{"id":"https://openalex.org/W2911428489","doi":"https://doi.org/10.1093/jn/nxy287","title":"Supplementation with N-Acetyl Cysteine Affects Motor and Cognitive Function in Young but Not Old Mice","display_name":"Supplementation with N-Acetyl Cysteine Affects Motor and Cognitive Function in Young but Not Old Mice","publication_year":2018,"publication_date":"2018-10-23","ids":{"openalex":"https://openalex.org/W2911428489","doi":"https://doi.org/10.1093/jn/nxy287","mag":"2911428489","pmid":"https://pubmed.ncbi.nlm.nih.gov/30770531","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6398433"},"language":"en","primary_location":{"id":"doi:10.1093/jn/nxy287","doi":"https://doi.org/10.1093/jn/nxy287","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jn/nxy287","pdf_url":null,"source":{"id":"https://openalex.org/S88153332","display_name":"Journal of Nutrition","issn_l":"0022-3166","issn":["0022-3166","1541-6100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1093/jn/nxy287","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063994804","display_name":"Uzoma S. Ikonne","orcid":"https://orcid.org/0000-0002-5938-0699","observed_orcids":["https://orcid.org/0000-0002-5938-0699"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]},{"id":"https://openalex.org/I4584351","display_name":"A.T. Still University","ror":"https://ror.org/05hr6q169","country_code":"US","type":"education","lineage":["https://openalex.org/I4584351"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uzoma S Ikonne","raw_affiliation_strings":["Basic Medical Science, School of Osteopathic Medicine Arizona, A.T. Still University, Mesa, AZ","Department of Pharmacology and Neuroscience and Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Medical Science, School of Osteopathic Medicine Arizona, A.T. Still University, Mesa, AZ","institution_ids":["https://openalex.org/I4584351"]},{"raw_affiliation_string":"Department of Pharmacology and Neuroscience and Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032136445","display_name":"Philip H. Vann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip H Vann","raw_affiliation_strings":["Department of Pharmacology and Neuroscience and Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Neuroscience and Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103644477","display_name":"Jessica M. Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica M Wong","raw_affiliation_strings":["Department of Pharmacology and Neuroscience and Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Neuroscience and Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106129609","display_name":"Michael J. Forster","orcid":"https://orcid.org/0000-0002-3284-2558","observed_orcids":["https://orcid.org/0000-0002-3284-2558"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J Forster","raw_affiliation_strings":["Department of Pharmacology and Neuroscience and Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Neuroscience and Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073698677","display_name":"Nathalie Sumien","orcid":"https://orcid.org/0000-0002-0077-9873","observed_orcids":["https://orcid.org/0000-0002-0077-9873"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nathalie Sumien","raw_affiliation_strings":["Department of Pharmacology and Neuroscience and Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX"],"raw_orcid":"https://orcid.org/0000-0002-0077-9873","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Neuroscience and Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX","institution_ids":["https://openalex.org/I165139151"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073698677"],"corresponding_institution_ids":["https://openalex.org/I165139151"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.10707071,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"149","issue":"3","first_page":"463","last_page":"470"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.788100004196167,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.788100004196167,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.04899999871850014,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13446","display_name":"Antioxidants, Aging, Portulaca oleracea","score":0.036400001496076584,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8970000147819519},{"id":"https://openalex.org/keywords/motor-function","display_name":"motor function","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9350000023841858},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.3490000069141388},{"id":"https://openalex.org/keywords/nootropic-effects","display_name":"nootropic effects","score":0.7129999995231628},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.8920000195503235},{"id":"https://openalex.org/keywords/spatial-learning","display_name":"spatial learning","score":0.5410000085830688},{"id":"https://openalex.org/keywords/aged-mice","display_name":"aged mice","score":0.36500000953674316}],"concepts":[{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.6557177901268005},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5679033994674683},{"id":"https://openalex.org/C2988438704","wikidata":"https://www.wikidata.org/wiki/Q2996165","display_name":"Motor function","level":2,"score":0.48316115140914917},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4455655813217163},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41320380568504333},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3914582133293152},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37626874446868896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36257946491241455},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3577478528022766},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33217883110046387},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32797932624816895},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3002298176288605},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21449145674705505},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.140733540058136},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09364306926727295}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000821","descriptor_name":"Animal Feed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065853","descriptor_name":"Spatial Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/jn/nxy287","doi":"https://doi.org/10.1093/jn/nxy287","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jn/nxy287","pdf_url":null,"source":{"id":"https://openalex.org/S88153332","display_name":"Journal of Nutrition","issn_l":"0022-3166","issn":["0022-3166","1541-6100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Nutrition","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5990134","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6398433","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6398433","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6398433","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Nutr","raw_type":"Text"},{"id":"pmid:30770531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30770531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of nutrition","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/jn/nxy287","doi":"https://doi.org/10.1093/jn/nxy287","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jn/nxy287","pdf_url":null,"source":{"id":"https://openalex.org/S88153332","display_name":"Journal of Nutrition","issn_l":"0022-3166","issn":["0022-3166","1541-6100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2948333616","display_name":"Brain aging and antioxidant supplementation","funder_award_id":"R01AG027353","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3565291582","display_name":null,"funder_award_id":"AG 022550","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8761618467","display_name":null,"funder_award_id":"AG027353","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000903356","display_name":"Training in the Neurobiology of Aging and Alzheimer's Disease","funder_award_id":"T32AG020494","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1965132831","https://openalex.org/W1967874462","https://openalex.org/W1976494740","https://openalex.org/W1977542129","https://openalex.org/W1979349684","https://openalex.org/W1984521955","https://openalex.org/W1986219537","https://openalex.org/W1991007222","https://openalex.org/W2001817718","https://openalex.org/W2007745798","https://openalex.org/W2017081132","https://openalex.org/W2022148560","https://openalex.org/W2030733295","https://openalex.org/W2034751609","https://openalex.org/W2037841972","https://openalex.org/W2041029983","https://openalex.org/W2045929574","https://openalex.org/W2046848338","https://openalex.org/W2053968878","https://openalex.org/W2054360287","https://openalex.org/W2060011496","https://openalex.org/W2072328912","https://openalex.org/W2075194339","https://openalex.org/W2078974726","https://openalex.org/W2080086352","https://openalex.org/W2084015464","https://openalex.org/W2084485820","https://openalex.org/W2088099182","https://openalex.org/W2090880672","https://openalex.org/W2094466584","https://openalex.org/W2101756828","https://openalex.org/W2104438296","https://openalex.org/W2116256673","https://openalex.org/W2117280515","https://openalex.org/W2119624946","https://openalex.org/W2121836743","https://openalex.org/W2122393056","https://openalex.org/W2124107177","https://openalex.org/W2124828104","https://openalex.org/W2132043124","https://openalex.org/W2132870100","https://openalex.org/W2133557409","https://openalex.org/W2135996987","https://openalex.org/W2151644670","https://openalex.org/W2157379864","https://openalex.org/W2158884281","https://openalex.org/W2166539778","https://openalex.org/W2170807824","https://openalex.org/W2263123173","https://openalex.org/W2287584360","https://openalex.org/W2289081559","https://openalex.org/W2341199927","https://openalex.org/W2372687103","https://openalex.org/W2558739631","https://openalex.org/W2980618919"],"related_works":["https://openalex.org/W4378514984","https://openalex.org/W4403818330","https://openalex.org/W7020851085","https://openalex.org/W2037841972","https://openalex.org/W2885274775","https://openalex.org/W2368304656","https://openalex.org/W1976678890","https://openalex.org/W2925858876","https://openalex.org/W2093935584","https://openalex.org/W3113601595"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-02-21T00:00:00"}