{"id":"https://openalex.org/W2910686754","doi":null,"title":"Design and Synthesis of CpG-Lytic Peptide Conjugate, Brachytherapy Beads and a Combinatorial Library of Primary Amines used as Potential Therapeutics in the Treatment of Cancers","display_name":"Design and Synthesis of CpG-Lytic Peptide Conjugate, Brachytherapy Beads and a Combinatorial Library of Primary Amines used as Potential Therapeutics in the Treatment of Cancers","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2910686754","mag":"2910686754"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.usf.edu:etd-8650","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.usf.edu/etd/7453","pdf_url":"https://digitalcommons.usf.edu/context/etd/article/8650/viewcontent/etd__7453.pdf","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.usf.edu/context/etd/article/8650/viewcontent/etd__7453.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043185261","display_name":"Josanne\u2013Dee Woodroffe","orcid":"https://orcid.org/0000-0002-3593-6322","observed_orcids":["https://orcid.org/0000-0002-3593-6322"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Josanne\u2013Dee Woodroffe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3593-6322","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5043185261"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":0.671999990940094},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9430000185966492},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.6819999814033508},{"id":"https://openalex.org/keywords/hdr-brachytherapy","display_name":"high-dose-rate brachytherapy","score":0.8460000157356262},{"id":"https://openalex.org/keywords/dota-chelator","display_name":"DOTA chelator","score":0.6959999799728394},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.4690000116825104},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.7295154333114624},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.6035594940185547},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5302345752716064},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.49823832511901855},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47677212953567505},{"id":"https://openalex.org/C2777416452","wikidata":"https://www.wikidata.org/wiki/Q896687","display_name":"Brachytherapy","level":3,"score":0.43791553378105164},{"id":"https://openalex.org/C2777977315","wikidata":"https://www.wikidata.org/wiki/Q7243056","display_name":"Primary (astronomy)","level":2,"score":0.4350598454475403},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4096390902996063},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35898637771606445},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3419558107852936},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.23871341347694397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23827555775642395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18347084522247314},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12247061729431152},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10491642355918884},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1005316972732544},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.0879652202129364},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:digitalcommons.usf.edu:etd-8650","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.usf.edu/etd/7453","pdf_url":"https://digitalcommons.usf.edu/context/etd/article/8650/viewcontent/etd__7453.pdf","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},{"id":"pmh:oai:scholarcommons.usf.edu:etd-8650","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.usf.edu/etd/7453","pdf_url":"https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=8650&context=etd","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},{"id":"mag:2910686754","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=8650&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.usf.edu:etd-8650","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.usf.edu/etd/7453","pdf_url":"https://digitalcommons.usf.edu/context/etd/article/8650/viewcontent/etd__7453.pdf","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2910686754.pdf","grobid_xml":"https://content.openalex.org/works/W2910686754.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2098920407"],"related_works":["https://openalex.org/W645407142","https://openalex.org/W2473538486","https://openalex.org/W4404231952","https://openalex.org/W2588922384","https://openalex.org/W4385827859","https://openalex.org/W7070426254","https://openalex.org/W2041914114","https://openalex.org/W2558523517","https://openalex.org/W3041206783","https://openalex.org/W2790142184"],"abstract_inverted_index":{"Cancer":[0,28],"remains":[1],"one":[2,24,209],"of":[3,21,54,62,70,78,113,154,170,174,199,206,210,216,222,230,251,259,276,307,313],"the":[4,9,18,60,94,99,103,111,125,133,138,152,168,204,211,220,228,249,274,287,305],"most":[5,212],"feared":[6],"diseases":[7],"affecting":[8,23],"modern":[10],"world.":[11],"Second":[12],"to":[13,74,90,97,105,131,167,191,247,280,285,299],"heart":[14],"disease,":[15],"it":[16,136],"is":[17,73,128],"largest":[19],"cause":[20,106],"deaths,":[22],"in":[25,110,123,143,146,158,283,301,304],"three":[26,76,202],"persons.":[27],"cells":[29,35,57,104,145],"are":[30,48],"formed":[31],"when":[32],"normal,":[33],"healthy":[34,231,318],"become":[36],"damage,":[37],"losing":[38],"their":[39],"normal":[40],"regulatory":[41],"mechanism":[42],"that":[43,58,124,278],"control":[44],"cell":[45,95,108],"growth.":[46],"There":[47],"many":[49],"different":[50],"types":[51,198],"and":[52,226,256],"progression":[53],"these":[55,260],"cancer":[56,252],"determine":[59],"type":[61],"treatment":[63,112,215,243,306],"a":[64,84,163,171,183,241,263,269,290],"patient":[65],"receives.":[66],"The":[67],"primary":[68,175],"focus":[69],"this":[71],"dissertation":[72],"propose":[75],"studies":[77,258,303],"anticancer":[79,155],"agents.":[80],"In":[81],"Chapter":[82,148,201],"one,":[83],"CpG-lytic":[85],"peptide":[86,101],"conjugate":[87,118],"was":[88,265],"designed":[89],"target":[91],"receptors":[92,140],"on":[93,151,196],"membrane":[96],"concentrate":[98],"lytic":[100],"around":[102],"triggered":[107],"death,":[109],"Myelodysplastic":[114],"Syndromes":[115],"(MDS).":[116],"This":[117],"act":[119],"like":[120],"monoclonal":[121],"antibodies":[122],"molecular":[126],"size":[127],"too":[129],"large":[130],"enter":[132],"cell,":[134],"therefore":[135],"targets":[137],"TLR9":[139],"expressed":[141],"extracellularly":[142],"precancer":[144],"MDS.":[147],"two,":[149],"focuses":[150],"screening":[153],"agents":[156],"used":[157,177,214,239,298],"targeted":[159],"therapy.":[160],"It":[161],"provides":[162],"general":[164],"scheme":[165],"applied":[166],"synthesis":[169],"combinatorial":[172],"library":[173],"amines":[176],"as":[178,240],"small-molecule":[179],"drugs":[180],"coupled":[181],"unto":[182],"solid":[184],"support":[185],"bead":[186],"(Positional":[187],"Scanning":[188],"Library":[189],"Method)":[190],"screen":[192],"for":[193],"biological":[194],"effects":[195],"various":[197],"cancers.":[200],"address":[203],"issue":[205],"radiotherapy":[207],"treatments,":[208],"widely":[213],"cancer.":[217],"To":[218,254],"improve":[219],"efficacy":[221],"conventional":[223],"radiation":[224,314],"therapy":[225],"reduce":[227],"cytotoxicity":[229],"tissue,":[232],"High-Dose":[233],"Rate":[234],"brachytherapy":[235,261,294],"(HDR)":[236],"may":[237],"be":[238,297],"stand-alone":[242],"or":[244],"after":[245],"surgery":[246],"prevent":[248],"recurrence":[250],"cells.":[253],"design":[255],"provide":[257],"beads,":[262],"model":[264],"developed":[266],"by":[267],"coupling":[268],"chelating":[270],"agent":[271],"DOTA":[272],"onto":[273],"surface":[275],"macrobeads":[277],"coordinated":[279],"Europium":[281],"(III)":[282],"efforts":[284],"mimic":[286],"radiolabeling":[288],"with":[289,310],"radioactive":[291],"metal.":[292],"These":[293],"beads":[295],"will":[296],"conduct":[300],"vitro":[302],"local":[308],"cancers":[309],"massive":[311],"concentrations":[312],"without":[315],"damaging":[316],"surrounding":[317],"tissue.":[319]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2019-01-25T00:00:00"}