture":[173],"model":[174],"induce":[176],"EMT":[177],"increased":[183],"E-cadherin":[186],"upregulated":[188],"intravenous":[191],"injection":[192],"inhibited":[193],"vivo":[195],"size":[197],"metastases":[199],"Signal":[203],"analysis":[204],"revealed":[205],"that":[206],"functioned":[208],"through":[209,238],"upregulation":[210],"\u03b2-catenin":[212,239],"inhibition":[214],"SMAD3.":[216,241],"CONCLUSION:":[217],"pattern":[220],"linked":[222],"survival;":[228],"transforming":[230],"function":[231],"more":[236],"relevant":[237],"HER2-targeted":[242],"recommended":[245],"suppress":[247],"HER2-mediated":[249],"during":[252],"postoperative":[253],"liver":[254],"regeneration.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-02-21T00:00:00"}
