{"id":"https://openalex.org/W2909767773","doi":"https://doi.org/10.14744/nci.2019.80664","title":"Pharmacologically induced absence seizures versus kindling in Wistar rats","display_name":"Pharmacologically induced absence seizures versus kindling in Wistar rats","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2909767773","doi":"https://doi.org/10.14744/nci.2019.80664","mag":"2909767773","pmid":"https://pubmed.ncbi.nlm.nih.gov/32232200","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7103736"},"language":"en","primary_location":{"id":"doi:10.14744/nci.2019.80664","doi":"https://doi.org/10.14744/nci.2019.80664","is_oa":true,"landing_page_url":"https://doi.org/10.14744/nci.2019.80664","pdf_url":"https://doi.org/10.14744/nci.2019.80664","source":{"id":"https://openalex.org/S4210215406","display_name":"Northern Clinics of Istanbul","issn_l":"2148-4902","issn":["2148-4902","2536-4553"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-2","tr-dizin"],"host_organization":"https://openalex.org/P4310318429","host_organization_name":"KARE Publishing","host_organization_lineage":["https://openalex.org/P4310318429"],"host_organization_lineage_names":["KARE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Northern Clinics of Istanbul","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.14744/nci.2019.80664","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049026313","display_name":"Nihan \u00c7ar\u00e7ak","orcid":"https://orcid.org/0000-0001-6254-4319","observed_orcids":["https://orcid.org/0000-0001-6254-4319"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Nihan \u00c7ar\u00e7ak","raw_affiliation_strings":["Department of Pharmacology, Istanbul University Faculty of Pharmacy, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Istanbul University Faculty of Pharmacy, Istanbul, Turkey","institution_ids":["https://openalex.org/I67581229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049026313"],"corresponding_institution_ids":["https://openalex.org/I67581229"],"apc_list":null,"apc_paid":null,"fwci":0.1667,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.47930154,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"7","issue":"1","first_page":"25","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kindling","display_name":"kindling","score":0.8579999804496765},{"id":"https://openalex.org/keywords/absence-seizures","display_name":"absence seizures","score":0.8730000257492065},{"id":"https://openalex.org/keywords/gamma-butyrolactone","display_name":"gamma-butyrolactone","score":0.9599999785423279},{"id":"https://openalex.org/keywords/gamma-hydroxybutyric-acid","display_name":"gamma-hydroxybutyric acid","score":0.9509999752044678},{"id":"https://openalex.org/keywords/temporal-lobe-epilepsy","display_name":"temporal lobe epilepsy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/basolateral-amygdala","display_name":"basolateral amygdala","score":0.9079999923706055},{"id":"https://openalex.org/keywords/seizure-resistance","display_name":"seizure resistance","score":0.3959999978542328},{"id":"https://openalex.org/keywords/generalized-spike-wave-discharges","display_name":"generalized spike-wave discharges","score":0.8019999861717224},{"id":"https://openalex.org/keywords/wistar-rats","display_name":"Wistar rats","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C100691959","wikidata":"https://www.wikidata.org/wiki/Q6410625","display_name":"Kindling","level":3,"score":0.9772575497627258},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.7918298244476318},{"id":"https://openalex.org/C57236427","wikidata":"https://www.wikidata.org/wiki/Q5382987","display_name":"Epileptogenesis","level":3,"score":0.5972154140472412},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.5364291071891785},{"id":"https://openalex.org/C2778302826","wikidata":"https://www.wikidata.org/wiki/Q1741970","display_name":"Kindling model","level":4,"score":0.47299203276634216},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.4299353361129761},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4109167158603668},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37682825326919556},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.35513997077941895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3440428078174591},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3290800452232361},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.07726633548736572}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.14744/nci.2019.80664","doi":"https://doi.org/10.14744/nci.2019.80664","is_oa":true,"landing_page_url":"https://doi.org/10.14744/nci.2019.80664","pdf_url":"https://doi.org/10.14744/nci.2019.80664","source":{"id":"https://openalex.org/S4210215406","display_name":"Northern Clinics of Istanbul","issn_l":"2148-4902","issn":["2148-4902","2536-4553"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-2","tr-dizin"],"host_organization":"https://openalex.org/P4310318429","host_organization_name":"KARE Publishing","host_organization_lineage":["https://openalex.org/P4310318429"],"host_organization_lineage_names":["KARE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Northern Clinics of Istanbul","raw_type":"journal-article"},{"id":"pmid:32232200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32232200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Northern clinics of Istanbul","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7103736","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7103736/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"North Clin Istanb","raw_type":"Text"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/243244","doi":null,"is_oa":true,"landing_page_url":"https://openaccess.marmara.edu.tr/bitstreams/3b1f1be4-3a22-4fce-8a86-3a4244f68814/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:acikerisim.demiroglu.bilim.edu.tr:8080:11446/3684","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.14744/nci.2019.80664","pdf_url":null,"source":{"id":"https://openalex.org/S4377196709","display_name":"Istanbul Science University (Istanbul Bilim University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I167138147","host_organization_name":"Istanbul Bilim University","host_organization_lineage":["https://openalex.org/I167138147"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:847e34ff8d694b588b60683233506799","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/847e34ff8d694b588b60683233506799","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0130stanbul Kuzey Klinikleri, Vol 7, Iss 1, Pp 25-34 (2020)","raw_type":"article"},{"id":"pmh:oai:openaccess.acibadem.edu.tr:11443/2496","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11443/2496","pdf_url":null,"source":{"id":"https://openalex.org/S7407055353","display_name":"Acibadem University Open Access Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.14744/nci.2019.80664","doi":"https://doi.org/10.14744/nci.2019.80664","is_oa":true,"landing_page_url":"https://doi.org/10.14744/nci.2019.80664","pdf_url":"https://doi.org/10.14744/nci.2019.80664","source":{"id":"https://openalex.org/S4210215406","display_name":"Northern Clinics of Istanbul","issn_l":"2148-4902","issn":["2148-4902","2536-4553"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-2","tr-dizin"],"host_organization":"https://openalex.org/P4310318429","host_organization_name":"KARE Publishing","host_organization_lineage":["https://openalex.org/P4310318429"],"host_organization_lineage_names":["KARE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Northern Clinics of Istanbul","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2909767773.pdf","grobid_xml":"https://content.openalex.org/works/W2909767773.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W31157382","https://openalex.org/W249845531","https://openalex.org/W1479700703","https://openalex.org/W1545913212","https://openalex.org/W1558419262","https://openalex.org/W1569284316","https://openalex.org/W1965769270","https://openalex.org/W1968988685","https://openalex.org/W1983487937","https://openalex.org/W1986555627","https://openalex.org/W1996957734","https://openalex.org/W1998951985","https://openalex.org/W2006880950","https://openalex.org/W2009809221","https://openalex.org/W2013420982","https://openalex.org/W2019884656","https://openalex.org/W2031414991","https://openalex.org/W2043304912","https://openalex.org/W2064266467","https://openalex.org/W2064576677","https://openalex.org/W2065145956","https://openalex.org/W2072517098","https://openalex.org/W2072863696","https://openalex.org/W2074197070","https://openalex.org/W2075311234","https://openalex.org/W2079042501","https://openalex.org/W2083567672","https://openalex.org/W2083818173","https://openalex.org/W2103946141","https://openalex.org/W2126222016","https://openalex.org/W2127296441","https://openalex.org/W2134609626","https://openalex.org/W2136514333","https://openalex.org/W2146434628","https://openalex.org/W2162165485","https://openalex.org/W2168960494","https://openalex.org/W2401958828","https://openalex.org/W2505423736"],"related_works":["https://openalex.org/W2031414991","https://openalex.org/W2315164467","https://openalex.org/W2009809221","https://openalex.org/W7016211436","https://openalex.org/W2138921841","https://openalex.org/W2468446155","https://openalex.org/W1968988685","https://openalex.org/W3095758484","https://openalex.org/W1976060351","https://openalex.org/W2003197938"],"abstract_inverted_index":{"K":[0],"indling":[1],"is":[2,42,81],"the":[3,16,28,55,74,91,105,129,138,143,155,165,178,195,201,209,239,253,256,269,273,282,289,295],"classical":[4],"model":[5,284],"for":[6,128,142,218,252],"temporal":[7],"lobe":[8],"epilepsy":[9],"with":[10,123],"a":[11,21,43,96],"repeated":[12],"focal":[13],"application":[14],"of":[15,52,76,93,98,107,114,186,197,203,249,255,297],"low-intensity":[17],"electrical":[18,192,224],"current":[19],"to":[20,34,89,278],"particular":[22],"forebrain":[23],"structure":[24],"that":[25],"predictably":[26],"triggers":[27],"initial":[29],"partial":[30],"seizure":[31,174,232,291],"[1][2][3][4].The":[32],"resistance":[33,277],"kindling":[35,108,204,280],"induced":[36],"secondary":[37],"generalization":[38],"from":[39,60,68],"limbic":[40],"seizures":[41,103,199,264],"phe-nomenon":[44],"observed":[45],"in":[46,109,154,177,208,268,281],"genetically":[47],"determined":[48],"genetic":[49,300],"rat":[50],"models":[51],"absence":[53,102,290],"epilepsy;":[54],"Genetic":[56],"Absence":[57],"Epilepsy":[58],"Rats":[59],"Strasbourg":[61],"(GAERS)":[62],"and":[63,148,157,194],"Wistar":[64,110,117],"Albino":[65],"Glaxo":[66],"rats":[67,118,241],"Rijswijk":[69],"(WAG/Rij)":[70],"[5,6].In":[71],"these":[72],"models,":[73],"presence":[75],"generalized":[77,263],"spikeand-wave":[78],"discharges":[79],"(SWDs)":[80],"clearly":[82],"associated":[83],"ABSTRACT":[84],"OBJECTIVE:":[85],"This":[86],"study":[87],"aimed":[88],"investigate":[90],"effects":[92,196],"\u03b3-butyrolactone":[94],"(GBL),":[95],"prodrug":[97],"gamma-Hydroxybutyric":[99],"acid":[100],"-induced":[101],"on":[104,200],"development":[106,202,254],"rats.":[111],"METHODS:Three":[112],"groups":[113,159],"adult":[115],"male":[116],"under":[119],"anesthesia":[120],"were":[121,160,205,212,265],"implanted":[122],"bilateral":[124],"cortical":[125],"recording":[126],"electrodes":[127,136],"GBL":[130,151,179,187,210,214,283],"group":[131,145,152,181,211,271],"(GBL)":[132],"and/or":[133],"bipolar":[134],"stimulation":[135],"into":[137],"right":[139],"basolateral":[140],"amygdala":[141,279],"Kindling":[144,149],"(KI)":[146],"alone":[147],"plus":[150],"(GBL+KI).Rats":[153],"KI":[156,227,274],"GBL+KI":[158,240,270],"stimulated":[161],"twice":[162,215],"daily":[163,216],"at":[164,234,243],"afterdischarge":[166],"threshold":[167],"until":[168],"they":[169],"reached":[170,229,242],"Racine's":[171],"stage":[172,230,233,258],"5":[173,231,262],"state.The":[175],"animals":[176,207,228],"+":[180],"had":[182],"an":[183,298],"i.p":[184],"injection":[185],"20":[188],"minutes":[189],"before":[190],"each":[191],"stimulation,":[193],"GBL-induced":[198],"investigated.The":[206],"injected":[213],"i.p.":[217],"15":[219],"days":[220],"without":[221,294],"receiving":[222],"any":[223],"stimulation.":[225],"RESULTS:The":[226],"12":[235],"th":[236,245],"stimulations,":[237],"whereas":[238],"27":[244],"stimulations.The":[246],"mean":[247],"numbers":[248],"stimulations":[250],"needed":[251],"first":[257],"3,":[259],"4,":[260],"or":[261],"significantly":[266],"higher":[267],"than":[272],"group.":[275],"CONCLUSION:The":[276],"can":[285],"be":[286],"modulated":[287],"by":[288],"mechanism":[292],"alone,":[293],"intervention":[296],"abnormal":[299],"background.":[301]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-01-25T00:00:00"}
