{"id":"https://openalex.org/W2910877299","doi":"https://doi.org/10.1080/1120009x.2018.1522472","title":"Acute kidney injury: an unusual complication of posaconazole use","display_name":"Acute kidney injury: an unusual complication of posaconazole use","publication_year":2018,"publication_date":"2018-11-17","ids":{"openalex":"https://openalex.org/W2910877299","doi":"https://doi.org/10.1080/1120009x.2018.1522472","mag":"2910877299","pmid":"https://pubmed.ncbi.nlm.nih.gov/30663547"},"language":"en","primary_location":{"id":"doi:10.1080/1120009x.2018.1522472","doi":"https://doi.org/10.1080/1120009x.2018.1522472","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1120009x.2018.1522472","pdf_url":null,"source":{"id":"https://openalex.org/S127202688","display_name":"Journal of Chemotherapy","issn_l":"1120-009X","issn":["1120-009X","1973-9478"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://research.manchester.ac.uk/en/publications/bc6d633e-920d-408c-8d0f-16bee19a8734","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026317486","display_name":"Akaninyene Asuquo Otu","orcid":"https://orcid.org/0000-0002-6009-2707","observed_orcids":["https://orcid.org/0000-0002-6009-2707"]},"institutions":[{"id":"https://openalex.org/I3970730","display_name":"University of Calabar","ror":"https://ror.org/05qderh61","country_code":"NG","type":"education","lineage":["https://openalex.org/I3970730"]},{"id":"https://openalex.org/I4210092852","display_name":"Manchester University NHS Foundation Trust","ror":"https://ror.org/00he80998","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210092852"]}],"countries":["GB","NG"],"is_corresponding":true,"raw_author_name":"Akaninyene Otu","raw_affiliation_strings":["The National Aspergillosis Centre, 2nd Floor Education and Research Centre, Manchester University NHS Foundation Trust, Manchester, UK,","University of Calabar, Calabar, Cross River State, Nigeria,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The National Aspergillosis Centre, 2nd Floor Education and Research Centre, Manchester University NHS Foundation Trust, Manchester, UK,","institution_ids":["https://openalex.org/I4210092852"]},{"raw_affiliation_string":"University of Calabar, Calabar, Cross River State, Nigeria,","institution_ids":["https://openalex.org/I3970730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028018224","display_name":"Felix Bongomin","orcid":"https://orcid.org/0000-0003-4515-8517","observed_orcids":["https://orcid.org/0000-0003-4515-8517","https://orcid.org/0000-0002-3268-0755"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210092852","display_name":"Manchester University NHS Foundation Trust","ror":"https://ror.org/00he80998","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210092852"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Felix Bongomin","raw_affiliation_strings":["Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK,","The National Aspergillosis Centre, 2nd Floor Education and Research Centre, Manchester University NHS Foundation Trust, Manchester, UK,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK,","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"The National Aspergillosis Centre, 2nd Floor Education and Research Centre, Manchester University NHS Foundation Trust, Manchester, UK,","institution_ids":["https://openalex.org/I4210092852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076159655","display_name":"Chris Kosmidis","orcid":"https://orcid.org/0000-0003-0662-1265","observed_orcids":["https://orcid.org/0000-0003-0662-1265"]},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I4210092852","display_name":"Manchester University NHS Foundation Trust","ror":"https://ror.org/00he80998","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210092852"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris Kosmidis","raw_affiliation_strings":["Manchester Academic Health Science Centre, 2nd Floor Education and Research Centre, Manchester University NHS Foundation Trust, Manchester, UK","The National Aspergillosis Centre, 2nd Floor Education and Research Centre, Manchester University NHS Foundation Trust, Manchester, UK,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Manchester Academic Health Science Centre, 2nd Floor Education and Research Centre, Manchester University NHS Foundation Trust, Manchester, UK","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I4210092852"]},{"raw_affiliation_string":"The National Aspergillosis Centre, 2nd Floor Education and Research Centre, Manchester University NHS Foundation Trust, Manchester, UK,","institution_ids":["https://openalex.org/I4210092852"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083752740","display_name":"David W. Denning","orcid":"https://orcid.org/0000-0001-5626-2251","observed_orcids":["https://orcid.org/0000-0001-5626-2251","https://orcid.org/0000-0002-0955-0151"]},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210092852","display_name":"Manchester University NHS Foundation Trust","ror":"https://ror.org/00he80998","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210092852"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David W. Denning","raw_affiliation_strings":["Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK,","Manchester Academic Health Science Centre, 2nd Floor Education and Research Centre, Manchester University NHS Foundation Trust, Manchester, UK","The National Aspergillosis Centre, 2nd Floor Education and Research Centre, Manchester University NHS Foundation Trust, Manchester, UK,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK,","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Manchester Academic Health Science Centre, 2nd Floor Education and Research Centre, Manchester University NHS Foundation Trust, Manchester, UK","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I4210092852"]},{"raw_affiliation_string":"The National Aspergillosis Centre, 2nd Floor Education and Research Centre, Manchester University NHS Foundation Trust, Manchester, UK,","institution_ids":["https://openalex.org/I4210092852"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5026317486"],"corresponding_institution_ids":["https://openalex.org/I3970730","https://openalex.org/I4210092852"],"apc_list":null,"apc_paid":null,"fwci":0.5765,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.68155802,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"30","issue":"6-8","first_page":"380","last_page":"383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.5669000148773193,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.5669000148773193,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.40720000863075256,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/posaconazole","display_name":"posaconazole","score":0.8650000095367432},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/triazole-antifungals","display_name":"triazole antifungals","score":0.8659999966621399},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.640999972820282},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.7820000052452087},{"id":"https://openalex.org/keywords/renal-function-monitoring","display_name":"renal function monitoring","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C2778566413","wikidata":"https://www.wikidata.org/wiki/Q906453","display_name":"Posaconazole","level":4,"score":0.9913885593414307},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6259211897850037},{"id":"https://openalex.org/C2779969316","wikidata":"https://www.wikidata.org/wiki/Q414996","display_name":"Lanosterol","level":4,"score":0.6038171052932739},{"id":"https://openalex.org/C2776391196","wikidata":"https://www.wikidata.org/wiki/Q259626","display_name":"Aspergillosis","level":2,"score":0.5301094055175781},{"id":"https://openalex.org/C2777910421","wikidata":"https://www.wikidata.org/wiki/Q143263","display_name":"Ergosterol","level":2,"score":0.5072762370109558},{"id":"https://openalex.org/C2777071850","wikidata":"https://www.wikidata.org/wiki/Q411229","display_name":"Itraconazole","level":3,"score":0.49735477566719055},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.4630219340324402},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41733109951019287},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33282482624053955},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.24986207485198975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2223002314567566},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.20829781889915466},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20800086855888367},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.13954302668571472},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.11076325178146362},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08887025713920593},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001228","descriptor_name":"Aspergillosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1080/1120009x.2018.1522472","doi":"https://doi.org/10.1080/1120009x.2018.1522472","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1120009x.2018.1522472","pdf_url":null,"source":{"id":"https://openalex.org/S127202688","display_name":"Journal of Chemotherapy","issn_l":"1120-009X","issn":["1120-009X","1973-9478"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemotherapy","raw_type":"journal-article"},{"id":"pmid:30663547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30663547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemotherapy (Florence, Italy)","raw_type":"Case Reports"},{"id":"pmh:oai:pure.atira.dk:openaire/bc6d633e-920d-408c-8d0f-16bee19a8734","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/bc6d633e-920d-408c-8d0f-16bee19a8734","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Otu, A, Bongomin, F, Kosmidis, C & Denning, D 2019, 'Acute kidney injury : an unusual complication of posaconazole use', Journal of Chemotherapy, vol. 30, no. 6-8, pp. 380-383. https://doi.org/10.1080/1120009X.2018.1522472, https://doi.org/10.1080/1120009X.2018.1522472","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pure.atira.dk:openaire/bc6d633e-920d-408c-8d0f-16bee19a8734","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/bc6d633e-920d-408c-8d0f-16bee19a8734","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Otu, A, Bongomin, F, Kosmidis, C & Denning, D 2019, 'Acute kidney injury : an unusual complication of posaconazole use', Journal of Chemotherapy, vol. 30, no. 6-8, pp. 380-383. https://doi.org/10.1080/1120009X.2018.1522472, https://doi.org/10.1080/1120009X.2018.1522472","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2028925504","https://openalex.org/W2101785863","https://openalex.org/W2137341230","https://openalex.org/W2147398907","https://openalex.org/W2162864885","https://openalex.org/W2189861011","https://openalex.org/W2261914993","https://openalex.org/W2573464562","https://openalex.org/W2594114396","https://openalex.org/W2700217986","https://openalex.org/W2756171598","https://openalex.org/W2763083089","https://openalex.org/W2765997220"],"related_works":["https://openalex.org/W2127338781","https://openalex.org/W2981744847","https://openalex.org/W4233464048","https://openalex.org/W2138705334","https://openalex.org/W2790418987","https://openalex.org/W2134911762","https://openalex.org/W3091734808","https://openalex.org/W2733112879","https://openalex.org/W1987214539","https://openalex.org/W7099068610"],"abstract_inverted_index":{"Triazole":[0],"antifungals":[1],"are":[2,87],"useful":[3],"in":[4,97,110],"the":[5,46,65],"treatment":[6],"of":[7,45,68,74,94,99,105,124,138],"Aspergillus":[8,114],"disease":[9,116],"and":[10,59,80,82],"these":[11],"drugs":[12],"have":[13],"side":[14,54,72,92],"effects":[15,73],"which":[16,31,142],"clinicians":[17],"should":[18],"be":[19,128],"aware":[20],"of.":[21],"Posaconazole":[22,50],"is":[23,57,143],"an":[24,35,90],"orally":[25],"administered":[26],"second-generation":[27],"triazole":[28,69],"antifungal":[29],"agent":[30],"inhibits":[32],"lanosterol":[33,39],"14-alpha-demethylase,":[34],"enzyme":[36],"that":[37],"converts":[38],"to":[40,64,134],"ergosterol,":[41],"a":[42,52,111],"vital":[43],"component":[44],"fungal":[47],"cell":[48],"membrane.":[49],"has":[51],"favorable":[53],"effect":[55,93],"profile,":[56],"safe":[58],"well":[60],"tolerated":[61],"when":[62],"compared":[63],"earlier":[66],"generation":[67],"antifungals.":[70],"Common":[71],"posaconazole":[75,133],"include":[76],"gastrointestinal,":[77],"hepatobiliary,":[78],"neurological,":[79],"skin":[81],"subcutaneous":[83],"disorders.":[84],"Renal":[85],"disorders":[86],"classed":[88],"as":[89],"uncommon":[91],"posaconazole,":[95],"occurring":[96],"\u223c0.1-1%":[98],"patients.":[100],"We":[101],"describe":[102],"2":[103],"episodes":[104],"acute":[106,139],"kidney":[107,140],"injury":[108,141],"(AKI)":[109],"Caucasian":[112],"whose":[113],"lung":[115],"was":[117],"being":[118],"treated":[119],"with":[120],"posaconazole.":[121],"Regular":[122],"monitoring":[123],"renal":[125],"function":[126],"may":[127],"necessary":[129],"for":[130],"patients":[131],"on":[132],"facilitate":[135],"early":[136],"identification":[137],"reversible.":[144]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-01-25T00:00:00"}
