{"id":"https://openalex.org/W2910080585","doi":"https://doi.org/10.1111/bph.14576","title":"Childhood adversity and mechanistic links to hypertension risk in adulthood","display_name":"Childhood adversity and mechanistic links to hypertension risk in adulthood","publication_year":2019,"publication_date":"2019-01-18","ids":{"openalex":"https://openalex.org/W2910080585","doi":"https://doi.org/10.1111/bph.14576","mag":"2910080585","pmid":"https://pubmed.ncbi.nlm.nih.gov/30656638","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6534788"},"language":"en","primary_location":{"id":"doi:10.1111/bph.14576","doi":"https://doi.org/10.1111/bph.14576","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bph.14576","pdf_url":null,"source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6534788","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ijeoma E. Obi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ijeoma E. Obi","raw_affiliation_strings":["CardioRenal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CardioRenal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085527672","display_name":"Kasi C. McPherson","orcid":"https://orcid.org/0000-0002-9377-9564","observed_orcids":["https://orcid.org/0000-0002-9377-9564"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kasi C. McPherson","raw_affiliation_strings":["CardioRenal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CardioRenal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003642259","display_name":"Jennifer S. Pollock","orcid":"https://orcid.org/0000-0003-1956-0449","observed_orcids":["https://orcid.org/0000-0003-1956-0449"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennifer S. Pollock","raw_affiliation_strings":["CardioRenal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States"],"raw_orcid":"https://orcid.org/0000-0003-1956-0449","affiliations":[{"raw_affiliation_string":"CardioRenal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003642259"],"corresponding_institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":0.5968,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.51904017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"176","issue":"12","first_page":"1932","last_page":"1950"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10426","display_name":"Child Abuse and Trauma","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10426","display_name":"Child Abuse and Trauma","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adverse-childhood-experiences","display_name":"adverse childhood experiences","score":0.9539999961853027},{"id":"https://openalex.org/keywords/early-life-stress","display_name":"early life stress","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6669999957084656},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.9380000233650208},{"id":"https://openalex.org/keywords/vasoactive-factors","display_name":"vasoactive factors","score":0.7369999885559082},{"id":"https://openalex.org/keywords/immune-mediators","display_name":"immune mediators","score":0.777999997138977},{"id":"https://openalex.org/keywords/pro-inflammatory-mediators","display_name":"pro-inflammatory mediators","score":0.9459999799728394},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9710000157356262},{"id":"https://openalex.org/keywords/childhood-abuse","display_name":"childhood abuse","score":0.6399999856948853},{"id":"https://openalex.org/keywords/household-dysfunction","display_name":"household dysfunction","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.6223205924034119},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5939190983772278},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5094826817512512},{"id":"https://openalex.org/C1691868","wikidata":"https://www.wikidata.org/wiki/Q1811049","display_name":"Life course approach","level":2,"score":0.41502827405929565},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3366953730583191},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.31805747747421265},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.2374453842639923},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1496809720993042}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/bph.14576","doi":"https://doi.org/10.1111/bph.14576","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bph.14576","pdf_url":null,"source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6534788","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6534788","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmid:30656638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30656638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6534788","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6534788","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1749925524","display_name":"INTRA-AIRWAY GAS PHASE MASS TRANSPORT","funder_award_id":"F32HL007912","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2858015359","display_name":"Stress Related Mechanisms of Hypertension Risk","funder_award_id":"P01HL069999","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7146760802","display_name":"Interdisciplinary Training in Kidney-Related Research","funder_award_id":"T32DK007545","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306799","display_name":"Pharmaceutical Research and Manufacturers of America Foundation","ror":"https://ror.org/01z88k350"},{"id":"https://openalex.org/F4320322112","display_name":"Korea Astronomy and Space Science Institute","ror":"https://ror.org/04g2pxh42"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":189,"referenced_works":["https://openalex.org/W101421942","https://openalex.org/W122947453","https://openalex.org/W143010615","https://openalex.org/W1501762129","https://openalex.org/W1525798600","https://openalex.org/W1551343048","https://openalex.org/W1560468264","https://openalex.org/W1560571961","https://openalex.org/W1564596764","https://openalex.org/W1581310431","https://openalex.org/W1584609572","https://openalex.org/W1721778868","https://openalex.org/W1732425222","https://openalex.org/W1734357571","https://openalex.org/W1786911182","https://openalex.org/W1836764230","https://openalex.org/W1889412525","https://openalex.org/W1920051840","https://openalex.org/W1924003686","https://openalex.org/W1954987504","https://openalex.org/W1966140207","https://openalex.org/W1966656140","https://openalex.org/W1967994686","https://openalex.org/W1968908220","https://openalex.org/W1970723735","https://openalex.org/W1971061178","https://openalex.org/W1971520601","https://openalex.org/W1972476800","https://openalex.org/W1976555160","https://openalex.org/W1978762354","https://openalex.org/W1980226498","https://openalex.org/W1981459575","https://openalex.org/W1985543379","https://openalex.org/W1988626382","https://openalex.org/W1991820507","https://openalex.org/W1993468695","https://openalex.org/W1993975304","https://openalex.org/W1995537251","https://openalex.org/W1997023449","https://openalex.org/W1997976062","https://openalex.org/W2000208057","https://openalex.org/W2001603257","https://openalex.org/W2004886377","https://openalex.org/W2005334574","https://openalex.org/W2011081879","https://openalex.org/W2021593749","https://openalex.org/W2021800338","https://openalex.org/W2028826609","https://openalex.org/W2030777261","https://openalex.org/W2034845795","https://openalex.org/W2036967765","https://openalex.org/W2038889433","https://openalex.org/W2040912840","https://openalex.org/W2042038416","https://openalex.org/W2044589280","https://openalex.org/W2047130731","https://openalex.org/W2047908047","https://openalex.org/W2049862929","https://openalex.org/W2050210416","https://openalex.org/W2053545242","https://openalex.org/W2054692302","https://openalex.org/W2054736165","https://openalex.org/W2058976010","https://openalex.org/W2059139697","https://openalex.org/W2059748176","https://openalex.org/W2060327000","https://openalex.org/W2061000745","https://openalex.org/W2063561249","https://openalex.org/W2066847273","https://openalex.org/W2067372623","https://openalex.org/W2067850707","https://openalex.org/W2069895235","https://openalex.org/W2072052992","https://openalex.org/W2073803432","https://openalex.org/W2077878361","https://openalex.org/W2077884399","https://openalex.org/W2078267799","https://openalex.org/W2079464767","https://openalex.org/W2084060129","https://openalex.org/W2084141237","https://openalex.org/W2090406694","https://openalex.org/W2093526174","https://openalex.org/W2094751877","https://openalex.org/W2099390922","https://openalex.org/W2099960919","https://openalex.org/W2100342988","https://openalex.org/W2100774873","https://openalex.org/W2103687576","https://openalex.org/W2105194498","https://openalex.org/W2105553268","https://openalex.org/W2107753021","https://openalex.org/W2107993295","https://openalex.org/W2109356273","https://openalex.org/W2110182057","https://openalex.org/W2113087028","https://openalex.org/W2113847305","https://openalex.org/W2116839388","https://openalex.org/W2117828851","https://openalex.org/W2118287470","https://openalex.org/W2122832304","https://openalex.org/W2124882888","https://openalex.org/W2125382661","https://openalex.org/W2127180883","https://openalex.org/W2129347383","https://openalex.org/W2129728198","https://openalex.org/W2131285266","https://openalex.org/W2132163349","https://openalex.org/W2134192460","https://openalex.org/W2134774120","https://openalex.org/W2135562556","https://openalex.org/W2135827706","https://openalex.org/W2137219871","https://openalex.org/W2137877778","https://openalex.org/W2139463883","https://openalex.org/W2140219025","https://openalex.org/W2141141027","https://openalex.org/W2141379992","https://openalex.org/W2141710243","https://openalex.org/W2144101679","https://openalex.org/W2144760654","https://openalex.org/W2145470660","https://openalex.org/W2146024217","https://openalex.org/W2148436412","https://openalex.org/W2149200346","https://openalex.org/W2149687914","https://openalex.org/W2157407278","https://openalex.org/W2160382960","https://openalex.org/W2160393148","https://openalex.org/W2160571418","https://openalex.org/W2160834292","https://openalex.org/W2160950754","https://openalex.org/W2161469339","https://openalex.org/W2162207163","https://openalex.org/W2162749464","https://openalex.org/W2164382299","https://openalex.org/W2164402789","https://openalex.org/W2164701614","https://openalex.org/W2165532181","https://openalex.org/W2167750356","https://openalex.org/W2171480404","https://openalex.org/W2182986036","https://openalex.org/W2183052693","https://openalex.org/W2209939113","https://openalex.org/W2219200263","https://openalex.org/W2234176399","https://openalex.org/W2264939983","https://openalex.org/W2275060080","https://openalex.org/W2276094656","https://openalex.org/W2301103165","https://openalex.org/W2323059925","https://openalex.org/W2340235891","https://openalex.org/W2414802985","https://openalex.org/W2415625256","https://openalex.org/W2469287579","https://openalex.org/W2473810718","https://openalex.org/W2507940175","https://openalex.org/W2509130976","https://openalex.org/W2518751885","https://openalex.org/W2524610039","https://openalex.org/W2528704889","https://openalex.org/W2529101908","https://openalex.org/W2539440113","https://openalex.org/W2550336455","https://openalex.org/W2580792129","https://openalex.org/W2594359131","https://openalex.org/W2597968411","https://openalex.org/W2605815243","https://openalex.org/W2612195027","https://openalex.org/W2613015861","https://openalex.org/W2613483874","https://openalex.org/W2656568860","https://openalex.org/W2741937967","https://openalex.org/W2748273887","https://openalex.org/W2751431338","https://openalex.org/W2759315216","https://openalex.org/W2765684626","https://openalex.org/W2766119667","https://openalex.org/W2766306821","https://openalex.org/W2767077155","https://openalex.org/W2768192743","https://openalex.org/W2769754352","https://openalex.org/W2771328536","https://openalex.org/W2789258876","https://openalex.org/W2789792211","https://openalex.org/W2805096634","https://openalex.org/W2805504067","https://openalex.org/W2827406253","https://openalex.org/W3008272135","https://openalex.org/W4210343616"],"related_works":["https://openalex.org/W7138884849","https://openalex.org/W2127180883","https://openalex.org/W4313893454","https://openalex.org/W6959870830","https://openalex.org/W1193057051","https://openalex.org/W3108522059","https://openalex.org/W4282920961","https://openalex.org/W2954889170","https://openalex.org/W3176690736","https://openalex.org/W4415472346"],"abstract_inverted_index":{"Adverse":[0],"childhood":[1,9],"experiences":[2],"(ACEs),":[3],"defined":[4],"as":[5,89,91,105,143],"traumatic":[6],"events":[7],"in":[8,30,69,73,94,101,173,180],"that":[10],"range":[11],"from":[12],"various":[13],"forms":[14],"of":[15,35,56,67,99,122,133,145,157,166],"abuse":[16],"to":[17,77,125],"household":[18],"challenges":[19],"and":[20,32,45,53,71,75,80,86,112,140,155],"dysfunction,":[21],"have":[22,40],"devastating":[23],"consequences":[24],"on":[25,63,116,170],"adult":[26],"health.":[27],"Epidemiological":[28],"studies":[29],"humans":[31,70],"animal":[33],"models":[34,132],"early":[36],"life":[37],"stress":[38],"(ELS)":[39],"revealed":[41],"a":[42,167],"strong":[43],"association":[44,121],"insight":[46],"into":[47],"the":[48,64,177],"mechanistic":[49,65],"link":[50],"between":[51,110],"ACEs":[52,68,111],"increased":[54],"risk":[55,114],"cardiovascular":[57],"disease":[58],"(CVD).":[59],"This":[60,162],"review":[61,103],"focuses":[62],"links":[66],"ELS":[72],"mice":[74],"rats":[76],"vasoactive":[78,128,141],"factors":[79,142],"immune":[81],"mediators":[82,139],"associated":[83],"with":[84],"CVD":[85,113],"hypertension":[87,135,147],"risk,":[88,136],"well":[90],"sex":[92],"differences":[93],"these":[95],"phenomena.":[96],"Major":[97],"topics":[98],"discussion":[100],"this":[102,181],"are":[104],"follows:":[106],"(a)":[107],"epidemiological":[108],"associations":[109],"focusing":[115],"hypertension,":[117],"(b)":[118],"evidence":[119],"for":[120],"ACE":[123],"exposures":[124],"immune-mediated":[126],"and/or":[127],"pathways,":[129],"(c)":[130],"rodent":[131],"ELS-induced":[134,146],"(d)":[137],"proinflammatory":[138],"mechanisms":[144],"risk.":[148],"We":[149],"also":[150],"provide":[151],"some":[152],"overall":[153],"conclusions":[154],"directions":[156],"further":[158],"research.":[159],"LINKED":[160],"ARTICLES:":[161],"article":[163],"is":[164],"part":[165],"themed":[168],"section":[169,182],"Immune":[171],"Targets":[172],"Hypertension.":[174],"To":[175],"view":[176],"other":[178],"articles":[179],"visit":[183],"http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.12/issuetoc.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-01-25T00:00:00"}