{"id":"https://openalex.org/W2909261016","doi":"https://doi.org/10.1182/blood-2018-99-118441","title":"Critical Role for Apobec and Its Interacting Partners in Mediating Mutations and Cell Growth in Multiple Myeloma (MM)","display_name":"Critical Role for Apobec and Its Interacting Partners in Mediating Mutations and Cell Growth in Multiple Myeloma (MM)","publication_year":2018,"publication_date":"2018-11-29","ids":{"openalex":"https://openalex.org/W2909261016","doi":"https://doi.org/10.1182/blood-2018-99-118441","mag":"2909261016"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2018-99-118441","doi":"https://doi.org/10.1182/blood-2018-99-118441","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-118441","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112389374","display_name":"Srikanth Talluri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Srikanth Talluri","raw_affiliation_strings":["The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","VA Boston Healthcare System, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"VA Boston Healthcare System, Boston, MA","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041668980","display_name":"Mehmet Samur","orcid":"https://orcid.org/0000-0002-9978-5682","observed_orcids":["https://orcid.org/0000-0002-9978-5682"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehmet Kemal Samur","raw_affiliation_strings":["Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027257617","display_name":"Jialan Shi","orcid":"https://orcid.org/0000-0001-5642-5436","observed_orcids":["https://orcid.org/0000-0001-5642-5436"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jialan Shi","raw_affiliation_strings":["Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","VA Boston Healthcare System, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"VA Boston Healthcare System, Boston, MA","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056254084","display_name":"RAO H. PRABHALA","orcid":"https://orcid.org/0000-0002-6375-0437","observed_orcids":["https://orcid.org/0000-0002-6375-0437"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rao Prabhala","raw_affiliation_strings":["Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","VA Boston Healthcare System, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"VA Boston Healthcare System, Boston, MA","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063422967","display_name":"Herv\u00e9 Avet\u2010Loiseau","orcid":"https://orcid.org/0000-0002-3050-0140","observed_orcids":["https://orcid.org/0000-0002-3050-0140"]},"institutions":[{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210098740","https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Herv\u00e9 Avet-Loiseau","raw_affiliation_strings":["Insititut Universitaire du Cancer, Unite de Genomique du Myelome, IUC-Oncopole, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insititut Universitaire du Cancer, Unite de Genomique du Myelome, IUC-Oncopole, Toulouse, France","institution_ids":["https://openalex.org/I4210098740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063099799","display_name":"Masood A. Shammas","orcid":"https://orcid.org/0000-0002-8932-6829","observed_orcids":["https://orcid.org/0000-0002-8932-6829"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Masood A. Shammas","raw_affiliation_strings":["Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","VA Boston Healthcare System, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"VA Boston Healthcare System, Boston, MA","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045740077","display_name":"Nikhil C. Munshi","orcid":"https://orcid.org/0000-0002-7344-9795","observed_orcids":["https://orcid.org/0000-0002-7344-9795","https://orcid.org/0000-0002-8397-100X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikhil Munshi","raw_affiliation_strings":["Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","J. Lipper Cancer Center for Multiple Myeloma, Dana-Farber Cancer Institute, Boston, MA","VA Boston Healthcare System, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"J. Lipper Cancer Center for Multiple Myeloma, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"VA Boston Healthcare System, Boston, MA","institution_ids":["https://openalex.org/I2801671727"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5063099799","https://openalex.org/A5063422967","https://openalex.org/A5112389374"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801671727","https://openalex.org/I4210098740","https://openalex.org/I4210117453","https://openalex.org/I4210134579"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"132","issue":"Supplement 1","first_page":"4462","last_page":"4462"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9259999990463257},{"id":"https://openalex.org/keywords/apobec","display_name":"APOBEC","score":0.7760000228881836},{"id":"https://openalex.org/keywords/apobec3g","display_name":"APOBEC3G","score":0.9419999718666077},{"id":"https://openalex.org/keywords/aid","display_name":"AID","score":0.6039999723434448},{"id":"https://openalex.org/keywords/somatic-hypermutation","display_name":"somatic hypermutation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/mutational-load","display_name":"mutational load","score":0.5199999809265137},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.953000009059906},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.597000002861023},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.890999972820282},{"id":"https://openalex.org/keywords/mir-221","display_name":"miR-221","score":0.8989999890327454},{"id":"https://openalex.org/keywords/dnd1","display_name":"DND1","score":0.8679999709129333},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.49799999594688416},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C2776162770","wikidata":"https://www.wikidata.org/wiki/Q4653351","display_name":"APOBEC","level":4,"score":0.9954501986503601},{"id":"https://openalex.org/C2776985229","wikidata":"https://www.wikidata.org/wiki/Q18021211","display_name":"Cytidine deaminase","level":3,"score":0.6661621928215027},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6268318295478821},{"id":"https://openalex.org/C2781310106","wikidata":"https://www.wikidata.org/wiki/Q14916265","display_name":"APOBEC3G","level":4,"score":0.6005869507789612},{"id":"https://openalex.org/C128526571","wikidata":"https://www.wikidata.org/wiki/Q619302","display_name":"Somatic hypermutation","level":4,"score":0.5499123334884644},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.44665923714637756},{"id":"https://openalex.org/C27082348","wikidata":"https://www.wikidata.org/wiki/Q21108149","display_name":"Activation-induced (cytidine) deaminase","level":5,"score":0.4447084367275238},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4308548867702484},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41335922479629517},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4006206691265106},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.379047691822052},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3402858376502991},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24272620677947998},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.23443421721458435},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1610659658908844},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.15355423092842102}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2018-99-118441","doi":"https://doi.org/10.1182/blood-2018-99-118441","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-118441","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2593489114","https://openalex.org/W3084841004","https://openalex.org/W2944771142","https://openalex.org/W2985664280","https://openalex.org/W2620427317","https://openalex.org/W3204759237","https://openalex.org/W2955262440","https://openalex.org/W2907838853","https://openalex.org/W3181612406","https://openalex.org/W2597316271"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"APOBEC":[2,15,81,115,124,205,215,241],"family":[3],"of":[4,35,104,114,149,172,204,229,235,248,283,287,291,321,326,332,342,359,398],"cytidine":[5],"deaminases":[6],"include":[7],"AID":[8,20],"(activity":[9],"induced":[10],"deaminase)":[11],"and":[12,18,31,55,75,121,126,141,179,220,233,257,267,314,340,386],"10":[13],"related":[14],"enzymes":[16],"(A1,A2,A3A,A3B,A3C,A3D,A3F,A3G,A3H":[17],"A4).":[19],"is":[21,128],"well":[22,135,380],"studied":[23],"for":[24,63,99,348,373],"its":[25,360],"role":[26,62,113,347,372],"in":[27,52,56,66,70,88,116,119,130,151,170,197,218,293,304,350,376,384],"somatic":[28,68],"hyper":[29],"mutation":[30],"class":[32],"switch":[33],"recombination":[34],"immunoglobulin":[36],"genes.":[37],"APOBECs":[38,150,187,349,374],"(apolipoprotein":[39],"B":[40],"mRNA":[41,53],"editing":[42,54],"enzyme,":[43],"catalytic":[44],"polypeptide-like)":[45],"have":[46,50,77,91],"been":[47,73],"shown":[48],"to":[49,107,193,226,313,318,336],"roles":[51],"antiviral":[57],"immunity.":[58],"Recently,":[59],"a":[60,85,190,346,369],"causal":[61],"the":[64,112,202,269,297,324,330],"AID/APOBECs":[65],"inducing":[67],"mutations":[69,83,96,100],"myeloma":[71,106,131,152,208,385],"has":[72],"proposed":[74],"we":[76,145,162,243,262],"previously":[78],"published":[79],"that":[80,94,123,147,185,213,264,310,355],"signature":[82],"as":[84,134,136,379,381],"frequent":[86],"event":[87],"Myeloma.":[89],"We":[90,109,199,211],"also":[92,244],"observed":[93,122,163,212,245],"APOBEC-mediated":[95],"may":[97,387],"account":[98],"associated":[101],"with":[102,240,301],"progression":[103],"smoldering":[105],"MM.":[108,198],"further":[110],"investigated":[111,201],"genomic":[117,156],"changes":[118],"MM":[120,222,230,352],"expression":[125,143],"activity":[127],"elevated":[129,337],"cell":[132,153,209,223,231,237,298,343,353,382],"lines":[133,154],"patient":[137],"samples.":[138],"Using":[139],"knockdown":[140],"over":[142,177],"approaches,":[144],"showed":[146],"depletion":[148,320],"reduces":[155],"instability.":[157],"Following":[158],"APOBEC3G":[159,265],"knock":[160,216],"down":[161,217],"decreased":[164],"DNA":[165],"damage":[166],"(by":[167],"g-H2AX),":[168],"decrease":[169,303],"acquisition":[171],"new":[173],"copy":[174],"number":[175],"events":[176],"time,":[178],"reduced":[180],"mutational":[181],"load,":[182],"strongly":[183],"suggesting":[184,345],"inhibiting":[186,280],"could":[188],"be":[189,357],"potential":[191],"approach":[192],"reduce":[194],"genome":[195,377],"evolution":[196,378],"next":[200],"effect":[203],"inhibition":[206,228,341],"on":[207],"proliferation.":[210],"Sh-RNA-based":[214],"MM1S":[219],"H929":[221],"lines,":[224],"led":[225],"significant":[227,370],"proliferation,":[232],"induction":[234],"apoptotic":[236],"death.":[238],"Associated":[239],"knockdown,":[242],"increased":[246],"levels":[247,339],"Cyclin-dependent":[249],"kinase":[250],"inhibitor":[251],"1B":[252],"(p27Kip1)":[253],"at":[254],"both":[255,375],"RNA":[256,270],"protein":[258,272],"level.":[259],"By":[260],"immunoprecipitation":[261],"found":[263],"interacts":[266],"inhibits":[268],"binding":[271],"DEAD-END":[273],"1":[274],"(DND1),":[275],"thereby":[276],"preventing":[277],"it":[278],"from":[279],"miR-221-mediated":[281,319],"targeting":[282],"p27":[284,305,333,338],"transcripts.":[285],"Knockdown":[286],"DND1,":[288,316],"or":[289],"over-expression":[290],"miR-221":[292],"APOBEC-depleted":[294],"cells":[295],"rescued":[296],"proliferation":[299,354],"defects":[300],"concomitant":[302],"levels.":[306],"These":[307],"results":[308,367],"show":[309],"APOBCs":[311],"bind":[312],"sequester":[315],"leading":[317,335],"p27.":[322],"In":[323],"absence":[325],"APOBEC,":[327],"DND1":[328],"prevents":[329],"degradation":[331],"mRNA,":[334],"cycle,":[344],"regulating":[351],"might":[356],"independent":[358],"RNA/DNA":[361],"mutator":[362],"function.":[363],"Taken":[364],"together,":[365],"these":[366],"indicate":[368],"functional":[371],"growth":[383],"constitute":[388],"an":[389],"important":[390],"therapeutic":[391],"target.":[392],"Disclosures":[393],"Munshi:":[394],"OncoPep:":[395],"Other:":[396],"Board":[397],"director.":[399]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-01-25T00:00:00"}