{"id":"https://openalex.org/W2911747652","doi":"https://doi.org/10.3389/fnins.2019.00043","title":"The Role of NMDA Receptors in Alzheimer\u2019s Disease","display_name":"The Role of NMDA Receptors in Alzheimer\u2019s Disease","publication_year":2019,"publication_date":"2019-02-07","ids":{"openalex":"https://openalex.org/W2911747652","doi":"https://doi.org/10.3389/fnins.2019.00043","mag":"2911747652","pmid":"https://pubmed.ncbi.nlm.nih.gov/30800052","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6375899"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2019.00043","doi":"https://doi.org/10.3389/fnins.2019.00043","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2019.00043","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2019.00043/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnins.2019.00043/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100606672","display_name":"Jinping Liu","orcid":"https://orcid.org/0000-0001-6748-8432","observed_orcids":["https://orcid.org/0000-0001-6748-8432","https://orcid.org/0000-0002-9356-4758"]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinping Liu","raw_affiliation_strings":["School of Medicine, Tsinghua University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086621139","display_name":"Lirong Chang","orcid":"https://orcid.org/0000-0001-7596-4291","observed_orcids":["https://orcid.org/0000-0001-7596-4291"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4405270397","display_name":"Beijing Institute for Brain Disorders","ror":"https://ror.org/00m0cqn82","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270397"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lirong Chang","raw_affiliation_strings":["Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4405270397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101019993","display_name":"Yizhi Song","orcid":"https://orcid.org/0000-0002-3005-382X","observed_orcids":["https://orcid.org/0000-0002-3005-382X"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4405270397","display_name":"Beijing Institute for Brain Disorders","ror":"https://ror.org/00m0cqn82","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270397"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yizhi Song","raw_affiliation_strings":["Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4405270397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423851","display_name":"Hui Li","orcid":"https://orcid.org/0000-0002-0355-5090","observed_orcids":["https://orcid.org/0000-0002-0355-5090"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4405270397","display_name":"Beijing Institute for Brain Disorders","ror":"https://ror.org/00m0cqn82","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270397"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Li","raw_affiliation_strings":["Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4405270397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100617369","display_name":"Yan Wu","orcid":"https://orcid.org/0000-0002-7032-8875","observed_orcids":["https://orcid.org/0000-0002-7032-8875"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4405270397","display_name":"Beijing Institute for Brain Disorders","ror":"https://ror.org/00m0cqn82","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270397"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Wu","raw_affiliation_strings":["Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4405270397"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100617369"],"corresponding_institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4405270397"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":5.6375,"has_fulltext":true,"cited_by_count":559,"citation_normalized_percentile":{"value":0.98423127,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"13","issue":null,"first_page":"43","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5938000082969666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5938000082969666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.39989998936653137,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9769999980926514},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/amyloid-beta-oligomers","display_name":"amyloid-beta oligomers","score":0.8889999985694885},{"id":"https://openalex.org/keywords/synaptic-dysfunction","display_name":"synaptic dysfunction","score":0.9100000262260437},{"id":"https://openalex.org/keywords/synaptic-depression","display_name":"synaptic depression","score":0.8980000019073486},{"id":"https://openalex.org/keywords/memantine","display_name":"memantine","score":0.9559999704360962},{"id":"https://openalex.org/keywords/nmda-receptor-subunits","display_name":"NMDA receptor subunits","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.9079697132110596},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.9001477956771851},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6944801807403564},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5290645360946655},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4749462902545929},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4529208540916443},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.45124173164367676},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.44765859842300415},{"id":"https://openalex.org/C73009533","wikidata":"https://www.wikidata.org/wiki/Q1517140","display_name":"Long-term depression","level":5,"score":0.4425103962421417},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4121035933494568},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3449595868587494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2131088674068451},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.11070165038108826},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08483231067657471},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fnins.2019.00043","doi":"https://doi.org/10.3389/fnins.2019.00043","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2019.00043","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2019.00043/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5379817","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6375899","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6375899","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6375899","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurosci","raw_type":"Text"},{"id":"pmid:30800052","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30800052","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f658067d98b048cb9680cb9d3840091e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f658067d98b048cb9680cb9d3840091e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, Vol 13 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnins.2019.00043","doi":"https://doi.org/10.3389/fnins.2019.00043","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2019.00043","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2019.00043/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2911747652.pdf","grobid_xml":"https://content.openalex.org/works/W2911747652.grobid-xml"},"referenced_works_count":340,"referenced_works":["https://openalex.org/W118386170","https://openalex.org/W565127267","https://openalex.org/W903670290","https://openalex.org/W1151348585","https://openalex.org/W1483876599","https://openalex.org/W1485244052","https://openalex.org/W1492233936","https://openalex.org/W1496193699","https://openalex.org/W1497761894","https://openalex.org/W1503609844","https://openalex.org/W1506960543","https://openalex.org/W1507257305","https://openalex.org/W1516122596","https://openalex.org/W1534060220","https://openalex.org/W1547104500","https://openalex.org/W1551854265","https://openalex.org/W1558113371","https://openalex.org/W1561114541","https://openalex.org/W1563422430","https://openalex.org/W1572219279","https://openalex.org/W1578038979","https://openalex.org/W1602771322","https://openalex.org/W1606946990","https://openalex.org/W1631718287","https://openalex.org/W1639407471","https://openalex.org/W1648575050","https://openalex.org/W1656913045","https://openalex.org/W1662249744","https://openalex.org/W1765307519","https://openalex.org/W1771256107","https://openalex.org/W1782072375","https://openalex.org/W1799512027","https://openalex.org/W1878342051","https://openalex.org/W1884366104","https://openalex.org/W1898334791","https://openalex.org/W1903831724","https://openalex.org/W1915631305","https://openalex.org/W1918304474","https://openalex.org/W1919210158","https://openalex.org/W1939127344","https://openalex.org/W1952831770","https://openalex.org/W1952887313","https://openalex.org/W1955491145","https://openalex.org/W1963482431","https://openalex.org/W1964049915","https://openalex.org/W1964151230","https://openalex.org/W1966314736","https://openalex.org/W1966515122","https://openalex.org/W1966556202","https://openalex.org/W1967017832","https://openalex.org/W1967117930","https://openalex.org/W1967236692","https://openalex.org/W1968024448","https://openalex.org/W1968072827","https://openalex.org/W1968937229","https://openalex.org/W1969338627","https://openalex.org/W1969793439","https://openalex.org/W1971781124","https://openalex.org/W1973794735","https://openalex.org/W1974044249","https://openalex.org/W1974467469","https://openalex.org/W1976118830","https://openalex.org/W1977529472","https://openalex.org/W1979773315","https://openalex.org/W1980307070","https://openalex.org/W1980582579","https://openalex.org/W1980750700","https://openalex.org/W1980937139","https://openalex.org/W1981238903","https://openalex.org/W1983247143","https://openalex.org/W1984858305","https://openalex.org/W1984924722","https://openalex.org/W1984996311","https://openalex.org/W1987093811","https://openalex.org/W1988466769","https://openalex.org/W1989034945","https://openalex.org/W1989918632","https://openalex.org/W1991449336","https://openalex.org/W1991517801","https://openalex.org/W1993465897","https://openalex.org/W1994030229","https://openalex.org/W1994037418","https://openalex.org/W1996263539","https://openalex.org/W1997568797","https://openalex.org/W1998049653","https://openalex.org/W1998237974","https://openalex.org/W1998347917","https://openalex.org/W1998551383","https://openalex.org/W2000204672","https://openalex.org/W2000863257","https://openalex.org/W2001154365","https://openalex.org/W2001580754","https://openalex.org/W2002287054","https://openalex.org/W2002515881","https://openalex.org/W2002664835","https://openalex.org/W2002831316","https://openalex.org/W2003701228","https://openalex.org/W2004041086","https://openalex.org/W2004546493","https://openalex.org/W2004852048","https://openalex.org/W2005506072","https://openalex.org/W2005740454","https://openalex.org/W2005766376","https://openalex.org/W2005795574","https://openalex.org/W2006815009","https://openalex.org/W2008589416","https://openalex.org/W2008811778","https://openalex.org/W2009847863","https://openalex.org/W2010204822","https://openalex.org/W2010926499","https://openalex.org/W2011875417","https://openalex.org/W2013364818","https://openalex.org/W2013625627","https://openalex.org/W2014408809","https://openalex.org/W2016061869","https://openalex.org/W2016323146","https://openalex.org/W2016575029","https://openalex.org/W2017522371","https://openalex.org/W2021144046","https://openalex.org/W2021803287","https://openalex.org/W2022532556","https://openalex.org/W2022873534","https://openalex.org/W2024380057","https://openalex.org/W2024431713","https://openalex.org/W2024849224","https://openalex.org/W2025653075","https://openalex.org/W2026052382","https://openalex.org/W2027230597","https://openalex.org/W2027900655","https://openalex.org/W2028594041","https://openalex.org/W2028686926","https://openalex.org/W2030377743","https://openalex.org/W2030756376","https://openalex.org/W2031150114","https://openalex.org/W2031392396","https://openalex.org/W2031739172","https://openalex.org/W2034101077","https://openalex.org/W2035594496","https://openalex.org/W2036408610","https://openalex.org/W2036796078","https://openalex.org/W2037322147","https://openalex.org/W2037852973","https://openalex.org/W2038676703","https://openalex.org/W2038724001","https://openalex.org/W2040936201","https://openalex.org/W2041851050","https://openalex.org/W2041890633","https://openalex.org/W2041956586","https://openalex.org/W2042550512","https://openalex.org/W2042669315","https://openalex.org/W2044146387","https://openalex.org/W2046571513","https://openalex.org/W2046952010","https://openalex.org/W2048570697","https://openalex.org/W2050066016","https://openalex.org/W2051395367","https://openalex.org/W2051690270","https://openalex.org/W2052330193","https://openalex.org/W2052704430","https://openalex.org/W2052712042","https://openalex.org/W2052822734","https://openalex.org/W2053361108","https://openalex.org/W2053665966","https://openalex.org/W2056038034","https://openalex.org/W2057704715","https://openalex.org/W2057771914","https://openalex.org/W2058880763","https://openalex.org/W2059709590","https://openalex.org/W2060653946","https://openalex.org/W2061342941","https://openalex.org/W2062928716","https://openalex.org/W2063407098","https://openalex.org/W2065169750","https://openalex.org/W2065430019","https://openalex.org/W2067129052","https://openalex.org/W2067648162","https://openalex.org/W2068198371","https://openalex.org/W2069918674","https://openalex.org/W2070094949","https://openalex.org/W2071337823","https://openalex.org/W2071495374","https://openalex.org/W2071768383","https://openalex.org/W2073221051","https://openalex.org/W2073508793","https://openalex.org/W2074426818","https://openalex.org/W2074850044","https://openalex.org/W2077369497","https://openalex.org/W2078366491","https://openalex.org/W2078729100","https://openalex.org/W2078917784","https://openalex.org/W2079438371","https://openalex.org/W2080357850","https://openalex.org/W2080811912","https://openalex.org/W2081070804","https://openalex.org/W2081282178","https://openalex.org/W2082151254","https://openalex.org/W2082429191","https://openalex.org/W2082871116","https://openalex.org/W2084280842","https://openalex.org/W2084973310","https://openalex.org/W2085424855","https://openalex.org/W2086292335","https://openalex.org/W2086740370","https://openalex.org/W2087207327","https://openalex.org/W2089094370","https://openalex.org/W2089963291","https://openalex.org/W2092001512","https://openalex.org/W2092356280","https://openalex.org/W2093250214","https://openalex.org/W2093716487","https://openalex.org/W2096361230","https://openalex.org/W2096410114","https://openalex.org/W2096681544","https://openalex.org/W2097095684","https://openalex.org/W2097293665","https://openalex.org/W2098759196","https://openalex.org/W2098815266","https://openalex.org/W2099370040","https://openalex.org/W2100193366","https://openalex.org/W2100290637","https://openalex.org/W2100824868","https://openalex.org/W2101151644","https://openalex.org/W2101257013","https://openalex.org/W2103274980","https://openalex.org/W2103795148","https://openalex.org/W2103960901","https://openalex.org/W2104417933","https://openalex.org/W2108549874","https://openalex.org/W2111200377","https://openalex.org/W2111623179","https://openalex.org/W2112239590","https://openalex.org/W2112273529","https://openalex.org/W2113179767","https://openalex.org/W2113944645","https://openalex.org/W2114091391","https://openalex.org/W2114163624","https://openalex.org/W2116328062","https://openalex.org/W2116635659","https://openalex.org/W2117260074","https://openalex.org/W2117396078","https://openalex.org/W2120699640","https://openalex.org/W2123609069","https://openalex.org/W2123941817","https://openalex.org/W2124274159","https://openalex.org/W2124955411","https://openalex.org/W2127554180","https://openalex.org/W2128401893","https://openalex.org/W2128469846","https://openalex.org/W2129761500","https://openalex.org/W2129803440","https://openalex.org/W2129943582","https://openalex.org/W2131180711","https://openalex.org/W2134269646","https://openalex.org/W2135164856","https://openalex.org/W2135793938","https://openalex.org/W2136008443","https://openalex.org/W2136019899","https://openalex.org/W2137000164","https://openalex.org/W2139396488","https://openalex.org/W2139748951","https://openalex.org/W2143514217","https://openalex.org/W2145772960","https://openalex.org/W2146521940","https://openalex.org/W2147917838","https://openalex.org/W2149492210","https://openalex.org/W2150603758","https://openalex.org/W2150999725","https://openalex.org/W2152000143","https://openalex.org/W2152402650","https://openalex.org/W2153438315","https://openalex.org/W2154142567","https://openalex.org/W2154596951","https://openalex.org/W2161998020","https://openalex.org/W2162454135","https://openalex.org/W2162642602","https://openalex.org/W2167768159","https://openalex.org/W2167904957","https://openalex.org/W2168538246","https://openalex.org/W2168649705","https://openalex.org/W2169761872","https://openalex.org/W2170383406","https://openalex.org/W2170398463","https://openalex.org/W2170867393","https://openalex.org/W2171668977","https://openalex.org/W2171728330","https://openalex.org/W2218016673","https://openalex.org/W2222372083","https://openalex.org/W2238771054","https://openalex.org/W2289953129","https://openalex.org/W2290636701","https://openalex.org/W2292902805","https://openalex.org/W2294665407","https://openalex.org/W2316145923","https://openalex.org/W2334290597","https://openalex.org/W2370012694","https://openalex.org/W2399488000","https://openalex.org/W2462234872","https://openalex.org/W2464492710","https://openalex.org/W2472788909","https://openalex.org/W2474794572","https://openalex.org/W2475050420","https://openalex.org/W2486908111","https://openalex.org/W2492539765","https://openalex.org/W2493275900","https://openalex.org/W2507510568","https://openalex.org/W2510475597","https://openalex.org/W2519747458","https://openalex.org/W2521991649","https://openalex.org/W2548346832","https://openalex.org/W2548997185","https://openalex.org/W2549381486","https://openalex.org/W2554647971","https://openalex.org/W2604542316","https://openalex.org/W2606113932","https://openalex.org/W2736307992","https://openalex.org/W2751570459","https://openalex.org/W2761921473","https://openalex.org/W2765877540","https://openalex.org/W2766782573","https://openalex.org/W2766813403","https://openalex.org/W2767447846","https://openalex.org/W2777541397","https://openalex.org/W2785104385","https://openalex.org/W2796905767","https://openalex.org/W2797071919","https://openalex.org/W2804444839","https://openalex.org/W2806876216","https://openalex.org/W2810261013","https://openalex.org/W2811141452","https://openalex.org/W2887831400","https://openalex.org/W2888972388","https://openalex.org/W2894102430","https://openalex.org/W2894357926","https://openalex.org/W2896396037","https://openalex.org/W2949152232","https://openalex.org/W2949574343","https://openalex.org/W2951728664","https://openalex.org/W6683072515","https://openalex.org/W6983794798","https://openalex.org/W7074026945"],"related_works":["https://openalex.org/W4407578508","https://openalex.org/W2052712042","https://openalex.org/W7220383952","https://openalex.org/W7204108447","https://openalex.org/W1974467469","https://openalex.org/W1966705931","https://openalex.org/W2897406530","https://openalex.org/W2293608890","https://openalex.org/W1561114541","https://openalex.org/W2294665407"],"abstract_inverted_index":{"In":[0],"Alzheimer's":[1],"disease":[2],"(AD),":[3],"early":[4],"synaptic":[5,18],"dysfunction":[6,55],"is":[7,42],"associated":[8],"with":[9],"the":[10,32,47],"increased":[11],"oligomeric":[12],"amyloid-beta":[13],"peptide,":[14],"which":[15],"causes":[16],"NMDAR-dependent":[17],"depression":[19],"and":[20,50,56],"spine":[21],"elimination.":[22],"Memantine,":[23],"low-affinity":[24],"NMDAR":[25,69,77],"channel":[26],"blocker,":[27],"has":[28],"been":[29],"used":[30],"in":[31,45,65],"treatment":[33],"of":[34,67,76],"moderate":[35],"to":[36],"severe":[37],"AD.":[38,57],"However,":[39],"clear":[40],"evidence":[41],"still":[43],"deficient":[44],"demonstrating":[46],"underlying":[48],"mechanisms":[49],"a":[51],"relationship":[52],"between":[53],"NMDARs":[54],"This":[58],"review":[59],"focuses":[60],"on":[61],"not":[62],"only":[63],"changes":[64],"expression":[66],"different":[68],"subunits,":[70],"but":[71],"also":[72],"some":[73],"unconventional":[74],"modes":[75],"action.":[78]},"counts_by_year":[{"year":2026,"cited_by_count":61},{"year":2025,"cited_by_count":85},{"year":2024,"cited_by_count":86},{"year":2023,"cited_by_count":106},{"year":2022,"cited_by_count":94},{"year":2021,"cited_by_count":70},{"year":2020,"cited_by_count":48},{"year":2019,"cited_by_count":9}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2019-02-21T00:00:00"}
