{"id":"https://openalex.org/W2911650995","doi":"https://doi.org/10.1039/c8cc09747j","title":"Hydrophilic 18 F-labeled trans -5-oxocene (oxoTCO) for efficient construction of PET agents with improved tumor-to-background ratios in neurotensin receptor (NTR) imaging","display_name":"Hydrophilic 18 F-labeled trans -5-oxocene (oxoTCO) for efficient construction of PET agents with improved tumor-to-background ratios in neurotensin receptor (NTR) imaging","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2911650995","doi":"https://doi.org/10.1039/c8cc09747j","mag":"2911650995","pmid":"https://pubmed.ncbi.nlm.nih.gov/30735213","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7347157"},"language":"en","primary_location":{"id":"doi:10.1039/c8cc09747j","doi":"https://doi.org/10.1039/c8cc09747j","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8cc09747j","pdf_url":null,"source":{"id":"https://openalex.org/S152760256","display_name":"Chemical Communications","issn_l":"1359-7345","issn":["1359-7345","1364-548X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7347157","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070297217","display_name":"Mengzhe Wang","orcid":"https://orcid.org/0000-0003-4654-6845","observed_orcids":["https://orcid.org/0000-0003-4654-6845"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mengzhe Wang","raw_affiliation_strings":["Chapel Hill","Department of Radiology and Biomedical Research Imaging Center","USA","University of North Carolina at Chapel Hill","Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chapel Hill","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology and Biomedical Research Imaging Center","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086632690","display_name":"Raghu Vannam","orcid":"https://orcid.org/0000-0002-6665-8548","observed_orcids":["https://orcid.org/0000-0002-6665-8548"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raghu Vannam","raw_affiliation_strings":["Brown Laboratories","Department of Chemistry and Biochemistry","Newark","USA","University of Delaware","Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA"],"raw_orcid":"https://orcid.org/0000-0002-6665-8548","affiliations":[{"raw_affiliation_string":"Brown Laboratories","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry","institution_ids":[]},{"raw_affiliation_string":"Newark","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of Delaware","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090052478","display_name":"William D. Lambert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William D. Lambert","raw_affiliation_strings":["Brown Laboratories","Department of Chemistry and Biochemistry","Newark","USA","University of Delaware","Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown Laboratories","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry","institution_ids":[]},{"raw_affiliation_string":"Newark","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of Delaware","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000614335","display_name":"Yixin Xie","orcid":"https://orcid.org/0000-0002-7274-7731","observed_orcids":["https://orcid.org/0000-0002-7274-7731"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yixin Xie","raw_affiliation_strings":["Brown Laboratories","Department of Chemistry and Biochemistry","Newark","USA","University of Delaware","Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown Laboratories","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry","institution_ids":[]},{"raw_affiliation_string":"Newark","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of Delaware","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100460755","display_name":"Hui Wang","orcid":"https://orcid.org/0000-0002-2346-8621","observed_orcids":["https://orcid.org/0000-0002-2346-8621"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Wang","raw_affiliation_strings":["Chapel Hill","Department of Radiology and Biomedical Research Imaging Center","USA","University of North Carolina at Chapel Hill","Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chapel Hill","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology and Biomedical Research Imaging Center","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069749762","display_name":"Benjamin Giglio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Giglio","raw_affiliation_strings":["Chapel Hill","Department of Radiology and Biomedical Research Imaging Center","USA","University of North Carolina at Chapel Hill","Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chapel Hill","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology and Biomedical Research Imaging Center","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055740842","display_name":"Xiaofen Ma","orcid":"https://orcid.org/0000-0002-3178-232X","observed_orcids":["https://orcid.org/0000-0002-3178-232X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofen Ma","raw_affiliation_strings":["Chapel Hill","Department of Radiology and Biomedical Research Imaging Center","USA","University of North Carolina at Chapel Hill","Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chapel Hill","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology and Biomedical Research Imaging Center","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049067213","display_name":"Zhanhong Wu","orcid":"https://orcid.org/0000-0002-3528-5603","observed_orcids":["https://orcid.org/0000-0002-3528-5603"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhanhong Wu","raw_affiliation_strings":["Chapel Hill","Department of Radiology and Biomedical Research Imaging Center","USA","University of North Carolina at Chapel Hill","Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chapel Hill","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology and Biomedical Research Imaging Center","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034235550","display_name":"Joseph M. Fox","orcid":"https://orcid.org/0000-0002-8258-1640","observed_orcids":["https://orcid.org/0000-0002-8258-1640"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph Fox","raw_affiliation_strings":["Brown Laboratories","Department of Chemistry and Biochemistry","Newark","USA","University of Delaware","Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA"],"raw_orcid":"https://orcid.org/0000-0002-8258-1640","affiliations":[{"raw_affiliation_string":"Brown Laboratories","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry","institution_ids":[]},{"raw_affiliation_string":"Newark","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of Delaware","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100675106","display_name":"Zibo Li","orcid":"https://orcid.org/0000-0002-1063-0298","observed_orcids":["https://orcid.org/0000-0002-1063-0298","https://orcid.org/0000-0002-5095-3761"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zibo Li","raw_affiliation_strings":["Chapel Hill","Department of Radiology and Biomedical Research Imaging Center","USA","University of North Carolina at Chapel Hill","Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA"],"raw_orcid":"https://orcid.org/0000-0002-5095-3761","affiliations":[{"raw_affiliation_string":"Chapel Hill","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology and Biomedical Research Imaging Center","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034235550","https://openalex.org/A5100675106"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I86501945"],"apc_list":null,"apc_paid":null,"fwci":2.8863,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.90618568,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"55","issue":"17","first_page":"2485","last_page":"2488"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetrazine-ligation","display_name":"tetrazine ligation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tumor-to-background-ratio","display_name":"tumor-to-background ratio","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tumor-uptake","display_name":"tumor uptake","score":0.6679999828338623},{"id":"https://openalex.org/keywords/radiolabeling-yield","display_name":"radiolabeling yield","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C2778976297","wikidata":"https://www.wikidata.org/wiki/Q419576","display_name":"Neurotensin","level":4,"score":0.6859897375106812},{"id":"https://openalex.org/C3017724952","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Pet imaging","level":3,"score":0.6117335557937622},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.535997211933136},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5001146793365479},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3231911063194275},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32135331630706787},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.301697701215744},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2305595576763153},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.2042563259601593},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16528305411338806}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/c8cc09747j","doi":"https://doi.org/10.1039/c8cc09747j","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8cc09747j","pdf_url":null,"source":{"id":"https://openalex.org/S152760256","display_name":"Chemical Communications","issn_l":"1359-7345","issn":["1359-7345","1364-548X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Communications","raw_type":"journal-article"},{"id":"pmid:30735213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30735213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical communications (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7347157","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7347157","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Commun (Camb)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7347157","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7347157","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Commun (Camb)","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1074587419","display_name":"The Tetrazine Ligation for Efficient 18F Labeling and Pretargeted Imaging/Radiotherapy of Cancer","funder_award_id":"R01EB014354","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G3037964080","display_name":"Discovery of Chemical Probes and Therapeutic Leads, Phase II","funder_award_id":"P20GM104316","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4188327313","display_name":"CRIF:MU  Cryprobe Upgrade of a NMR Spectrometer","funder_award_id":"0840401","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5455067336","display_name":"Small Animal PET/CT for Preclinical Imaging Research","funder_award_id":"S10OD023611","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7558382895","display_name":"High Performance Digital NMR Spectrometer","funder_award_id":"S10RR026962","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8612150275","display_name":"Molecular Design of Advanced Biomaterials","funder_award_id":"P30GM110758","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G886931444","display_name":"MRI: Acquisition of a High Resolution Mass Spectrometer for Small Molecule Analysis","funder_award_id":"1229234","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000913976","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016086","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G93081233","display_name":"Q-Exactive Orbitrap LC-MC/MS System","funder_award_id":"1s10od016267-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309342","display_name":"University of North Carolina","ror":"https://ror.org/0130frc33"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1980232662","https://openalex.org/W1990765611","https://openalex.org/W1995754625","https://openalex.org/W2009531051","https://openalex.org/W2015551880","https://openalex.org/W2043821378","https://openalex.org/W2055706807","https://openalex.org/W2062524026","https://openalex.org/W2078680567","https://openalex.org/W2104899629","https://openalex.org/W2115001654","https://openalex.org/W2126921829","https://openalex.org/W2133333622","https://openalex.org/W2134194795","https://openalex.org/W2134413630","https://openalex.org/W2148944360","https://openalex.org/W2149148789","https://openalex.org/W2152209682","https://openalex.org/W2155106185","https://openalex.org/W2158502376","https://openalex.org/W2169626866","https://openalex.org/W2322302718","https://openalex.org/W2323389052","https://openalex.org/W2344885917","https://openalex.org/W2396856709","https://openalex.org/W2529009204","https://openalex.org/W2537987901","https://openalex.org/W2541085427","https://openalex.org/W2610553072","https://openalex.org/W2739112668","https://openalex.org/W2749134172","https://openalex.org/W2753489078","https://openalex.org/W2772875308"],"related_works":["https://openalex.org/W4387718763","https://openalex.org/W3004437356","https://openalex.org/W2344885917","https://openalex.org/W1959251555","https://openalex.org/W4399739268","https://openalex.org/W2855856887","https://openalex.org/W2104899629","https://openalex.org/W4281254146","https://openalex.org/W870680356","https://openalex.org/W2258741062"],"abstract_inverted_index":{"An":[0],"18F-labeled":[1,59],"trans-5-oxocene":[2],"(oxoTCO)":[3],"that":[4,55],"is":[5,20,34],"used":[6],"to":[7,80],"construct":[8],"a":[9,69],"PET":[10,23,46],"probe":[11,24,47,67],"for":[12],"neurotensin":[13],"receptor":[14],"(NTR)":[15],"imaging":[16],"through":[17],"tetrazine":[18],"ligation":[19],"described":[21],"here.":[22],"construction":[25],"proceeds":[26],"with":[27,50],"70%":[28],"RCY":[29],"based":[30,45],"on":[31],"18F-oxoTCO":[32,66],"and":[33,61,83],"completed":[35],"within":[36],"seconds.":[37],"The":[38,64],"in":[39],"vivo":[40],"behaviour":[41],"of":[42,52],"the":[43,81],"oxoTCO":[44],"was":[48],"compared":[49],"those":[51],"analogous":[53],"probes":[54],"were":[56],"prepared":[57],"from":[58],"s-TCO":[60],"d-TCO":[62],"tracers.":[63],"hydrophilic":[65],"showed":[68],"significantly":[70],"higher":[71],"tumor-to-background":[72],"ratio":[73],"while":[74],"displaying":[75],"comparable":[76],"tumor":[77],"uptake":[78],"relative":[79],"18F-dTCO":[82],"18F-sTCO":[84],"derived":[85],"probes.":[86]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2019-02-21T00:00:00"}