{"id":"https://openalex.org/W2911417841","doi":"https://doi.org/10.3389/fphar.2019.00007","title":"Platelet-Derived Microparticles From Obese Individuals: Characterization of Number, Size, Proteomics, and Crosstalk With Cancer and Endothelial Cells","display_name":"Platelet-Derived Microparticles From Obese Individuals: Characterization of Number, Size, Proteomics, and Crosstalk With Cancer and Endothelial Cells","publication_year":2019,"publication_date":"2019-01-21","ids":{"openalex":"https://openalex.org/W2911417841","doi":"https://doi.org/10.3389/fphar.2019.00007","mag":"2911417841","pmid":"https://pubmed.ncbi.nlm.nih.gov/30723407","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6349702"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2019.00007","doi":"https://doi.org/10.3389/fphar.2019.00007","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2019.00007","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2019.00007/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2019.00007/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006174440","display_name":"Rosalia Grande","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosalia Grande","raw_affiliation_strings":["Center of Research on Aging and Translational Medicine (CeSI-MeT), Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","Department of Neurosciences, Imaging and Clinical Sciences, Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Research on Aging and Translational Medicine (CeSI-MeT), Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]},{"raw_affiliation_string":"Department of Neurosciences, Imaging and Clinical Sciences, Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060810522","display_name":"Melania Dovizio","orcid":"https://orcid.org/0000-0003-0301-7767","observed_orcids":["https://orcid.org/0000-0003-0301-7767"]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Melania Dovizio","raw_affiliation_strings":["Center of Research on Aging and Translational Medicine (CeSI-MeT), Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","Department of Neurosciences, Imaging and Clinical Sciences, Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Research on Aging and Translational Medicine (CeSI-MeT), Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]},{"raw_affiliation_string":"Department of Neurosciences, Imaging and Clinical Sciences, Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050281843","display_name":"Simone Marcone","orcid":"https://orcid.org/0000-0001-5516-4000","observed_orcids":["https://orcid.org/0000-0001-5516-4000"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Simone Marcone","raw_affiliation_strings":["Systems Biology Ireland, Conway SPHERE Research Group Ireland, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Ireland, Conway SPHERE Research Group Ireland, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069297217","display_name":"Paulina B. Szklanna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Paulina B. Szklanna","raw_affiliation_strings":["Conway SPHERE Research Group Ireland, UCD Conway Institute, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conway SPHERE Research Group Ireland, UCD Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025062710","display_name":"Annalisa Bruno","orcid":"https://orcid.org/0000-0002-6167-7141","observed_orcids":["https://orcid.org/0000-0002-6167-7141"]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annalisa Bruno","raw_affiliation_strings":["Center of Research on Aging and Translational Medicine (CeSI-MeT), Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","Department of Neurosciences, Imaging and Clinical Sciences, Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Research on Aging and Translational Medicine (CeSI-MeT), Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]},{"raw_affiliation_string":"Department of Neurosciences, Imaging and Clinical Sciences, Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054449714","display_name":"Holger Alexander Ebhardt","orcid":"https://orcid.org/0000-0001-9019-8388","observed_orcids":["https://orcid.org/0000-0001-9019-8388"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"H. Alexander Ebhardt","raw_affiliation_strings":["Systems Biology Ireland, Conway SPHERE Research Group Ireland, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Ireland, Conway SPHERE Research Group Ireland, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065002510","display_name":"Hilary Cassidy","orcid":"https://orcid.org/0000-0001-6334-8379","observed_orcids":["https://orcid.org/0000-0001-6334-8379"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Hilary Cassidy","raw_affiliation_strings":["Systems Biology Ireland, Conway SPHERE Research Group Ireland, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Ireland, Conway SPHERE Research Group Ireland, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062217593","display_name":"Fionnuala N\u00ed \u00c1inle","orcid":"https://orcid.org/0000-0003-0163-792X","observed_orcids":["https://orcid.org/0000-0003-0163-792X"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Fionnuala N\u00ed \u00c1inle","raw_affiliation_strings":["Conway SPHERE Research Group Ireland, UCD Conway Institute, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conway SPHERE Research Group Ireland, UCD Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111587496","display_name":"Anna Caprodossi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Caprodossi","raw_affiliation_strings":["Department of Internal Medicine, Catholic University, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Catholic University, Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010992446","display_name":"Paola Lanuti","orcid":"https://orcid.org/0000-0003-4197-9780","observed_orcids":["https://orcid.org/0000-0003-4197-9780"]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Lanuti","raw_affiliation_strings":["Center of Research on Aging and Translational Medicine (CeSI-MeT), Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","Department of Medicine and Aging Sciences, Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Research on Aging and Translational Medicine (CeSI-MeT), Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]},{"raw_affiliation_string":"Department of Medicine and Aging Sciences, Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088919162","display_name":"Marco Marchisio","orcid":"https://orcid.org/0000-0003-3058-3422","observed_orcids":["https://orcid.org/0000-0003-3058-3422"]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Marchisio","raw_affiliation_strings":["Center of Research on Aging and Translational Medicine (CeSI-MeT), Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","Department of Medicine and Aging Sciences, Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Research on Aging and Translational Medicine (CeSI-MeT), Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]},{"raw_affiliation_string":"Department of Medicine and Aging Sciences, Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053488036","display_name":"Geltrude Mingrone","orcid":"https://orcid.org/0000-0003-2021-528X","observed_orcids":["https://orcid.org/0000-0003-2021-528X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geltrude Mingrone","raw_affiliation_strings":["Department of Internal Medicine, Catholic University, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Catholic University, Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027950733","display_name":"Patricia B. Maguire","orcid":"https://orcid.org/0000-0002-0362-3778","observed_orcids":["https://orcid.org/0000-0002-0362-3778"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Patricia B. Maguire","raw_affiliation_strings":["Conway SPHERE Research Group Ireland, UCD Conway Institute, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conway SPHERE Research Group Ireland, UCD Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071758568","display_name":"Paola Patrignani","orcid":"https://orcid.org/0000-0003-1419-2691","observed_orcids":["https://orcid.org/0000-0003-1419-2691"]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Paola Patrignani","raw_affiliation_strings":["Center of Research on Aging and Translational Medicine (CeSI-MeT), Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","Department of Neurosciences, Imaging and Clinical Sciences, Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Research on Aging and Translational Medicine (CeSI-MeT), Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]},{"raw_affiliation_string":"Department of Neurosciences, Imaging and Clinical Sciences, Universit\u00e0 degli Studi \"G. d'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071758568"],"corresponding_institution_ids":["https://openalex.org/I39387349"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.6827,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.9166248,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"7","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.08869999647140503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-microparticles","display_name":"platelet microparticles","score":0.9860000014305115},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thrombin-activated-platelets","display_name":"thrombin-activated platelets","score":0.9390000104904175},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8450000286102295},{"id":"https://openalex.org/keywords/endothelial-mesenchymal-transition","display_name":"endothelial-to-mesenchymal transition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.8870000243186951},{"id":"https://openalex.org/keywords/colorectal-cancer-cells","display_name":"colorectal cancer cells","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cardiac-microvascular-endothelial-cells","display_name":"cardiac microvascular endothelial cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.8270000219345093},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.7379999756813049},{"id":"https://openalex.org/keywords/atherothrombosis","display_name":"atherothrombosis","score":0.7889999747276306},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.599516749382019},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.5879590511322021},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5682621002197266},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4282549023628235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3938300311565399},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3848358392715454},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3821741044521332},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3528502583503723},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3497680425643921},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.33700427412986755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.331623911857605},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32486218214035034},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.29197174310684204},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28131094574928284},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2100658416748047},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10802590847015381},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09893748164176941},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.3389/fphar.2019.00007","doi":"https://doi.org/10.3389/fphar.2019.00007","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2019.00007","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2019.00007/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5339851","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6349702","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30723407","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30723407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6349702","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6349702/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:http://www.rian.ie/167749/","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10197/10700","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal article"},{"id":"pmh:oai:doaj.org/article:6d7e099b74d74b9aaf8873d2be5b2e59","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6d7e099b74d74b9aaf8873d2be5b2e59","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 10 (2019)","raw_type":"article"},{"id":"pmh:oai:publicatt.unicatt.it:10807/147838","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10807/147838","pdf_url":null,"source":{"id":"https://openalex.org/S4306400564","display_name":"PubliCatt (Universit\u00e0 Cattolica del Sacro Cuore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:researchrepository.ucd.ie:10197/10700","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10197/10700","pdf_url":null,"source":{"id":"https://openalex.org/S4306402280","display_name":"Research Repository UCD (University College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I100930933","host_organization_name":"University College Dublin","host_organization_lineage":["https://openalex.org/I100930933"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2019.00007","doi":"https://doi.org/10.3389/fphar.2019.00007","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2019.00007","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2019.00007/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1563557662","display_name":null,"funder_award_id":"20365","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G1855991024","display_name":null,"funder_award_id":"IG-2017","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G2318108903","display_name":null,"funder_award_id":"10/IN.1/B3012","funder_id":"https://openalex.org/F4320321056","funder_display_name":"Irish Research Council"},{"id":"https://openalex.org/G531194814","display_name":null,"funder_award_id":"GOIPG/2014/575","funder_id":"https://openalex.org/F4320321056","funder_display_name":"Irish Research Council"},{"id":"https://openalex.org/G7989473473","display_name":"Wnt pathway in vascular biology: a novel target in atherothrombosis","funder_award_id":"10/IN.1/B3012","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"}],"funders":[{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320321056","display_name":"Irish Research Council","ror":"https://ror.org/051xex213"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2911417841.pdf","grobid_xml":"https://content.openalex.org/works/W2911417841.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W644234521","https://openalex.org/W1557543416","https://openalex.org/W1746876201","https://openalex.org/W1829220066","https://openalex.org/W1970375775","https://openalex.org/W1988212011","https://openalex.org/W1988506697","https://openalex.org/W1994824043","https://openalex.org/W2000807708","https://openalex.org/W2002699471","https://openalex.org/W2010740201","https://openalex.org/W2013234962","https://openalex.org/W2038326745","https://openalex.org/W2087092058","https://openalex.org/W2115342244","https://openalex.org/W2127702161","https://openalex.org/W2154589460","https://openalex.org/W2157820287","https://openalex.org/W2399965300","https://openalex.org/W2418237318","https://openalex.org/W2512611204","https://openalex.org/W2615170291","https://openalex.org/W2806134841","https://openalex.org/W2809383808","https://openalex.org/W6647753406"],"related_works":["https://openalex.org/W2160624766","https://openalex.org/W1826967184","https://openalex.org/W7133567066","https://openalex.org/W2058184747","https://openalex.org/W1538612491","https://openalex.org/W1967170278","https://openalex.org/W2164557057","https://openalex.org/W2002639815","https://openalex.org/W6922858140","https://openalex.org/W2594516084"],"abstract_inverted_index":{"Rationale.":[0],"Obesity":[1],"is":[2],"a":[3,148,151],"risk":[4,311],"factor":[5],"for":[6,38,312],"atherothrombosis":[7],"and":[8,35,41,44,64,71,80,84,96,106,139,160,180,185,216,226,247,270,279,296,300,317],"various":[9],"cancers.":[10],"However,":[11],"the":[12,25,45,51,58,65,76,174,177,192,209,241,292,309,313],"mechanisms":[13],"are":[14],"not":[15,118],"yet":[16],"completely":[17],"clarified.":[18],"Objectives.":[19],"We":[20],"aimed":[21],"to":[22,47,57,60,67,207,277,288,301,308],"verify":[23],"whether":[24],"microparticles":[26],"(MPs)":[27],"released":[28,198],"from":[29,89,114,166,199,252,282],"thrombin-activated":[30],"platelets":[31,92,200],"differed":[32],"in":[33,49,75,120,126,163,173,183,191,237,257,268,291,320],"obese":[34,95,115,129,167,195,202,238,253,263,283],"nonobese":[36,99,169],"women":[37,116,254,264],"number,":[39],"size,":[40],"proteomics":[42],"cargo":[43],"capacity":[46,287],"modulate":[48],"vitro":[50],"expression":[52,210,293],"of":[53,78,93,150,176,194,201,211,214,262,274,294,315],"(i)":[54],"genes":[55,213,299],"related":[56],"epithelial":[59],"mesenchymal":[61,68],"transition":[62,69],"(EMT)":[63],"endothelial":[66,230],"(EndMT),":[70],"(ii)":[72],"cyclooxygenase(COX)-2":[73],"involved":[74,182],"production":[77],"angiogenic":[79],"inflammatory":[81],"mediators.":[82],"Methods":[83],"Results.":[85],"MPs":[86,101,113,131,164,193,197,251,261,281],"were":[87,102,117,204],"obtained":[88,165],"thrombin":[90],"activated":[91],"four":[94],"their":[97],"matched":[98],"women.":[100,170],"analyzed":[103],"by":[104,109],"cytofluorimeter":[105],"protein":[107,244],"content":[108],"liquid":[110],"chromatography-mass":[111],"spectrometry.":[112],"different":[119,272],"number":[121,328],"but":[122],"showed":[123,265],"increased":[124,140,310],"heterogeneity":[125,267],"size.":[127],"In":[128],"individuals,":[130],"containing":[132],"mitochondria":[133],"(mitoMPs)":[134],"expressed":[135],"lower":[136],"CD41":[137],"levels":[138,273],"phosphatidylserine":[141],"associated":[142],"with":[143,220,245],"enhanced":[144,236,286],"Factor":[145],"V":[146],"representing":[147],"signature":[149],"prothrombotic":[152],"state.":[153],"Proteomics":[154],"analysis":[155],"identified":[156],"44":[157],"proteins":[158,175,275],"downregulated":[159],"three":[161],"upregulated":[162],"versus":[168],"A":[171,233],"reduction":[172],"a-granular":[178],"membrane":[179,188],"those":[181],"mitophagy":[184],"antioxidant":[186],"defenses-granular":[187],"was":[189,240],"detected":[190],"individuals.":[196],"individuals":[203,284],"more":[205],"prone":[206],"induce":[208,302],"marker":[212,298],"EMT":[215,295],"EndMT":[217,297],"when":[218],"incubated":[219],"HT29":[221],"human":[222,227],"colorectal":[223],"cancer":[224],"cells":[225],"cardiac":[228],"microvascular":[229],"cells(HCMEC),":[231],"respectively.":[232],"protein,":[234],"highly":[235],"MPs,":[239],"pro-platelet":[242],"basic":[243],"pro-inflammatory":[246],"tumorigenic":[248],"actions.":[249],"Exclusively":[250],"induced":[255],"COX-2":[256],"HCMEC.":[258],"Conclusions.":[259],"Platelet-derived":[260],"higher":[266],"size":[269],"contained":[271],"relevant":[276],"thrombosis":[278,316],"tumorigenesis.":[280],"presented":[285],"cause":[289],"changes":[290],"COX-2.":[303],"These":[304],"effects":[305],"might":[306],"contribute":[307],"development":[314],"multiple":[318],"malignancies":[319],"obesity.":[321],"Clinical":[322],"Trial":[323],"Registration":[324,327],"number:":[325],"Clinicaltrials.gov":[326],"NCT01581801":[329]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-02-21T00:00:00"}