{"id":"https://openalex.org/W2909433309","doi":"https://doi.org/10.1152/ajpendo.00377.2018","title":"Physical activity counteracts metabolic syndrome-induced hypogonadotropic hypogonadism and erectile dysfunction in the rabbit","display_name":"Physical activity counteracts metabolic syndrome-induced hypogonadotropic hypogonadism and erectile dysfunction in the rabbit","publication_year":2019,"publication_date":"2019-01-15","ids":{"openalex":"https://openalex.org/W2909433309","doi":"https://doi.org/10.1152/ajpendo.00377.2018","mag":"2909433309","pmid":"https://pubmed.ncbi.nlm.nih.gov/30645174"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.00377.2018","doi":"https://doi.org/10.1152/ajpendo.00377.2018","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00377.2018","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020102317","display_name":"Annamaria Morelli","orcid":"https://orcid.org/0000-0001-8027-9870","observed_orcids":["https://orcid.org/0000-0001-8027-9870"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annamaria Morelli","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101970213","display_name":"Sandra Filippi","orcid":"https://orcid.org/0000-0001-8843-4900","observed_orcids":["https://orcid.org/0000-0001-8843-4900"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sandra Filippi","raw_affiliation_strings":["Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Neuroscience, Psychology, Pharmacology and Child Health, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Neuroscience, Psychology, Pharmacology and Child Health, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021208002","display_name":"Paolo Comeglio","orcid":"https://orcid.org/0009-0004-9336-4694","observed_orcids":["https://orcid.org/0009-0004-9336-4694"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Comeglio","raw_affiliation_strings":["Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044220964","display_name":"Erica Sarchielli","orcid":"https://orcid.org/0000-0002-4273-7858","observed_orcids":["https://orcid.org/0000-0002-4273-7858"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Erica Sarchielli","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020071187","display_name":"Ilaria Cellai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Cellai","raw_affiliation_strings":["Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046920982","display_name":"Marco Pallecchi","orcid":"https://orcid.org/0000-0002-0057-6531","observed_orcids":["https://orcid.org/0000-0002-0057-6531"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Pallecchi","raw_affiliation_strings":["Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081793175","display_name":"Gianluca Bartolucci","orcid":"https://orcid.org/0000-0002-5631-8769","observed_orcids":["https://orcid.org/0000-0002-5631-8769"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Bartolucci","raw_affiliation_strings":["Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068827262","display_name":"Giovanna Danza","orcid":"https://orcid.org/0000-0002-0320-3167","observed_orcids":["https://orcid.org/0000-0002-0320-3167"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanna Danza","raw_affiliation_strings":["Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049129057","display_name":"Giulia Rastrelli","orcid":"https://orcid.org/0000-0002-6164-4278","observed_orcids":["https://orcid.org/0000-0002-6164-4278"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Rastrelli","raw_affiliation_strings":["Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028240168","display_name":"Chiara Corno","orcid":"https://orcid.org/0000-0002-0012-6522","observed_orcids":["https://orcid.org/0000-0002-0012-6522"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Corno","raw_affiliation_strings":["Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040521854","display_name":"Giulia Guarnieri","orcid":"https://orcid.org/0000-0002-3056-7492","observed_orcids":["https://orcid.org/0000-0002-3056-7492"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Guarnieri","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001706631","display_name":"Elisa Fuochi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisa Fuochi","raw_affiliation_strings":["Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059786789","display_name":"Linda Vignozzi","orcid":"https://orcid.org/0000-0003-0907-0630","observed_orcids":["https://orcid.org/0000-0003-0907-0630"]},"institutions":[{"id":"https://openalex.org/I4210140048","display_name":"Istituto Nazionale Biostrutture e Biosistemi","ror":"https://ror.org/043bhwh19","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210140048"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Linda Vignozzi","raw_affiliation_strings":["Istituto Nazionale Biostrutture e Biosistemi, Rome, Italy","Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Biostrutture e Biosistemi, Rome, Italy","institution_ids":["https://openalex.org/I4210140048"]},{"raw_affiliation_string":"Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049759930","display_name":"Mario Maggi","orcid":"https://orcid.org/0000-0003-3267-4221","observed_orcids":["https://orcid.org/0000-0003-3267-4221"]},"institutions":[{"id":"https://openalex.org/I4210140048","display_name":"Istituto Nazionale Biostrutture e Biosistemi","ror":"https://ror.org/043bhwh19","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210140048"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Mario Maggi","raw_affiliation_strings":["Istituto Nazionale Biostrutture e Biosistemi, Rome, Italy","Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Biostrutture e Biosistemi, Rome, Italy","institution_ids":["https://openalex.org/I4210140048"]},{"raw_affiliation_string":"Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049759930"],"corresponding_institution_ids":["https://openalex.org/I4210140048","https://openalex.org/I45084792"],"apc_list":null,"apc_paid":null,"fwci":6.6333,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.97911344,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"316","issue":"3","first_page":"E519","last_page":"E535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.6747999787330627,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.6747999787330627,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.30640000104904175,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9399999976158142},{"id":"https://openalex.org/keywords/hypogonadotropic-hypogonadism","display_name":"hypogonadotropic hypogonadism","score":0.9679999947547913},{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9010000228881836},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-testis-axis","display_name":"hypothalamic-pituitary-testis axis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/gonadotropin-releasing-hormone","display_name":"gonadotropin-releasing hormone","score":0.9459999799728394},{"id":"https://openalex.org/keywords/testosterone-production","display_name":"testosterone production","score":0.656000018119812},{"id":"https://openalex.org/keywords/testicular-inflammation","display_name":"testicular inflammation","score":0.6690000295639038},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.8450000286102295},{"id":"https://openalex.org/keywords/steroidogenic-enzymes","display_name":"steroidogenic enzymes","score":0.7730000019073486},{"id":"https://openalex.org/keywords/kisspeptin","display_name":"kisspeptin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dynorphin","display_name":"dynorphin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypothalamic-inflammation","display_name":"hypothalamic inflammation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.8529999852180481},{"id":"https://openalex.org/keywords/visceral-fat","display_name":"visceral fat","score":0.9800000190734863},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8746861219406128},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8701773881912231},{"id":"https://openalex.org/C2779929075","wikidata":"https://www.wikidata.org/wiki/Q184674","display_name":"Erectile dysfunction","level":2,"score":0.7742831707000732},{"id":"https://openalex.org/C2781255401","wikidata":"https://www.wikidata.org/wiki/Q1641332","display_name":"Hypogonadotropic hypogonadism","level":3,"score":0.6988043785095215},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.6908335089683533},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.5696340799331665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5488851070404053},{"id":"https://openalex.org/C2776808119","wikidata":"https://www.wikidata.org/wiki/Q909371","display_name":"Kisspeptin","level":3,"score":0.5406209826469421},{"id":"https://openalex.org/C80446465","wikidata":"https://www.wikidata.org/wiki/Q412483","display_name":"Cholesterol side-chain cleavage enzyme","level":4,"score":0.4789329469203949},{"id":"https://openalex.org/C146819174","wikidata":"https://www.wikidata.org/wiki/Q1703595","display_name":"Hypothalamic\u2013pituitary\u2013gonadal axis","level":4,"score":0.4500572383403778},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.4443438947200775},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4413619041442871},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.41350629925727844},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.4133601188659668},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.3253011703491211},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2717747688293457},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.15520256757736206},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004399","descriptor_name":"Dynorphins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007006","descriptor_name":"Hypogonadism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010805","descriptor_name":"Physical Conditioning, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D059648","descriptor_name":"Kisspeptins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpendo.00377.2018","doi":"https://doi.org/10.1152/ajpendo.00377.2018","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00377.2018","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmid:30645174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30645174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Endocrinology and metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:flore.unifi.it:2158/1151175","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/1151175","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W791798302","https://openalex.org/W1548257999","https://openalex.org/W1664663910","https://openalex.org/W1895274382","https://openalex.org/W1964683861","https://openalex.org/W1966035579","https://openalex.org/W1971272236","https://openalex.org/W1973147888","https://openalex.org/W1982222099","https://openalex.org/W1994754777","https://openalex.org/W1999378743","https://openalex.org/W2002409914","https://openalex.org/W2015039177","https://openalex.org/W2015126772","https://openalex.org/W2015294286","https://openalex.org/W2015327259","https://openalex.org/W2027053551","https://openalex.org/W2027437492","https://openalex.org/W2040155152","https://openalex.org/W2052066994","https://openalex.org/W2058313314","https://openalex.org/W2059541778","https://openalex.org/W2059764696","https://openalex.org/W2062498555","https://openalex.org/W2062907730","https://openalex.org/W2065987608","https://openalex.org/W2074119828","https://openalex.org/W2082204861","https://openalex.org/W2096135790","https://openalex.org/W2096237552","https://openalex.org/W2102933102","https://openalex.org/W2106689064","https://openalex.org/W2107277218","https://openalex.org/W2110425298","https://openalex.org/W2124892033","https://openalex.org/W2125926292","https://openalex.org/W2130784408","https://openalex.org/W2132200219","https://openalex.org/W2133412303","https://openalex.org/W2136439241","https://openalex.org/W2139403802","https://openalex.org/W2142623609","https://openalex.org/W2146014366","https://openalex.org/W2156867396","https://openalex.org/W2158314006","https://openalex.org/W2161661353","https://openalex.org/W2198884807","https://openalex.org/W2336592156","https://openalex.org/W2473052778","https://openalex.org/W2481968947","https://openalex.org/W2517314869","https://openalex.org/W2530431372","https://openalex.org/W2577473992","https://openalex.org/W2606683325","https://openalex.org/W2615024914","https://openalex.org/W2738559609","https://openalex.org/W2757932130","https://openalex.org/W2773652641","https://openalex.org/W2792580162","https://openalex.org/W2793004320","https://openalex.org/W2793932909","https://openalex.org/W2802935173"],"related_works":["https://openalex.org/W2943161649","https://openalex.org/W7143684498","https://openalex.org/W2607473541","https://openalex.org/W2124892033","https://openalex.org/W2943083935","https://openalex.org/W3033190975","https://openalex.org/W1861164035","https://openalex.org/W3009421747","https://openalex.org/W2971649306","https://openalex.org/W2730502911"],"abstract_inverted_index":{"Metabolic":[0],"syndrome":[1],"(MetS)":[2],"clusters":[3],"cardiovascular":[4],"and":[5,12,39,88,90,103,105,111,124,138,145,160,170,189,209,228,230,234,249],"metabolic":[6],"risk":[7],"factors":[8],"along":[9],"with":[10,203],"hypogonadism":[11,248],"erectile":[13,40,93,221,250],"dysfunction.":[14,251],"Lifestyle":[15],"modifications":[16],"including":[17,84],"physical":[18],"exercise":[19],"(PhyEx)":[20],"are":[21],"well-known":[22],"treatments":[23],"for":[24,242],"this":[25,28],"condition.":[26],"In":[27,130,148,192,212],"study,":[29],"we":[30],"analyzed":[31],"the":[32,106,131,140,149,199],"effect":[33],"of":[34,44,70,92,142,173],"PhyEx":[35,95,133,151,184,218],"on":[36,75,226],"hypothalamic-pituitary-testis":[37],"axis":[38],"function":[41],"by":[42,120],"use":[43],"an":[45,114],"animal":[46],"MetS":[47,82,182],"model,":[48],"previously":[49],"established":[50],"in":[51,96,206],"rabbits":[52,79,98],"fed":[53,59],"a":[54,60,76,239],"high-fat":[55],"diet":[56,62],"(HFD).":[57],"Rabbits":[58],"regular":[61],"(RD)":[63],"were":[64],"used":[65],"as":[66,198],"controls.":[67],"A":[68],"subset":[69],"both":[71],"groups":[72],"was":[73,118],"trained":[74],"treadmill.":[77],"HFD":[78,97],"showed":[80],"typical":[81],"features,":[83],"HG":[85],"(reduced":[86],"T":[87,102,122,146,235],"LH)":[89],"impairment":[91],"function.":[94],"completely":[99],"restored":[100,163],"plasma":[101],"LH":[104,232],"penile":[107],"alterations.":[108],"At":[109],"testicular":[110],"hypothalamic":[112,210],"levels,":[113,169],"HFD-induced":[115,153],"inflammatory":[116],"status":[117],"accompanied":[119],"reduced":[121,186],"synthesis":[123],"gonadotropin-releasing":[125],"hormone":[126],"(GnRH)":[127],"immunopositivity,":[128],"respectively.":[129],"testis,":[132,229],"normalized":[134,152],"HFD-related":[135],"macrophage":[136],"infiltration":[137],"increased":[139],"expression":[141,155,172],"steroidogenic":[143],"enzymes":[144],"synthesis.":[147],"hypothalamus,":[150],"gene":[154],"changes":[156],"related":[157,175],"to":[158,176,245],"inflammation":[159],"glucose":[161],"metabolism,":[162],"GnRH":[164,177],"expression,":[165],"particularly":[166],"doubling":[167],"mRNA":[168],"regulated":[171],"molecules":[174],"release":[178],"(kisspeptin,":[179],"dynorphin).":[180],"Concerning":[181],"components,":[183],"significantly":[185],"circulating":[187],"cholesterol":[188,195],"visceral":[190],"fat.":[191],"multivariate":[193],"analyses,":[194],"levels":[196,233],"resulted":[197],"main":[200],"factor":[201],"associated":[202],"MetS-related":[204],"alterations":[205],"penile,":[207],"testicular,":[208],"districts.":[211],"conclusion,":[213],"our":[214],"results":[215],"show":[216],"that":[217],"may":[219],"rescue":[220],"function,":[222],"exert":[223],"anti-inflammatory":[224],"effects":[225],"hypothalamus":[227],"increase":[231],"production,":[236],"thus":[237],"supporting":[238],"primary":[240],"role":[241],"lifestyle":[243],"modification":[244],"combat":[246],"MetS-associated":[247]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-01-25T00:00:00"}