{"id":"https://openalex.org/W2911545950","doi":"https://doi.org/10.1038/s41598-018-38218-7","title":"Analysis of the relationship between the gut microbiome and dementia: a cross-sectional study conducted in Japan","display_name":"Analysis of the relationship between the gut microbiome and dementia: a cross-sectional study conducted in Japan","publication_year":2019,"publication_date":"2019-01-30","ids":{"openalex":"https://openalex.org/W2911545950","doi":"https://doi.org/10.1038/s41598-018-38218-7","mag":"2911545950","pmid":"https://pubmed.ncbi.nlm.nih.gov/30700769","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6353871"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-38218-7","doi":"https://doi.org/10.1038/s41598-018-38218-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-38218-7","pdf_url":"https://www.nature.com/articles/s41598-018-38218-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-38218-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026148947","display_name":"Naoki Saji","orcid":"https://orcid.org/0000-0003-4228-1122","observed_orcids":["https://orcid.org/0000-0003-4228-1122"]},"institutions":[{"id":"https://openalex.org/I4405287281","display_name":"Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology","ror":"https://ror.org/04ppx2c62","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210160102","https://openalex.org/I4405287281"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Naoki Saji","raw_affiliation_strings":["Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Aichi, Japan. sajink@nifty.com","Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Aichi, Japan. sajink@nifty.com","institution_ids":["https://openalex.org/I4405287281"]},{"raw_affiliation_string":"Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Aichi, Japan","institution_ids":["https://openalex.org/I4405287281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082018968","display_name":"Shumpei Niida","orcid":"https://orcid.org/0000-0002-6192-8035","observed_orcids":["https://orcid.org/0000-0002-6192-8035"]},"institutions":[{"id":"https://openalex.org/I4405286437","display_name":"Medical Genome Center, National Center for Geriatrics and Gerontology","ror":"https://ror.org/0248mm645","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210160102","https://openalex.org/I4405286437"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shumpei Niida","raw_affiliation_strings":["Medical Genome Center, National Center for Geriatrics and Gerontology, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Genome Center, National Center for Geriatrics and Gerontology, Aichi, Japan","institution_ids":["https://openalex.org/I4405286437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020304167","display_name":"Kenta Murotani","orcid":"https://orcid.org/0000-0003-0623-9365","observed_orcids":["https://orcid.org/0000-0003-0623-9365"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenta Murotani","raw_affiliation_strings":["Biostatistics Center, Graduate School of Medicine, Kurume University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Center, Graduate School of Medicine, Kurume University, Fukuoka, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035881903","display_name":"Takayoshi Hisada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264133","display_name":"Technosuruga Laboratory Co., Ltd. (Japan)","ror":"https://ror.org/012a1z186","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264133"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayoshi Hisada","raw_affiliation_strings":["TechnoSuruga Laboratory Co., Ltd, Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TechnoSuruga Laboratory Co., Ltd, Shizuoka, Japan","institution_ids":["https://openalex.org/I4405264133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038004243","display_name":"Tsuyoshi Tsuduki","orcid":"https://orcid.org/0000-0001-7810-0528","observed_orcids":["https://orcid.org/0000-0001-7810-0528"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Tsuduki","raw_affiliation_strings":["Laboratory of Food and Biomolecular Science, Department of Bioscience and Biotechnology for Future Bioindustries, Graduate School of Agricultural Science, Tohoku University, Miyagi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Food and Biomolecular Science, Department of Bioscience and Biotechnology for Future Bioindustries, Graduate School of Agricultural Science, Tohoku University, Miyagi, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018238342","display_name":"Taiki Sugimoto","orcid":"https://orcid.org/0000-0002-6418-0755","observed_orcids":["https://orcid.org/0000-0002-6418-0755"]},"institutions":[{"id":"https://openalex.org/I4405287281","display_name":"Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology","ror":"https://ror.org/04ppx2c62","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210160102","https://openalex.org/I4405287281"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taiki Sugimoto","raw_affiliation_strings":["Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Aichi, Japan","institution_ids":["https://openalex.org/I4405287281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067740210","display_name":"Ai Kimura","orcid":"https://orcid.org/0000-0001-5641-514X","observed_orcids":["https://orcid.org/0000-0001-5641-514X"]},"institutions":[{"id":"https://openalex.org/I4405287281","display_name":"Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology","ror":"https://ror.org/04ppx2c62","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210160102","https://openalex.org/I4405287281"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ai Kimura","raw_affiliation_strings":["Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Aichi, Japan","institution_ids":["https://openalex.org/I4405287281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109376120","display_name":"Kenji Toba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287281","display_name":"Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology","ror":"https://ror.org/04ppx2c62","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210160102","https://openalex.org/I4405287281"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Toba","raw_affiliation_strings":["Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Aichi, Japan","institution_ids":["https://openalex.org/I4405287281"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074633419","display_name":"Takashi Sakurai","orcid":"https://orcid.org/0000-0002-2369-3095","observed_orcids":["https://orcid.org/0000-0002-2369-3095"]},"institutions":[{"id":"https://openalex.org/I4405287281","display_name":"Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology","ror":"https://ror.org/04ppx2c62","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210160102","https://openalex.org/I4405287281"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Sakurai","raw_affiliation_strings":["Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Aichi, Japan","Department of Cognition and Behavioural Science, Nagoya University Graduate School of Medicine, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Aichi, Japan","institution_ids":["https://openalex.org/I4405287281"]},{"raw_affiliation_string":"Department of Cognition and Behavioural Science, Nagoya University Graduate School of Medicine, Aichi, Japan","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5026148947"],"corresponding_institution_ids":["https://openalex.org/I4405287281"],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":{"value":1790,"currency":"USD","value_usd":1790},"fwci":8.8456,"has_fulltext":true,"cited_by_count":230,"citation_normalized_percentile":{"value":0.9893136,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"9","issue":"1","first_page":"1008","last_page":"1008"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/enterotypes","display_name":"enterotypes","score":0.8100000023841858},{"id":"https://openalex.org/keywords/bacteroides","display_name":"Bacteroides","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.6240000128746033},{"id":"https://openalex.org/keywords/memory-clinic-patients","display_name":"memory clinic patients","score":0.7900000214576721},{"id":"https://openalex.org/keywords/fecal-microbiota","display_name":"fecal microbiota","score":0.6930000185966492},{"id":"https://openalex.org/keywords/risk-factors-for-dementia","display_name":"dementia risk factors","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.8613206148147583},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.599031925201416},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5168545842170715},{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.49839282035827637},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48188620805740356},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.46099451184272766},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4350038468837738},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35876476764678955},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.30363643169403076},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23235318064689636},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22419610619544983},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.176259845495224},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.17062103748321533},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.13688114285469055},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.12142425775527954}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-018-38218-7","doi":"https://doi.org/10.1038/s41598-018-38218-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-38218-7","pdf_url":"https://www.nature.com/articles/s41598-018-38218-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5340842","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6353871","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30700769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30700769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6353871","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6353871/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f24cc0949dd340eca5abb343edde2451","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f24cc0949dd340eca5abb343edde2451","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-38218-7","doi":"https://doi.org/10.1038/s41598-018-38218-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-38218-7","pdf_url":"https://www.nature.com/articles/s41598-018-38218-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G159904393","display_name":null,"funder_award_id":"27-21, 28-15","funder_id":"https://openalex.org/F4320324312","funder_display_name":"National Center for Geriatrics and Gerontology"},{"id":"https://openalex.org/G4111985","display_name":null,"funder_award_id":"28-15","funder_id":"https://openalex.org/F4320324312","funder_display_name":"National Center for Geriatrics and Gerontology"},{"id":"https://openalex.org/G5165851080","display_name":null,"funder_award_id":"27-21","funder_id":"https://openalex.org/F4320324312","funder_display_name":"National Center for Geriatrics and Gerontology"}],"funders":[{"id":"https://openalex.org/F4320324312","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812"},{"id":"https://openalex.org/F4320335209","display_name":"Bio-oriented Technology Research Advancement Institution","ror":"https://ror.org/02f62sy66"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2911545950.pdf","grobid_xml":"https://content.openalex.org/works/W2911545950.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W38490725","https://openalex.org/W94125745","https://openalex.org/W755741475","https://openalex.org/W1624006680","https://openalex.org/W1847168837","https://openalex.org/W1953027527","https://openalex.org/W1965107490","https://openalex.org/W1971351343","https://openalex.org/W1974704788","https://openalex.org/W1980827933","https://openalex.org/W1986619117","https://openalex.org/W1991952617","https://openalex.org/W1997340294","https://openalex.org/W2008854521","https://openalex.org/W2032230795","https://openalex.org/W2075819229","https://openalex.org/W2086219374","https://openalex.org/W2112519660","https://openalex.org/W2115944543","https://openalex.org/W2128529067","https://openalex.org/W2130900065","https://openalex.org/W2148080316","https://openalex.org/W2158742097","https://openalex.org/W2162078360","https://openalex.org/W2163940893","https://openalex.org/W2167311298","https://openalex.org/W2287094926","https://openalex.org/W2293306613","https://openalex.org/W2295882128","https://openalex.org/W2346266308","https://openalex.org/W2396017371","https://openalex.org/W2466402964","https://openalex.org/W2508213551","https://openalex.org/W2508485654","https://openalex.org/W2519408637","https://openalex.org/W2549361670","https://openalex.org/W2600656194","https://openalex.org/W2626091936","https://openalex.org/W2736307756","https://openalex.org/W2761210275","https://openalex.org/W2765468584","https://openalex.org/W2786817892","https://openalex.org/W2790808039","https://openalex.org/W3182827017"],"related_works":["https://openalex.org/W2911773899","https://openalex.org/W3011559614","https://openalex.org/W3024321144","https://openalex.org/W3043167826","https://openalex.org/W4401222640","https://openalex.org/W4414491271","https://openalex.org/W7130924412","https://openalex.org/W4390198454","https://openalex.org/W2913828628","https://openalex.org/W4324387425"],"abstract_inverted_index":{"Dysregulation":[0],"of":[1,21,59,97,142,148,157,175,188,195,198],"the":[2,19,24,27,83,98,128,140,143,146,155,173,189,196,205],"gut":[3,28,84,109,144,199],"microbiome":[4,85],"is":[5],"associated":[6,131,184],"with":[7,132,185],"several":[8],"life-threatening":[9],"conditions":[10],"and":[11,31,57,64,72,82,101,118,154,178],"thus":[12],"might":[13],"represent":[14],"a":[15],"useful":[16],"target":[17],"for":[18,107],"prevention":[20],"dementia.":[22,133],"However,":[23],"relationship":[25],"between":[26],"microbial":[29],"population":[30],"dementia":[32,191],"has":[33],"not":[34],"yet":[35],"been":[36],"fully":[37],"clarified.":[38],"We":[39],"recruited":[40],"outpatients":[41],"visiting":[42],"our":[43],"memory":[44],"clinic":[45],"to":[46,126,203],"participate":[47],"in":[48,139,164],"this":[49,208],"study.":[50],"Information":[51],"on":[52],"patient":[53],"demographics,":[54],"risk":[55],"factors,":[56],"activities":[58],"daily":[60],"living":[61],"was":[62,67,86,152,162],"collected,":[63],"cognitive":[65],"function":[66],"assessed":[68,87],"using":[69],"neuropsychological":[70],"tests":[71],"brain":[73],"magnetic":[74],"resonance":[75],"imaging":[76],"scans.":[77],"Faecal":[78],"samples":[79],"were":[80,112,124,182],"obtained,":[81],"by":[88],"terminal":[89],"restriction":[90],"fragment":[91],"length":[92],"polymorphism":[93],"(T-RFLP)":[94],"analysis,":[95],"one":[96],"most":[99],"well-established":[100],"reliable":[102],"16S":[103],"ribosomal":[104],"RNA-based":[105],"methods":[106],"classifying":[108],"microbiota.":[110],"Patients":[111],"divided":[113],"into":[114],"two":[115],"groups,":[116],"demented":[117,165],"non-demented.":[119],"Multivariable":[120,169],"logistic":[121],"regression":[122],"models":[123],"used":[125],"identify":[127],"variables":[129],"independently":[130],"The":[134],"T-RFLP":[135],"analysis":[136],"revealed":[137],"differences":[138],"composition":[141],"microbiome:":[145],"number":[147,156],"Bacteroides":[149],"(enterotype":[150,160],"I)":[151],"lower":[153],"'other'":[158],"bacteria":[159,181],"III)":[161],"higher":[163],"than":[166],"non-demented":[167],"patients.":[168],"analyses":[170],"showed":[171],"that":[172],"populations":[174],"enterotype":[176,179],"I":[177],"III":[180],"strongly":[183],"dementia,":[186],"independent":[187],"traditional":[190],"biomarkers.":[192],"Further":[193],"studies":[194],"metabolites":[197],"microbes":[200],"are":[201],"needed":[202],"determine":[204],"mechanism":[206],"underlying":[207],"association.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":27},{"year":2024,"cited_by_count":33},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":44},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":34},{"year":2019,"cited_by_count":18}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2019-02-21T00:00:00"}
