{"id":"https://openalex.org/W2910042991","doi":"https://doi.org/10.3390/ijms20010210","title":"Interplay between Autophagy and the Ubiquitin-Proteasome System and Its Role in the Pathogenesis of Age-Related Macular Degeneration","display_name":"Interplay between Autophagy and the Ubiquitin-Proteasome System and Its Role in the Pathogenesis of Age-Related Macular Degeneration","publication_year":2019,"publication_date":"2019-01-08","ids":{"openalex":"https://openalex.org/W2910042991","doi":"https://doi.org/10.3390/ijms20010210","mag":"2910042991","pmid":"https://pubmed.ncbi.nlm.nih.gov/30626110","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6337628"},"language":"en","primary_location":{"id":"doi:10.3390/ijms20010210","doi":"https://doi.org/10.3390/ijms20010210","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20010210","pdf_url":"https://www.mdpi.com/1422-0067/20/1/210/pdf?version=1546945847","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/20/1/210/pdf?version=1546945847","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052186294","display_name":"Janusz B\u0142asiak","orcid":"https://orcid.org/0000-0001-9539-9584","observed_orcids":["https://orcid.org/0000-0001-9539-9584"]},"institutions":[{"id":"https://openalex.org/I34250744","display_name":"University of \u0141\u00f3d\u017a","ror":"https://ror.org/05cq64r17","country_code":"PL","type":"education","lineage":["https://openalex.org/I34250744"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Janusz Blasiak","raw_affiliation_strings":["Department of Molecular Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland"],"raw_orcid":"https://orcid.org/0000-0001-9539-9584","affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland","institution_ids":["https://openalex.org/I34250744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016282083","display_name":"El\u017cbieta Paw\u0142owska","orcid":"https://orcid.org/0000-0002-5373-4783","observed_orcids":["https://orcid.org/0000-0002-5373-4783"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Elzbieta Pawlowska","raw_affiliation_strings":["Department of Orthodontics, Medical University of Lodz, 92-216 Lodz, Poland"],"raw_orcid":"https://orcid.org/0000-0002-5373-4783","affiliations":[{"raw_affiliation_string":"Department of Orthodontics, Medical University of Lodz, 92-216 Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023441629","display_name":"Joanna Szczepa\u0144ska","orcid":"https://orcid.org/0000-0001-9912-5345","observed_orcids":["https://orcid.org/0000-0001-9912-5345"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Joanna Szczepanska","raw_affiliation_strings":["Department of Pediatric Dentistry, Medical University of Lodz, 92-216 Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Dentistry, Medical University of Lodz, 92-216 Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021448617","display_name":"Kai Kaarniranta","orcid":"https://orcid.org/0000-0003-2600-8679","observed_orcids":["https://orcid.org/0000-0003-2600-8679"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Kai Kaarniranta","raw_affiliation_strings":["Department of Ophthalmology, Kuopio University Hospital, 70029 Kuopio, Finland","Department of Ophthalmology, University of Eastern Finland, Kuopio 70211, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Kuopio University Hospital, 70029 Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]},{"raw_affiliation_string":"Department of Ophthalmology, University of Eastern Finland, Kuopio 70211, Finland","institution_ids":["https://openalex.org/I175532246"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021448617"],"corresponding_institution_ids":["https://openalex.org/I175532246","https://openalex.org/I4210092991"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":2.5883,"has_fulltext":true,"cited_by_count":135,"citation_normalized_percentile":{"value":0.92349507,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"20","issue":"1","first_page":"210","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.864300012588501,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.864300012588501,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.11259999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9980000257492065},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":1.0},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9950000047683716},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.996999979019165},{"id":"https://openalex.org/keywords/all-trans-retinal","display_name":"all-trans-retinal","score":0.7670000195503235},{"id":"https://openalex.org/keywords/drusen","display_name":"drusen","score":0.9890000224113464},{"id":"https://openalex.org/keywords/lipofuscin","display_name":"lipofuscin","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8479999899864197},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9470000267028809},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.871172308921814},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.8669493198394775},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7773866653442383},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7031622529029846},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.643867015838623},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.5245219469070435},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4220474660396576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41359975934028625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.410590797662735},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36171191930770874},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3594515323638916},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2589462399482727},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23135754466056824},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.20697715878486633},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.11191216111183167},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10930746793746948}],"mesh":[{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms20010210","doi":"https://doi.org/10.3390/ijms20010210","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20010210","pdf_url":"https://www.mdpi.com/1422-0067/20/1/210/pdf?version=1546945847","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5317646","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6337628","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6337628","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6337628","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:30626110","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30626110","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0c482b18d03b4afb9eaf55641083ada2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0c482b18d03b4afb9eaf55641083ada2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 20, Iss 1, p 210 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms20010210","doi":"https://doi.org/10.3390/ijms20010210","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20010210","pdf_url":"https://www.mdpi.com/1422-0067/20/1/210/pdf?version=1546945847","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4923560736","display_name":null,"funder_award_id":"2017/27/B/NZ3/00872","funder_id":"https://openalex.org/F4320322650","funder_display_name":"Narodowym Centrum Nauki"}],"funders":[{"id":"https://openalex.org/F4320322650","display_name":"Narodowym Centrum Nauki","ror":"https://ror.org/03ha2q922"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2910042991.pdf","grobid_xml":"https://content.openalex.org/works/W2910042991.grobid-xml"},"referenced_works_count":158,"referenced_works":["https://openalex.org/W108060262","https://openalex.org/W137478356","https://openalex.org/W152146682","https://openalex.org/W166459020","https://openalex.org/W191557745","https://openalex.org/W1480070492","https://openalex.org/W1491374817","https://openalex.org/W1505600359","https://openalex.org/W1523693806","https://openalex.org/W1566636169","https://openalex.org/W1568021116","https://openalex.org/W1573038875","https://openalex.org/W1604547442","https://openalex.org/W1762620449","https://openalex.org/W1762842507","https://openalex.org/W1764833860","https://openalex.org/W1874829170","https://openalex.org/W1883306593","https://openalex.org/W1965902690","https://openalex.org/W1967493255","https://openalex.org/W1969201332","https://openalex.org/W1972958434","https://openalex.org/W1973530425","https://openalex.org/W1973668650","https://openalex.org/W1974015025","https://openalex.org/W1976601347","https://openalex.org/W1980062352","https://openalex.org/W1984036841","https://openalex.org/W1986275598","https://openalex.org/W1986721511","https://openalex.org/W1987319020","https://openalex.org/W1987558049","https://openalex.org/W1991058166","https://openalex.org/W1991390827","https://openalex.org/W1994133882","https://openalex.org/W2004112218","https://openalex.org/W2010352524","https://openalex.org/W2010632526","https://openalex.org/W2013429682","https://openalex.org/W2013826094","https://openalex.org/W2018082393","https://openalex.org/W2022675211","https://openalex.org/W2023897774","https://openalex.org/W2026843861","https://openalex.org/W2027212523","https://openalex.org/W2028934382","https://openalex.org/W2032217161","https://openalex.org/W2032679742","https://openalex.org/W2033056129","https://openalex.org/W2033295839","https://openalex.org/W2033662964","https://openalex.org/W2034041091","https://openalex.org/W2034130805","https://openalex.org/W2034655889","https://openalex.org/W2039204471","https://openalex.org/W2042294920","https://openalex.org/W2043276141","https://openalex.org/W2043433277","https://openalex.org/W2045454625","https://openalex.org/W2047537735","https://openalex.org/W2050987407","https://openalex.org/W2051612655","https://openalex.org/W2052550497","https://openalex.org/W2054554887","https://openalex.org/W2055642010","https://openalex.org/W2057518766","https://openalex.org/W2061774676","https://openalex.org/W2064492560","https://openalex.org/W2068564200","https://openalex.org/W2069558973","https://openalex.org/W2070367241","https://openalex.org/W2071313689","https://openalex.org/W2073499357","https://openalex.org/W2076570319","https://openalex.org/W2076769172","https://openalex.org/W2079869359","https://openalex.org/W2080693065","https://openalex.org/W2081233800","https://openalex.org/W2081690682","https://openalex.org/W2082325637","https://openalex.org/W2089128950","https://openalex.org/W2089952011","https://openalex.org/W2103460528","https://openalex.org/W2104412320","https://openalex.org/W2105465142","https://openalex.org/W2107114877","https://openalex.org/W2109936231","https://openalex.org/W2111567059","https://openalex.org/W2120957446","https://openalex.org/W2123554280","https://openalex.org/W2126525177","https://openalex.org/W2127916470","https://openalex.org/W2128128928","https://openalex.org/W2129325060","https://openalex.org/W2131643880","https://openalex.org/W2133904455","https://openalex.org/W2135110724","https://openalex.org/W2138311396","https://openalex.org/W2140654974","https://openalex.org/W2140750082","https://openalex.org/W2142432153","https://openalex.org/W2144414956","https://openalex.org/W2144839999","https://openalex.org/W2147461641","https://openalex.org/W2153455224","https://openalex.org/W2157535220","https://openalex.org/W2158780541","https://openalex.org/W2160226180","https://openalex.org/W2160550697","https://openalex.org/W2165453045","https://openalex.org/W2165500012","https://openalex.org/W2173240499","https://openalex.org/W2227187219","https://openalex.org/W2246788823","https://openalex.org/W2286682292","https://openalex.org/W2296704298","https://openalex.org/W2317261522","https://openalex.org/W2330453389","https://openalex.org/W2341577039","https://openalex.org/W2344497882","https://openalex.org/W2411835663","https://openalex.org/W2467803365","https://openalex.org/W2530455255","https://openalex.org/W2543254189","https://openalex.org/W2556373182","https://openalex.org/W2558480713","https://openalex.org/W2563497525","https://openalex.org/W2568609612","https://openalex.org/W2569601267","https://openalex.org/W2580787355","https://openalex.org/W2591403620","https://openalex.org/W2592666178","https://openalex.org/W2598565412","https://openalex.org/W2606524366","https://openalex.org/W2618382267","https://openalex.org/W2620784367","https://openalex.org/W2735303773","https://openalex.org/W2738996050","https://openalex.org/W2755330602","https://openalex.org/W2756601401","https://openalex.org/W2765467346","https://openalex.org/W2766775513","https://openalex.org/W2773731557","https://openalex.org/W2788703149","https://openalex.org/W2789947919","https://openalex.org/W2791655201","https://openalex.org/W2792892933","https://openalex.org/W2793499514","https://openalex.org/W2802370819","https://openalex.org/W2807558306","https://openalex.org/W2811301994","https://openalex.org/W2864177024","https://openalex.org/W2890021586","https://openalex.org/W2890808697","https://openalex.org/W2892928169","https://openalex.org/W2897744620","https://openalex.org/W6635869713","https://openalex.org/W6736958016"],"related_works":["https://openalex.org/W4388973600","https://openalex.org/W2344497882","https://openalex.org/W1438640379","https://openalex.org/W2005487633","https://openalex.org/W2559175446","https://openalex.org/W2004112218","https://openalex.org/W4312032441","https://openalex.org/W4401219086","https://openalex.org/W7126021813","https://openalex.org/W2889959895"],"abstract_inverted_index":{"Age-related":[0],"macular":[1],"degeneration":[2],"(AMD)":[3],"is":[4,95,171],"a":[5,67,161],"complex":[6],"eye":[7],"disease":[8],"with":[9,66],"many":[10],"pathogenesis":[11],"factors,":[12,143],"including":[13,110],"defective":[14],"cellular":[15,24,114,187],"waste":[16,25,115,188],"management":[17,189],"in":[18,26,45,79,90,107,117,122,163],"retinal":[19],"pigment":[20],"epithelium":[21],"(RPE).":[22],"Main":[23],"AMD":[27,118,141,164],"are:":[28],"all-trans":[29],"retinal,":[30],"drusen":[31],"and":[32,37,43,55,103,136,147,155,166,176],"lipofuscin,":[33],"containing":[34],"unfolded,":[35],"damaged":[36],"unneeded":[38],"proteins,":[39],"which":[40],"are":[41,88],"degraded":[42,96],"recycled":[44],"RPE":[46],"cells":[47],"by":[48,97],"two":[49,139,186],"main":[50],"machineries-the":[51],"ubiquitin-proteasome":[52],"system":[53],"(UPS)":[54],"autophagy.":[56,98,148],"Recent":[57],"findings":[58],"show":[59],"that":[60],"these":[61,132,185],"systems":[62,133],"can":[63,157],"act":[64],"together":[65],"significant":[68],"role":[69],"of":[70,125,131,153,182,184],"the":[71,83,123,180],"EI24":[72],"(etoposide-induced":[73],"protein":[74],"2.4":[75],"homolog)":[76],"ubiquitin":[77],"ligase":[78],"their":[80],"action.":[81],"On":[82],"other":[84],"hand,":[85],"E3":[86,94],"ligases":[87],"essential":[89],"both":[91,145],"systems,":[92],"but":[93],"The":[99],"interplay":[100,127],"between":[101],"UPS":[102,146,154],"autophagy":[104,156],"was":[105],"targeted":[106],"several":[108],"diseases,":[109],"Alzheimer":[111],"disease.":[112],"Therefore,":[113],"clearing":[116],"should":[119],"be":[120,158],"considered":[121,159],"context":[124],"such":[126],"rather":[128],"than":[129],"either":[130],"singly.":[134],"Aging":[135],"oxidative":[137],"stress,":[138],"major":[140],"risk":[142],"reduce":[144],"In":[149],"conclusion,":[150],"molecular":[151],"mechanisms":[152],"as":[160],"target":[162],"prevention":[165],"therapeutic":[167],"perspective.":[168],"Further":[169],"work":[170],"needed":[172],"to":[173],"identify":[174],"molecules":[175],"effects":[177],"important":[178],"for":[179],"coordination":[181],"action":[183],"systems.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":26},{"year":2019,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-01-25T00:00:00"}