{"id":"https://openalex.org/W2909824596","doi":null,"title":"Investigating Nonlinear Enzyme Kinetics as an Internal Control System for Nanoreactor Drug Release","display_name":"Investigating Nonlinear Enzyme Kinetics as an Internal Control System for Nanoreactor Drug Release","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2909824596","mag":"2909824596"},"language":"en","primary_location":{"id":"pmh:oai:etheses.whiterose.ac.uk:22207","doi":null,"is_oa":true,"landing_page_url":"https://etheses.whiterose.ac.uk/22207/1/Thesis.pdf","pdf_url":"https://etheses.whiterose.ac.uk/22207/1/Thesis.pdf","source":{"id":"https://openalex.org/S4306401585","display_name":"White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://etheses.whiterose.ac.uk/22207/1/Thesis.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036800703","display_name":"Stephen J. Jones","orcid":"https://orcid.org/0000-0002-5704-9054","observed_orcids":["https://orcid.org/0000-0002-5704-9054"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stephen J. Jones","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5704-9054","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5036800703"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.04439999908208847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanoreactors","display_name":"nanoreactors","score":0.8949999809265137},{"id":"https://openalex.org/keywords/drug-release","display_name":"drug release","score":0.47699999809265137},{"id":"https://openalex.org/keywords/nano-drug-delivery","display_name":"nano-drug delivery","score":0.7749999761581421},{"id":"https://openalex.org/keywords/confinement-effects","display_name":"confinement effects","score":0.656000018119812},{"id":"https://openalex.org/keywords/membrane-transport","display_name":"membrane transport","score":0.796999990940094},{"id":"https://openalex.org/keywords/ph-dependent-permeability","display_name":"pH-dependent permeability","score":0.875}],"concepts":[{"id":"https://openalex.org/C190818770","wikidata":"https://www.wikidata.org/wiki/Q6964123","display_name":"Nanoreactor","level":3,"score":0.600699245929718},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5678575038909912},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.564640998840332},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.5108582377433777},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.45773911476135254},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42579710483551025},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.42116838693618774},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.41387292742729187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38425758481025696},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.3302155137062073},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2517431080341339},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18483558297157288},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etheses.whiterose.ac.uk:22207","doi":null,"is_oa":true,"landing_page_url":"https://etheses.whiterose.ac.uk/22207/1/Thesis.pdf","pdf_url":"https://etheses.whiterose.ac.uk/22207/1/Thesis.pdf","source":{"id":"https://openalex.org/S4306401585","display_name":"White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2909824596","doi":null,"is_oa":false,"landing_page_url":"https://etheses.whiterose.ac.uk/22207/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etheses.whiterose.ac.uk:22207","doi":null,"is_oa":true,"landing_page_url":"https://etheses.whiterose.ac.uk/22207/1/Thesis.pdf","pdf_url":"https://etheses.whiterose.ac.uk/22207/1/Thesis.pdf","source":{"id":"https://openalex.org/S4306401585","display_name":"White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2909824596.pdf","grobid_xml":"https://content.openalex.org/works/W2909824596.grobid-xml"},"referenced_works_count":223,"referenced_works":["https://openalex.org/W1489326505","https://openalex.org/W1534199056","https://openalex.org/W1536886974","https://openalex.org/W1566933063","https://openalex.org/W1583480464","https://openalex.org/W1597123776","https://openalex.org/W1615667134","https://openalex.org/W1766206251","https://openalex.org/W1803876176","https://openalex.org/W1814744265","https://openalex.org/W1865256550","https://openalex.org/W1965710067","https://openalex.org/W1966591029","https://openalex.org/W1967139808","https://openalex.org/W1967910078","https://openalex.org/W1967921248","https://openalex.org/W1968391779","https://openalex.org/W1968544483","https://openalex.org/W1968720341","https://openalex.org/W1968940071","https://openalex.org/W1969729750","https://openalex.org/W1970239046","https://openalex.org/W1971216177","https://openalex.org/W1973072881","https://openalex.org/W1975109518","https://openalex.org/W1975559222","https://openalex.org/W1976483646","https://openalex.org/W1977665107","https://openalex.org/W1977688569","https://openalex.org/W1977802533","https://openalex.org/W1979333743","https://openalex.org/W1980661496","https://openalex.org/W1980923443","https://openalex.org/W1981998283","https://openalex.org/W1982576308","https://openalex.org/W1984248485","https://openalex.org/W1984471712","https://openalex.org/W1984903816","https://openalex.org/W1986765506","https://openalex.org/W1987348669","https://openalex.org/W1989230986","https://openalex.org/W1990065987","https://openalex.org/W1991541464","https://openalex.org/W1992357848","https://openalex.org/W1995185717","https://openalex.org/W1995930972","https://openalex.org/W1996044226","https://openalex.org/W1998020561","https://openalex.org/W1998461045","https://openalex.org/W1999157466","https://openalex.org/W2000469585","https://openalex.org/W2001252250","https://openalex.org/W2001316795","https://openalex.org/W2002536502","https://openalex.org/W2002947610","https://openalex.org/W2004745515","https://openalex.org/W2005079170","https://openalex.org/W2005761035","https://openalex.org/W2006460587","https://openalex.org/W2007344686","https://openalex.org/W2008536525","https://openalex.org/W2009099913","https://openalex.org/W2009131449","https://openalex.org/W2009444873","https://openalex.org/W2010008279","https://openalex.org/W2011494799","https://openalex.org/W2011582357","https://openalex.org/W2013726610","https://openalex.org/W2015712188","https://openalex.org/W2016647892","https://openalex.org/W2016723020","https://openalex.org/W2018185889","https://openalex.org/W2019036104","https://openalex.org/W2021787005","https://openalex.org/W2024738831","https://openalex.org/W2027102361","https://openalex.org/W2029193960","https://openalex.org/W2030945597","https://openalex.org/W2031183376","https://openalex.org/W2033047573","https://openalex.org/W2034033759","https://openalex.org/W2034773569","https://openalex.org/W2034793166","https://openalex.org/W2035342592","https://openalex.org/W2036904104","https://openalex.org/W2038307452","https://openalex.org/W2038873106","https://openalex.org/W2041222862","https://openalex.org/W2043253666","https://openalex.org/W2046604196","https://openalex.org/W2046882552","https://openalex.org/W2047681925","https://openalex.org/W2047997534","https://openalex.org/W2050140383","https://openalex.org/W2050912266","https://openalex.org/W2051972752","https://openalex.org/W2052831989","https://openalex.org/W2053019592","https://openalex.org/W2055709217","https://openalex.org/W2056370235","https://openalex.org/W2058652191","https://openalex.org/W2058858477","https://openalex.org/W2060614446","https://openalex.org/W2060713279","https://openalex.org/W2061498410","https://openalex.org/W2061510929","https://openalex.org/W2061718144","https://openalex.org/W2061772705","https://openalex.org/W2062562477","https://openalex.org/W2062569251","https://openalex.org/W2063098299","https://openalex.org/W2064390452","https://openalex.org/W2066340912","https://openalex.org/W2068103596","https://openalex.org/W2068359975","https://openalex.org/W2070802265","https://openalex.org/W2070981224","https://openalex.org/W2071647584","https://openalex.org/W2072214443","https://openalex.org/W2073432826","https://openalex.org/W2074223329","https://openalex.org/W2077112895","https://openalex.org/W2077827127","https://openalex.org/W2078348980","https://openalex.org/W2079513831","https://openalex.org/W2079736261","https://openalex.org/W2081208715","https://openalex.org/W2082375220","https://openalex.org/W2083651852","https://openalex.org/W2085765714","https://openalex.org/W2086614894","https://openalex.org/W2087372079","https://openalex.org/W2088306031","https://openalex.org/W2093275839","https://openalex.org/W2094469304","https://openalex.org/W2094608596","https://openalex.org/W2095551753","https://openalex.org/W2096778625","https://openalex.org/W2099376929","https://openalex.org/W2099787805","https://openalex.org/W2101275678","https://openalex.org/W2105517087","https://openalex.org/W2109239812","https://openalex.org/W2111261780","https://openalex.org/W2111403841","https://openalex.org/W2115420263","https://openalex.org/W2115752416","https://openalex.org/W2116067233","https://openalex.org/W2117228502","https://openalex.org/W2117507179","https://openalex.org/W2120457032","https://openalex.org/W2120983965","https://openalex.org/W2121283603","https://openalex.org/W2124425296","https://openalex.org/W2126600254","https://openalex.org/W2127400370","https://openalex.org/W2130339488","https://openalex.org/W2130691496","https://openalex.org/W2130930036","https://openalex.org/W2132859930","https://openalex.org/W2136238914","https://openalex.org/W2138475390","https://openalex.org/W2140170994","https://openalex.org/W2141061210","https://openalex.org/W2142605105","https://openalex.org/W2144596510","https://openalex.org/W2149376555","https://openalex.org/W2155200379","https://openalex.org/W2156121976","https://openalex.org/W2157176224","https://openalex.org/W2158238750","https://openalex.org/W2160661199","https://openalex.org/W2160940771","https://openalex.org/W2161580101","https://openalex.org/W2165725920","https://openalex.org/W2166149491","https://openalex.org/W2166458266","https://openalex.org/W2167416452","https://openalex.org/W2168354280","https://openalex.org/W2171193481","https://openalex.org/W2171970118","https://openalex.org/W2188567897","https://openalex.org/W2213316138","https://openalex.org/W2214433804","https://openalex.org/W2219339537","https://openalex.org/W2227133081","https://openalex.org/W2231781758","https://openalex.org/W2265800186","https://openalex.org/W2273460296","https://openalex.org/W2273936014","https://openalex.org/W2287843702","https://openalex.org/W2294679570","https://openalex.org/W2301087567","https://openalex.org/W2313378197","https://openalex.org/W2314448445","https://openalex.org/W2317705390","https://openalex.org/W2319931276","https://openalex.org/W2324435896","https://openalex.org/W2327010950","https://openalex.org/W2327048176","https://openalex.org/W2332621967","https://openalex.org/W2337003117","https://openalex.org/W2344180621","https://openalex.org/W2408219538","https://openalex.org/W2409616517","https://openalex.org/W2412956603","https://openalex.org/W2495471174","https://openalex.org/W2496205720","https://openalex.org/W2515132246","https://openalex.org/W2551023523","https://openalex.org/W2554773181","https://openalex.org/W2558217333","https://openalex.org/W2586819972","https://openalex.org/W2599928540","https://openalex.org/W2735334137","https://openalex.org/W2740071901","https://openalex.org/W2740402920","https://openalex.org/W2774354480","https://openalex.org/W2786759930","https://openalex.org/W2792232681","https://openalex.org/W2802759810","https://openalex.org/W2805248373","https://openalex.org/W7096354244"],"related_works":["https://openalex.org/W2889878770","https://openalex.org/W7009857416","https://openalex.org/W2782703833","https://openalex.org/W4237076733","https://openalex.org/W6950664327","https://openalex.org/W2146536848","https://openalex.org/W2794719993","https://openalex.org/W4245261701","https://openalex.org/W4234629403","https://openalex.org/W2589574020"],"abstract_inverted_index":{"The":[0],"improper":[1],"administration":[2],"of":[3,18,39,59,79,87,117,122,167,181,203,218,230,254,281,293,298,322,330,357],"therapeutic":[4],"compounds":[5],"is":[6,50,112,129,161,173,339],"not":[7,313],"only":[8,314],"financially":[9],"inefficient,":[10],"but,":[11],"there":[12],"exists":[13],"a":[14,31,67,99,139,219,241,267,336],"very":[15],"real":[16],"risk":[17],"harmful,":[19],"or":[20,61],"potentially":[21],"life-threatening":[22],"effects.":[23],"To":[24],"gain":[25],"control,":[26],"nano-drug":[27],"delivery":[28,83,146,366],"systems":[29],"provide":[30],"discernible":[32],"option":[33],"for":[34],"temporal":[35,48],"and":[36,110,142,165,178,187,210,213,239,249,301,343,367],"spatial":[37],"regulation":[38],"drug":[40,82,94,365],"bioavailability":[41],"within":[42],"the":[43,70,77,115,153,176,216,228,252,279,291,294,319,323,332,355],"body.":[44],"In":[45,103,124],"current":[46],"regimes,":[47],"control":[49,318],"realised":[51],"through":[52,131,227],"gradual":[53],"release":[54,63,95],"over":[55],"an":[56,80,185,257,328],"extended":[57],"period":[58],"time,":[60],"triggered":[62],"in":[64,69,96,283,296],"response":[65,97],"to":[66,91,98,107,114,137,151,247,317,350,361],"change":[68],"physiochemical":[71],"environment.":[72],"Of":[73,155],"course,":[74,156],"when":[75],"considering":[76],"design":[78],"ideal":[81],"system,":[84,360],"we":[85,234,264,311],"think":[86],"adaptivity":[88,90],"\u2013":[89],"dynamically":[92],"modulate":[93],"changing":[100],"biological":[101],"macroenvironment.":[102],"nature,":[104],"this":[105,127,193,262,309,340],"ability":[106],"sense,":[108],"communicate,":[109],"respond":[111],"fundamental":[113],"existence":[116],"any":[118,144],"living":[119],"organism,":[120],"irrespective":[121],"complexity.":[123],"most":[125],"instances,":[126],"responsiveness":[128],"achieved":[130],"feedback-controlled":[132,220],"biochemical":[133],"processes":[134],"that":[135,243,346],"work":[136],"regulate":[138],"functional":[140],"process,":[141,263],"so,":[143],"\u201csmart\u201d":[145],"system":[147,268,295,333],"would":[148],"be":[149],"smart":[150],"do":[152],"same.":[154],"where":[157],"conventional":[158],"chemical":[159],"feedback":[160,183,259],"concerned,":[162],"potential":[163],"toxicity":[164],"lack":[166],"biocompatibility,":[168],"caused":[169],"by":[170,278,290,307],"inappropriate":[171],"catalysts,":[172],"problematic,":[174],"however,":[175],"emergence":[177],"enhanced":[179],"understanding":[180],"enzymatic":[182,258],"provides":[184],"interesting":[186],"more":[188,269,288],"compatible":[189],"alternative.":[190],"As":[191],"such,":[192],"doctoral":[194],"thesis":[195],"focuses":[196],"on":[197,256],"drawing":[198],"together":[199],"two":[200],"distinct":[201],"entities":[202],"intense":[204],"scientific":[205],"focus,":[206],"nonlinear":[207],"enzyme":[208],"kinetics":[209],"nanoreactor":[211],"technology,":[212],"works":[214],"towards":[215],"idealism":[217],"secondary":[221],"response.":[222],"\\n":[223],"\\nTo":[224],"achieve":[225,362],"this,":[226],"utilisation":[229],"bottom-up":[231],"synthetic":[232],"chemistry,":[233],"have":[235,265,312,326],"successfully":[236],"built,":[237],"investigated,":[238],"optimised":[240],"platform":[242],"has":[244,347],"allowed":[245,348],"up":[246],"systematically":[248],"extensively":[250],"investigate":[251],"effect":[253],"confinement":[255],"reaction.":[260],"Through":[261],"uncovered":[266],"complicated":[270],"than":[271],"first":[272],"anticipated.":[273],"This":[274],"complexity,":[275],"driven":[276],"firstly":[277],"fragility":[280],"constituents":[282],"relatively":[284],"harsh":[285],"conditions,":[286],"but":[287,325],"importantly":[289],"dynamism":[292],"terms":[297],"membrane":[299],"transport,":[300],"associated":[302],"pH-linked":[303],"permeability":[304],"coefficients.":[305],"However,":[306],"building":[308],"platform,":[310],"learned":[315],"how":[316,331],"kinetic":[320],"output":[321],"reaction,":[324],"gained":[327],"overview":[329],"behaves":[334],"as":[335],"whole.":[337],"It":[338],"organic":[341],"discovery,":[342],"ultimate":[344],"understanding,":[345],"us":[349],"extend":[351],"our":[352,358],"reach,":[353],"pushing":[354],"functionality":[356],"novel":[359],"both":[363],"temporally-controlled":[364],"nano-motor-based":[368],"vesicular":[369],"propulsion.":[370]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-01-25T00:00:00"}
