{"id":"https://openalex.org/W2909903598","doi":"https://doi.org/10.3390/nu11010171","title":"n-6 Linoleic Acid Induces Epigenetics Alterations Associated with Colonic Inflammation and Cancer","display_name":"n-6 Linoleic Acid Induces Epigenetics Alterations Associated with Colonic Inflammation and Cancer","publication_year":2019,"publication_date":"2019-01-15","ids":{"openalex":"https://openalex.org/W2909903598","doi":"https://doi.org/10.3390/nu11010171","mag":"2909903598","pmid":"https://pubmed.ncbi.nlm.nih.gov/30650553","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6356359"},"language":"en","primary_location":{"id":"doi:10.3390/nu11010171","doi":"https://doi.org/10.3390/nu11010171","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/nu11010171","pdf_url":"https://www.mdpi.com/2072-6643/11/1/171/pdf?version=1547541017","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6643/11/1/171/pdf?version=1547541017","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112386626","display_name":"Donato F. Romagnolo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donato F. Romagnolo","raw_affiliation_strings":["Department of Nutritional Sciences, University of Arizona, Tucson, AZ 85721, USA","The University of Arizona Cancer Center, Tucson, AZ 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences, University of Arizona, Tucson, AZ 85721, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"The University of Arizona Cancer Center, Tucson, AZ 85724, USA","institution_ids":["https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028532330","display_name":"Micah G. Donovan","orcid":"https://orcid.org/0000-0002-3463-2570","observed_orcids":["https://orcid.org/0000-0002-3463-2570"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Micah G. Donovan","raw_affiliation_strings":["Interdisciplinary Cancer Biology Graduate Program, University of Arizona, Tucson, AZ 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Cancer Biology Graduate Program, University of Arizona, Tucson, AZ 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111955769","display_name":"Tom C. Doetschman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom C. Doetschman","raw_affiliation_strings":["Department of Cellular & Molecular Medicine, University of Arizona, Tucson, AZ 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular & Molecular Medicine, University of Arizona, Tucson, AZ 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084037167","display_name":"Ornella I. Selmin","orcid":"https://orcid.org/0000-0003-3992-7834","observed_orcids":["https://orcid.org/0000-0003-3992-7834"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ornella I. Selmin","raw_affiliation_strings":["Department of Nutritional Sciences, University of Arizona, Tucson, AZ 85721, USA","The University of Arizona Cancer Center, Tucson, AZ 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences, University of Arizona, Tucson, AZ 85721, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"The University of Arizona Cancer Center, Tucson, AZ 85724, USA","institution_ids":["https://openalex.org/I4390039223"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112386626"],"corresponding_institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2026},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2026},"fwci":2.0819,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.8787431,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"171","last_page":"171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8457000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8457000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.05649999901652336,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9350000023841858},{"id":"https://openalex.org/keywords/farnesoid-x-receptor","display_name":"farnesoid X receptor","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cpg-methylation","display_name":"CpG methylation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/colonic-inflammation","display_name":"colonic inflammation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8629999756813049},{"id":"https://openalex.org/keywords/bile-acid-homeostasis","display_name":"bile acid homeostasis","score":0.875},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/apc","display_name":"APC","score":0.6679999828338623},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.8949999809265137},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.6060000061988831},{"id":"https://openalex.org/keywords/hdac1","display_name":"HDAC1","score":0.890999972820282},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/intestinal-mucosa","display_name":"intestinal mucosa","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C2778237340","wikidata":"https://www.wikidata.org/wiki/Q14883378","display_name":"Adenomatous polyposis coli","level":4,"score":0.6896896362304688},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6131978631019592},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5970525145530701},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5893240571022034},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5114983320236206},{"id":"https://openalex.org/C2780809830","wikidata":"https://www.wikidata.org/wiki/Q407426","display_name":"Linoleic acid","level":3,"score":0.5065613985061646},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.4904806315898895},{"id":"https://openalex.org/C203862802","wikidata":"https://www.wikidata.org/wiki/Q14905041","display_name":"Farnesoid X receptor","level":5,"score":0.4766008257865906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4239344596862793},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3719991445541382},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3362804055213928},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.3231351971626282},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.223704993724823},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.21689417958259583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21056461334228516},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16428375244140625},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.12356358766555786},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.11017721891403198},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.07138365507125854},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016758","descriptor_name":"Genes, jun","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019787","descriptor_name":"Linoleic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019787","descriptor_name":"Linoleic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025601","descriptor_name":"Adenomatous Polyposis Coli Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025601","descriptor_name":"Adenomatous Polyposis Coli Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D033042","descriptor_name":"Fetal Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/nu11010171","doi":"https://doi.org/10.3390/nu11010171","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/nu11010171","pdf_url":"https://www.mdpi.com/2072-6643/11/1/171/pdf?version=1547541017","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5341561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6356359","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6356359","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6356359","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Text"},{"id":"pmid:30650553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30650553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Journal Article"},{"id":"pmh:oai:repository.arizona.edu:10150/632482","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10150/632482","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nutrients","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:a6e56d749ed94093a18eb8e3a32fdb52","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a6e56d749ed94093a18eb8e3a32fdb52","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nutrients, Vol 11, Iss 1, p 171 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/nu11010171","doi":"https://doi.org/10.3390/nu11010171","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/nu11010171","pdf_url":"https://www.mdpi.com/2072-6643/11/1/171/pdf?version=1547541017","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9927999973297119,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2768207982","display_name":"Integrative Cancer Scholars Training Grant","funder_award_id":"T32CA009213","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8676653134","display_name":null,"funder_award_id":"GRANT12445471","funder_id":"https://openalex.org/F4320332299","funder_display_name":"National Institute of Food and Agriculture"},{"id":"https://openalex.org/G9000909272","display_name":"University of Arizona Cancer Center - Cancer Center Support Grant","funder_award_id":"P30CA023074","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332299","display_name":"National Institute of Food and Agriculture","ror":"https://ror.org/05qx3fv49"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2909903598.pdf","grobid_xml":"https://content.openalex.org/works/W2909903598.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1079775","https://openalex.org/W1507485474","https://openalex.org/W1512492520","https://openalex.org/W1545975510","https://openalex.org/W1554815317","https://openalex.org/W1677336966","https://openalex.org/W1809445845","https://openalex.org/W1967137553","https://openalex.org/W1986744559","https://openalex.org/W1988224465","https://openalex.org/W1996131810","https://openalex.org/W2006839756","https://openalex.org/W2014034874","https://openalex.org/W2014995450","https://openalex.org/W2015278027","https://openalex.org/W2017784875","https://openalex.org/W2018425992","https://openalex.org/W2020030503","https://openalex.org/W2021706178","https://openalex.org/W2021998283","https://openalex.org/W2022575763","https://openalex.org/W2028821626","https://openalex.org/W2032561291","https://openalex.org/W2045679196","https://openalex.org/W2047711197","https://openalex.org/W2049642587","https://openalex.org/W2054141897","https://openalex.org/W2058118671","https://openalex.org/W2059813946","https://openalex.org/W2062930664","https://openalex.org/W2063502039","https://openalex.org/W2070837086","https://openalex.org/W2076230286","https://openalex.org/W2077201156","https://openalex.org/W2086700507","https://openalex.org/W2087369082","https://openalex.org/W2091317169","https://openalex.org/W2092040814","https://openalex.org/W2095692554","https://openalex.org/W2098692754","https://openalex.org/W2100396630","https://openalex.org/W2100399645","https://openalex.org/W2109069210","https://openalex.org/W2118378798","https://openalex.org/W2121138770","https://openalex.org/W2123103215","https://openalex.org/W2126173591","https://openalex.org/W2131408519","https://openalex.org/W2131443627","https://openalex.org/W2131474316","https://openalex.org/W2137846548","https://openalex.org/W2139023251","https://openalex.org/W2140290331","https://openalex.org/W2144767423","https://openalex.org/W2146167376","https://openalex.org/W2148907720","https://openalex.org/W2153535399","https://openalex.org/W2156087668","https://openalex.org/W2162366859","https://openalex.org/W2165822588","https://openalex.org/W2166277258","https://openalex.org/W2167474785","https://openalex.org/W2172292275","https://openalex.org/W2178161066","https://openalex.org/W2199051871","https://openalex.org/W2333853059","https://openalex.org/W2341263653","https://openalex.org/W2344739684","https://openalex.org/W2398917510","https://openalex.org/W2441277973","https://openalex.org/W2524383830","https://openalex.org/W2527895436","https://openalex.org/W2588773014","https://openalex.org/W2617339965","https://openalex.org/W2685652065","https://openalex.org/W6630330856","https://openalex.org/W6630630037","https://openalex.org/W6681643683","https://openalex.org/W6684708900"],"related_works":["https://openalex.org/W2982030562","https://openalex.org/W848807163","https://openalex.org/W1465506187","https://openalex.org/W3094500093","https://openalex.org/W3084172518","https://openalex.org/W1862516590","https://openalex.org/W2118037763","https://openalex.org/W2124175978","https://openalex.org/W4379376967","https://openalex.org/W2178161066"],"abstract_inverted_index":{"The":[0,68,172,192],"farnesoid-X-receptor":[1],"(FXR)":[2],"protects":[3],"against":[4],"inflammation":[5,31,292],"and":[6,24,32,94,99,112,167,185,203,222,226,281,285,293],"cancer":[7,33,294],"of":[8,13,22,34,54,65,70,81,92,105,174,201,214,220,240,247,263,274,279,283,291,295],"the":[9,35,38,46,79,100,103,158,199,230,235,238,245,261,289,296],"colon":[10],"through":[11],"maintenance":[12],"intestinal":[14,66],"bile":[15,177],"acid":[16,43],"(BA)":[17],"homeostasis.":[18,270],"Conversely,":[19],"higher":[20,63],"levels":[21],"BA":[23,269],"cyclooxygenase-2":[25],"(COX-2)":[26],"are":[27],"risk":[28,64,290],"factors":[29,265],"for":[30,124,229],"colon.":[36,297],"In":[37],"United":[39],"States,":[40],"n-6":[41,55],"linoleic":[42],"(LA)":[44],"is":[45],"most":[47],"commonly":[48],"used":[49],"dietary":[50],"vegetable":[51],"fat.":[52],"Metabolism":[53],"fatty":[56],"acids":[57],"has":[58],"been":[59],"linked":[60],"to":[61,74,218,260],"a":[62,82,144],"cancer.":[67],"objectives":[69],"this":[71],"study":[72],"were":[73,122],"investigate":[75],"in":[76,86,208,268],"colonic":[77,209],"mucosa":[78],"effects":[80],"high-fat":[83],"diet":[84,149],"rich":[85],"LA":[87,140],"(n-6HFD)":[88],"on":[89,102],"CpG":[90,165,196,206],"methylation":[91,166,207],"Fxr":[93,163,170],"prostaglandin-endoperoxide":[95],"synthase-2":[96],"(Ptsg-2)":[97],"genes,":[98],"impact":[101],"expression":[104,173,200,213,239],"tumor":[106],"suppressor":[107],"adenomatous":[108],"polyposis":[109],"Coli":[110],"(Apc)":[111],"proliferative":[113],"cyclin":[114],"D1":[115],"(Ccnd1)":[116],"genes.":[117],"Weaned":[118],"C57BL/6J":[119],"male":[120],"mice":[121],"fed":[123,157],"6":[125],"weeks":[126],"either":[127],"an":[128,254],"n-6HFD":[129,159,193,236,255],"containing":[130],"44%":[131],"energy":[132,146],"(44%E)":[133],"from":[134,151],"22%":[135],"safflower":[136],"oil":[137],"(SO,":[138],"76%":[139],"by":[141,154],"weight)":[142],"or":[143],"13%":[145],"(13%E)":[147],"control":[148],"(Control)":[150],"SO":[152],"(5%":[153],"weight).":[155],"Mice":[156],"had":[160],"reduced":[161,194,212,237],"(60%)":[162],"promoter":[164],"increased":[168,198,204],"(~50%)":[169],"mRNA.":[171],"FXR-target":[175],"ileal":[176],"acid-binding":[178],"protein":[179,183],"(Ibabp),":[180],"small":[181],"heterodimer":[182],"(Shp),":[184],"anti-inflammatory":[186],"peroxisome":[187],"proliferator-activated-\u03b31":[188],"genes":[189],"was":[190,216],"increased.":[191],"Ptgs-2":[195],"methylation,":[197],"Cox-2,":[202],"Apc":[205,215,280],"mucosa.":[210],"Accordingly,":[211],"coupled":[217,276],"accumulation":[219,246,282],"c-JUN":[221],"Ccnd1,":[223],"respectively":[224],"cofactor":[225],"gene":[227],"targets":[228],"\u03b2-catenin/Wnt":[231],"signaling":[232],"pathway.":[233],"Finally,":[234],"histone":[241,249],"deacetylase-1":[242],"while":[243],"favoring":[244],"acetylated":[248],"3.":[250],"We":[251],"conclude":[252],"that":[253,266],"epigenetically":[256],"modifies":[257],"Fxr,":[258],"leading":[259],"activation":[262,273],"downstream":[264],"participate":[267],"However,":[271],"epigenetic":[272],"Ptsg-2":[275],"with":[277],"silencing":[278],"C-JUN":[284],"Ccnd1":[286],"may":[287],"increase":[288]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-01-25T00:00:00"}