{"id":"https://openalex.org/W2909948739","doi":null,"title":"Gender differences in adverse drug reaction reports; How can they be explained?","display_name":"Gender differences in adverse drug reaction reports; How can they be explained?","publication_year":2018,"publication_date":"2018-11-01","ids":{"openalex":"https://openalex.org/W2909948739","mag":"2909948739"},"language":"en","primary_location":{"id":"mag:2909948739","doi":null,"is_oa":true,"landing_page_url":"https://link.springer.com/article/10.1007/s40264-018-0719-2","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CINECA IRIS Institutial research information system (University of Pisa)","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://link.springer.com/article/10.1007/s40264-018-0719-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038636193","display_name":"Sietske de Vries","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sietske de Vries","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073876435","display_name":"Eug\u00e8ne van Puijenbroek","orcid":"https://orcid.org/0000-0002-2236-1398","observed_orcids":["https://orcid.org/0000-0002-2236-1398"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eug\u00e8ne van Puijenbroek","raw_affiliation_strings":["PharmacoTherapy, -Epidemiology and -Economics"],"raw_orcid":"https://orcid.org/0000-0002-2236-1398","affiliations":[{"raw_affiliation_string":"PharmacoTherapy, -Epidemiology and -Economics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110468234","display_name":"Petrus Mol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Petrus Mol","raw_affiliation_strings":["Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059895069","display_name":"Corine Ekhart","orcid":"https://orcid.org/0000-0002-2252-0467","observed_orcids":["https://orcid.org/0000-0002-2252-0467"]},"institutions":[{"id":"https://openalex.org/I4210139651","display_name":"Netherlands Pharmacovigilance Centre Lareb","ror":"https://ror.org/04fp8ns78","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210139651"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Corine Ekhart","raw_affiliation_strings":["Netherlands Pharmacovigilance Centre Lareb"],"raw_orcid":"https://orcid.org/0000-0002-2252-0467","affiliations":[{"raw_affiliation_string":"Netherlands Pharmacovigilance Centre Lareb","institution_ids":["https://openalex.org/I4210139651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029966007","display_name":"Petra Denig","orcid":"https://orcid.org/0000-0002-7929-4739","observed_orcids":["https://orcid.org/0000-0002-7929-4739"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Petra Denig","raw_affiliation_strings":["Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)"],"raw_orcid":"https://orcid.org/0000-0002-7929-4739","affiliations":[{"raw_affiliation_string":"Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18656621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13252","display_name":"Sex and Gender in Healthcare","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.859000027179718},{"id":"https://openalex.org/keywords/gender-differences","display_name":"gender differences","score":0.8569999933242798},{"id":"https://openalex.org/keywords/pharmacovigilance","display_name":"pharmacovigilance","score":0.8679999709129333},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.5049999952316284},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.7210000157356262},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7459999918937683},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9760000109672546},{"id":"https://openalex.org/keywords/sex-differences-in-drug-response","display_name":"sex differences in drug response","score":0.7059999704360962},{"id":"https://openalex.org/keywords/patient-reporting","display_name":"patient reporting","score":0.3319999873638153},{"id":"https://openalex.org/keywords/alopecia","display_name":"hair loss","score":0.5099999904632568},{"id":"https://openalex.org/keywords/tendon-rupture","display_name":"tendon rupture","score":0.492000013589859},{"id":"https://openalex.org/keywords/aggression","display_name":"aggression","score":0.7689999938011169},{"id":"https://openalex.org/keywords/dose-dependent-adverse-effects","display_name":"dose-dependent adverse effects","score":0.6359999775886536},{"id":"https://openalex.org/keywords/psychotropic-drugs","display_name":"psychotropic drugs","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C57658597","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Pharmacovigilance","level":3,"score":0.9242445230484009},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9182301759719849},{"id":"https://openalex.org/C199475168","wikidata":"https://www.wikidata.org/wiki/Q1539689","display_name":"MedDRA","level":4,"score":0.760168194770813},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6947858333587646},{"id":"https://openalex.org/C23276603","wikidata":"https://www.wikidata.org/wiki/Q158230","display_name":"Pharmacoepidemiology","level":3,"score":0.5696108937263489},{"id":"https://openalex.org/C2780542314","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Adverse drug reaction","level":3,"score":0.487150639295578},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.4524187445640564},{"id":"https://openalex.org/C2993432071","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug reaction","level":3,"score":0.4348203241825104},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4249628186225891},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35496413707733154},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3290398120880127},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.1410352885723114}],"mesh":[],"locations_count":3,"locations":[{"id":"mag:2909948739","doi":null,"is_oa":true,"landing_page_url":"https://link.springer.com/article/10.1007/s40264-018-0719-2","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CINECA IRIS Institutial research information system (University of Pisa)","raw_type":null},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/acad2aab-c8c6-444c-8dcc-449271945e76","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11370/acad2aab-c8c6-444c-8dcc-449271945e76","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"De Vries, S, Van Puijenbroek, E, Mol, P, Ekhart, C & Denig, P 2018, 'Gender differences in adverse drug reaction reports; How can they be explained?', pp. 1142.","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:rug:oai:pure.rug.nl:publications/acad2aab-c8c6-444c-8dcc-449271945e76","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/acad2aab-c8c6-444c-8dcc-449271945e76","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TITLE=None","raw_type":"info:eu-repo/semantics/conferenceitemnotinproceedings"}],"best_oa_location":{"id":"mag:2909948739","doi":null,"is_oa":true,"landing_page_url":"https://link.springer.com/article/10.1007/s40264-018-0719-2","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CINECA IRIS Institutial research information system (University of Pisa)","raw_type":null},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.6025999784469604,"display_name":"Gender equality","id":"https://metadata.un.org/sdg/5"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2935014396","https://openalex.org/W2129122186","https://openalex.org/W2090909991","https://openalex.org/W4214523030","https://openalex.org/W2617757413","https://openalex.org/W2898765557","https://openalex.org/W4387996915","https://openalex.org/W2662889458","https://openalex.org/W4200363928","https://openalex.org/W2981369305"],"abstract_inverted_index":{"Background/Introduction:":[0],"In":[1,407],"general,":[2],"women":[3,219,236,248,291,327],"have":[4,286],"a":[5,250,372],"higher":[6],"risk":[7],"for":[8,41,47,87,125,159,180,218,235,247,270],"adverse":[9],"drug":[10,48,90,184],"reactions":[11],"(ADRs)":[12],"being":[13,324],"reported":[14,75,97,116,215,234,246,267,325],"than":[15],"men":[16,27,392],"[1].":[17],"Women":[18],"also":[19,354],"generally":[20],"use":[21],"more":[22,216,232,268,388],"drugs":[23,126,253,342],"as":[24,368,399],"compared":[25],"to":[26,78,103,157,281,295,396,452,466],"in":[28,38,63,74,83,89,134,168,205,276,293,310,312,326,349,358,390,405,410,413,425,431,437],"various":[29,287,305],"therapeutic":[30],"areas":[31],"[2].":[32],"It":[33],"is":[34,377,387,394],"unclear":[35],"which":[36,328,343,386],"differences":[37,73,88,167,200,275,284,311,348,352,409,430],"reporting":[39,277,426,432,438],"pattern":[40],"both":[42,418],"genders":[43,419],"exist":[44,420],"after":[45],"correcting":[46],"use.":[49,91],"Knowledge":[50],"of":[51,162,183,192,210,228,252,304,320,337,356,380,440],"these":[52,211],"differences,":[53],"and":[54,70,101,123,240,256,264,290,300,302,314,334,362,383,415,421,458],"possible":[55],"mechanisms":[56],"that":[57,114,127,135,230],"may":[58,61,285,308,329,344,353,422,433,463],"explain":[59],"them,":[60],"help":[62],"optimizing":[64],"gender-specific":[65,373,467],"pharmacotherapy.":[66],"Objective/Aim:":[67],"To":[68],"assess":[69,453],"characterize":[71],"gender":[72,274,429],"drug-ADR":[76,95,170,194,212],"combinations":[77,96,110,171,195,207,213],"the":[79,84,104,150,160,181,225,318,335,378,441],"national":[80],"pharmacovigilance":[81],"centre":[82],"Netherlands,":[85],"corrected":[86],"Methods:":[92],"We":[93],"included":[94,237],"by":[98,130,347,360],"healthcare":[99,444],"professionals":[100],"patients":[102],"Netherlands":[105],"Pharmacovigilance":[106],"Centre":[107],"Lareb.":[108],"Only":[109],"(ATC-MedDRA":[111],"preferred":[112],"term)":[113],"were":[115,128,137,146,155,172,196,203,214,231,244,266],"at":[117],"least":[118],"10":[119],"times":[120],"between":[121,417],"2003":[122],"2016":[124],"used":[129,156],"\u2265":[131],"10,000":[132],"persons":[133],"period":[136],"taken":[138],"into":[139],"account.":[140],"Genderspecific":[141],"ADRs,":[142],"like":[143,254,261],"gynaecological":[144],"problems,":[145],"excluded.":[147],"Data":[148],"from":[149,435],"National":[151],"Health":[152],"Care":[153],"Institute":[154],"correct":[158],"number":[161,182,191,227],"users":[163,185],"per":[164,186],"drug.":[165],"Gender":[166,351],"specific":[169],"tested":[173],"using":[174],"bivariate":[175],"logistic":[176],"regression":[177],"analyses,":[178],"adjusted":[179],"gender.":[187],"Results:":[188],"A":[189],"total":[190],"2482":[193],"analysed.":[197],"Statistically":[198],"significant":[199],"(p":[201],"<0.05)":[202],"shown":[204],"363":[206],"(15%).":[208],"Most":[209],"often":[217,233,269,279],"(321":[220],"combinations,":[221],"88%).":[222],"Drugs":[223],"with":[224,340],"highest":[226],"ADRs":[229,243,260,278,323,338],"thyroid":[238],"hormones,":[239],"antidepressants.":[241],"Some":[242],"predominantly":[245],"across":[249],"range":[251],"headache":[255],"dizziness":[257],"whereas":[258],"other":[259],"tendon":[262],"ruptures":[263],"aggression":[265],"men.":[271],"Conclusion:":[272],"Identified":[273],"referred":[280],"women.":[282,406],"These":[283],"causes.":[288],"Men":[289],"differ":[292],"respect":[294],"their":[296],"physiology,":[297],"immunological":[298],"processes":[299],"type":[301],"function":[303],"hormones.":[306],"This":[307],"result":[309,355,434],"pharmacokinetics":[313],"pharmacodynamics.":[315,350],"Examples":[316],"are":[317,366,450],"predominance":[319,336],"dose":[321],"depending":[322,370],"depend":[330],"on":[331,371],"pharmacokinetic":[332],"properties":[333],"associated":[339],"psychotropic":[341],"be":[345,397,423],"caused":[346],"variations":[357,436],"perception":[359],"reporter":[361],"patient":[363],"since":[364],"they":[365],"experienced":[367],"bothersome":[369],"self-image.":[374],"An":[375],"example":[376],"occurrence":[379],"hair":[381,384],"thinning":[382],"loss,":[385],"common":[389],"aging":[391],"but":[393],"likely":[395],"considered":[398],"disturbing":[400],"particularly":[401],"when":[402],"it":[403],"occurs":[404],"addition,":[408],"background":[411],"incidence":[412],"disorders":[414],"diseases":[416],"reflected":[424],"ADRs.":[427],"Finally,":[428],"behaviour":[439],"reporter,":[442],"either":[443],"professional":[445],"or":[446,469],"patient.":[447],"Further":[448],"studies":[449],"needed":[451],"underlying":[454],"reasons,":[455],"including":[456],"pharmacological":[457],"behavioural":[459],"factors.":[460],"The":[461],"results":[462],"ultimately":[464],"lead":[465],"prescribing":[468],"monitoring":[470],"recommendations.":[471]},"counts_by_year":[],"updated_date":"2026-10-18T09:31:52.927876","created_date":"2019-01-25T00:00:00"}
