{"id":"https://openalex.org/W2911283567","doi":"https://doi.org/10.1016/j.devcel.2018.12.019","title":"Dying Neurons Utilize Innate Immune Signaling to Prime Glia for Phagocytosis during Development","display_name":"Dying Neurons Utilize Innate Immune Signaling to Prime Glia for Phagocytosis during Development","publication_year":2019,"publication_date":"2019-02-01","ids":{"openalex":"https://openalex.org/W2911283567","doi":"https://doi.org/10.1016/j.devcel.2018.12.019","mag":"2911283567","pmid":"https://pubmed.ncbi.nlm.nih.gov/30745142","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6394877"},"language":"en","primary_location":{"id":"doi:10.1016/j.devcel.2018.12.019","doi":"https://doi.org/10.1016/j.devcel.2018.12.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.devcel.2018.12.019","pdf_url":"http://www.cell.com/article/S1534580718310876/pdf","source":{"id":"https://openalex.org/S83804233","display_name":"Developmental Cell","issn_l":"1534-5807","issn":["1534-5807","1878-1551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1534580718310876/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048060413","display_name":"Colleen N. McLaughlin","orcid":"https://orcid.org/0000-0002-7518-8920","observed_orcids":["https://orcid.org/0000-0002-7518-8920"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Colleen N. McLaughlin","raw_affiliation_strings":["Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: colleen.mclaughlin@case.edu","Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: colleen.mclaughlin@case.edu","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077694631","display_name":"Jahci J. Perry-Richardson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jahci J. Perry-Richardson","raw_affiliation_strings":["Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044768199","display_name":"Jaeda Coutinho\u2010Budd","orcid":"https://orcid.org/0000-0002-7055-5701","observed_orcids":["https://orcid.org/0000-0002-7055-5701"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaeda C. Coutinho-Budd","raw_affiliation_strings":["Department of Biology, University of Vermont, Burlington, VT 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028768032","display_name":"Heather Tarczy Broihier","orcid":"https://orcid.org/0000-0003-1363-3088","observed_orcids":["https://orcid.org/0000-0003-1363-3088"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Heather T. Broihier","raw_affiliation_strings":["Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: heather.broihier@case.edu","Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: heather.broihier@case.edu","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028768032","https://openalex.org/A5048060413"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":3.2509,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.92409662,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"48","issue":"4","first_page":"506","last_page":"522.e6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.054099999368190765,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.0357000008225441,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.6880000233650208},{"id":"https://openalex.org/keywords/glial-phagocytosis","display_name":"glial phagocytosis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/toll-like-receptor-signaling","display_name":"Toll-like receptor signaling","score":0.656000018119812},{"id":"https://openalex.org/keywords/neuronal-glial-interactions","display_name":"neuron-glia interactions","score":0.6859999895095825},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.5149999856948853},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.828000009059906},{"id":"https://openalex.org/keywords/neuronal-development","display_name":"neuronal development","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8608273267745972},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7832431793212891},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6589489579200745},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5481423139572144},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.5481278896331787},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5468797087669373},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.49271586537361145},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47558534145355225},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4524752199649811},{"id":"https://openalex.org/C201934248","wikidata":"https://www.wikidata.org/wiki/Q2492999","display_name":"Neuroimmunology","level":3,"score":0.4365394711494446},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4238261878490448},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.41888123750686646},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28503328561782837},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.16729307174682617},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0759103000164032},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06718149781227112},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.devcel.2018.12.019","doi":"https://doi.org/10.1016/j.devcel.2018.12.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.devcel.2018.12.019","pdf_url":"http://www.cell.com/article/S1534580718310876/pdf","source":{"id":"https://openalex.org/S83804233","display_name":"Developmental Cell","issn_l":"1534-5807","issn":["1534-5807","1878-1551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Cell","raw_type":"journal-article"},{"id":"pmid:30745142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30745142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental cell","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6394877","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6394877","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Dev Cell","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.devcel.2018.12.019","doi":"https://doi.org/10.1016/j.devcel.2018.12.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.devcel.2018.12.019","pdf_url":"http://www.cell.com/article/S1534580718310876/pdf","source":{"id":"https://openalex.org/S83804233","display_name":"Developmental Cell","issn_l":"1534-5807","issn":["1534-5807","1878-1551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1793152271","display_name":null,"funder_award_id":"S10OD016164","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G7134411673","display_name":"Acquisition of a Leica TCS SP5 Confocal Microscope For A Multi-User Facility","funder_award_id":"S10OD016164","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8931947809","display_name":"Establishing a transcriptional pathway for cell-fate and synaptic plasticity","funder_award_id":"R21NS090369","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000862237","display_name":"Case Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA043703","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000906240","display_name":"Linking an activity-dependent BMP pathway to synapse structure and function","funder_award_id":"R01NS095895","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2911283567.pdf"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W4063809","https://openalex.org/W1496444476","https://openalex.org/W1503369776","https://openalex.org/W1871390418","https://openalex.org/W1908692741","https://openalex.org/W1965130745","https://openalex.org/W1966626266","https://openalex.org/W1972589133","https://openalex.org/W1973396930","https://openalex.org/W1975543396","https://openalex.org/W1978655989","https://openalex.org/W1986918091","https://openalex.org/W1993076702","https://openalex.org/W1995915955","https://openalex.org/W1997393571","https://openalex.org/W1997816650","https://openalex.org/W2002753890","https://openalex.org/W2011488306","https://openalex.org/W2015936607","https://openalex.org/W2019522924","https://openalex.org/W2026386725","https://openalex.org/W2027215260","https://openalex.org/W2033617297","https://openalex.org/W2044278174","https://openalex.org/W2051007447","https://openalex.org/W2053974741","https://openalex.org/W2056762193","https://openalex.org/W2058503779","https://openalex.org/W2059996790","https://openalex.org/W2073133778","https://openalex.org/W2077328898","https://openalex.org/W2078532650","https://openalex.org/W2079156871","https://openalex.org/W2088354566","https://openalex.org/W2094458576","https://openalex.org/W2095168793","https://openalex.org/W2098084836","https://openalex.org/W2107360458","https://openalex.org/W2114546997","https://openalex.org/W2114589067","https://openalex.org/W2115185894","https://openalex.org/W2116760607","https://openalex.org/W2117775547","https://openalex.org/W2119171331","https://openalex.org/W2119747146","https://openalex.org/W2121347099","https://openalex.org/W2125236750","https://openalex.org/W2126464408","https://openalex.org/W2128910881","https://openalex.org/W2130145174","https://openalex.org/W2131350617","https://openalex.org/W2132259121","https://openalex.org/W2134998339","https://openalex.org/W2136123169","https://openalex.org/W2136437831","https://openalex.org/W2139587743","https://openalex.org/W2142013845","https://openalex.org/W2142290831","https://openalex.org/W2143311793","https://openalex.org/W2144203350","https://openalex.org/W2151326362","https://openalex.org/W2152914442","https://openalex.org/W2154007629","https://openalex.org/W2156831108","https://openalex.org/W2157071511","https://openalex.org/W2159875818","https://openalex.org/W2161999580","https://openalex.org/W2171326152","https://openalex.org/W2270928752","https://openalex.org/W2281944328","https://openalex.org/W2297627090","https://openalex.org/W2333008150","https://openalex.org/W2488088692","https://openalex.org/W2500984141","https://openalex.org/W2510435545","https://openalex.org/W2572710398","https://openalex.org/W2593447930","https://openalex.org/W2605232447","https://openalex.org/W2768019512","https://openalex.org/W2770012336","https://openalex.org/W2790822372","https://openalex.org/W2793872352","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2147319333","https://openalex.org/W2915220763","https://openalex.org/W4323864131","https://openalex.org/W2051007447","https://openalex.org/W4220959180","https://openalex.org/W3126069866","https://openalex.org/W1973396930","https://openalex.org/W2076751578","https://openalex.org/W4387026932","https://openalex.org/W168085335"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2019-02-21T00:00:00"}