{"id":"https://openalex.org/W2909765484","doi":"https://doi.org/10.1002/jcp.28086","title":"EXPRESSION OF CONCERN: Increased autocrine interleukin\u20106 production is significantly associated with worse clinical outcome in patients with chronic lymphocytic leukemia","display_name":"EXPRESSION OF CONCERN: Increased autocrine interleukin\u20106 production is significantly associated with worse clinical outcome in patients with chronic lymphocytic leukemia","publication_year":2019,"publication_date":"2019-01-08","ids":{"openalex":"https://openalex.org/W2909765484","doi":"https://doi.org/10.1002/jcp.28086","mag":"2909765484","pmid":"https://pubmed.ncbi.nlm.nih.gov/30623437","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6590298"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.28086","doi":"https://doi.org/10.1002/jcp.28086","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcp.28086","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.28086","source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2909765484"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.28086","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100779576","display_name":"Huaqing Wang","orcid":"https://orcid.org/0000-0001-8751-110X","observed_orcids":["https://orcid.org/0000-0001-8751-110X"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua\u2010Qing Wang","raw_affiliation_strings":["Department of Hematology and Oncology, Tianjin Union Medial Center of Nankai University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Tianjin Union Medial Center of Nankai University, Tianjin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100729154","display_name":"Li Jia","orcid":"https://orcid.org/0000-0002-6076-8455","observed_orcids":["https://orcid.org/0000-0002-6076-8455"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Li Jia","raw_affiliation_strings":["Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-6076-8455","affiliations":[{"raw_affiliation_string":"Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100377779","display_name":"Yuting Li","orcid":"https://orcid.org/0009-0009-7987-6438","observed_orcids":["https://orcid.org/0009-0009-7987-6438"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu\u2010Ting Li","raw_affiliation_strings":["Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Centre for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin's Clinical Research Center for Cancer, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Centre for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin's Clinical Research Center for Cancer, Tianjin, China","institution_ids":["https://openalex.org/I2802573037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056553355","display_name":"Timothy Farren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405263501","display_name":"Blizard Institute","ror":"https://ror.org/01y7pzx08","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405263501"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Timothy Farren","raw_affiliation_strings":["Pathology Group, Blizard Institute, Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Group, Blizard Institute, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105250348","display_name":"Samir G. Agrawal","orcid":"https://orcid.org/0000-0003-3294-4076","observed_orcids":["https://orcid.org/0000-0003-3294-4076"]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Samir G. Agrawal","raw_affiliation_strings":["Division of Haemato-Oncology, St Bartholomew's Hospital, Barts Health NHS Trust and Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Haemato-Oncology, St Bartholomew's Hospital, Barts Health NHS Trust and Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I166337079","https://openalex.org/I225661044"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018297744","display_name":"Fengting Liu","orcid":"https://orcid.org/0000-0002-0332-257X","observed_orcids":["https://orcid.org/0000-0002-0332-257X"]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]}],"countries":["CN","GB"],"is_corresponding":true,"raw_author_name":"Feng\u2010Ting Liu","raw_affiliation_strings":["Department of Hematology and Oncology, Tianjin Union Medial Center of Nankai University, Tianjin, China","Division of Haemato-Oncology, St Bartholomew's Hospital, Barts Health NHS Trust and Queen Mary University of London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-0332-257X","affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Tianjin Union Medial Center of Nankai University, Tianjin, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Division of Haemato-Oncology, St Bartholomew's Hospital, Barts Health NHS Trust and Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I166337079","https://openalex.org/I225661044"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5018297744"],"corresponding_institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I166337079","https://openalex.org/I205237279","https://openalex.org/I225661044"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":3.1043,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.91988647,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"234","issue":"8","first_page":"13994","last_page":"14006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.902999997138977},{"id":"https://openalex.org/keywords/autocrine-signaling","display_name":"autocrine signaling","score":0.8690000176429749},{"id":"https://openalex.org/keywords/il-6-receptor","display_name":"IL-6 receptor","score":0.8259999752044678},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.8109999895095825},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9959999918937683},{"id":"https://openalex.org/keywords/jak2-inhibition","display_name":"JAK2 inhibition","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cll-cell-survival","display_name":"CLL cell survival","score":0.7160000205039978},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.5759999752044678},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7900000214576721},{"id":"https://openalex.org/keywords/binet-stage","display_name":"Binet stage","score":0.7459999918937683},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.625},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.838723361492157},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.6936057209968567},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.6911985874176025},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4951581060886383},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.4843612611293793},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.4330926537513733},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4256021976470947},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4115754961967468},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3763589859008789},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3308095633983612},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.28486987948417664},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.17965224385261536},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11522343754768372},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C144237770","wikidata":"https://www.wikidata.org/wiki/Q747534","display_name":"Mathematical economics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019898","descriptor_name":"Autocrine Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/jcp.28086","doi":"https://doi.org/10.1002/jcp.28086","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcp.28086","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.28086","source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5578627","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6590298","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30623437","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30623437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6590298","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6590298/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Physiol","raw_type":"Text"},{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/55138","doi":null,"is_oa":true,"landing_page_url":"https://qmro.qmul.ac.uk/xmlui/handle/123456789/55138","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1002/jcp.28086","doi":"https://doi.org/10.1002/jcp.28086","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcp.28086","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.28086","source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3467887516","display_name":"\u4ee5HMGB1\u4e3a\u65b0\u9776\u5411\u6cbb\u7597\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u4f5c\u7528\u673a\u5236\u548c\u5e94\u7528\u4ef7\u503c\u7684\u7814\u7a76","funder_award_id":"81570194","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7237529928","display_name":"IL-6\u81ea\u4e3b\u5206\u6ccc\u4ecb\u5bfc\u7684B\u7ec6\u80de\u6765\u6e90\u6dcb\u5df4\u9020\u8840\u7cfb\u7edf\u80bf\u7624\u8010\u836f\u7684\u76f8\u5173\u673a\u5236\u7814\u7a76","funder_award_id":"81172109","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8374962452","display_name":"\u7ebf\u7c92\u4f53\u7247\u6bb5\u5316\u5f15\u8d77\u7684\u7ec6\u80de\u51cb\u4ea1\u4e0e\u574f\u6b7b\u4e4b\u95f4\u8f6c\u6362\u673a\u5236\u7684\u7814\u7a76","funder_award_id":"81570191","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2909765484.pdf","grobid_xml":"https://content.openalex.org/works/W2909765484.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1928213272","https://openalex.org/W1931245889","https://openalex.org/W1963508543","https://openalex.org/W1965344560","https://openalex.org/W1971308765","https://openalex.org/W1971636277","https://openalex.org/W1975301877","https://openalex.org/W1981000484","https://openalex.org/W1986976471","https://openalex.org/W1987168967","https://openalex.org/W1991285265","https://openalex.org/W1993986769","https://openalex.org/W2004107422","https://openalex.org/W2007998678","https://openalex.org/W2015317524","https://openalex.org/W2021766591","https://openalex.org/W2024250991","https://openalex.org/W2025523323","https://openalex.org/W2027092131","https://openalex.org/W2027253055","https://openalex.org/W2028971492","https://openalex.org/W2042503285","https://openalex.org/W2044227662","https://openalex.org/W2054854541","https://openalex.org/W2059287377","https://openalex.org/W2062005942","https://openalex.org/W2070242833","https://openalex.org/W2072162251","https://openalex.org/W2073551128","https://openalex.org/W2081107312","https://openalex.org/W2082626794","https://openalex.org/W2093766370","https://openalex.org/W2096909009","https://openalex.org/W2099805317","https://openalex.org/W2101039041","https://openalex.org/W2103422355","https://openalex.org/W2104324375","https://openalex.org/W2105269215","https://openalex.org/W2105921327","https://openalex.org/W2117600467","https://openalex.org/W2126247355","https://openalex.org/W2127087491","https://openalex.org/W2133650808","https://openalex.org/W2138717155","https://openalex.org/W2152181022","https://openalex.org/W2152310279","https://openalex.org/W2167715370","https://openalex.org/W2208428713","https://openalex.org/W2316244721","https://openalex.org/W2316443707","https://openalex.org/W2318933236","https://openalex.org/W2558290791","https://openalex.org/W2737438197","https://openalex.org/W2759622660"],"related_works":["https://openalex.org/W1999819740","https://openalex.org/W1989484064","https://openalex.org/W2979420184","https://openalex.org/W2980059007","https://openalex.org/W2093766370","https://openalex.org/W2013241306","https://openalex.org/W2056772662","https://openalex.org/W2027092131","https://openalex.org/W3021395179","https://openalex.org/W179748155"],"abstract_inverted_index":{"Chronic":[0],"lymphocytic":[1],"leukemia":[2],"(CLL)":[3],"remains":[4],"incurable":[5],"with":[6,36,53,78,145,151],"current":[7],"standard":[8],"therapy.":[9],"We":[10,184],"have":[11],"previously":[12],"reported":[13],"that":[14,69,134,186],"an":[15,135],"increased":[16,136],"expression":[17],"of":[18,26,72,127,179,189],"interleukin-6":[19],"(IL-6)":[20],"receptor":[21,121,173],"CD126":[22],"leads":[23],"to":[24,29,98,182,197],"resistance":[25,178],"CLL":[27,48,64,117,141,155,180],"cells":[28,50,181],"chemotherapy":[30],"and":[31,57,95,102,109,122,129,162],"worse":[32,146],"prognosis":[33],"for":[34,149],"patients":[35,84,150],"CLL.":[37,152],"In":[38],"this":[39],"study,":[40],"we":[41],"determine":[42],"whether":[43],"autocrine":[44,73,137,190],"IL-6":[45,74,105,120,138,153,169,172,191],"production":[46,139],"by":[47,140,158],"B":[49,113],"is":[51],"associated":[52,77,144],"poor":[54],"clinical":[55,147,199],"outcome":[56,148],"explore":[58],"IL-6-mediated":[59,125],"survival":[60,157],"mechanism":[61],"in":[62,115],"primary":[63,116],"cells.":[65,118],"Our":[66,131],"results":[67],"demonstrate":[68],"higher":[70],"levels":[71],"are":[75,143],"significantly":[76],"shorter":[79,96],"absolute":[80],"lymphocyte":[81],"doubling":[82],"time,":[83],"received":[85],"treatment,":[86],"without":[87],"complete":[88],"remission,":[89],"advanced":[90],"Binet":[91],"stages,":[92],"17p/11q":[93],"deletion,":[94],"time":[97,100],"first":[99],"treatment":[101],"progression-free":[103],"survival.":[104],"activated":[106],"both":[107,160],"STAT3":[108,128,161],"nuclear":[110],"factor":[111],"kappa":[112],"(NF-\u03baB)":[114],"Blocking":[119],"JAK2":[123],"inhibited":[124],"activation":[126],"NF-\u03baB.":[130],"study":[132],"demonstrates":[133],"B-cells":[142],"promotes":[154],"cell":[156],"activating":[159],"NF-\u03baB":[163],"through":[164],"diverse":[165],"signaling":[166],"cascades.":[167],"Neutralizing":[168],"or":[170],"blocking":[171],"might":[174],"contribute":[175],"overcoming":[176],"the":[177,187],"chemotherapy.":[183],"propose":[185],"measurement":[188],"could":[192],"be":[193],"a":[194],"useful":[195],"approach":[196],"predict":[198],"outcome.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-01-25T00:00:00"}