{"id":"https://openalex.org/W2909600249","doi":"https://doi.org/10.1080/21645515.2018.1560772","title":"Immune escape and immune camouflage may reduce the efficacy of RTS,S vaccine in Malawi","display_name":"Immune escape and immune camouflage may reduce the efficacy of RTS,S vaccine in Malawi","publication_year":2019,"publication_date":"2019-01-08","ids":{"openalex":"https://openalex.org/W2909600249","doi":"https://doi.org/10.1080/21645515.2018.1560772","mag":"2909600249","pmid":"https://pubmed.ncbi.nlm.nih.gov/30614773","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7062414"},"language":"en","primary_location":{"id":"doi:10.1080/21645515.2018.1560772","doi":"https://doi.org/10.1080/21645515.2018.1560772","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21645515.2018.1560772","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/21645515.2018.1560772?needAccess=true","source":{"id":"https://openalex.org/S2483136528","display_name":"Human Vaccines & Immunotherapeutics","issn_l":"2164-5515","issn":["2164-5515","2164-554X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Vaccines &amp; Immunotherapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/21645515.2018.1560772?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025115282","display_name":"Sundos Khan","orcid":"https://orcid.org/0000-0001-9426-715X","observed_orcids":["https://orcid.org/0000-0001-9426-715X"]},"institutions":[{"id":"https://openalex.org/I17626003","display_name":"University of Rhode Island","ror":"https://ror.org/013ckk937","country_code":"US","type":"education","lineage":["https://openalex.org/I17626003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sundos Khan","raw_affiliation_strings":["Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, RI, USA"],"raw_orcid":"https://orcid.org/0000-0001-9426-715X","affiliations":[{"raw_affiliation_string":"Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, RI, USA","institution_ids":["https://openalex.org/I17626003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049216466","display_name":"Matthew Parrillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17626003","display_name":"University of Rhode Island","ror":"https://ror.org/013ckk937","country_code":"US","type":"education","lineage":["https://openalex.org/I17626003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Parrillo","raw_affiliation_strings":["Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, RI, USA","institution_ids":["https://openalex.org/I17626003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042297045","display_name":"Andr\u00e9s H. Guti\u00e9rrez","orcid":"https://orcid.org/0000-0002-6127-8327","observed_orcids":["https://orcid.org/0000-0002-6127-8327"]},"institutions":[{"id":"https://openalex.org/I4210147457","display_name":"EpiVax (United States)","ror":"https://ror.org/055qxpb63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147457"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andres H. Gutierrez","raw_affiliation_strings":["EpiVax, Inc., Providence, RI, USA"],"raw_orcid":"https://orcid.org/0000-0002-6127-8327","affiliations":[{"raw_affiliation_string":"EpiVax, Inc., Providence, RI, USA","institution_ids":["https://openalex.org/I4210147457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102849637","display_name":"Frances E. Terry","orcid":"https://orcid.org/0000-0002-8670-4310","observed_orcids":["https://orcid.org/0000-0002-8670-4310"]},"institutions":[{"id":"https://openalex.org/I4210147457","display_name":"EpiVax (United States)","ror":"https://ror.org/055qxpb63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147457"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frances E. Terry","raw_affiliation_strings":["EpiVax, Inc., Providence, RI, USA"],"raw_orcid":"https://orcid.org/0000-0002-8670-4310","affiliations":[{"raw_affiliation_string":"EpiVax, Inc., Providence, RI, USA","institution_ids":["https://openalex.org/I4210147457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061582756","display_name":"Leonard Moise","orcid":"https://orcid.org/0000-0002-4410-865X","observed_orcids":["https://orcid.org/0000-0002-4410-865X"]},"institutions":[{"id":"https://openalex.org/I17626003","display_name":"University of Rhode Island","ror":"https://ror.org/013ckk937","country_code":"US","type":"education","lineage":["https://openalex.org/I17626003"]},{"id":"https://openalex.org/I4210147457","display_name":"EpiVax (United States)","ror":"https://ror.org/055qxpb63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147457"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard Moise","raw_affiliation_strings":["EpiVax, Inc., Providence, RI, USA","Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, RI, USA"],"raw_orcid":"https://orcid.org/0000-0002-4410-865X","affiliations":[{"raw_affiliation_string":"EpiVax, Inc., Providence, RI, USA","institution_ids":["https://openalex.org/I4210147457"]},{"raw_affiliation_string":"Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, RI, USA","institution_ids":["https://openalex.org/I17626003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053675979","display_name":"William D Martin","orcid":"https://orcid.org/0000-0001-8694-494X","observed_orcids":["https://orcid.org/0000-0001-8694-494X"]},"institutions":[{"id":"https://openalex.org/I4210147457","display_name":"EpiVax (United States)","ror":"https://ror.org/055qxpb63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147457"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William D. Martin","raw_affiliation_strings":["EpiVax, Inc., Providence, RI, USA"],"raw_orcid":"https://orcid.org/0000-0001-8694-494X","affiliations":[{"raw_affiliation_string":"EpiVax, Inc., Providence, RI, USA","institution_ids":["https://openalex.org/I4210147457"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089204881","display_name":"Anne Searls De Groot","orcid":"https://orcid.org/0000-0001-5911-1459","observed_orcids":["https://orcid.org/0000-0001-5911-1459"]},"institutions":[{"id":"https://openalex.org/I17626003","display_name":"University of Rhode Island","ror":"https://ror.org/013ckk937","country_code":"US","type":"education","lineage":["https://openalex.org/I17626003"]},{"id":"https://openalex.org/I4210147457","display_name":"EpiVax (United States)","ror":"https://ror.org/055qxpb63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147457"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anne S. De Groot","raw_affiliation_strings":["EpiVax, Inc., Providence, RI, USA","Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, RI, USA"],"raw_orcid":"https://orcid.org/0000-0001-5911-1459","affiliations":[{"raw_affiliation_string":"EpiVax, Inc., Providence, RI, USA","institution_ids":["https://openalex.org/I4210147457"]},{"raw_affiliation_string":"Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, RI, USA","institution_ids":["https://openalex.org/I17626003"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089204881"],"corresponding_institution_ids":["https://openalex.org/I17626003","https://openalex.org/I4210147457"],"apc_list":{"value":2895,"currency":"EUR","value_usd":3175},"apc_paid":{"value":2895,"currency":"EUR","value_usd":3175},"fwci":0.7325,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.64325331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"16","issue":"2","first_page":"214","last_page":"227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rts-s-as01-vaccine","display_name":"RTS,S/AS01 vaccine","score":0.925000011920929},{"id":"https://openalex.org/keywords/malaria-vaccine-efficacy","display_name":"malaria vaccine efficacy","score":0.8460000157356262},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.9010000228881836},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.8889999985694885},{"id":"https://openalex.org/keywords/circumsporozoite-protein","display_name":"circumsporozoite protein","score":0.9959999918937683},{"id":"https://openalex.org/keywords/t-cell-epitopes","display_name":"T cell epitopes","score":0.9629999995231628},{"id":"https://openalex.org/keywords/hla-drb1-alleles","display_name":"HLA-DRB1 alleles","score":0.9409999847412109},{"id":"https://openalex.org/keywords/epitope-conservation","display_name":"epitope conservation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/t-cell-tolerance","display_name":"T cell tolerance","score":0.6880000233650208},{"id":"https://openalex.org/keywords/malawi","display_name":"Malawi","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.8877673149108887},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6548119187355042},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.648552417755127},{"id":"https://openalex.org/C2781034427","wikidata":"https://www.wikidata.org/wiki/Q6741353","display_name":"Malaria vaccine","level":4,"score":0.647981584072113},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6091500520706177},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5993340015411377},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5945218205451965},{"id":"https://openalex.org/C2781074509","wikidata":"https://www.wikidata.org/wiki/Q24778282","display_name":"Circumsporozoite protein","level":4,"score":0.540735125541687},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.538382887840271},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5275832414627075},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.48638203740119934},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.4685669243335724},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4244413375854492},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.4219772219657898},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.3933529555797577},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.3160698413848877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1917116343975067},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008295","descriptor_name":"Malawi","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1080/21645515.2018.1560772","doi":"https://doi.org/10.1080/21645515.2018.1560772","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21645515.2018.1560772","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/21645515.2018.1560772?needAccess=true","source":{"id":"https://openalex.org/S2483136528","display_name":"Human Vaccines & Immunotherapeutics","issn_l":"2164-5515","issn":["2164-5515","2164-554X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Vaccines &amp; Immunotherapeutics","raw_type":"journal-article"},{"id":"pmid:30614773","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30614773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human vaccines & immunotherapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7062414","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7062414/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Vaccin Immunother","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.uri.edu:cmb_facpubs-1129","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.uri.edu/cmb_facpubs/126","pdf_url":null,"source":{"id":"https://openalex.org/S2764761010","display_name":"Journal of Media Literacy Education","issn_l":"2167-8715","issn":["2167-8715"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","jufo-1","norway-1","poland-20","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310316378","host_organization_name":"National Association for Media Literacy Education","host_organization_lineage":["https://openalex.org/P4310316378"],"host_organization_lineage_names":["National Association for Media Literacy Education"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell and Molecular Biology Faculty Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:b25679b1043d468187d7b251086ecf24","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b25679b1043d468187d7b251086ecf24","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Vaccines & Immunotherapeutics, Vol 16, Iss 2, Pp 214-227 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/21645515.2018.1560772","doi":"https://doi.org/10.1080/21645515.2018.1560772","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21645515.2018.1560772","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/21645515.2018.1560772?needAccess=true","source":{"id":"https://openalex.org/S2483136528","display_name":"Human Vaccines & Immunotherapeutics","issn_l":"2164-5515","issn":["2164-5515","2164-554X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Vaccines &amp; Immunotherapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2909600249.pdf","grobid_xml":"https://content.openalex.org/works/W2909600249.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W65828984","https://openalex.org/W1557300036","https://openalex.org/W1557719924","https://openalex.org/W1796116693","https://openalex.org/W1944657476","https://openalex.org/W1950627877","https://openalex.org/W1964339501","https://openalex.org/W1999452089","https://openalex.org/W2002288384","https://openalex.org/W2006804423","https://openalex.org/W2014916785","https://openalex.org/W2023168923","https://openalex.org/W2026424947","https://openalex.org/W2038910210","https://openalex.org/W2041721882","https://openalex.org/W2041937744","https://openalex.org/W2045377848","https://openalex.org/W2049580315","https://openalex.org/W2054577865","https://openalex.org/W2054621277","https://openalex.org/W2060171137","https://openalex.org/W2070373359","https://openalex.org/W2070457810","https://openalex.org/W2074122062","https://openalex.org/W2079688453","https://openalex.org/W2100923855","https://openalex.org/W2106703370","https://openalex.org/W2107181087","https://openalex.org/W2108393524","https://openalex.org/W2108476551","https://openalex.org/W2113251371","https://openalex.org/W2118287049","https://openalex.org/W2118599971","https://openalex.org/W2124892357","https://openalex.org/W2134342374","https://openalex.org/W2139217795","https://openalex.org/W2139344524","https://openalex.org/W2143594833","https://openalex.org/W2144296388","https://openalex.org/W2145733064","https://openalex.org/W2155357850","https://openalex.org/W2157427941","https://openalex.org/W2166304356","https://openalex.org/W2166808662","https://openalex.org/W2169170846","https://openalex.org/W2175690666","https://openalex.org/W2244674613","https://openalex.org/W2264544376","https://openalex.org/W2340524139","https://openalex.org/W2766557445"],"related_works":["https://openalex.org/W2793507472","https://openalex.org/W7099467111","https://openalex.org/W2047316862","https://openalex.org/W2095901889","https://openalex.org/W3206150152","https://openalex.org/W3188142626","https://openalex.org/W2289977218","https://openalex.org/W4392450376","https://openalex.org/W4205700730","https://openalex.org/W2760237399"],"abstract_inverted_index":{"The":[0,116,194],"RTS,S/AS01":[1,16],"malaria":[2,248],"vaccine":[3,49,64,101,200,218],"will":[4],"undergo":[5],"a":[6,203],"pilot":[7],"vaccination":[8],"study":[9,37,137],"in":[10,14,62,99,114,134,146,152,162,175,184],"sub-Saharan":[11],"Africa":[12],"beginning":[13],"2019.":[15],"Phase":[17],"III":[18],"trials":[19],"reported":[20],"an":[21,81],"efficacy":[22,45,219],"of":[23,46,59,72,118,130,149,197,206,230,246],"28.3%":[24],"(children":[25],"5\u201317":[26],"months)":[27],"and":[28,50,66,240],"18.3%":[29],"(infants":[30],"6\u201312":[31],"weeks),":[32],"with":[33,103,128,243],"substantial":[34],"variability":[35,51],"across":[36,52,172],"sites.":[38],"We":[39],"postulated":[40],"that":[41,168,180,216],"the":[42,47,63,69,73,131,135,147,163,185,198,244],"relatively":[43],"low":[44,204,224],"RTS,S":[48,100,199,217],"sites":[53],"may":[54,220],"be":[55,221],"due":[56,67,77],"to":[57,68,78,93,210],"lack":[58],"T-cell":[60,144,166,190,207,225,231],"epitopes":[61,97,119,145,167,232],"antigen,":[65],"HLA":[70],"distribution":[71],"vaccinated":[74],"population,":[75,138],"and/or":[76],"\u2018immune":[79],"camouflage\u2019,":[80],"immune":[82,140],"escape":[83],"mechanism.":[84],"To":[85],"examine":[86],"these":[87],"hypotheses,":[88],"we":[89],"used":[90],"immunoinformatics":[91],"tools":[92],"compare":[94],"T":[95],"helper":[96],"contained":[98],"antigens":[102],"Plasmodium":[104],"falciparum":[105],"circumsporozoite":[106],"protein":[107],"(CSP)":[108],"variants":[109,174],"isolated":[110],"from":[111],"infected":[112],"individuals":[113],"Malawi.":[115],"prevalence":[117,129],"restricted":[120,157],"by":[121,158,223,233],"specific":[122],"HLA-DRB1":[123,132,160],"alleles":[124,161],"was":[125],"inversely":[126],"associated":[127],"allele":[133],"Malawi":[136,153,176],"suggesting":[139],"escape.":[141],"In":[142],"addition,":[143],"CSP":[148,173,195,245],"strains":[150],"circulating":[151,211,247],"were":[154,169,181],"more":[155],"often":[156],"low-frequency":[159],"population.":[164],"Furthermore,":[165],"highly":[170,182],"conserved":[171,183],"possessed":[177],"TCR-facing":[178],"residues":[179],"human":[186],"proteome,":[187],"potentially":[188],"reducing":[189],"help":[191],"through":[192],"tolerance.":[193],"component":[196],"also":[201],"exhibited":[202],"degree":[205],"epitope":[208,226],"relatedness":[209],"variants.":[212],"These":[213],"results":[214],"suggest":[215],"impacted":[222],"content,":[227],"reduced":[228],"presentation":[229],"prevalent":[234],"HLA-DRB1,":[235],"high":[236],"potential":[237],"for":[238],"human-cross-reactivity,":[239],"limited":[241],"conservation":[242],"strains.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-01-25T00:00:00"}
