{"id":"https://openalex.org/W2911950311","doi":"https://doi.org/10.14309/00000434-201710001-00917","title":"Hepatorenal Syndrome: 2000-2014 Inpatient Hospitalization and Mortality Trends","display_name":"Hepatorenal Syndrome: 2000-2014 Inpatient Hospitalization and Mortality Trends","publication_year":2017,"publication_date":"2017-10-01","ids":{"openalex":"https://openalex.org/W2911950311","doi":"https://doi.org/10.14309/00000434-201710001-00917","mag":"2911950311"},"language":"en","primary_location":{"id":"doi:10.14309/00000434-201710001-00917","doi":"https://doi.org/10.14309/00000434-201710001-00917","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201710001-00917","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063852509","display_name":"Karthik Kailasam","orcid":"https://orcid.org/0000-0001-7300-3251","observed_orcids":["https://orcid.org/0000-0001-7300-3251"]},"institutions":[{"id":"https://openalex.org/I141649380","display_name":"Western Michigan University","ror":"https://ror.org/04j198w64","country_code":"US","type":"education","lineage":["https://openalex.org/I141649380"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karthik Kailasam","raw_affiliation_strings":["Western Michigan University School of Medicine, Kalamazoo, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western Michigan University School of Medicine, Kalamazoo, MI","institution_ids":["https://openalex.org/I141649380"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070189250","display_name":"Marie Ravichandar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159337121","display_name":"Madras Medical College","ror":"https://ror.org/050ztxn78","country_code":"IN","type":"education","lineage":["https://openalex.org/I159337121"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Marie Ravichandar","raw_affiliation_strings":["Madras Medical College, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Madras Medical College, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I159337121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112475408","display_name":"Naveen Prasad Gopalakrishnan Ravikumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naveen Prasad Gopalakrishnan Ravikumar","raw_affiliation_strings":["State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082729194","display_name":"Hardik Satish Chhatrala","orcid":"https://orcid.org/0000-0002-8894-2777","observed_orcids":["https://orcid.org/0000-0002-8894-2777"]},"institutions":[{"id":"https://openalex.org/I141649380","display_name":"Western Michigan University","ror":"https://ror.org/04j198w64","country_code":"US","type":"education","lineage":["https://openalex.org/I141649380"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hardik Chhatrala","raw_affiliation_strings":["Western Michigan University School of Medicine, Kalamazoo, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western Michigan University School of Medicine, Kalamazoo, MI","institution_ids":["https://openalex.org/I141649380"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.1533,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.56391561,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"112","issue":null,"first_page":"S514","last_page":"S515"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatorenal-syndrome","display_name":"hepatorenal syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/in-hospital-mortality","display_name":"in-hospital mortality","score":0.9570000171661377},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.9950000047683716},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.968999981880188},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.871999979019165},{"id":"https://openalex.org/keywords/albumin-therapy","display_name":"albumin therapy","score":0.656000018119812},{"id":"https://openalex.org/keywords/nationwide-inpatient-sample","display_name":"National Inpatient Sample","score":0.800000011920929},{"id":"https://openalex.org/keywords/hospitalization-rates","display_name":"hospitalization rates","score":0.45500001311302185},{"id":"https://openalex.org/keywords/end-stage-liver-disease","display_name":"end-stage liver disease","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9495048522949219},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.533674418926239},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5239658355712891},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.40121734142303467},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.39220452308654785},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.383100688457489},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3806998133659363},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/00000434-201710001-00917","doi":"https://doi.org/10.14309/00000434-201710001-00917","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201710001-00917","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3209171320","https://openalex.org/W3212858509","https://openalex.org/W2312452146","https://openalex.org/W2921324761","https://openalex.org/W3217181634","https://openalex.org/W2409862531","https://openalex.org/W4302275159","https://openalex.org/W4316079989","https://openalex.org/W4316085444","https://openalex.org/W2606115999"],"abstract_inverted_index":{"Introduction:":[0],"To":[1],"study":[2],"the":[3,28,39,74,107,158,247,257,290,296],"hospitalization":[4,149,161,291],"and":[5,69,101,134,208,286,310],"inpatient":[6,70,102,210,316],"mortality":[7,103,135,211,221,300],"trends":[8,61],"for":[9,27,49,60,81,114],"hepatorenal":[10],"syndrome":[11,253],"(HRS)":[12],"between":[13],"2000-2014.":[14,30],"Methods:":[15],"An":[16],"observational":[17],"analysis":[18],"was":[19,56,98,104,131,136,143,155],"performed":[20],"using":[21],"Nationwide":[22],"Inpatient":[23,220,279,338],"Sample":[24],"(NIS)":[25],"database":[26],"years":[29],"NIS":[31],"represents":[32],"20%":[33],"of":[34,66,86,95,119,128,160,183,237,256,259,283,318,320,328,341],"all":[35],"hospital":[36,67,96,129,184],"data":[37],"in":[38,62,148,263],"US.":[40],"Patients":[41],"were":[42,78,111],"identified":[43],"by":[44,163,187,213,223],"ICD":[45],"9":[46,132],"code":[47],"572.4":[48],"HRS.":[50],"A":[51],"simple":[52],"linear":[53],"regression":[54],"model":[55],"used":[57],"to":[58,140,171,197,229,307],"analyze":[59],"admission":[63],"rates,":[64],"length":[65,94,127,182],"stay":[68,97,130,185],"mortality.":[71],"Results:":[72],"In":[73,106],"year":[75,108,191,226,249],"2000,":[76],"there":[77,110,142],"1,408":[79],"admissions":[80,113],"HRS":[82,115,252],"with":[83,116,173,199,234,265,276],"a":[84,117,243,273],"rate":[85,118,159,334],"4.99":[87],"per":[88,121,165,167,190,225,335],"one":[89,122,255],"million":[90,123,166,336],"population.":[91,124],"The":[92,125,180],"mean":[93,126,181],"7.6":[99],"days":[100,133,189],"51.3%.":[105],"2014,":[109,172,198,209],"3,440":[112],"10.79":[120],"23.9%.":[137],"Between":[138,206],"2000":[139,196,207,228],"2006,":[141],"no":[144],"statistically":[145],"significant":[146,244],"difference":[147],"rates":[150,292,301],"(Pearson's":[151],"correlation":[152],"coefficient":[153],"r":[154,174,200,235],"0).":[156],"However,":[157],"increased":[162,186,294],"0.8":[164],"year,":[168],"from":[169,195,227],"2007":[170],"value":[175,201,236],"0.93":[176],"(p":[177,192,203,231,239],"<":[178,193,204,218,232,240],"0.001).":[179,205,219],"0.15":[188],"0.001),":[194,233,241],"0.84":[202],"decreased":[212,222],"27.36%":[214],"(CI":[215],"24.33-30.35":[216],"p":[217],"1.82%":[224],"2014":[230],"-0.98":[238],"demonstrating":[242],"decrease":[245],"over":[246,295],"fifteen":[248,298],"period.":[250],"Conclusion:":[251],"is":[254,272],"causes":[258],"acute":[260,266],"kidney":[261],"injury,":[262],"patients":[264,329],"or":[267],"chronic":[268],"liver":[269,323,331],"disease.":[270],"It":[271],"life-threatening":[274],"condition":[275],"poor":[277],"prognosis.":[278],"management":[280,317],"mainly":[281],"consists":[282],"albumin,":[284],"octreotide":[285],"vasopressors.":[287],"Even":[288],"though,":[289],"have":[293,302],"last":[297],"years,":[299],"significantly":[303],"reduced;":[304],"likely":[305],"due":[306],"early":[308],"recognition":[309],"prompt":[311],"medical":[312],"management.":[313],"Therefore,":[314],"successful":[315],"complications":[319],"end":[321],"stage":[322],"disease":[324],"will":[325],"improve":[326],"outcomes":[327],"awaiting":[330],"transplantation.Figure:":[332],"Hospitalization":[333],"population.Figure:":[337],"mortality.Figure:":[339],"Length":[340],"stay.":[342]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-02-21T00:00:00"}