{"id":"https://openalex.org/W2911675986","doi":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a218","title":"Abstract A218: Modulating glucocorticoid receptor-mediated signaling for enhancement of cancer immunotherapy","display_name":"Abstract A218: Modulating glucocorticoid receptor-mediated signaling for enhancement of cancer immunotherapy","publication_year":2019,"publication_date":"2019-02-01","ids":{"openalex":"https://openalex.org/W2911675986","doi":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a218","mag":"2911675986"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6074.cricimteatiaacr18-a218","doi":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a218","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a218","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084607092","display_name":"Qin Tang","orcid":"https://orcid.org/0000-0002-9487-570X","observed_orcids":["https://orcid.org/0000-0002-9487-570X"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qin Tang","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033532061","display_name":"Myles A Brown","orcid":"https://orcid.org/0000-0002-8213-1658","observed_orcids":["https://orcid.org/0000-0002-8213-1658"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myles A. Brown","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210117453"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"2_Supplement","first_page":"A218","last_page":"A218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8560000061988831},{"id":"https://openalex.org/keywords/lymphodepletion","display_name":"lymphocyte depletion","score":0.7620000243186951},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.8640000224113464},{"id":"https://openalex.org/keywords/anti-pd-1-antibody","display_name":"anti-PD-1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/anti-ctla-4","display_name":"anti-CTLA-4","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cold-tumors","display_name":"cold tumors","score":0.6110000014305115},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.8360000252723694},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7760000228881836},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.7010079622268677},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6771668195724487},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5785056352615356},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.572468638420105},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.565141499042511},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.5153753161430359},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49138012528419495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4745239317417145},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.4599427878856659},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4304051995277405},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.42746207118034363},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.398372620344162},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33699020743370056},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2326-6074.cricimteatiaacr18-a218","doi":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a218","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a218","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2562561497","https://openalex.org/W4313381255","https://openalex.org/W7139084183","https://openalex.org/W2794786066","https://openalex.org/W4377691195","https://openalex.org/W7127635445","https://openalex.org/W3028846529","https://openalex.org/W3208174448","https://openalex.org/W2979876135","https://openalex.org/W7127908336"],"abstract_inverted_index":{"Abstract":[0],"Glucocorticoids":[1,57],"are":[2,30,39,58,89],"a":[3,13,178,208,223,262,272],"class":[4],"of":[5,12,15,28,54,80,120,128,165,171,185,189,205,221,232,245,251,268,280,337,387,405,408,420,426,487,493],"steroid":[6],"hormones":[7],"essential":[8],"to":[9,50,64,66,91,95,149,211,228,241,260,270,434],"the":[10,33,43,77,138,169,200,219,230,243,249,292,346,376,385,398,406,439,449,455,459,494],"modulation":[11,204,247,267],"number":[14,157,386],"physiologic":[16],"processes,":[17],"including":[18,70],"cellular":[19],"metabolism,":[20],"neural":[21],"development":[22],"and":[23,47,73,135,158,160,187,195,216,259,277,289,304,327,367,418,428,463],"immune":[24,81,97,110,213,226,252,275,293,379,461],"system":[25],"function.":[26],"Functions":[27],"glucocorticoids":[29,38,88,102,130,319],"mediated":[31],"through":[32],"glucocorticoid":[34,151,246,362,456,482],"receptor":[35,457],"(GR).":[36],"Synthetic":[37],"front-line":[40],"therapies":[41,63,84,255,382],"in":[42,109,199,235,248,256,282,296,323,397,413,471],"clinic":[44],"for":[45,180,264,335,424,467,485],"leukemia":[46],"lymphoma":[48],"due":[49,182],"their":[51,107],"potent":[52],"induction":[53],"lymphocyte":[55,105,156,373],"death.":[56],"also":[59],"prescribed":[60],"as":[61],"adjuvant":[62],"chemotherapies":[65],"alleviate":[67],"adverse":[68],"effects":[69,127,407],"nausea,":[71],"emesis":[72],"allergic":[74],"reactions.":[75],"In":[76,345,441],"current":[78],"regimen":[79],"checkpoint":[82,111,253,380],"blockade":[83,112,254,381],"against":[85],"solid":[86,174,236,283,415,472],"tumors,":[87],"incorporated":[90],"manage":[92],"symptoms":[93],"related":[94],"acute":[96],"hyperactivation.":[98],"However,":[99],"given":[100],"that":[101,431],"preferentially":[103],"cause":[104],"death,":[106],"inclusion":[108],"regimens":[113],"which":[114,454],"capitalize":[115],"on":[116,132,137,291,411,422],"cytotoxic":[117,162,395],"T-cell-mediated":[118,163],"killing":[119,164],"tumor":[121,133,166,175,201,225,274,294,416,460],"cells":[122,191,392],"is":[123],"controversial.":[124],"The":[125],"precise":[126],"systematic":[129],"use":[131],"development,":[134],"particularly,":[136],"tumor-immune":[139],"microenvironment":[140,227,276,295,462],"comprised":[141],"tumor-infiltrating":[142],"leukocytes":[143],"(TILs)":[144],"remains":[145,177],"unknown.":[146],"Conversely,":[147],"methods":[148],"antagonize":[150],"signaling":[152,484],"could":[153],"potentially":[154],"boost":[155,435],"function":[159,217,437],"potentiate":[161],"cells.":[167],"Presently,":[168],"treatment":[170],"\u201cimmune":[172],"cold\u201d":[173],"types":[176],"challenge":[179],"immunotherapy":[181,489],"low":[183],"level":[184],"TILs":[186,412,423],"presence":[188],"immunosuppressive":[190],"(including":[192],"regulatory":[193],"T-cells":[194,396],"myeloid-derived":[196],"suppressor":[197],"cells)":[198],"microenvironment.":[202],"Pharmacologic":[203],"GR":[206,269,287,321,409],"presents":[207],"unique":[209],"opportunity":[210],"regulate":[212],"cell":[214],"homeostasis":[215],"with":[218,325,365],"goal":[220],"promoting":[222],"favorable":[224,273],"augment":[229],"effectiveness":[231],"cancer":[233,302,306,349,469,488],"immunotherapies":[234,281,470],"tumors.":[237,284,473],"Our":[238,400],"research":[239],"seeks":[240],"understand":[242],"impact":[244],"context":[250],"preclinical":[257],"models,":[258,417],"provide":[261,432,446,464],"rationale":[263],"selective":[265],"pharmacologic":[266],"promote":[271],"increased":[278,372],"efficacy":[279],"We":[285],"investigated":[286],"activation":[288],"inhibition":[290,410],"murine":[297,414],"syngeneic":[298],"melanoma":[299],"(B16),":[300],"breast":[301,348],"(4T1)":[303],"colorectal":[305],"(CT26)":[307],"models.":[308],"Mice":[309],"bearing":[310],"allograft":[311],"tumors":[312,332],"were":[313,333],"randomized":[314],"into":[315,375,448,503],"groups":[316],"receiving":[317],"synthetic":[318,361],"or":[320],"inhibitors":[322],"combination":[324],"anti-PD-1":[326],"anti-CTLA4":[328],"therapies.":[329],"Following":[330],"treatment,":[331],"assessed":[334],"composition":[336],"intratumoral":[338],"leukocyte":[339],"infiltration":[340,374],"by":[341,358,453],"flow":[342],"cytometry":[343],"phenotyping.":[344],"mouse":[347],"model":[350],"(4T1),":[351],"we":[352],"found":[353],"evidence":[354],"supporting":[355],"substantial":[356],"lymphodepletion":[357],"dexamethasone":[359],"(a":[360],"compound).":[363],"Treatment":[364],"PD-1":[366],"CTLA-4":[368],"blocking":[369],"monoclonal":[370],"antibodies":[371],"tumor.":[377,399,440],"Interestingly,":[378],"significantly":[383],"raised":[384],"more":[388],"CD4+":[389],"T":[390],"helper":[391],"than":[393],"CD8+":[394],"future":[401],"plan":[402],"includes":[403],"investigation":[404],"utilization":[419],"RNA-sequencing":[421],"identification":[425],"genes":[427],"molecular":[429,451],"pathways":[430],"opportunities":[433],"TIL":[436],"within":[438],"summary,":[442],"our":[443],"work":[444],"can":[445],"insight":[447],"fundamental":[450],"mechanisms":[452],"modulates":[458],"novel":[465],"avenues":[466],"enhancing":[468],"Citation":[474],"Format:":[475],"Qin":[476],"Tang,":[477],"Myles":[478],"A.":[479],"Brown.":[480],"Modulating":[481],"receptor-mediated":[483],"enhancement":[486],"[abstract].":[490],"In:":[491],"Proceedings":[492],"Fourth":[495],"CRI-CIMT-EATI-AACR":[496],"International":[497],"Cancer":[498,515],"Immunotherapy":[499],"Conference:":[500],"Translating":[501],"Science":[502],"Survival;":[504],"Sept":[505],"30-Oct":[506],"3,":[507],"2018;":[508],"New":[509],"York,":[510],"NY.":[511],"Philadelphia":[512],"(PA):":[513],"AACR;":[514],"Immunol":[516],"Res":[517],"2019;7(2":[518],"Suppl):Abstract":[519],"nr":[520],"A218.":[521]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2019-02-21T00:00:00"}