{"id":"https://openalex.org/W2909979580","doi":"https://doi.org/10.1182/blood-2018-99-114273","title":"Differences in Genomic Patterns between African Americans and Whites with Acute Myeloid Leukemia","display_name":"Differences in Genomic Patterns between African Americans and Whites with Acute Myeloid Leukemia","publication_year":2018,"publication_date":"2018-11-29","ids":{"openalex":"https://openalex.org/W2909979580","doi":"https://doi.org/10.1182/blood-2018-99-114273","mag":"2909979580"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2018-99-114273","doi":"https://doi.org/10.1182/blood-2018-99-114273","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-114273","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028554428","display_name":"Rachel Hu","orcid":"https://orcid.org/0000-0002-4467-1856","observed_orcids":["https://orcid.org/0000-0002-4467-1856"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Hu","raw_affiliation_strings":["Taussig Cancer Institute, Department of Hematology & Medical Oncology, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taussig Cancer Institute, Department of Hematology & Medical Oncology, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086233229","display_name":"Aziz Nazha","orcid":"https://orcid.org/0000-0002-6695-7994","observed_orcids":["https://orcid.org/0000-0002-6695-7994"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aziz Nazha","raw_affiliation_strings":["Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101184210","display_name":"Xuefei Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xuefei Jia","raw_affiliation_strings":["Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002744671","display_name":"Brian Paul Hobbs","orcid":"https://orcid.org/0000-0003-2189-5846","observed_orcids":["https://orcid.org/0000-0003-2189-5846"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian P. Hobbs","raw_affiliation_strings":["Cancer Biostatistics, Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biostatistics, Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016810759","display_name":"Hetty E. Carraway","orcid":"https://orcid.org/0000-0001-5241-3614","observed_orcids":["https://orcid.org/0000-0001-5241-3614"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hetty E. Carraway","raw_affiliation_strings":["Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102826236","display_name":"Sudipto Mukherjee","orcid":"https://orcid.org/0000-0002-8325-2603","observed_orcids":["https://orcid.org/0000-0002-8325-2603","https://orcid.org/0009-0002-0717-6319"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudipto Mukherjee","raw_affiliation_strings":["Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023728016","display_name":"Aaron Thomas Gerds","orcid":"https://orcid.org/0000-0002-3422-1309","observed_orcids":["https://orcid.org/0000-0002-3422-1309"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron T. Gerds","raw_affiliation_strings":["Cleveland Clinic Taussig Cancer Institute, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Taussig Cancer Institute, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082944296","display_name":"Anjali S. Advani","orcid":"https://orcid.org/0000-0003-0015-5902","observed_orcids":["https://orcid.org/0000-0003-0015-5902"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anjali S. Advani","raw_affiliation_strings":["Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015705148","display_name":"Yasunobu Nagata","orcid":"https://orcid.org/0000-0002-0866-929X","observed_orcids":["https://orcid.org/0000-0002-0866-929X"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yasunobu Nagata","raw_affiliation_strings":["Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112104644","display_name":"Cassandra M. Hirsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cassandra M. Hirsch","raw_affiliation_strings":["Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022299669","display_name":"Bartlomiej P. Przychodzen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bartlomiej P. Przychodzen","raw_affiliation_strings":["Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057121925","display_name":"Babal Kant Jha","orcid":"https://orcid.org/0000-0002-7660-5255","observed_orcids":["https://orcid.org/0000-0002-7660-5255"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Babal K. Jha","raw_affiliation_strings":["Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085974329","display_name":"Jaroslaw Pawel Maciejewski","orcid":"https://orcid.org/0000-0002-6837-4346","observed_orcids":["https://orcid.org/0000-0002-6837-4346"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaroslaw P. Maciejewski","raw_affiliation_strings":["Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055740968","display_name":"Mikkael Aaron Sekeres","orcid":"https://orcid.org/0000-0003-2009-6524","observed_orcids":["https://orcid.org/0000-0003-2009-6524"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikkael A. Sekeres","raw_affiliation_strings":["Leukemia Program, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia Program, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002744671","https://openalex.org/A5015705148","https://openalex.org/A5022299669","https://openalex.org/A5057121925","https://openalex.org/A5101184210","https://openalex.org/A5112104644"],"corresponding_institution_ids":["https://openalex.org/I1316902750"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"132","issue":"Supplement 1","first_page":"1527","last_page":"1527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/racial-disparities","display_name":"racial disparities","score":0.8489999771118164},{"id":"https://openalex.org/keywords/african-americans","display_name":"African Americans","score":0.9629999995231628},{"id":"https://openalex.org/keywords/genomic-profiling","display_name":"genomic profiling","score":0.5730000138282776},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cytogenetic-risk-classification","display_name":"cytogenetic risk classification","score":0.6940000057220459},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6970000267028809},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.46799999475479126},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.550000011920929},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/chromatin-modification","display_name":"chromatin modification","score":0.6859999895095825},{"id":"https://openalex.org/keywords/splicing","display_name":"splicing","score":0.5230000019073486},{"id":"https://openalex.org/keywords/receptor-kinases","display_name":"receptor kinases","score":0.671999990940094},{"id":"https://openalex.org/keywords/rna-helicase","display_name":"RNA helicase","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8109999895095825},{"id":"https://openalex.org/keywords/disease-biology","display_name":"disease biology","score":0.4819999933242798},{"id":"https://openalex.org/keywords/age-at-diagnosis","display_name":"age at diagnosis","score":0.5139999985694885},{"id":"https://openalex.org/keywords/the-cancer-genome-atlas","display_name":"TCGA","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6902157664299011},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5761563777923584},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5352087616920471},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5241311192512512},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.45842424035072327}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2018-99-114273","doi":"https://doi.org/10.1182/blood-2018-99-114273","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-114273","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.7390999794006348,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4310105114","https://openalex.org/W7162510715","https://openalex.org/W7162494471","https://openalex.org/W4417016696","https://openalex.org/W2129632994","https://openalex.org/W3097880139","https://openalex.org/W4206523820","https://openalex.org/W7148936648","https://openalex.org/W4389235227","https://openalex.org/W2075938749"],"abstract_inverted_index":{"Abstract":[0,14],"Differences":[1,59],"in":[2,24,61,148,295,339,404,434,441,484,494,514,537,546,608,628],"Genomic":[3,138],"Patterns":[4],"Between":[5],"African":[6,30],"Americans":[7,31],"and":[8,48,66,71,75,98,108,124,150,182,190,202,209,223,262,316,321,379,386,410,416,568,584,594,614,630],"Whites":[9],"with":[10,52,102,107,117,133,421,519,526,541,559,575],"Acute":[11],"Myeloid":[12],"Leukemia":[13],"ID:":[15],"114273":[16],"Background:":[17],"In":[18],"the":[19,93,127,331,478],"United":[20],"States,":[21],"racial":[22,196],"disparities":[23],"acute":[25],"myeloid":[26,152],"leukemia":[27],"(AML)":[28],"include":[29],"(AAs)":[32],"presenting":[33],"at":[34,112,233,301,563],"an":[35,650,663,683,728,748,761,772,783,794],"earlier":[36],"age":[37,236,322],"compared":[38,194,277,287,523,565],"to":[39,80,278,288,401,419,473,524,566,571,590,617],"whites":[40,232,280,290,298,387,446,525,549,567],"(a":[41],"median":[42,256,303,367],"of":[43,57,96,140,237,304,341,369,480,496,501,581,653,666,686,731,751,764,775,786,797],"48":[44],"vs":[45,241,253,259,266,297,308,392,407,413,424,445,488,499,548],"55":[46],"years)":[47],"having":[49],"worse":[50,626],"outcomes,":[51],"a":[53,89,302,511,520,527,542],"12%":[54],"increased":[55],"risk":[56,157],"death.":[58],"persist":[60],"studies":[62,577],"demonstrating":[63],"similar":[64,248,300],"induction":[65],"post-remission":[67],"treatment,":[68],"treatment":[69],"intensity,":[70],"follow-up":[72],"for":[73,78,110,319,436,508,517],"AA":[74,97,222,270,296,385,397,442,471,485,497,518,547,557,609,629],"whites,":[76],"controlling":[77,318],"access":[79],"health":[81],"care.":[82],"To":[83],"determine":[84],"if":[85],"disease":[86],"biology":[87],"plays":[88],"role,":[90],"we":[91],"studied":[92],"genomic":[94],"profile":[95],"white":[99,474,502,612],"patients":[100],"(pts)":[101],"AML.":[103],"Methods:":[104],"Pts":[105],"diagnosed":[106],"treated":[109],"AML":[111,149,560],"Cleveland":[113],"Clinic":[114],"between":[115,195,384,455],"2001-2013":[116],"next":[118],"generation":[119],"target":[120],"sequencing":[121],"(NGS)":[122],"available":[123,135],"pts":[125,217,558],"from":[126],"The":[128,366],"Cancer":[129],"Genome":[130],"Atlas":[131],"(TCGA)":[132],"NGS":[134],"were":[136,154,166,193,221,226,229,336,398,429,438,453,459,539],"included.":[137],"panels":[139],"60":[141],"gene":[142,596],"mutations":[143,370,403,428,433,458,593],"that":[144,477],"are":[145,561],"commonly":[146],"mutated":[147,334,493],"other":[151,451],"malignancies":[153],"sequenced.":[155],"Cytogenetic":[156],"classification":[158],"was":[159,299,373,381,482,492],"per":[160,371],"CALBG/Alliance":[161],"criteria.":[162],"Functional":[163],"molecular":[164,599],"groups":[165,456],"classified":[167],"as":[168],"follows:":[169],"cohesion,":[170],"splicing,":[171],"DNA":[172],"methylation,":[173],"transcription,":[174],"chromatin":[175],"modifications,":[176],"receptor/kinases,":[177],"RAS":[178],"pathway,":[179],"RNA":[180],"helicase,":[181],"tumor":[183],"suppressor":[184],"(see":[185],"Table":[186,464],"1).":[187],"Baseline":[188],"characteristics":[189],"mutation":[191,522,529],"incidence":[192],"cohorts":[197],"using":[198],"Wilcoxon":[199],"rank":[200],"sum":[201],"chi-square":[203],"tests.":[204],"Survival":[205,505],"analyses":[206],"used":[207],"log-rank":[208],"Cox":[210],"proportional":[211],"hazards":[212],"regression.":[213],"Results:":[214],"Of":[215],"320":[216],"analyzed,":[218],"25":[219],"(7.8%)":[220],"295":[224],"(92.2%)":[225],"whites.":[227],"AAs":[228],"younger":[230,562],"than":[231,611],"diagnosis":[234,564],"(median":[235,388],"59":[238],"[range":[239,390],"25-80]":[240],"65":[242],"years":[243],"[21-100],":[244],"P=.03)":[245],"but":[246,587],"had":[247,274,284],"sex":[249],"distribution":[250],"(52%":[251],"male":[252],"53.6%,":[254],"P=1.0),":[255],"WBC":[257],"(5.91":[258],"5.29,":[260],"P=.73)":[261],"blast":[263],"percentage":[264],"(47":[265],"39,":[267],"P=.30).":[268],"Among":[269],"pts,":[271],"18":[272],"(75%)":[273],"intermediate-risk":[275],"cytogenetics":[276,286,320],"222":[279],"(76.6%);":[281],"6":[282],"(25%)":[283],"unfavorable":[285],"68":[289],"(23.4%,":[291],"P=1.0).":[292],"Overall":[293],"survival":[294,544,627],"10.6":[305],"(range":[306,311,375],".13-63)":[307],"14.6":[309],"months":[310],".03-114)":[312],"(P":[313],"=":[314],".50),":[315],"when":[317,457],"(HR":[323,530,550],"1.05,":[324],"95%":[325,532,552],"CI":[326,533,553],"0.60-1.85,":[327],"P":[328],"=.87).":[329],"Overall,":[330],"most":[332],"frequently":[333],"genes":[335,435],"NPM1":[337],"(seen":[338],"74%":[340],"all":[342],"pts),":[343],"DNMT3A":[344],"(63%),":[345],"TET2":[346,422,592],"(50%),":[347],"FLT3":[348],"(44%),":[349],"RUNX1":[350],"(35%),":[351],"ASXL1":[352],"(34%),":[353],"IDH2":[354],"(27%),":[355],"NRAS":[356],"(25%),":[357,359],"STAG2":[358],"IDH1":[360],"(23%),":[361,363],"TP53":[362,411,491,538,573],"U2AF1":[364],"(21%).":[365],"number":[368],"sample":[372],"2":[374,389,393],"0":[376],"-":[377],"15)":[378],"there":[380],"no":[382],"difference":[383,545],"0-6]":[391],"[0-15],":[394],"P=":[395],"0.35).":[396],"more":[399,569,606],"likely":[400,418,570,589],"have":[402,572,591],"RAD21":[405,481,521,528,585,604],"(13":[406],"2%,":[408,489],"P=.019)":[409],"(20":[412],"6%,":[414],"P=.03),":[415],"less":[417,439,588],"present":[420],"(0":[423],"17%,":[425],"P=0.050).":[426],"When":[427],"grouped":[430,460],"by":[431,461,468],"function,":[432,462],"methylation":[437,595],"common":[440,607],"(n=2,":[443],"15.4%)":[444],"(n=78,":[447],"49.4%)":[448],"(P=.038).":[449],"No":[450],"differences":[452],"seen":[454],"see":[463],"1.":[465],"Stratified":[466],"analysis":[467],"sex,":[469],"comparing":[470],"males":[472,486,498,503,610,613],"males,":[475],"revealed":[476],"prevalence":[479],"higher":[483,579],"(23":[487],"P<.001).":[490],"23%":[495],"7.6%":[500],"(P=.166).":[504],"analyses,":[506],"adjusting":[507],"age,":[509],"estimated":[510],"10-fold":[512],"increase":[513],"death":[515,619],"rate":[516],"0.1,":[531],"0.01-1.82,":[534],"P=.12).":[535],"Mutations":[536],"associated":[540],"non-significant":[543],"0.68,":[551],"0.24-1.90,":[554],"P=.46)":[555],"Conclusion:":[556],"(consistent":[574],"previous":[576],"showing":[578],"rates":[580],"complex":[582],"cytogenetics)":[583],"mutations,":[586],"mutations.":[597],"Some":[598],"abnormalities":[600],"may":[601,615,623,631],"be":[602],"sex-specific.":[603],"is":[605],"contribute":[616],"excess":[618],"rates.":[620],"These":[621],"findings":[622],"help":[624],"explain":[625],"suggest":[632],"differential":[633],"therapeutic":[634],"efficacy.":[635],"Disclosures":[636],"Nazha:":[637],"MEI:":[638],"Consultancy.":[639,700,711],"Carraway:Agios:":[640],"Consultancy,":[641,725,745],"Speakers":[642,645,658,673,678,736,756],"Bureau;":[643,646,659,674,679,737],"Jazz:":[644],"Balaxa:":[647],"Membership":[648,661,681,726,746,759,770,781,792],"on":[649,662,682,727,747,760,771,782,793],"entity's":[651,664,684,729,749,762,773,784,795],"Board":[652,665,685,730,750,763,774,785,796],"Directors":[654,667,687,732,752,765,776,787,798],"or":[655,668,688,733,753,766,777,788,799],"advisory":[656,669,689,734,754,767,778,789,800],"committees,":[657,670,735,755],"Celgene:":[660,780],"Research":[671,702,706],"Funding,":[672],"FibroGen:":[675],"Consultancy;":[676,692,695,697,709,715,718,721,741],"Novartis:":[677,710],"Amgen:":[680],"committees.":[690,801],"Gerds:Celgene:":[691],"Apexx":[693],"Oncology:":[694],"Incyte:":[696],"CTI":[698],"Biopharma:":[699],"Advani:Amgen:":[701],"Funding;":[703,707],"Pfizer:":[704],"Honoraria,":[705],"Glycomimetics:":[708],"Maciejewski:Ra":[712],"Pharmaceuticals,":[713,723,739,743],"Inc:":[714,740],"Apellis":[716,719],"Pharmaceuticals:":[717,720],"Alexion":[722,742],"Inc.:":[724,744],"Ra":[738],"Bureau.":[757],"Sekeres:Celgene:":[758],"committees;":[768,779,790],"Opsona:":[769,791]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2019-01-25T00:00:00"}