{"id":"https://openalex.org/W2909446653","doi":"https://doi.org/10.1136/flgastro-2018-101116","title":"Rituximab to the rescue: novel therapy for chronic gastrointestinal bleeding due to angiodysplasia and acquired von Willebrand syndrome","display_name":"Rituximab to the rescue: novel therapy for chronic gastrointestinal bleeding due to angiodysplasia and acquired von Willebrand syndrome","publication_year":2019,"publication_date":"2019-01-09","ids":{"openalex":"https://openalex.org/W2909446653","doi":"https://doi.org/10.1136/flgastro-2018-101116","mag":"2909446653","pmid":"https://pubmed.ncbi.nlm.nih.gov/31656571","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6788123"},"language":"en","primary_location":{"id":"doi:10.1136/flgastro-2018-101116","doi":"https://doi.org/10.1136/flgastro-2018-101116","is_oa":false,"landing_page_url":"https://doi.org/10.1136/flgastro-2018-101116","pdf_url":null,"source":{"id":"https://openalex.org/S125615467","display_name":"Frontline Gastroenterology","issn_l":"2041-4137","issn":["2041-4137","2041-4145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontline Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6788123","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068068385","display_name":"James Hawken","orcid":"https://orcid.org/0000-0001-8097-5868","observed_orcids":["https://orcid.org/0000-0001-8097-5868"]},"institutions":[{"id":"https://openalex.org/I2799281195","display_name":"Weston General Hospital","ror":"https://ror.org/03mc19e15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799281195","https://openalex.org/I4405276282"]},{"id":"https://openalex.org/I2800789647","display_name":"University Hospitals Bristol NHS Foundation Trust","ror":"https://ror.org/04nm1cv11","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800789647","https://openalex.org/I4392738148","https://openalex.org/I4405276282"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"James Hawken","raw_affiliation_strings":["Department of Gastroenterology, Weston General Hospital, Weston-super-Mare, UK","Department of Hepatology, University Hospitals Bristol NHS Foundation Trust, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Weston General Hospital, Weston-super-Mare, UK","institution_ids":["https://openalex.org/I2799281195"]},{"raw_affiliation_string":"Department of Hepatology, University Hospitals Bristol NHS Foundation Trust, Bristol, UK","institution_ids":["https://openalex.org/I2800789647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025734846","display_name":"Amy Knott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800789647","display_name":"University Hospitals Bristol NHS Foundation Trust","ror":"https://ror.org/04nm1cv11","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800789647","https://openalex.org/I4392738148","https://openalex.org/I4405276282"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amy Knott","raw_affiliation_strings":["Bristol Haematology Unit, University Hospitals Bristol NHS Foundation Trust, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol Haematology Unit, University Hospitals Bristol NHS Foundation Trust, Bristol, UK","institution_ids":["https://openalex.org/I2800789647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007966639","display_name":"Wesam Alsakkaf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799281195","display_name":"Weston General Hospital","ror":"https://ror.org/03mc19e15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799281195","https://openalex.org/I4405276282"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Wesam Alsakkaf","raw_affiliation_strings":["Department of Haematology, Weston General Hospital, Weston-super-Mare, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Weston General Hospital, Weston-super-Mare, UK","institution_ids":["https://openalex.org/I2799281195"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Amanda Clark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800789647","display_name":"University Hospitals Bristol NHS Foundation Trust","ror":"https://ror.org/04nm1cv11","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800789647","https://openalex.org/I4392738148","https://openalex.org/I4405276282"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amanda Clark","raw_affiliation_strings":["Bristol Haematology Unit, University Hospitals Bristol NHS Foundation Trust, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol Haematology Unit, University Hospitals Bristol NHS Foundation Trust, Bristol, UK","institution_ids":["https://openalex.org/I2800789647"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000431314","display_name":"Faisal Fayyaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799281195","display_name":"Weston General Hospital","ror":"https://ror.org/03mc19e15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799281195","https://openalex.org/I4405276282"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Faisal Fayyaz","raw_affiliation_strings":["Department of Gastroenterology, Weston General Hospital, Weston-super-Mare, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Weston General Hospital, Weston-super-Mare, UK","institution_ids":["https://openalex.org/I2799281195"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068068385"],"corresponding_institution_ids":["https://openalex.org/I2799281195","https://openalex.org/I2800789647"],"apc_list":null,"apc_paid":null,"fwci":0.8843,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.7412512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"10","issue":"4","first_page":"434","last_page":"437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.06449999660253525,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.9399999976158142},{"id":"https://openalex.org/keywords/acquired-von-willebrand-syndrome","display_name":"acquired von Willebrand syndrome","score":0.9909999966621399},{"id":"https://openalex.org/keywords/angiodysplasia","display_name":"angiodysplasia","score":0.9269999861717224},{"id":"https://openalex.org/keywords/gastrointestinal-bleeding","display_name":"gastrointestinal bleeding","score":0.8169999718666077},{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.8629999756813049},{"id":"https://openalex.org/keywords/von-willebrand-factor-concentrate","display_name":"von Willebrand factor concentrate","score":0.9319999814033508},{"id":"https://openalex.org/keywords/thalidomide","display_name":"thalidomide","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tranexamic-acid","display_name":"tranexamic acid","score":0.9869999885559082},{"id":"https://openalex.org/keywords/argon-plasma-coagulation","display_name":"argon plasma coagulation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/red-blood-cell-transfusion","display_name":"red blood cell transfusion","score":0.6299999952316284},{"id":"https://openalex.org/keywords/anti-cd20-therapy","display_name":"anti-CD20 therapy","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9661465883255005},{"id":"https://openalex.org/C2778281985","wikidata":"https://www.wikidata.org/wiki/Q539491","display_name":"Angiodysplasia","level":2,"score":0.8988370895385742},{"id":"https://openalex.org/C2778792578","wikidata":"https://www.wikidata.org/wiki/Q4121501","display_name":"Argon plasma coagulation","level":3,"score":0.8949419260025024},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.8880910873413086},{"id":"https://openalex.org/C2779637338","wikidata":"https://www.wikidata.org/wiki/Q418666","display_name":"Tranexamic acid","level":3,"score":0.7005177736282349},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.6242691278457642},{"id":"https://openalex.org/C2778080469","wikidata":"https://www.wikidata.org/wiki/Q1495657","display_name":"Gastrointestinal bleeding","level":2,"score":0.6153057217597961},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.45565012097358704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39545950293540955},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36382657289505005},{"id":"https://openalex.org/C2778451229","wikidata":"https://www.wikidata.org/wiki/Q212809","display_name":"Endoscopy","level":2,"score":0.2128143012523651},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.1659640073776245},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.15596997737884521},{"id":"https://openalex.org/C2991743468","wikidata":"https://www.wikidata.org/wiki/Q166019","display_name":"Blood loss","level":2,"score":0.08855658769607544}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1136/flgastro-2018-101116","doi":"https://doi.org/10.1136/flgastro-2018-101116","is_oa":false,"landing_page_url":"https://doi.org/10.1136/flgastro-2018-101116","pdf_url":null,"source":{"id":"https://openalex.org/S125615467","display_name":"Frontline Gastroenterology","issn_l":"2041-4137","issn":["2041-4137","2041-4145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontline Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6788123","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6788123","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontline Gastroenterol","raw_type":"Text"},{"id":"pmid:31656571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31656571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontline gastroenterology","raw_type":"Case Reports"},{"id":"pmh:oai:open-archive.highwire.org:flgastro:10/4/434","doi":null,"is_oa":false,"landing_page_url":"http://fg.bmj.com/cgi/content/short/10/4/434","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/0cb3a12e-9b7e-4df0-bd1e-5c0a13726699","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1983/0cb3a12e-9b7e-4df0-bd1e-5c0a13726699","pdf_url":null,"source":{"id":"https://openalex.org/S7407055359","display_name":"Explore Bristol Research","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hawken, J, Knott, A, Alsakkaf, W, Clark, A & Fayyaz, F 2019, 'Rituximab to the rescue : Novel therapy for chronic gastrointestinal bleeding due to angiodysplasia and acquired von Willebrand syndrome', Frontline Gastroenterology, vol. 10, pp. 434-437. https://doi.org/10.1136/flgastro-2018-101116","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6788123","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6788123","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontline Gastroenterol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2036927323","https://openalex.org/W2056547870","https://openalex.org/W2092164518","https://openalex.org/W2113525532","https://openalex.org/W2532322090"],"related_works":["https://openalex.org/W2056547870","https://openalex.org/W2131966401","https://openalex.org/W4417165041","https://openalex.org/W2167071500","https://openalex.org/W4210825945","https://openalex.org/W2036360270","https://openalex.org/W2981990619","https://openalex.org/W1966980733","https://openalex.org/W4379509220","https://openalex.org/W2119984918"],"abstract_inverted_index":{"Identification":[0],"of":[1,58,64,108,124,144],"acquired":[2],"von":[3,69],"Willebrand":[4,70],"syndrome":[5],"(AVWS)":[6],"was":[7,29,49,60,90],"key":[8],"to":[9,19,117,140],"treating":[10],"a":[11,121],"patient":[12,28,89,105],"with":[13,32],"chronic":[14,38],"gastrointestinal":[15],"(GI)":[16],"bleeding":[17,40],"due":[18],"angiodysplasia.":[20,45,148],"After":[21,120],"exhausting":[22],"endoscopic":[23,81],"and":[24,43,74,83,106],"pharmacological":[25],"options,":[26],"the":[27,88,104,138,142],"successfully":[30],"treated":[31],"rituximab.":[33],"A":[34,56],"78-year-old":[35],"man":[36],"developed":[37],"GI":[39],"from":[41,62,98],"caecal":[42],"jejunal":[44],"Red":[46],"cell":[47],"transfusion":[48],"required":[50],"weekly":[51],"despite":[52],"argon":[53],"plasma":[54],"coagulation.":[55],"diagnosis":[57],"AVWS":[59],"made":[61],"analysis":[63],"clotting":[65],"factors.":[66],"Therapies":[67],"including":[68],"factor":[71],"concentrate,":[72],"thalidomide":[73],"tranexamic":[75],"acid":[76],"were":[77,133],"unsuccessful.":[78],"With":[79],"failed":[80],"therapy":[82],"no":[84,126],"viable":[85],"surgical":[86],"option,":[87],"given":[91],"intravenous":[92],"immunoglobulins":[93],"(IVIGs).":[94],"Haemoglobin":[95],"remained":[96],"stable":[97],"this":[99],"point.":[100],"The":[101],"impact":[102],"on":[103],"hospital":[107],"attending":[109],"for":[110],"IVIG":[111,130],"every":[112],"3":[113],"weeks":[114],"necessitated":[115],"consideration":[116],"longer-term":[118],"therapy.":[119],"single":[122],"course":[123],"rituximab,":[125],"further":[127],"blood":[128],"products,":[129],"or":[131],"rituximab":[132,145],"required.":[134],"This":[135],"case":[136],"is":[137],"first":[139],"describe":[141],"use":[143],"in":[146],"AVWS-associated":[147]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-01-25T00:00:00"}