{"id":"https://openalex.org/W2911280754","doi":"https://doi.org/10.4049/jimmunol.198.supp.211.13","title":"IL-33/ST2 macrophage crosstalk promotes lung epithelial repair","display_name":"IL-33/ST2 macrophage crosstalk promotes lung epithelial repair","publication_year":2017,"publication_date":"2017-05-01","ids":{"openalex":"https://openalex.org/W2911280754","doi":"https://doi.org/10.4049/jimmunol.198.supp.211.13","mag":"2911280754"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.198.supp.211.13","doi":"https://doi.org/10.4049/jimmunol.198.supp.211.13","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.198.supp.211.13","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047730142","display_name":"Rania Dagher","orcid":"https://orcid.org/0000-0002-3335-2921","observed_orcids":["https://orcid.org/0000-0002-3335-2921"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rania Dagher","raw_affiliation_strings":["MedImmune","1MedImmune"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune","institution_ids":[]},{"raw_affiliation_string":"1MedImmune","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064140831","display_name":"Alan M. Copenhaver","orcid":"https://orcid.org/0000-0001-5952-0455","observed_orcids":["https://orcid.org/0000-0001-5952-0455"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan M Copenhaver","raw_affiliation_strings":["MedImmune","1MedImmune"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune","institution_ids":[]},{"raw_affiliation_string":"1MedImmune","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055564924","display_name":"Val\u00e9rie Besnard","orcid":"https://orcid.org/0000-0002-2614-629X","observed_orcids":["https://orcid.org/0000-0002-2614-629X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Valerie Besnard","raw_affiliation_strings":["Natl Inst. of Hlth. and Med. Res., France (INSERM) ,","2Natl Inst. of Hlth. and Med. Res., France (INSERM), France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natl Inst. of Hlth. and Med. Res., France (INSERM) ,","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"2Natl Inst. of Hlth. and Med. Res., France (INSERM), France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084439955","display_name":"Marielle Maret","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marielle Maret","raw_affiliation_strings":["Natl Inst. of Hlth. and Med. Res., France (INSERM) ,","2Natl Inst. of Hlth. and Med. Res., France (INSERM), France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natl Inst. of Hlth. and Med. Res., France (INSERM) ,","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"2Natl Inst. of Hlth. and Med. Res., France (INSERM), France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047833431","display_name":"Fatima Hamidi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fatima Hamidi","raw_affiliation_strings":["Natl Inst. of Hlth. and Med. Res., France (INSERM) ,","2Natl Inst. of Hlth. and Med. Res., France (INSERM), France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natl Inst. of Hlth. and Med. Res., France (INSERM) ,","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"2Natl Inst. of Hlth. and Med. Res., France (INSERM), France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037668891","display_name":"Aaron A. Berlin","orcid":"https://orcid.org/0000-0002-4499-8074","observed_orcids":["https://orcid.org/0000-0002-4499-8074"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aaron A Berlin","raw_affiliation_strings":["MedImmune","1MedImmune"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune","institution_ids":[]},{"raw_affiliation_string":"1MedImmune","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082700583","display_name":"Michel Aubier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Aubier","raw_affiliation_strings":["Assistance Publique Hopitaux de Paris (APHP) ,","3Assistance Publique Hopitaux de Paris (APHP), France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique Hopitaux de Paris (APHP) ,","institution_ids":["https://openalex.org/I4210097159"]},{"raw_affiliation_string":"3Assistance Publique Hopitaux de Paris (APHP), France","institution_ids":["https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109223635","display_name":"Roland Kolbeck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roland Kolbeck","raw_affiliation_strings":["MedImmune","1MedImmune"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune","institution_ids":[]},{"raw_affiliation_string":"1MedImmune","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061309096","display_name":"Alison A. Humbles","orcid":"https://orcid.org/0000-0003-0045-9340","observed_orcids":["https://orcid.org/0000-0003-0045-9340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alison A Humbles","raw_affiliation_strings":["MedImmune","1MedImmune"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune","institution_ids":[]},{"raw_affiliation_string":"1MedImmune","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021630549","display_name":"Marina Pretolani","orcid":"https://orcid.org/0000-0003-4576-5990","observed_orcids":["https://orcid.org/0000-0003-4576-5990"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marina Pretolani","raw_affiliation_strings":["Natl Inst. of Hlth. and Med. Res., France (INSERM) ,","2Natl Inst. of Hlth. and Med. Res., France (INSERM), France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natl Inst. of Hlth. and Med. Res., France (INSERM) ,","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"2Natl Inst. of Hlth. and Med. Res., France (INSERM), France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"198","issue":"Supplement_1","first_page":"211.13","last_page":"211.13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-33-st2-axis","display_name":"IL-33/ST2 axis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.9620000123977661},{"id":"https://openalex.org/keywords/lung-epithelial-repair","display_name":"lung epithelial repair","score":0.7300000190734863},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.9259999990463257},{"id":"https://openalex.org/keywords/ccl2-ccr2-axis","display_name":"CCL2/CCR2 axis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/monocyte-derived-cells","display_name":"monocyte-derived cells","score":0.6449999809265137},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.6449999809265137},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5884404182434082},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5583909749984741},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5282365679740906},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.527959942817688},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.5135488510131836},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.49586352705955505},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4780188798904419},{"id":"https://openalex.org/C206615009","wikidata":"https://www.wikidata.org/wiki/Q4035572","display_name":"CCR2","level":5,"score":0.47249260544776917},{"id":"https://openalex.org/C101666144","wikidata":"https://www.wikidata.org/wiki/Q2587862","display_name":"CCL2","level":4,"score":0.44119542837142944},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.42860960960388184},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4266572594642639},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4263530969619751},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.40435194969177246},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.40018701553344727},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3722003102302551},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.28145015239715576},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2711363732814789},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10439124703407288},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10307881236076355},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.0979296863079071},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.07533606886863708},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.198.supp.211.13","doi":"https://doi.org/10.4049/jimmunol.198.supp.211.13","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.198.supp.211.13","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3088610553","https://openalex.org/W4399364814","https://openalex.org/W2051063796","https://openalex.org/W4312202062","https://openalex.org/W2252889442","https://openalex.org/W4313356080","https://openalex.org/W2773158155","https://openalex.org/W3116033534","https://openalex.org/W2897713835","https://openalex.org/W2132247162"],"abstract_inverted_index":{"Abstract":[0],"Increasing":[1],"evidence":[2],"points":[3],"to":[4,152,188],"a":[5,31,45,105,110,116],"central":[6],"role":[7,33,50],"for":[8,51,146],"macrophages":[9,36,80],"in":[10,37,55,112,135,156,192],"tissue":[11],"regeneration,":[12],"however,":[13,148],"the":[14,52,84,87,90,113,133,140,162,171],"molecular":[15],"mechanisms":[16],"underlying":[17],"this":[18],"function":[19],"remain":[20],"unknown.":[21],"Here,":[22],"using":[23],"depletion":[24],"and":[25,47,76,109,160,179,185],"adoptive":[26],"transfer":[27],"approaches,":[28],"we":[29,43],"demonstrate":[30],"major":[32],"of":[34,67,89,115,119,126],"alveolar":[35],"facilitating":[38],"bronchial":[39,91,180],"re-epithelialization.":[40],"In":[41,138],"addition,":[42],"identify":[44],"novel,":[46],"paradoxical,":[48],"protective":[49],"IL-33/ST2":[53,172],"axis":[54,143],"epithelial":[56,99,158],"repair":[57,100],"following":[58],"naphthalene":[59],"(NA)-induced":[60],"lung":[61],"injury.":[62,169],"We":[63],"defined":[64],"two":[65],"subsets":[66],"ST2":[68],"expressing":[69],"myeloid":[70],"cells,":[71],"namely":[72],"recruited":[73],"monocyte-derived":[74],"cells":[75],"resident":[77],"alternatively":[78],"activated":[79],"(AAMs),":[81],"which":[82,101],"infiltrate":[83],"airways":[85],"during":[86],"regeneration":[88,159,178],"epithelium.":[92],"Further,":[93],"ST2-deficient":[94,136],"mice":[95,154],"exhibited":[96],"an":[97],"incomplete":[98],"was":[102,144],"associated":[103],"with":[104,165],"dysfunctional":[106],"AAM":[107,183],"phenotype":[108],"reduction":[111],"proliferation":[114],"self-renewing":[117],"subset":[118],"Clara":[120,176],"progenitor":[121],"stem":[122],"cells.":[123],"Notably,":[124],"reconstitution":[125],"ST2+":[127],"AAMs,":[128],"post":[129],"NA,":[130],"completely":[131],"restored":[132],"epithelium":[134],"animals.":[137],"contrast,":[139],"monocyte/macrophage-dependent":[141],"CCL2/CCR2":[142],"redundant":[145],"repair,":[147],"anti":[149],"ST2-antibody":[150],"treatment":[151],"CCR2\u2212/\u2212":[153],"resulted":[155],"ineffective":[157],"confirmed":[161],"observations":[163],"seen":[164],"ST2-deficiency":[166],"after":[167],"NA-induced":[168],"Thus,":[170],"pathway":[173],"regulates":[174],"effective":[175],"cell":[177],"re-epithelialization":[181],"via":[182],"polarization":[184],"may":[186],"lead":[187],"new":[189],"therapeutic":[190],"insights":[191],"acute":[193],"respiratory":[194],"diseases.":[195]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2019-02-21T00:00:00"}