{"id":"https://openalex.org/W2910126224","doi":"https://doi.org/10.1681/asn.2018080853","title":"Therapeutic Inhibition of VEGF Signaling and Associated Nephrotoxicities","display_name":"Therapeutic Inhibition of VEGF Signaling and Associated Nephrotoxicities","publication_year":2019,"publication_date":"2019-01-14","ids":{"openalex":"https://openalex.org/W2910126224","doi":"https://doi.org/10.1681/asn.2018080853","mag":"2910126224","pmid":"https://pubmed.ncbi.nlm.nih.gov/30642877","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6362621"},"language":"en","primary_location":{"id":"doi:10.1681/asn.2018080853","doi":"https://doi.org/10.1681/asn.2018080853","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2018080853","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6362621","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006443353","display_name":"Chelsea C. Estrada","orcid":"https://orcid.org/0000-0002-3249-045X","observed_orcids":["https://orcid.org/0000-0002-3249-045X"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chelsea C. Estrada","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, New York; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, New York; and","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025381227","display_name":"Alejandro Maldonado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandro Maldonado","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, New York; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, New York; and","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055025477","display_name":"Sandeep K. Mallipattu","orcid":"https://orcid.org/0000-0002-6324-7807","observed_orcids":["https://orcid.org/0000-0002-6324-7807"]},"institutions":[{"id":"https://openalex.org/I4210109353","display_name":"Northport VA Medical Center","ror":"https://ror.org/01xtpc441","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210109353"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sandeep K. Mallipattu","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, New York; and","Renal Section, Northport Veterans Affairs Medical Center, Northport, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, New York; and","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Renal Section, Northport Veterans Affairs Medical Center, Northport, New York","institution_ids":["https://openalex.org/I4210109353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055025477"],"corresponding_institution_ids":["https://openalex.org/I4210109353","https://openalex.org/I59553526"],"apc_list":null,"apc_paid":null,"fwci":1.857,"has_fulltext":false,"cited_by_count":225,"citation_normalized_percentile":{"value":0.88337591,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"30","issue":"2","first_page":"187","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.6958000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.6958000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.2329999953508377,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vegf-inhibition","display_name":"VEGF inhibition","score":0.8069999814033508},{"id":"https://openalex.org/keywords/vegfa-vegfr2-signaling","display_name":"VEGFA-VEGFR2 signaling","score":0.847000002861023},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9679999947547913},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.6710000038146973},{"id":"https://openalex.org/keywords/thrombotic-microangiopathy","display_name":"thrombotic microangiopathy","score":0.9419999718666077},{"id":"https://openalex.org/keywords/glomerular-disease","display_name":"glomerular disease","score":0.7239999771118164},{"id":"https://openalex.org/keywords/minimal-change-disease","display_name":"minimal change disease","score":0.9660000205039978},{"id":"https://openalex.org/keywords/focal-segmental-glomerulosclerosis","display_name":"focal segmental glomerulosclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mapk-erk-pathway","display_name":"MAPK/ERK pathway","score":0.8429999947547913},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9120000004768372},{"id":"https://openalex.org/keywords/mtor-inhibition","display_name":"mTOR inhibition","score":0.8259999752044678},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.8479999899864197},{"id":"https://openalex.org/keywords/podocyte-injury","display_name":"podocyte injury","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tubulointerstitial-injury","display_name":"tubulointerstitial injury","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/vegf-trap","display_name":"VEGF trap","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.5491663217544556},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5281902551651001},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4695129096508026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3877996802330017},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38358697295188904},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36894112825393677},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33486318588256836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28262972831726074},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2572649121284485}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009404","descriptor_name":"Nephrotic Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009404","descriptor_name":"Nephrotic Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1681/asn.2018080853","doi":"https://doi.org/10.1681/asn.2018080853","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2018080853","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6362621","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6362621","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Soc Nephrol","raw_type":"Text"},{"id":"pmid:30642877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30642877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology : JASN","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6362621","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6362621","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Soc Nephrol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7330498521","display_name":"The Role of KLF15 as a transcriptional regulator of podocyte differentiation","funder_award_id":"K08DK102519","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G741185792","display_name":null,"funder_award_id":"I01BX003698","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G8156823946","display_name":"The Role of Kr\u00fcppel-Like Factor 4 as a Key Mediator of Renal Endothelial Injury In Antibody Mediated Rejection.","funder_award_id":"F32DK112618","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000870499","display_name":"Podocyte-Proximal Tubule Interactions in Diabetic Kidney Disease","funder_award_id":"R01DK112984","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":108,"referenced_works":["https://openalex.org/W146001025","https://openalex.org/W1487257968","https://openalex.org/W1544142122","https://openalex.org/W1559286003","https://openalex.org/W1880225464","https://openalex.org/W1965163065","https://openalex.org/W1969328947","https://openalex.org/W1973662262","https://openalex.org/W1974183395","https://openalex.org/W1975608072","https://openalex.org/W1977379029","https://openalex.org/W1978432535","https://openalex.org/W1980725734","https://openalex.org/W1982246723","https://openalex.org/W1985478624","https://openalex.org/W1986559037","https://openalex.org/W1993827632","https://openalex.org/W1996409623","https://openalex.org/W1997619520","https://openalex.org/W1998014314","https://openalex.org/W2000292756","https://openalex.org/W2001655253","https://openalex.org/W2002870649","https://openalex.org/W2005994924","https://openalex.org/W2016695234","https://openalex.org/W2017181626","https://openalex.org/W2022254881","https://openalex.org/W2024988923","https://openalex.org/W2026351725","https://openalex.org/W2027887693","https://openalex.org/W2028031291","https://openalex.org/W2031978178","https://openalex.org/W2032429643","https://openalex.org/W2035127867","https://openalex.org/W2038545399","https://openalex.org/W2041034845","https://openalex.org/W2041804946","https://openalex.org/W2045247659","https://openalex.org/W2046516822","https://openalex.org/W2046525214","https://openalex.org/W2048818094","https://openalex.org/W2049827480","https://openalex.org/W2050980183","https://openalex.org/W2051563676","https://openalex.org/W2051719011","https://openalex.org/W2051833563","https://openalex.org/W2055923362","https://openalex.org/W2058328321","https://openalex.org/W2062271737","https://openalex.org/W2069728704","https://openalex.org/W2070114011","https://openalex.org/W2078720314","https://openalex.org/W2086099915","https://openalex.org/W2091193879","https://openalex.org/W2093498435","https://openalex.org/W2093862824","https://openalex.org/W2094156578","https://openalex.org/W2095482730","https://openalex.org/W2096063383","https://openalex.org/W2097563994","https://openalex.org/W2098369792","https://openalex.org/W2100837885","https://openalex.org/W2107046797","https://openalex.org/W2111049271","https://openalex.org/W2113652101","https://openalex.org/W2119191274","https://openalex.org/W2119358583","https://openalex.org/W2120822810","https://openalex.org/W2126195817","https://openalex.org/W2127649624","https://openalex.org/W2129331774","https://openalex.org/W2130127620","https://openalex.org/W2132272301","https://openalex.org/W2145224595","https://openalex.org/W2145638206","https://openalex.org/W2147249280","https://openalex.org/W2147919276","https://openalex.org/W2150893441","https://openalex.org/W2154921775","https://openalex.org/W2156871508","https://openalex.org/W2166559064","https://openalex.org/W2168677058","https://openalex.org/W2214160621","https://openalex.org/W2256209295","https://openalex.org/W2291683698","https://openalex.org/W2295734057","https://openalex.org/W2307934198","https://openalex.org/W2310643631","https://openalex.org/W2331524970","https://openalex.org/W2348392815","https://openalex.org/W2406309081","https://openalex.org/W2509030753","https://openalex.org/W2554519074","https://openalex.org/W2559556008","https://openalex.org/W2561353042","https://openalex.org/W2562401512","https://openalex.org/W2591550189","https://openalex.org/W2593110218","https://openalex.org/W2673668916","https://openalex.org/W2725958576","https://openalex.org/W2753841357","https://openalex.org/W2767560462","https://openalex.org/W2774483419","https://openalex.org/W2793204967","https://openalex.org/W2793682575","https://openalex.org/W2799576164","https://openalex.org/W2892087897","https://openalex.org/W4294214970"],"related_works":["https://openalex.org/W3205079833","https://openalex.org/W3142954022","https://openalex.org/W7138917295","https://openalex.org/W1970623463","https://openalex.org/W7167504894","https://openalex.org/W4412121579","https://openalex.org/W3041966591","https://openalex.org/W2435142345","https://openalex.org/W34401446","https://openalex.org/W2587344007"],"abstract_inverted_index":{"Inhibition":[0,119,132],"of":[1,46,55,59,73,103,120,133,173],"vascular":[2],"endothelial":[3,8,66],"growth":[4,9],"factor":[5,10],"A":[6],"(VEGFA)/vascular":[7],"receptor":[11],"2":[12],"(VEGFR2)":[13],"signaling":[14,62],"is":[15,89,107,135],"a":[16],"common":[17],"therapeutic":[18,199],"strategy":[19],"in":[20,26],"oncology,":[21],"with":[22,43,91,110,129,139,180],"new":[23],"drugs":[24],"continuously":[25],"development.":[27],"In":[28,152],"this":[29,47],"review,":[30],"we":[31,154],"consider":[32],"the":[33,39,44,52,104,121,156,170],"experimental":[34],"and":[35,70,117,141],"clinical":[36,174],"evidence":[37],"behind":[38],"diverse":[40],"nephrotoxicities":[41],"associated":[42,90,109,128,138],"inhibition":[45,78,102],"pathway.":[48],"We":[49,183],"also":[50,97,146,184],"review":[51,155],"renal":[53],"effects":[54],"VEGF":[56,83,105],"inhibition\u2019s":[57],"mediation":[58],"key":[60],"downstream":[61,122],"pathways,":[63],"specifically":[64],"MAPK/ERK1/2,":[65],"nitric":[67],"oxide":[68],"synthase,":[69],"mammalian":[71],"target":[72],"rapamycin":[74],"(mTOR).":[75],"Direct":[76],"VEGFA":[77],"via":[79],"antibody":[80],"binding":[81],"or":[82],"trap":[84],"(a":[85],"soluble":[86],"decoy":[87],"receptor)":[88],"renal-specific":[92,150],"thrombotic":[93],"microangiopathy":[94],"(TMA).":[95],"Reports":[96],"indicate":[98],"that":[99,176],"tyrosine":[100],"kinase":[101],"receptors":[106],"preferentially":[108],"glomerulopathies":[111],"such":[112],"as":[113,167,169],"minimal":[114],"change":[115],"disease":[116],"FSGS.":[118],"pathway":[123],"RAF/MAPK/ERK":[124],"has":[125,145],"largely":[126],"been":[127,147,178],"tubulointerstitial":[130],"injury.":[131],"mTOR":[134],"most":[136],"commonly":[137],"albuminuria":[140],"podocyte":[142],"injury,":[143],"but":[144],"linked":[148],"to":[149,165,191],"TMA.":[151],"all,":[153],"experimentally":[157],"validated":[158],"mechanisms":[159,193],"by":[160],"which":[161],"VEGFA-VEGFR2":[162],"inhibitors":[163],"contribute":[164],"nephrotoxicity,":[166],"well":[168],"wide":[171],"range":[172],"manifestations":[175],"have":[177],"reported":[179],"their":[181],"use.":[182],"highlight":[185],"potential":[186],"avenues":[187],"for":[188,194],"future":[189],"research":[190],"elucidate":[192],"minimizing":[195],"nephrotoxicity":[196],"while":[197],"maintaining":[198],"efficacy.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":32},{"year":2025,"cited_by_count":37},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":39},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":36},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-01-25T00:00:00"}
