{"id":"https://openalex.org/W2910083643","doi":"https://doi.org/10.1016/j.bone.2019.01.015","title":"Cellular senescence in bone","display_name":"Cellular senescence in bone","publication_year":2019,"publication_date":"2019-01-16","ids":{"openalex":"https://openalex.org/W2910083643","doi":"https://doi.org/10.1016/j.bone.2019.01.015","mag":"2910083643","pmid":"https://pubmed.ncbi.nlm.nih.gov/30659978","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6485943"},"language":"eo","primary_location":{"id":"doi:10.1016/j.bone.2019.01.015","doi":"https://doi.org/10.1016/j.bone.2019.01.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bone.2019.01.015","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Bone","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.bone.2019.01.015","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035959642","display_name":"Joshua N. Farr","orcid":"https://orcid.org/0000-0002-3179-6414","observed_orcids":["https://orcid.org/0000-0002-3179-6414"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua N. Farr","raw_affiliation_strings":["Division of Endocrinology and Metabolism and Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Electronic address: farr.joshua@mayo.edu","Division of Endocrinology and Metabolism and Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":"https://orcid.org/0000-0002-3179-6414","affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism and Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Electronic address: farr.joshua@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Endocrinology and Metabolism and Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027073303","display_name":"Sundeep Khosla","orcid":"https://orcid.org/0000-0002-2936-4372","observed_orcids":["https://orcid.org/0000-0002-2936-4372"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sundeep Khosla","raw_affiliation_strings":["Division of Endocrinology and Metabolism and Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Electronic address: khosla.sundeep@mayo.edu","Division of Endocrinology and Metabolism and Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":"https://orcid.org/0000-0002-2936-4372","affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism and Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Electronic address: khosla.sundeep@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Endocrinology and Metabolism and Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027073303","https://openalex.org/A5035959642"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":2.5809,"has_fulltext":false,"cited_by_count":264,"citation_normalized_percentile":{"value":0.92238267,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"121","issue":null,"first_page":"121","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":1.0},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9380000233650208},{"id":"https://openalex.org/keywords/bone-aging","display_name":"bone aging","score":0.7730000019073486},{"id":"https://openalex.org/keywords/age-related-bone-loss","display_name":"age-related bone loss","score":0.9509999752044678},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/senolytics","display_name":"senolytics","score":0.9829999804496765},{"id":"https://openalex.org/keywords/senomorphics","display_name":"senomorphics","score":0.9319999814033508},{"id":"https://openalex.org/keywords/senotherapeutics","display_name":"senotherapeutics","score":0.9449999928474426},{"id":"https://openalex.org/keywords/healthspan","display_name":"healthspan","score":0.8859999775886536},{"id":"https://openalex.org/keywords/bone-microenvironment","display_name":"bone microenvironment","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.8507442474365234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.555580735206604},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5511309504508972},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5073429942131042},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4809962213039398},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.47652944922447205},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.4737309217453003},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4275706112384796},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4219367504119873},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.4193948209285736},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.38744020462036133},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3524063527584076},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34622323513031006},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.166813462972641},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12291756272315979}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010011","descriptor_name":"Osteocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010011","descriptor_name":"Osteocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bone.2019.01.015","doi":"https://doi.org/10.1016/j.bone.2019.01.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bone.2019.01.015","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Bone","raw_type":"journal-article"},{"id":"pmid:30659978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30659978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6485943","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6485943","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Bone","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.bone.2019.01.015","doi":"https://doi.org/10.1016/j.bone.2019.01.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bone.2019.01.015","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Bone","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5299999713897705}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3975516939","display_name":"Estrogen receptor regulation of bone metabolism in adult mice","funder_award_id":"R01AG048792","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G641235025","display_name":"Physiology of Bone Metabolism in an Aging Population","funder_award_id":"P01AG004875","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7145008822","display_name":"The Role of Cellular Senescence in Mediating Age-Related Bone Loss","funder_award_id":"K01AR070241","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7391181871","display_name":"Epidemiology of Age-Related Bone Loss and Fractures","funder_award_id":"R01AR027065","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":113,"referenced_works":["https://openalex.org/W1520658182","https://openalex.org/W1570233039","https://openalex.org/W1606867770","https://openalex.org/W1722531939","https://openalex.org/W1932046626","https://openalex.org/W1968442155","https://openalex.org/W1968929544","https://openalex.org/W1970924670","https://openalex.org/W1972186273","https://openalex.org/W1976635482","https://openalex.org/W1977362098","https://openalex.org/W1980550139","https://openalex.org/W1980878904","https://openalex.org/W1981148605","https://openalex.org/W1982481909","https://openalex.org/W1982602899","https://openalex.org/W1986602198","https://openalex.org/W1988233144","https://openalex.org/W1993571663","https://openalex.org/W1995262934","https://openalex.org/W2003743012","https://openalex.org/W2007248715","https://openalex.org/W2010417927","https://openalex.org/W2013724724","https://openalex.org/W2015178646","https://openalex.org/W2019582558","https://openalex.org/W2020859582","https://openalex.org/W2024209230","https://openalex.org/W2026180657","https://openalex.org/W2030362606","https://openalex.org/W2034656280","https://openalex.org/W2038050797","https://openalex.org/W2047319406","https://openalex.org/W2048415747","https://openalex.org/W2052113230","https://openalex.org/W2052388837","https://openalex.org/W2052845629","https://openalex.org/W2062661157","https://openalex.org/W2064871936","https://openalex.org/W2066442023","https://openalex.org/W2069519394","https://openalex.org/W2070547371","https://openalex.org/W2073429636","https://openalex.org/W2074494444","https://openalex.org/W2087999409","https://openalex.org/W2088789328","https://openalex.org/W2090067193","https://openalex.org/W2094285429","https://openalex.org/W2096627331","https://openalex.org/W2097049162","https://openalex.org/W2104908670","https://openalex.org/W2108887402","https://openalex.org/W2110396808","https://openalex.org/W2111378495","https://openalex.org/W2115852450","https://openalex.org/W2120122580","https://openalex.org/W2125764628","https://openalex.org/W2126525177","https://openalex.org/W2128807350","https://openalex.org/W2130410032","https://openalex.org/W2134847038","https://openalex.org/W2135564059","https://openalex.org/W2140930678","https://openalex.org/W2142302926","https://openalex.org/W2143714801","https://openalex.org/W2145212251","https://openalex.org/W2150940840","https://openalex.org/W2160287478","https://openalex.org/W2162229546","https://openalex.org/W2170352596","https://openalex.org/W2191745121","https://openalex.org/W2220849524","https://openalex.org/W2262370504","https://openalex.org/W2264758825","https://openalex.org/W2266290735","https://openalex.org/W2266900518","https://openalex.org/W2460799613","https://openalex.org/W2467271588","https://openalex.org/W2515194864","https://openalex.org/W2524380905","https://openalex.org/W2524977260","https://openalex.org/W2540176592","https://openalex.org/W2544670169","https://openalex.org/W2547082780","https://openalex.org/W2553392495","https://openalex.org/W2560676950","https://openalex.org/W2565099834","https://openalex.org/W2567873497","https://openalex.org/W2586614683","https://openalex.org/W2605674430","https://openalex.org/W2606663768","https://openalex.org/W2608899726","https://openalex.org/W2624997514","https://openalex.org/W2732630371","https://openalex.org/W2734636788","https://openalex.org/W2745697328","https://openalex.org/W2749511637","https://openalex.org/W2750509325","https://openalex.org/W2752668646","https://openalex.org/W2753141329","https://openalex.org/W2755862485","https://openalex.org/W2762150484","https://openalex.org/W2762611634","https://openalex.org/W2788548733","https://openalex.org/W2789912326","https://openalex.org/W2792935832","https://openalex.org/W2801517377","https://openalex.org/W2860743873","https://openalex.org/W2886661663","https://openalex.org/W2888559669","https://openalex.org/W2891521436","https://openalex.org/W2891678928","https://openalex.org/W6681621528"],"related_works":["https://openalex.org/W3150967961","https://openalex.org/W2915780055","https://openalex.org/W4210505456","https://openalex.org/W4391465736","https://openalex.org/W2789912326","https://openalex.org/W2936595916","https://openalex.org/W3049096591","https://openalex.org/W2750509325","https://openalex.org/W4411154274","https://openalex.org/W7214018817"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":44},{"year":2025,"cited_by_count":46},{"year":2024,"cited_by_count":46},{"year":2023,"cited_by_count":41},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":30},{"year":2019,"cited_by_count":7}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2019-01-25T00:00:00"}
