{"id":"https://openalex.org/W2911337652","doi":"https://doi.org/10.1016/j.fct.2019.02.008","title":"A six-month systems toxicology inhalation/cessation study in ApoE\u2212/\u2212 mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes","display_name":"A six-month systems toxicology inhalation/cessation study in ApoE\u2212/\u2212 mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes","publication_year":2019,"publication_date":"2019-02-12","ids":{"openalex":"https://openalex.org/W2911337652","doi":"https://doi.org/10.1016/j.fct.2019.02.008","mag":"2911337652","pmid":"https://pubmed.ncbi.nlm.nih.gov/30763686"},"language":"en","primary_location":{"id":"doi:10.1016/j.fct.2019.02.008","doi":"https://doi.org/10.1016/j.fct.2019.02.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.fct.2019.02.008","pdf_url":null,"source":{"id":"https://openalex.org/S84231135","display_name":"Food and Chemical Toxicology","issn_l":"0278-6915","issn":["0278-6915","1873-6351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food and Chemical Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.fct.2019.02.008","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017568469","display_name":"Blaine Wesley Phillips","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Blaine Phillips","raw_affiliation_strings":["PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore. Electronic address: Blaine.Phillips@pmi.com","PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore. Electronic address: Blaine.Phillips@pmi.com","institution_ids":[]},{"raw_affiliation_string":"PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021007589","display_name":"Justyna Szostak","orcid":"https://orcid.org/0000-0002-6233-612X","observed_orcids":["https://orcid.org/0000-0002-6233-612X"]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Justyna Szostak","raw_affiliation_strings":["PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Justyna.Szostak@pmi.com","PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Justyna.Szostak@pmi.com","institution_ids":["https://openalex.org/I2800621710"]},{"raw_affiliation_string":"PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045793906","display_name":"Bjoern Titz","orcid":"https://orcid.org/0000-0003-4414-4105","observed_orcids":["https://orcid.org/0000-0003-4414-4105"]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Bjoern Titz","raw_affiliation_strings":["PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Bjorn.Titz@pmi.com"],"raw_orcid":"https://orcid.org/0000-0003-4414-4105","affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Bjorn.Titz@pmi.com","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112609781","display_name":"Walter K. Schlage","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter K. Schlage","raw_affiliation_strings":["Max-Baermann-Str. 21, 51429, Bergisch Gladbach, Germany. Electronic address: wk.schlage@t-online.de","Max-Baermann-Str. 21, 51429, Bergisch Gladbach, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Baermann-Str. 21, 51429, Bergisch Gladbach, Germany. Electronic address: wk.schlage@t-online.de","institution_ids":[]},{"raw_affiliation_string":"Max-Baermann-Str. 21, 51429, Bergisch Gladbach, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008160276","display_name":"Emmanuel Guedj","orcid":"https://orcid.org/0000-0002-6166-1027","observed_orcids":["https://orcid.org/0000-0002-6166-1027"]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Emmanuel Guedj","raw_affiliation_strings":["PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Emmanuel.Guedj@pmi.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Emmanuel.Guedj@pmi.com","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047111847","display_name":"Patrice Leroy","orcid":"https://orcid.org/0000-0001-8587-9517","observed_orcids":["https://orcid.org/0000-0001-8587-9517"]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Patrice Leroy","raw_affiliation_strings":["PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Patrice.Leroy@pmi.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Patrice.Leroy@pmi.com","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065384499","display_name":"Gr\u00e9gory Vuillaume","orcid":"https://orcid.org/0000-0003-2115-4562","observed_orcids":["https://orcid.org/0000-0003-2115-4562"]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gregory Vuillaume","raw_affiliation_strings":["PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Gregory.Vuillaume@pmi.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Gregory.Vuillaume@pmi.com","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058143169","display_name":"Florian Pierre Martin","orcid":"https://orcid.org/0000-0002-5968-5484","observed_orcids":["https://orcid.org/0000-0002-5968-5484"]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Florian Martin","raw_affiliation_strings":["PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Florian.Martin@pmi.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Florian.Martin@pmi.com","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112411481","display_name":"Ansgar Buettner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ansgar Buettner","raw_affiliation_strings":["Histovia GmbH, Sch\u00f6ne Aussicht 5, 51491, Overath, Germany. Electronic address: a.buettner@histovia.com","Histovia GmbH, Sch\u00f6ne Aussicht 5, 51491, Overath, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Histovia GmbH, Sch\u00f6ne Aussicht 5, 51491, Overath, Germany. Electronic address: a.buettner@histovia.com","institution_ids":[]},{"raw_affiliation_string":"Histovia GmbH, Sch\u00f6ne Aussicht 5, 51491, Overath, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113718425","display_name":"Ashraf Elamin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ashraf Elamin","raw_affiliation_strings":["PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Ashraf.Elamin@pmi.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Ashraf.Elamin@pmi.com","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109389668","display_name":"Alain Sewer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alain Sewer","raw_affiliation_strings":["PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Alain.Sewer@pmi.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Alain.Sewer@pmi.com","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039023090","display_name":"Nicolas Sierro","orcid":"https://orcid.org/0000-0003-2793-5896","observed_orcids":["https://orcid.org/0000-0003-2793-5896"]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nicolas Sierro","raw_affiliation_strings":["PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Nicolas.Sierro@pmi.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Nicolas.Sierro@pmi.com","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064463525","display_name":"Mohamed-Amin Choukrallah","orcid":"https://orcid.org/0000-0001-9997-8620","observed_orcids":["https://orcid.org/0000-0001-9997-8620"]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mohamed Amin Choukrallah","raw_affiliation_strings":["PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: MohamedAmin.Choukrallah@pmi.com"],"raw_orcid":"https://orcid.org/0000-0001-9997-8620","affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: MohamedAmin.Choukrallah@pmi.com","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028123583","display_name":"Thomas Schneider","orcid":"https://orcid.org/0000-0003-1125-0518","observed_orcids":["https://orcid.org/0000-0003-1125-0518"]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas Schneider","raw_affiliation_strings":["PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Thomas.Schneider@pmi.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Thomas.Schneider@pmi.com","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032018257","display_name":"Nikolai V. Ivanov","orcid":"https://orcid.org/0000-0002-2052-4333","observed_orcids":["https://orcid.org/0000-0002-2052-4333"]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nikolai V. Ivanov","raw_affiliation_strings":["PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Nikolai.Ivanov@pmi.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Nikolai.Ivanov@pmi.com","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Charles Teng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Teng","raw_affiliation_strings":["PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore. Electronic address: Charles.Teng@pmi.com","PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore. Electronic address: Charles.Teng@pmi.com","institution_ids":[]},{"raw_affiliation_string":"PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067497771","display_name":"Ching Keong Tung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ching Keong Tung","raw_affiliation_strings":["PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore. Electronic address: ChingKeong.Tung@pmi.com","PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore. Electronic address: ChingKeong.Tung@pmi.com","institution_ids":[]},{"raw_affiliation_string":"PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050035136","display_name":"Wei Ting Lim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Ting Lim","raw_affiliation_strings":["PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore. Electronic address: WeiTing.Lim@pmi.com","PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore. Electronic address: WeiTing.Lim@pmi.com","institution_ids":[]},{"raw_affiliation_string":"PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077677256","display_name":"Ying Shan Yeo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Shan Yeo","raw_affiliation_strings":["PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore. Electronic address: YingShan.Yeo@pmi.com","PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore. Electronic address: YingShan.Yeo@pmi.com","institution_ids":[]},{"raw_affiliation_string":"PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017919384","display_name":"Patrick Vanscheeuwijck","orcid":"https://orcid.org/0000-0002-8232-1734","observed_orcids":["https://orcid.org/0000-0002-8232-1734"]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Patrick Vanscheeuwijck","raw_affiliation_strings":["PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Patrick.Vanscheeuwijck@pmi.com"],"raw_orcid":"https://orcid.org/0000-0002-8232-1734","affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Patrick.Vanscheeuwijck@pmi.com","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012278670","display_name":"Manuel C. Peitsch","orcid":"https://orcid.org/0000-0001-5324-359X","observed_orcids":["https://orcid.org/0000-0001-5324-359X"]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Manuel C. Peitsch","raw_affiliation_strings":["PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Manuel.Peitsch@pmi.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Manuel.Peitsch@pmi.com","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087038430","display_name":"Julia Hoeng","orcid":"https://orcid.org/0000-0001-5371-6801","observed_orcids":["https://orcid.org/0000-0001-5371-6801"]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Julia Hoeng","raw_affiliation_strings":["PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Julia.Hoeng@pmi.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuch\u00e2tel, Switzerland. Electronic address: Julia.Hoeng@pmi.com","institution_ids":["https://openalex.org/I2800621710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087038430"],"corresponding_institution_ids":["https://openalex.org/I2800621710"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":9.4005,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.98562117,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"126","issue":null,"first_page":"113","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modified-risk-tobacco-products","display_name":"modified risk tobacco products","score":0.9200000166893005},{"id":"https://openalex.org/keywords/heated-tobacco-products","display_name":"heated tobacco products","score":0.7870000004768372},{"id":"https://openalex.org/keywords/tobacco-heating-system-2-2","display_name":"tobacco heating system 2.2","score":0.972000002861023},{"id":"https://openalex.org/keywords/cigarette-smoke","display_name":"cigarette smoke","score":0.7599999904632568},{"id":"https://openalex.org/keywords/cardiovascular-effects","display_name":"cardiovascular effects","score":0.4959999918937683},{"id":"https://openalex.org/keywords/respiratory-effects","display_name":"respiratory effects","score":0.9549999833106995},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.7820000052452087},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.8709999918937683},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.718999981880188},{"id":"https://openalex.org/keywords/smoking-cessation","display_name":"smoking cessation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.8679999709129333},{"id":"https://openalex.org/keywords/systems-toxicology","display_name":"systems toxicology","score":0.6779999732971191},{"id":"https://openalex.org/keywords/aerosol-exposure","display_name":"aerosol exposure","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C117437137","wikidata":"https://www.wikidata.org/wiki/Q5038720","display_name":"Cardiorespiratory fitness","level":2,"score":0.828887939453125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6731203198432922},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.5839037299156189},{"id":"https://openalex.org/C2777843972","wikidata":"https://www.wikidata.org/wiki/Q2462253","display_name":"Smoking cessation","level":2,"score":0.546730101108551},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5423744916915894},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.5350433588027954},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.527579665184021},{"id":"https://openalex.org/C2779777708","wikidata":"https://www.wikidata.org/wiki/Q6033622","display_name":"Inhalation exposure","level":3,"score":0.49877309799194336},{"id":"https://openalex.org/C2778355491","wikidata":"https://www.wikidata.org/wiki/Q2386268","display_name":"Tobacco smoke","level":2,"score":0.48243770003318787},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4419366717338562},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.43718114495277405},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4146946668624878},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3787539005279541},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32254183292388916},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.31987863779067993},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2085062861442566}],"mesh":[{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012906","descriptor_name":"Smoke","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019570","descriptor_name":"Inhalation Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062789","descriptor_name":"Tobacco Products","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D062789","descriptor_name":"Tobacco Products","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D066300","descriptor_name":"Electronic Nicotine Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.fct.2019.02.008","doi":"https://doi.org/10.1016/j.fct.2019.02.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.fct.2019.02.008","pdf_url":null,"source":{"id":"https://openalex.org/S84231135","display_name":"Food and Chemical Toxicology","issn_l":"0278-6915","issn":["0278-6915","1873-6351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food and Chemical Toxicology","raw_type":"journal-article"},{"id":"pmid:30763686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30763686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.fct.2019.02.008","doi":"https://doi.org/10.1016/j.fct.2019.02.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.fct.2019.02.008","pdf_url":null,"source":{"id":"https://openalex.org/S84231135","display_name":"Food and Chemical Toxicology","issn_l":"0278-6915","issn":["0278-6915","1873-6351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food and Chemical Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315260","display_name":"Philip Morris International","ror":"https://ror.org/005rxfw29"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W121129961","https://openalex.org/W1209674312","https://openalex.org/W1613133166","https://openalex.org/W1900995897","https://openalex.org/W1968069972","https://openalex.org/W1970612537","https://openalex.org/W1974240937","https://openalex.org/W1976029010","https://openalex.org/W1979778692","https://openalex.org/W1988633497","https://openalex.org/W1988964726","https://openalex.org/W1996454798","https://openalex.org/W1997707189","https://openalex.org/W2005533938","https://openalex.org/W2007383329","https://openalex.org/W2009343792","https://openalex.org/W2020979989","https://openalex.org/W2022525201","https://openalex.org/W2023010129","https://openalex.org/W2024904679","https://openalex.org/W2029662843","https://openalex.org/W2031562994","https://openalex.org/W2035756448","https://openalex.org/W2036412628","https://openalex.org/W2039053594","https://openalex.org/W2041515611","https://openalex.org/W2042930277","https://openalex.org/W2048605574","https://openalex.org/W2050391714","https://openalex.org/W2059879972","https://openalex.org/W2059887272","https://openalex.org/W2069388373","https://openalex.org/W2083155349","https://openalex.org/W2106343349","https://openalex.org/W2113048216","https://openalex.org/W2113475163","https://openalex.org/W2119621267","https://openalex.org/W2120890012","https://openalex.org/W2124664397","https://openalex.org/W2125328211","https://openalex.org/W2125709882","https://openalex.org/W2143215863","https://openalex.org/W2143984502","https://openalex.org/W2147030538","https://openalex.org/W2154431017","https://openalex.org/W2155121555","https://openalex.org/W2159545009","https://openalex.org/W2159981521","https://openalex.org/W2163411228","https://openalex.org/W2164530099","https://openalex.org/W2167423201","https://openalex.org/W2171319214","https://openalex.org/W2180943013","https://openalex.org/W2222531348","https://openalex.org/W2254323136","https://openalex.org/W2313709757","https://openalex.org/W2334663002","https://openalex.org/W2395253867","https://openalex.org/W2476842411","https://openalex.org/W2503411126","https://openalex.org/W2529623586","https://openalex.org/W2540431787","https://openalex.org/W2551737554","https://openalex.org/W2563273586","https://openalex.org/W2565570313","https://openalex.org/W2573670608","https://openalex.org/W2609543937","https://openalex.org/W2744090333","https://openalex.org/W2757703359","https://openalex.org/W2789997601","https://openalex.org/W2791630349","https://openalex.org/W2798245630","https://openalex.org/W2803694512","https://openalex.org/W4236918658","https://openalex.org/W4245562741","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2254323136","https://openalex.org/W2985752783","https://openalex.org/W2888019334","https://openalex.org/W3048471443","https://openalex.org/W1988964726","https://openalex.org/W2791630349","https://openalex.org/W2252910309","https://openalex.org/W2789358468","https://openalex.org/W2798245630","https://openalex.org/W3018462184"],"abstract_inverted_index":{"Smoking":[0],"is":[1],"one":[2],"of":[3,14,64,115,136,177],"the":[4,10,46,53,62,69,81,98,134,154,174,192],"major":[5],"modifiable":[6],"risk":[7],"factors":[8],"in":[9,139],"development":[11],"and":[12,20,90,127,144,163,166,187],"progression":[13],"chronic":[15],"obstructive":[16],"pulmonary":[17],"disease":[18,22],"(COPD)":[19],"cardiovascular":[21],"(CVD).":[23],"Modified-risk":[24],"tobacco":[25,86,91],"products":[26,34],"(MRTP)":[27],"are":[28,38],"being":[29],"developed":[30],"to":[31,42,44,60,110,132,141,159,189,196],"provide":[32],"substitute":[33],"for":[35],"smokers":[36],"who":[37],"unable":[39],"or":[40,73,108],"unwilling":[41],"quit,":[43],"lessen":[45],"smoking-related":[47],"health":[48],"risks.":[49],"In":[50,105],"this":[51],"study,":[52],"ApoE":[54],"-/-":[55],"mouse":[56],"model":[57],"was":[58,118,130],"used":[59,131],"investigate":[61],"impact":[63,135,152],"cigarette":[65,71],"smoke":[66],"(CS)":[67],"from":[68,75],"reference":[70],"3R4F,":[72],"aerosol":[74],"two":[76],"potential":[77],"MRTPs":[78],"based":[79],"on":[80,97,153],"heat-not-burn":[82],"principle,":[83],"carbon":[84],"heated":[85],"product":[87],"1.2":[88],"(CHTP1.2)":[89],"heating":[92],"system":[93,100],"2.2":[94],"(THS":[95],"2.2),":[96],"cardiorespiratory":[99,155],"over":[101],"a":[102],"6-month":[103],"period.":[104],"addition,":[106],"cessation":[107,186],"switching":[109,188],"CHTP1.2":[111,143,190],"after":[112],"3":[113],"months":[114],"CS":[116,194],"exposure":[117,199],"assessed.":[119],"A":[120],"systems":[121],"toxicology":[122],"approach":[123],"combining":[124],"physiology,":[125],"histology":[126],"molecular":[128],"measurements":[129],"evaluate":[133],"MRTP":[137,181],"aerosols":[138,182],"comparison":[140],"CS.":[142,184],"THS2.2":[145],"aerosols,":[146],"compared":[147],"with":[148],"CS,":[149],"demonstrated":[150],"lower":[151,175],"system,":[156],"including":[157],"low":[158],"absent":[160],"lung":[161],"inflammation":[162],"emphysematous":[164],"changes,":[165],"reduced":[167,191],"atherosclerotic":[168],"plaque":[169],"formation.":[170],"Molecular":[171],"analyses":[172],"confirmed":[173],"engagement":[176],"pathological":[178],"mechanisms":[179],"by":[180],"than":[183],"Both":[185],"observed":[193],"effects":[195],"almost":[197],"sham":[198],"levels.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-02-21T00:00:00"}