{"id":"https://openalex.org/W29116100","doi":null,"title":"Cytogenetic Analysis Of Depleted Uranium Exposure And Age-Dependent Susceptibility To Ionizing Radiation","display_name":"Cytogenetic Analysis Of Depleted Uranium Exposure And Age-Dependent Susceptibility To Ionizing Radiation","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W29116100","mag":"29116100"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.wayne.edu:oa_dissertations-1634","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_dissertations/635","pdf_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1634&context=oa_dissertations","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Dissertations","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1634&context=oa_dissertations","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015272221","display_name":"Marina V. Bakhmutsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marina V. Bakhmutsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5015272221"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.5307999849319458,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.5307999849319458,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10946","display_name":"Radioactivity and Radon Measurements","score":0.2493000030517578,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.19779999554157257,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depleted-uranium","display_name":"depleted uranium","score":0.921999990940094},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.8679999709129333},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/gulf-war-veterans","display_name":"Gulf War veterans","score":0.675000011920929},{"id":"https://openalex.org/keywords/chromosomal-damage","display_name":"chromosomal damage","score":0.6769999861717224},{"id":"https://openalex.org/keywords/micronuclei","display_name":"micronuclei","score":0.9190000295639038},{"id":"https://openalex.org/keywords/chromosomal-translocation","display_name":"chromosomal translocation","score":0.6209999918937683},{"id":"https://openalex.org/keywords/dicentric-chromosomes","display_name":"dicentric chromosomes","score":0.699999988079071},{"id":"https://openalex.org/keywords/age-related-susceptibility","display_name":"age-related susceptibility","score":0.6970000267028809},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.6690000295639038},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.37299999594688416},{"id":"https://openalex.org/keywords/whole-chromosome-painting","display_name":"whole chromosome painting","score":0.5630000233650208},{"id":"https://openalex.org/keywords/cytogenetic-markers","display_name":"cytogenetic markers","score":0.5339999794960022},{"id":"https://openalex.org/keywords/gulf-war-illness","display_name":"Gulf War illness","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.8147510886192322},{"id":"https://openalex.org/C555451288","wikidata":"https://www.wikidata.org/wiki/Q1098","display_name":"Uranium","level":2,"score":0.4748014509677887},{"id":"https://openalex.org/C2779925993","wikidata":"https://www.wikidata.org/wiki/Q336938","display_name":"Radiation exposure","level":2,"score":0.41939157247543335},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32967472076416016},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.26115351915359497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17501932382583618},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16753551363945007},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.12407690286636353},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.08539566397666931}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.wayne.edu:oa_dissertations-1634","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_dissertations/635","pdf_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1634&context=oa_dissertations","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Dissertations","raw_type":"dissertation"},{"id":"mag:29116100","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1634&context=oa_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.wayne.edu:oa_dissertations-1634","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_dissertations/635","pdf_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1634&context=oa_dissertations","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Dissertations","raw_type":"dissertation"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W29116100.pdf","grobid_xml":"https://content.openalex.org/works/W29116100.grobid-xml"},"referenced_works_count":102,"referenced_works":["https://openalex.org/W49180221","https://openalex.org/W59058388","https://openalex.org/W139289893","https://openalex.org/W567362281","https://openalex.org/W1831259184","https://openalex.org/W1855111343","https://openalex.org/W1931908861","https://openalex.org/W1939068747","https://openalex.org/W1963538194","https://openalex.org/W1968120866","https://openalex.org/W1968796417","https://openalex.org/W1969237880","https://openalex.org/W1972498223","https://openalex.org/W1973677817","https://openalex.org/W1975187141","https://openalex.org/W1975410130","https://openalex.org/W1976334783","https://openalex.org/W1983910859","https://openalex.org/W1984608300","https://openalex.org/W1985786559","https://openalex.org/W1986685377","https://openalex.org/W1989964790","https://openalex.org/W1991910958","https://openalex.org/W2002071900","https://openalex.org/W2007279119","https://openalex.org/W2011016951","https://openalex.org/W2013946215","https://openalex.org/W2014378344","https://openalex.org/W2021367141","https://openalex.org/W2024682344","https://openalex.org/W2028982230","https://openalex.org/W2029265439","https://openalex.org/W2031575431","https://openalex.org/W2031911313","https://openalex.org/W2033280320","https://openalex.org/W2039954337","https://openalex.org/W2040266233","https://openalex.org/W2041134140","https://openalex.org/W2048346312","https://openalex.org/W2049018291","https://openalex.org/W2049520394","https://openalex.org/W2050896501","https://openalex.org/W2052178019","https://openalex.org/W2056204497","https://openalex.org/W2056204961","https://openalex.org/W2057515042","https://openalex.org/W2060290425","https://openalex.org/W2061051981","https://openalex.org/W2065243736","https://openalex.org/W2066189840","https://openalex.org/W2066357142","https://openalex.org/W2072635185","https://openalex.org/W2074858747","https://openalex.org/W2075198215","https://openalex.org/W2077674789","https://openalex.org/W2077957524","https://openalex.org/W2083806987","https://openalex.org/W2087418238","https://openalex.org/W2087837232","https://openalex.org/W2088402931","https://openalex.org/W2090974930","https://openalex.org/W2096707644","https://openalex.org/W2097019485","https://openalex.org/W2098883242","https://openalex.org/W2098956055","https://openalex.org/W2100800590","https://openalex.org/W2103474203","https://openalex.org/W2104562569","https://openalex.org/W2104862493","https://openalex.org/W2106625186","https://openalex.org/W2110485392","https://openalex.org/W2111418068","https://openalex.org/W2114547427","https://openalex.org/W2115919451","https://openalex.org/W2118643584","https://openalex.org/W2120892886","https://openalex.org/W2121732515","https://openalex.org/W2124803506","https://openalex.org/W2126673711","https://openalex.org/W2130554457","https://openalex.org/W2131784805","https://openalex.org/W2145116593","https://openalex.org/W2147110431","https://openalex.org/W2148468748","https://openalex.org/W2148487891","https://openalex.org/W2149177144","https://openalex.org/W2150905911","https://openalex.org/W2151867783","https://openalex.org/W2154058258","https://openalex.org/W2154363034","https://openalex.org/W2159000200","https://openalex.org/W2163419397","https://openalex.org/W2164811914","https://openalex.org/W2164972724","https://openalex.org/W2166446224","https://openalex.org/W2168255163","https://openalex.org/W2179101840","https://openalex.org/W2314304457","https://openalex.org/W2325142807","https://openalex.org/W2419201299","https://openalex.org/W2798979737","https://openalex.org/W4300005459"],"related_works":["https://openalex.org/W2154058258","https://openalex.org/W1969217969","https://openalex.org/W2159000200","https://openalex.org/W2072635185","https://openalex.org/W1999954859","https://openalex.org/W2002071900","https://openalex.org/W2260176676","https://openalex.org/W2118643584","https://openalex.org/W2061051981","https://openalex.org/W2066189840"],"abstract_inverted_index":{"Chapters":[0],"2":[1],"and":[2,27,30,75,107,115,162,176,200,277,286,291,295,332,347,359,427,452,464,511,549],"3:":[3],"Depleted":[4],"Uranium":[5,183,251],"(DU)":[6],"is":[7,24],"a":[8,53,128],"high-density":[9],"heavy":[10],"metal":[11],"that":[12,216,389],"has":[13],"been":[14],"used":[15,473],"in":[16,47,64,77,98,105,127,196,222,236,238,246,402,456,507,534,555],"munitions":[17,102],"since":[18],"the":[19,69,135,144,197,317,369,409,429,476,481,550],"1991":[20,99],"Gulf":[21,48,87,223],"War.":[22],"DU":[23,45,93,101,114,118,221,229,393],"weakly":[25],"radioactive":[26],"chemically":[28],"toxic":[29],"long":[31,129],"term":[32,130],"exposure":[33,46,109,173,219,391],"may":[34],"cause":[35],"adverse":[36],"health":[37,131],"effects.":[38],"This":[39],"study":[40],"evaluates":[41],"genotoxic":[42],"effects":[43,318],"of":[44,55,113,141,254,319,325,337,371,399,432,446,478,480,484,544,552],"War":[49,88,224],"I":[50,89,225],"Veterans":[51,90,124,154,226,247,269],"as":[52,203],"function":[54],"uranium":[56],"(U)":[57],"body":[58],"burden":[59],"by":[60],"measuring":[61],"chromosome":[62,82,259,281,400,462,468],"damage":[63,401],"peripheral":[65,239],"blood":[66,240,326,372,420,500],"lymphocytes":[67,241],"with":[68,188,210,227,248,339,377,383,460,539],"cytokinesis":[70],"blocked":[71],"micronucleus":[72],"assay":[73],"(CBMN)":[74],"fluorescence":[76],"situ":[78],"hybridization":[79],"(FISH)":[80],"whole":[81,258,461],"painting.":[83],"Study":[84],"subjects":[85,142,255],"are":[86,125],"exposed":[91,152,267,438],"to":[92,110,157,220,243,272,315,392,411,417,439,444,474,487,491,498,518,546],"during":[94,557],"friendly":[95],"fire":[96],"incidents":[97],"involving":[100],"which":[103,412],"resulted":[104],"inhalation":[106],"ingestion":[108],"small":[111],"particles":[112],"soft":[116],"tissue":[117],"fragments":[119,230],"from":[120,150,265,424,428,501,516],"traumatic":[121],"injuries.":[122],"The":[123,167,541],"enrolled":[126],"surveillance":[132],"program":[133],"at":[134,323,368,523],"Baltimore":[136],"VA":[137],"Medical":[138],"Center.":[139],"Evaluation":[140,253],"using":[143,256],"CBMN":[145],"assay:":[146,261],"Blood":[147,262],"was":[148,263,493],"drawn":[149,264],"35":[151,266],"male":[153,268],"aged":[155,270],"36":[156],"59":[158],"years,":[159,274],"then":[160,275],"cultured":[161,276],"evaluated":[163,465],"for":[164,279,381,466,514],"micronuclei":[165],"(MN).":[166],"participants":[168],"were":[169,288,297,308,313,353,422,436,458,472,528,537],"divided":[170],"into":[171],"two":[172],"groups,":[174],"low":[175],"high,":[177],"based":[178],"on":[179],"their":[180],"mean":[181,189],"urine":[182,190,250],"concentrations.":[184],"Poisson":[185],"regression":[186,311],"analyses":[187,312,471],"U":[191],"concentrations,":[192],"current":[193],"smoking,":[194,363],"X-rays":[195],"past":[198],"year":[199],"donor":[201],"age":[202,322,413],"dependent":[204,494],"variables":[205],"revealed":[206],"no":[207,531],"significant":[208,234,351,375,397,505,532],"relationships":[209,352,376],"MN":[211,237,244],"frequencies.":[212],"Our":[213],"results":[214,387],"indicate":[215,388],"ongoing":[217],"systemic":[218],"embedded":[228],"does":[231,394],"not":[232,395,522],"induce":[233,396],"increases":[235,506],"compared":[242],"frequencies":[245,336,477],"normal":[249],"levels.":[252],"FISH":[257],"painting":[260],"39":[271],"62":[273],"harvested":[278],"metaphase":[280,304,457],"analyses.":[282],"Chromosomes":[283],"1,":[284,449],"2,":[285,450],"4":[287,453,524],"painted":[289],"red":[290],"chromosomes":[292],"3,":[293],"5,":[294],"6":[296],"simultaneously":[298],"labeled":[299,459],"green.":[300],"At":[301],"least":[302],"1800":[303],"cells":[305,338,382],"per":[306],"subject":[307],"scored.":[309],"Univariate":[310],"performed":[314],"evaluate":[316,475],"log(urine":[320,360],"Uranium),":[321],"time":[324,370],"draw,":[327],"log(lifetime":[328,365],"X-rays),":[329],"pack-years":[330],"smoked":[331],"alcohol":[333],"use":[334],"against":[335],"translocated":[340,508],"chromosomes,":[341,509],"dicentrics,":[342,510],"acentric":[343,384],"fragments,":[344],"color":[345,512],"junctions":[346,513],"abnormal":[348],"cells.":[349],"No":[350],"observed":[354,538],"between":[355],"any":[356,553],"cytogenetic":[357],"endpoint":[358],"Uranium)":[361],"levels,":[362],"or":[364],"X-rays).":[366],"Age":[367],"draw":[373],"showed":[374,503],"all":[378],"endpoints":[379],"except":[380],"fragments.":[385],"These":[386],"chronic":[390],"levels":[398],"these":[403],"Veterans.":[404],"Chapter":[405],"4:":[406],"To":[407],"determine":[408,488],"extent":[410],"influences":[414],"individual":[415],"susceptibility":[416,490,536,543,556],"ionizing":[418,547],"radiation,":[419,548],"samples":[421],"collected":[423],"20":[425],"adults":[426,527],"umbilical":[430],"cords":[431],"10":[433],"newborns.":[434],"Samples":[435],"acutely":[437],"Cobalt":[440],"60":[441],"gamma":[442],"rays":[443],"doses":[445,515],"0":[447,517],"(control),":[448],"3":[451,519],"Gy.":[454,525],"Cells":[455],"paints":[463],"structural":[467,485],"aberrations.":[469],"Regression":[470],"each":[479],"major":[482],"classes":[483],"aberrations":[486],"whether":[489],"radiation":[492,535],"upon":[495],"age.":[496,540],"Compared":[497],"adults,":[499],"newborns":[502,545],"statistically":[504],"Gy,":[520],"but":[521],"When":[526],"considered":[529],"alone,":[530],"changes":[533],"increased":[542],"absence":[551],"change":[554],"adulthood,":[558],"should":[559],"be":[560],"relevant":[561],"when":[562],"making":[563],"radiation-exposure":[564],"risk":[565],"assessments.":[566]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}