{"id":"https://openalex.org/W2910696060","doi":"https://doi.org/10.1177/2058738418820760","title":"Blocking of checkpoint receptor PD-L1 aggravates osteoarthritis in macrophage-dependent manner in the mice model","display_name":"Blocking of checkpoint receptor PD-L1 aggravates osteoarthritis in macrophage-dependent manner in the mice model","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2910696060","doi":"https://doi.org/10.1177/2058738418820760","mag":"2910696060","pmid":"https://pubmed.ncbi.nlm.nih.gov/30791745"},"language":"en","primary_location":{"id":"doi:10.1177/2058738418820760","doi":"https://doi.org/10.1177/2058738418820760","is_oa":true,"landing_page_url":"https://doi.org/10.1177/2058738418820760","pdf_url":null,"source":{"id":"https://openalex.org/S199192407","display_name":"International Journal of Immunopathology and Pharmacology","issn_l":"0394-6320","issn":["0394-6320","2058-7384"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Immunopathology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/2058738418820760","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103062164","display_name":"Shenghou Liu","orcid":"https://orcid.org/0000-0002-1556-4154","observed_orcids":["https://orcid.org/0000-0002-1556-4154"]},"institutions":[{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shenghou Liu","raw_affiliation_strings":["Department of Joint Surgery, The Second Hospital of Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Joint Surgery, The Second Hospital of Shandong University, Jinan, China","institution_ids":["https://openalex.org/I4210103957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015206809","display_name":"Jiqiang Mi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiqiang Mi","raw_affiliation_strings":["Department of Orthopaedics, Jinan Zhangqiu District Hospital of TCM, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Jinan Zhangqiu District Hospital of TCM, Jinan, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100662803","display_name":"Wenguang Liu","orcid":"https://orcid.org/0009-0009-1218-6184","observed_orcids":["https://orcid.org/0009-0009-1218-6184"]},"institutions":[{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenguang Liu","raw_affiliation_strings":["Department of Joint Surgery, The Second Hospital of Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Joint Surgery, The Second Hospital of Shandong University, Jinan, China","institution_ids":["https://openalex.org/I4210103957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075976606","display_name":"Shipeng Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shipeng Xiao","raw_affiliation_strings":["Department of Joint Surgery, The Second Hospital of Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Joint Surgery, The Second Hospital of Shandong University, Jinan, China","institution_ids":["https://openalex.org/I4210103957"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101774849","display_name":"Chunzheng Gao","orcid":"https://orcid.org/0000-0002-2290-8410","observed_orcids":["https://orcid.org/0000-0002-2290-8410","https://orcid.org/0000-0002-2375-7626"]},"institutions":[{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunzheng Gao","raw_affiliation_strings":["Department of Spinal Surgery, The Second Hospital of Shandong University, Jinan, China"],"raw_orcid":"https://orcid.org/0000-0002-2290-8410","affiliations":[{"raw_affiliation_string":"Department of Spinal Surgery, The Second Hospital of Shandong University, Jinan, China","institution_ids":["https://openalex.org/I4210103957"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101774849"],"corresponding_institution_ids":["https://openalex.org/I4210103957"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":0.9854,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.74280481,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"33","issue":null,"first_page":"2058738418820760","last_page":"2058738418820760"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.8370000123977661},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9129999876022339},{"id":"https://openalex.org/keywords/joint-inflammation","display_name":"joint inflammation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.984000027179718},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/collagenase-induced-osteoarthritis","display_name":"collagenase-induced osteoarthritis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/anterior-cruciate-ligament-transection","display_name":"anterior cruciate ligament transection","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pd-l1-blockade","display_name":"PD-L1 blockade","score":0.6119999885559082},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.8388768434524536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6867098808288574},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.656462550163269},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.62450110912323},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6016244292259216},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5117292404174805},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47131258249282837},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45411327481269836},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43540021777153015},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4292212128639221},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4240027070045471},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26424509286880493},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21855145692825317},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1257723569869995},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1177/2058738418820760","doi":"https://doi.org/10.1177/2058738418820760","is_oa":true,"landing_page_url":"https://doi.org/10.1177/2058738418820760","pdf_url":null,"source":{"id":"https://openalex.org/S199192407","display_name":"International Journal of Immunopathology and Pharmacology","issn_l":"0394-6320","issn":["0394-6320","2058-7384"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Immunopathology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:30791745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30791745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of immunopathology and pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5316694","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6328950","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6328950","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6328950","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Immunopathol Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:0fdc677842804bf79a0f42c645252b5e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0fdc677842804bf79a0f42c645252b5e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Immunopathology and Pharmacology, Vol 33 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/2058738418820760","doi":"https://doi.org/10.1177/2058738418820760","is_oa":true,"landing_page_url":"https://doi.org/10.1177/2058738418820760","pdf_url":null,"source":{"id":"https://openalex.org/S199192407","display_name":"International Journal of Immunopathology and Pharmacology","issn_l":"0394-6320","issn":["0394-6320","2058-7384"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Immunopathology and Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1943006715","display_name":null,"funder_award_id":"2015GSF118107","funder_id":"https://openalex.org/F4320333596","funder_display_name":"Key Technology Research and Development Program of Shandong"}],"funders":[{"id":"https://openalex.org/F4320333596","display_name":"Key Technology Research and Development Program of Shandong","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W145472058","https://openalex.org/W1538902372","https://openalex.org/W1848620583","https://openalex.org/W1988791506","https://openalex.org/W2013352191","https://openalex.org/W2036752543","https://openalex.org/W2067665631","https://openalex.org/W2087390550","https://openalex.org/W2096946805","https://openalex.org/W2118263045","https://openalex.org/W2129806226","https://openalex.org/W2131577873","https://openalex.org/W2136722399","https://openalex.org/W2141363952","https://openalex.org/W2153718647","https://openalex.org/W2155464214","https://openalex.org/W2560367415","https://openalex.org/W2772575461","https://openalex.org/W2916654015","https://openalex.org/W4213270426","https://openalex.org/W4247623962"],"related_works":["https://openalex.org/W4379052364","https://openalex.org/W2416795054","https://openalex.org/W2392126385","https://openalex.org/W1992848314","https://openalex.org/W2571013527","https://openalex.org/W3039146159","https://openalex.org/W2015667478","https://openalex.org/W1955721074","https://openalex.org/W4206781811","https://openalex.org/W1977028102"],"abstract_inverted_index":{"As":[0],"a":[1,195],"chronic":[2],"degenerative":[3],"joint":[4,28],"disease,":[5],"osteoarthritis":[6,133,187,202],"is":[7,46,161],"among":[8],"the":[9,15,25,31,36,48,58,70,85,130,156,169,177,184],"most":[10],"common":[11],"diseases":[12],"all":[13],"over":[14],"world.":[16],"In":[17],"osteoarthritis,":[18],"inflammation":[19],"plays":[20],"an":[21],"important":[22],"role":[23],"in":[24,62,65,134,150,163,174,188],"generation":[26],"of":[27,33,60,72,87,99,122,132,158,171,179,186],"symptoms":[29],"and":[30,108,128,140,182,198],"development":[32,131,185],"disease.":[34],"When":[35],"programmed":[37],"cell":[38],"death-1":[39],"(PD-1)/programmed":[40],"death-ligand":[41],"1":[42],"(PD-L1)":[43],"immune":[44],"checkpoint":[45],"blocked,":[47],"antitumor":[49],"immunity":[50],"will":[51],"be":[52,192],"enhanced.":[53],"We":[54],"aim":[55],"to":[56,83],"illustrate":[57],"function":[59],"PD-L1":[61,123,148,172],"osteoarthritis.":[63],"Osteoarthritis":[64,152],"mice":[66],"was":[67,81,101,111,153],"induced":[68],"by":[69,95,103,113,147],"injection":[71],"collagenase":[73],"or":[74],"anterior":[75],"cruciate":[76],"ligament":[77],"transection":[78],"(ACLT).":[79],"Anti-PD-L1":[80],"employed":[82],"block":[84],"signal":[86,124,173],"PD-L1.":[88],"Knee":[89],"joints":[90],"histological":[91],"sections":[92],"were":[93,145],"stained":[94],"Safranin-O.":[96],"The":[97,120,136],"level":[98,110],"cytokine":[100,138,160,181],"checked":[102],"enzyme-linked":[104],"immunosorbent":[105],"assay":[106],"(ELISA)":[107],"mRNA":[109],"shown":[112],"quantitative":[114],"reverse":[115],"transcriptase":[116],"polymerase":[117],"chain":[118],"reaction.":[119],"blockade":[121,170],"up-regulated":[125],"inflammatory":[126,137,159,180],"response":[127],"promoted":[129,146],"mice.":[135],"interleukin-6":[139],"tumor":[141],"necrosis":[142],"factor-\u03b1":[143],"expression":[144,157,178],"blocking":[149],"macrophages.":[151,164],"aggravated":[154],"when":[155],"elevated":[162],"Our":[165],"results":[166],"indicated":[167],"that":[168],"macrophages":[175],"elevates":[176],"promotes":[183],"mice,":[189],"which":[190],"could":[191],"utilized":[193],"as":[194],"potential":[196],"diagnostic":[197],"therapeutic":[199],"target":[200],"for":[201],"patients.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}