{"id":"https://openalex.org/W2911539014","doi":"https://doi.org/10.3390/pharmaceutics11020070","title":"Applicability of a Modified Rat Model of Acute Arthritis for Long-Term Testing of Drug Delivery Systems","display_name":"Applicability of a Modified Rat Model of Acute Arthritis for Long-Term Testing of Drug Delivery Systems","publication_year":2019,"publication_date":"2019-02-07","ids":{"openalex":"https://openalex.org/W2911539014","doi":"https://doi.org/10.3390/pharmaceutics11020070","mag":"2911539014","pmid":"https://pubmed.ncbi.nlm.nih.gov/30736430","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6409650"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics11020070","doi":"https://doi.org/10.3390/pharmaceutics11020070","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/pharmaceutics11020070","pdf_url":"https://www.mdpi.com/1999-4923/11/2/70/pdf?version=1550484950","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/11/2/70/pdf?version=1550484950","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027699581","display_name":"Imke Rudnik\u2010Jansen","orcid":"https://orcid.org/0000-0002-2508-3610","observed_orcids":["https://orcid.org/0000-0002-2508-3610"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Imke Rudnik-Jansen","raw_affiliation_strings":["Department of Orthopedics, University Medical Center Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-2508-3610","affiliations":[{"raw_affiliation_string":"Department of Orthopedics, University Medical Center Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038864501","display_name":"Nina Woike","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127558574","display_name":"DSM (Netherlands)","ror":"https://ror.org/00k01kt20","country_code":"NL","type":"company","lineage":["https://openalex.org/I127558574"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nina Woike","raw_affiliation_strings":["DSM Biomedical B.V., Koestraat 1, 6167 RA Geleen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DSM Biomedical B.V., Koestraat 1, 6167 RA Geleen, The Netherlands","institution_ids":["https://openalex.org/I127558574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065245987","display_name":"Suzanne de Jong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Suzanne de Jong","raw_affiliation_strings":["Department of Orthopedics, University Medical Center Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, University Medical Center Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043735668","display_name":"Sabine Versteeg","orcid":"https://orcid.org/0000-0001-8457-3452","observed_orcids":["https://orcid.org/0000-0001-8457-3452"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sabine Versteeg","raw_affiliation_strings":["Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-8457-3452","affiliations":[{"raw_affiliation_string":"Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086435562","display_name":"Marja J. L. Kik","orcid":"https://orcid.org/0000-0003-4113-1405","observed_orcids":["https://orcid.org/0000-0003-4113-1405"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marja Kik","raw_affiliation_strings":["Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085736490","display_name":"Pieter J. Emans","orcid":"https://orcid.org/0000-0001-9370-5525","observed_orcids":["https://orcid.org/0000-0001-9370-5525"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]},{"id":"https://openalex.org/I4405268545","display_name":"Care and Public Health Research Institute","ror":"https://ror.org/01930wn69","country_code":"NL","type":"facility","lineage":["https://openalex.org/I34352273","https://openalex.org/I4405268545"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pieter Emans","raw_affiliation_strings":["Department of Orthopaedic Surgery, Research School CAPHRI, Maastricht University Medical Centre, P. Debyelaan, 25, 6229 HX Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Research School CAPHRI, Maastricht University Medical Centre, P. Debyelaan, 25, 6229 HX Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I4405268545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112198547","display_name":"George Mihov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127558574","display_name":"DSM (Netherlands)","ror":"https://ror.org/00k01kt20","country_code":"NL","type":"company","lineage":["https://openalex.org/I127558574"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"George Mihov","raw_affiliation_strings":["DSM Biomedical B.V., Koestraat 1, 6167 RA Geleen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DSM Biomedical B.V., Koestraat 1, 6167 RA Geleen, The Netherlands","institution_ids":["https://openalex.org/I127558574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113581406","display_name":"Jens Thies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127558574","display_name":"DSM (Netherlands)","ror":"https://ror.org/00k01kt20","country_code":"NL","type":"company","lineage":["https://openalex.org/I127558574"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jens Thies","raw_affiliation_strings":["DSM Biomedical B.V., Koestraat 1, 6167 RA Geleen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DSM Biomedical B.V., Koestraat 1, 6167 RA Geleen, The Netherlands","institution_ids":["https://openalex.org/I127558574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069621745","display_name":"Niels Eijkelkamp","orcid":"https://orcid.org/0000-0003-0039-7063","observed_orcids":["https://orcid.org/0000-0003-0039-7063"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Niels Eijkelkamp","raw_affiliation_strings":["Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073803993","display_name":"Marianna A. Tryfonidou","orcid":"https://orcid.org/0000-0002-2333-7162","observed_orcids":["https://orcid.org/0000-0002-2333-7162"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marianna Tryfonidou","raw_affiliation_strings":["Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-2333-7162","affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057275242","display_name":"Laura B. Creemers","orcid":"https://orcid.org/0000-0002-1585-3052","observed_orcids":["https://orcid.org/0000-0002-1585-3052"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Laura Creemers","raw_affiliation_strings":["Department of Orthopedics, University Medical Center Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-1585-3052","affiliations":[{"raw_affiliation_string":"Department of Orthopedics, University Medical Center Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5057275242"],"corresponding_institution_ids":["https://openalex.org/I3018483916"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1621},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1621},"fwci":1.4352,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.75456442,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"2","first_page":"70","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.6122999787330627,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.6122999787330627,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.28200000524520874,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/corticosteroid-delivery","display_name":"corticosteroid delivery","score":0.6589999794960022},{"id":"https://openalex.org/keywords/triamcinolone-acetonide","display_name":"triamcinolone acetonide","score":0.9639999866485596},{"id":"https://openalex.org/keywords/plga-microspheres","display_name":"PLGA microspheres","score":0.972000002861023},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6359999775886536},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.878000020980835},{"id":"https://openalex.org/keywords/osteophyte-formation","display_name":"osteophyte formation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/systemic-side-effects","display_name":"systemic side effects","score":0.8050000071525574},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.7880913019180298},{"id":"https://openalex.org/C2779244835","wikidata":"https://www.wikidata.org/wiki/Q538432","display_name":"Synovitis","level":3,"score":0.765068531036377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7524073123931885},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5917262434959412},{"id":"https://openalex.org/C2778903070","wikidata":"https://www.wikidata.org/wiki/Q2211240","display_name":"Triamcinolone acetonide","level":2,"score":0.5363010168075562},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.4822976589202881},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4739679992198944},{"id":"https://openalex.org/C2775956843","wikidata":"https://www.wikidata.org/wiki/Q924421","display_name":"Septic arthritis","level":3,"score":0.4520350992679596},{"id":"https://openalex.org/C2781227287","wikidata":"https://www.wikidata.org/wiki/Q421991","display_name":"Carrageenan","level":2,"score":0.4405679702758789},{"id":"https://openalex.org/C2779771469","wikidata":"https://www.wikidata.org/wiki/Q1428918","display_name":"Lameness","level":2,"score":0.4326787292957306},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.333984375},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3317587971687317},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.324302077293396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26049578189849854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09046915173530579},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":12,"locations":[{"id":"doi:10.3390/pharmaceutics11020070","doi":"https://doi.org/10.3390/pharmaceutics11020070","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/pharmaceutics11020070","pdf_url":"https://www.mdpi.com/1999-4923/11/2/70/pdf?version=1550484950","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5418106","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6409650","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6409650","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6409650","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmid:30736430","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30736430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/4323ad68-4e95-467b-9175-84d36a273f4e","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/4323ad68-4e95-467b-9175-84d36a273f4e","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rudnik-Jansen, I, Woike, N, de Jong, S, Versteeg, S, Kik, M, Emans, P, Mihov, G, Thies, J, Eijkelkamp, N, Tryfonidou, M & Creemers, L 2019, 'Applicability of a Modified Rat Model of Acute Arthritis for Long-Term Testing of Drug Delivery Systems', Pharmaceutics, vol. 11, no. 2, 70. https://doi.org/10.3390/pharmaceutics11020070","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/f2040b5a-4096-4377-b020-0740dac000da","doi":null,"is_oa":true,"landing_page_url":"http://www.mdpi.com/1999-4923/11/2/70","pdf_url":"http://www.mdpi.com/1999-4923/11/2/70","source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rudnik-jansen, I, Woike, N, De Jong, S, Versteeg, S, Kik, M, Emans, P, Mihov, G, Thies, J, Eijkelkamp, N, Tryfonidou, M & Creemers, L 2019, 'Applicability of a Modified Rat Model of Acute Arthritis for Long-Term Testing of Drug Delivery Systems', Pharmaceutics, vol. 11, no. 2, pp. 70. https://doi.org/10.3390/pharmaceutics11020070","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:0c9438dc7d7e4f48992300a5adaa807e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0c9438dc7d7e4f48992300a5adaa807e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 11, Iss 2, p 70 (2019)","raw_type":"article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/377946","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/377946","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/388534","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/388534","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/4323ad68-4e95-467b-9175-84d36a273f4e","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/4323ad68-4e95-467b-9175-84d36a273f4e","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, 11(2):70. Multidisciplinary Digital Publishing Institute (MDPI)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/388534","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/388534","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, 11(2)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/377946","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/377946","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Pharmaceutics, 11(2). American Chemical Society","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics11020070","doi":"https://doi.org/10.3390/pharmaceutics11020070","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/pharmaceutics11020070","pdf_url":"https://www.mdpi.com/1999-4923/11/2/70/pdf?version=1550484950","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320331585","display_name":"Dutch Arthritis Association","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2911539014.pdf","grobid_xml":"https://content.openalex.org/works/W2911539014.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W43502400","https://openalex.org/W799912760","https://openalex.org/W1925599086","https://openalex.org/W1926610892","https://openalex.org/W1964756939","https://openalex.org/W1978255418","https://openalex.org/W2006383068","https://openalex.org/W2024461025","https://openalex.org/W2046297549","https://openalex.org/W2048976516","https://openalex.org/W2051725755","https://openalex.org/W2053916112","https://openalex.org/W2120840387","https://openalex.org/W2121496050","https://openalex.org/W2123454415","https://openalex.org/W2150691073","https://openalex.org/W2154461664","https://openalex.org/W2160989052","https://openalex.org/W2167795966","https://openalex.org/W2172201406","https://openalex.org/W2413232455","https://openalex.org/W2427410389","https://openalex.org/W2553909066","https://openalex.org/W2586898822","https://openalex.org/W2591860844","https://openalex.org/W2599720289","https://openalex.org/W2606554067","https://openalex.org/W2742630504","https://openalex.org/W2774144962","https://openalex.org/W2783582719","https://openalex.org/W2786076295","https://openalex.org/W2796684805","https://openalex.org/W2799710215","https://openalex.org/W2801140633","https://openalex.org/W2888426471","https://openalex.org/W4298032478","https://openalex.org/W6601795805","https://openalex.org/W6843523315"],"related_works":["https://openalex.org/W2802775690","https://openalex.org/W2920883437","https://openalex.org/W2936375680","https://openalex.org/W2591860844","https://openalex.org/W3138484018","https://openalex.org/W2966942807","https://openalex.org/W2659996878","https://openalex.org/W2094100409","https://openalex.org/W6903567744","https://openalex.org/W2336332762"],"abstract_inverted_index":{"Episodes":[0],"of":[1,8,24,34,53,61,83,106,119,127,131,136,157,163],"inflammation":[2,18,52,105],"and":[3,19,68,96,104,133,184,188],"pain":[4,20,91,189],"are":[5],"predominant":[6],"features":[7],"arthritic":[9],"joint":[10,89,186],"diseases.":[11],"Drug":[12],"delivery":[13],"systems":[14],"(DDS)":[15],"could":[16],"reduce":[17],"long-term":[21,32,125],"without":[22],"chances":[23],"infection":[25],"upon":[26],"multiple":[27],"injections.":[28],"To":[29,115],"allow":[30],"for":[31,79,124,155,159],"evaluation":[33],"DDS,":[35,128],"we":[36],"modified":[37,121,149],"a":[38,80,137,160],"previously":[39],"published":[40],"acute":[41],"arthritis":[42,122,150],"model":[43,123,151],"by":[44,58,72],"extending":[45],"follow-up":[46],"periods":[47],"between":[48],"flare-ups.":[49],"Unilateral":[50],"synovial":[51],"the":[54,117,120,129,166],"knee":[55],"was":[56,145,177],"induced":[57,71],"intra-articular":[59],"injection":[60],"streptococcal":[62],"cell":[63],"wall":[64],"peptidoglycan":[65],"polysaccharide":[66],"(PGPS),":[67],"flare-ups":[69],"were":[70,99,109],"intravenous":[73],"PGPS":[74],"injections":[75],"every":[76],"4":[77],"weeks":[78],"total":[81],"duration":[82,130],"84":[84],"days.":[85],"In":[86],"PGPS-reactivated":[87],"animals,":[88],"swelling,":[90],"behavior,":[92],"post":[93],"mortem":[94],"synovitis,":[95],"osteophyte":[97],"formation":[98],"notable":[100],"features.":[101],"Hepatitis,":[102],"splenitis":[103],"non-primed":[107],"joints":[108],"observed":[110],"as":[111],"systemic":[112],"side":[113],"effects.":[114],"test":[116],"applicability":[118,154],"testing":[126,156],"anti-inflammatory":[132],"analgesic":[134],"effects":[135],"corticosteroid":[138],"released":[139],"from":[140],"two":[141],"different":[142],"polymer-based":[143],"platforms":[144],"evaluated.":[146],"The":[147],"current":[148],"has":[152],"good":[153],"DDS":[158],"prolonged":[161],"period":[162],"time.":[164],"Furthermore,":[165],"novel":[167],"autoregulatory":[168],"polyesteramide":[169],"(PEA)":[170],"microsphere":[171],"platform":[172],"releasing":[173],"triamcinolone":[174],"acetonide":[175],"(TAA)":[176],"benchmarked":[178],"against":[179],"poly":[180],"lactic-co-glycolic":[181],"acid":[182],"(PLGA)":[183],"reduced":[185],"swelling":[187],"behavior":[190],"more":[191],"potently":[192],"compared":[193],"to":[194],"TAA-loaded":[195],"PLGA":[196],"microspheres.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-02-21T00:00:00"}
