{"id":"https://openalex.org/W2910536741","doi":"https://doi.org/10.1088/1755-1315/217/1/012016","title":"Phytochemical Screening and Antioxidant Activity of Ethanol Extract of Leilem (Clerodendrum minahassae Teijsm. & Binn) as an Antihyperlipidemic and Antiatherosclerotic Agent","display_name":"Phytochemical Screening and Antioxidant Activity of Ethanol Extract of Leilem (Clerodendrum minahassae Teijsm. & Binn) as an Antihyperlipidemic and Antiatherosclerotic Agent","publication_year":2019,"publication_date":"2019-01-09","ids":{"openalex":"https://openalex.org/W2910536741","doi":"https://doi.org/10.1088/1755-1315/217/1/012016","mag":"2910536741"},"language":"en","primary_location":{"id":"doi:10.1088/1755-1315/217/1/012016","doi":"https://doi.org/10.1088/1755-1315/217/1/012016","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1755-1315/217/1/012016","pdf_url":"https://iopscience.iop.org/article/10.1088/1755-1315/217/1/012016/pdf","source":{"id":"https://openalex.org/S4210195883","display_name":"IOP Conference Series Earth and Environmental Science","issn_l":"1755-1315","issn":["1755-1315","1755-1307"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IOP Conference Series: Earth and Environmental Science","raw_type":"journal-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://iopscience.iop.org/article/10.1088/1755-1315/217/1/012016/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000223381","display_name":"Carla F. Kairupan","orcid":"https://orcid.org/0000-0002-6835-3908","observed_orcids":["https://orcid.org/0000-0002-6835-3908"]},"institutions":[{"id":"https://openalex.org/I55214057","display_name":"Sam Ratulangi University","ror":"https://ror.org/01cn6ph21","country_code":"ID","type":"education","lineage":["https://openalex.org/I55214057"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"C F Kairupan","raw_affiliation_strings":["Bagian Patologi Anatomi, Universitas Sam Ratulangi, Kampus UNSRAT Malalayang Satu Barat, Manado 95162, Sulawesi Utara, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bagian Patologi Anatomi, Universitas Sam Ratulangi, Kampus UNSRAT Malalayang Satu Barat, Manado 95162, Sulawesi Utara, Indonesia","institution_ids":["https://openalex.org/I55214057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082158579","display_name":"Feky Recky Mantiri","orcid":"https://orcid.org/0000-0003-2294-8620","observed_orcids":["https://orcid.org/0000-0003-2294-8620"]},"institutions":[{"id":"https://openalex.org/I55214057","display_name":"Sam Ratulangi University","ror":"https://ror.org/01cn6ph21","country_code":"ID","type":"education","lineage":["https://openalex.org/I55214057"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"F R Mantiri","raw_affiliation_strings":["Jurusan Biologi, Universitas Sam Ratulangi, Kampus UNSRAT Kleak, Manado 95115, Sulawesi Utara, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jurusan Biologi, Universitas Sam Ratulangi, Kampus UNSRAT Kleak, Manado 95115, Sulawesi Utara, Indonesia","institution_ids":["https://openalex.org/I55214057"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012788739","display_name":"Rooije R.H. Rumende","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55214057","display_name":"Sam Ratulangi University","ror":"https://ror.org/01cn6ph21","country_code":"ID","type":"education","lineage":["https://openalex.org/I55214057"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"R R H Rumende","raw_affiliation_strings":["Jurusan Biologi, Universitas Sam Ratulangi, Kampus UNSRAT Kleak, Manado 95115, Sulawesi Utara, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jurusan Biologi, Universitas Sam Ratulangi, Kampus UNSRAT Kleak, Manado 95115, Sulawesi Utara, Indonesia","institution_ids":["https://openalex.org/I55214057"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000223381"],"corresponding_institution_ids":["https://openalex.org/I55214057"],"apc_list":null,"apc_paid":null,"fwci":0.9249,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.8862238,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"217","issue":null,"first_page":"012016","last_page":"012016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.4975999891757965,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.4975999891757965,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.4269999861717224,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.03970000147819519,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phytochemical-screening","display_name":"phytochemical screening","score":0.9169999957084656},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipid-lowering-effect","display_name":"hypolipidemic effect","score":0.8479999899864197},{"id":"https://openalex.org/keywords/anti-atherosclerotic-effects","display_name":"anti-atherosclerotic effects","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ethanolic-leaf-extract","display_name":"ethanolic leaf extract","score":0.6769999861717224},{"id":"https://openalex.org/keywords/total-phenolic-content","display_name":"total phenolic content","score":0.7799999713897705},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dpph-radical-scavenging-activity","display_name":"DPPH radical scavenging","score":0.9769999980926514},{"id":"https://openalex.org/keywords/ferric-reducing-antioxidant-power","display_name":"ferric reducing antioxidant power","score":0.8790000081062317},{"id":"https://openalex.org/keywords/natural-antioxidants","display_name":"natural antioxidants","score":0.6729999780654907},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.8999674320220947},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.836000919342041},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8072744607925415},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.77492356300354},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.5709215402603149},{"id":"https://openalex.org/C2777728882","wikidata":"https://www.wikidata.org/wiki/Q407142","display_name":"Phenols","level":2,"score":0.5506941676139832},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5121505260467529},{"id":"https://openalex.org/C2780534640","wikidata":"https://www.wikidata.org/wiki/Q3233795","display_name":"Ferric","level":2,"score":0.4718368351459503},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.44602999091148376},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.44362184405326843},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.41335296630859375},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20744088292121887},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14431658387184143},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1284077763557434},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05363026261329651}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1088/1755-1315/217/1/012016","doi":"https://doi.org/10.1088/1755-1315/217/1/012016","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1755-1315/217/1/012016","pdf_url":"https://iopscience.iop.org/article/10.1088/1755-1315/217/1/012016/pdf","source":{"id":"https://openalex.org/S4210195883","display_name":"IOP Conference Series Earth and Environmental Science","issn_l":"1755-1315","issn":["1755-1315","1755-1307"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IOP Conference Series: Earth and Environmental Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1088/1755-1315/217/1/012016","doi":"https://doi.org/10.1088/1755-1315/217/1/012016","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1755-1315/217/1/012016","pdf_url":"https://iopscience.iop.org/article/10.1088/1755-1315/217/1/012016/pdf","source":{"id":"https://openalex.org/S4210195883","display_name":"IOP Conference Series Earth and Environmental Science","issn_l":"1755-1315","issn":["1755-1315","1755-1307"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IOP Conference Series: Earth and Environmental Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320330149","display_name":"Universitas Sam Ratulangi","ror":"https://ror.org/01cn6ph21"},{"id":"https://openalex.org/F4320335079","display_name":"Direktorat Jenderal Pendidikan Tinggi","ror":"https://ror.org/03sxt1c89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2910536741.pdf","grobid_xml":"https://content.openalex.org/works/W2910536741.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1538764270","https://openalex.org/W1599482461","https://openalex.org/W1969632877","https://openalex.org/W1978213683","https://openalex.org/W1982739909","https://openalex.org/W1986334044","https://openalex.org/W1986608361","https://openalex.org/W1990064402","https://openalex.org/W2001795223","https://openalex.org/W2027947939","https://openalex.org/W2034689201","https://openalex.org/W2046453713","https://openalex.org/W2065380210","https://openalex.org/W2076173976","https://openalex.org/W2082762975","https://openalex.org/W2165292984","https://openalex.org/W2283632926","https://openalex.org/W2568684875","https://openalex.org/W2598991711","https://openalex.org/W2615920207","https://openalex.org/W2748840643","https://openalex.org/W2790773110","https://openalex.org/W2811222402","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4393353373","https://openalex.org/W3089172240","https://openalex.org/W2995505578","https://openalex.org/W3001011677","https://openalex.org/W2017174647","https://openalex.org/W2598462615","https://openalex.org/W7220509790","https://openalex.org/W3132230241","https://openalex.org/W2585556381","https://openalex.org/W922904585"],"abstract_inverted_index":{"Leilem,":[0],"which":[1],"is":[2,10,42],"known":[3],"with":[4,92],"the":[5,30,36,86,105,132,144,179,237,257,279],"botanical":[6],"name":[7],"Clerodendrum":[8],"minahassae,":[9],"a":[11,17],"plant":[12,56],"species":[13],"commonly":[14],"used":[15,60,293],"as":[16,61,230,294],"component":[18],"of":[19,40,49,54,77,88,111,114,125,147,175,181,197,206,214,222,240,247,260,281],"almost":[20],"all":[21],"meat-":[22],"and":[23,32,67,82,95,108,127,135,165,186,190,203,209,287,290],"fish-based":[24],"cuisine.":[25],"In":[26,130],"addition":[27],"to":[28,35,45,64,151,297],"enhancing":[29],"flavor":[31],"taste":[33],"suited":[34],"local":[37],"people,":[38],"leaves":[39,53,177,199,242,283],"leilem":[41,78,115,148,176,198,215,241,261,282],"also":[43,58],"believed":[44],"possess":[46],"high":[47,93],"level":[48],"natural":[50],"antioxidant.":[51],"The":[52,98,172,195],"this":[55,272],"has":[57,79,262,284],"been":[59],"traditional":[62],"medicine":[63],"treat":[65],"stomachache":[66],"lung":[68],"diseases.":[69],"Our":[70],"previous":[71,276],"study":[72,100,273],"revealed":[73,178],"that":[74,256,278],"ethanol":[75,112,258],"extract":[76,113,146,196,217,239,259,280],"beneficial":[80,285],"antihyperlipidemic":[81,286],"antiatherosclerotic":[83,288],"effects":[84,289],"on":[85],"aorta":[87],"Wistar":[89],"rats":[90],"fed":[91],"lipid":[94],"cholesterol":[96],"levels.":[97],"present":[99],"was":[101,119,149,228],"aimed":[102],"at":[103],"investigating":[104],"phytochemical":[106,173],"contents":[107],"antioxidant":[109,156,168,266],"activity":[110],"leaves.":[116],"Phytochemical":[117],"screening":[118,174],"carried":[120],"out":[121],"using":[122,140,158],"standard":[123],"methods":[124],"precipitation":[126],"coloration":[128],"reactions.":[129],"addition,":[131],"total":[133],"phenolics":[134,202],"flavonoids":[136],"were":[137,192],"determined":[138],"by":[139],"spectrophotometric":[141],"methods.":[142],"Finally,":[143],"leaf":[145],"assayed":[150],"evaluate":[152],"its":[153],"in":[154,250,264],"vitro":[155,265],"properties":[157],"1,1-Diphenyl":[159],"picryl":[160],"hydrazyl":[161],"(DPPH)":[162],"radical":[163,224],"assay":[164],"ferric":[166,244],"reducing":[167,245],"potential":[169,263],"(FRAP)":[170],"assay.":[171,252],"presence":[180],"alkaloids,":[182],"saponins,":[183],"flavonoids,":[184],"steroids,":[185],"phenols,":[187],"while":[188],"terpenes":[189],"tannins":[191],"not":[193],"detected.":[194],"showed":[200,243],"estimated":[201],"flavonoid":[204],"content":[205],"139.88":[207],"mg/g":[208,211],"34.46":[210],"respectively.":[212],"Concentration":[213],"leave":[216],"required":[218],"for":[219],"50%":[220],"inhibition":[221],"DPPH":[223],"scavenging":[225],"effect":[226],"(IC50)":[227],"recorded":[229],"565.45":[231],"\u03bcg/mL.":[232],"At":[233],"1":[234],"mg/mL":[235],"concentration,":[236],"aqueous":[238],"power":[246],"123.62":[248],"\u03bcmoles/mg":[249],"FRAP":[251],"These":[253],"findings":[254],"suggest":[255],"activities.":[267],"Overall,":[268],"results":[269],"obtained":[270],"from":[271],"support":[274],"our":[275],"finding":[277],"can":[291],"be":[292],"an":[295],"alternative":[296],"synthetic":[298],"antioxidants.":[299]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2019-01-25T00:00:00"}
