{"id":"https://openalex.org/W2909209010","doi":"https://doi.org/10.1016/j.ehpc.2019.01.001","title":"Successful treatment of gamma 1 heavy chain deposition disease with bortezomib and dexamethasone","display_name":"Successful treatment of gamma 1 heavy chain deposition disease with bortezomib and dexamethasone","publication_year":2019,"publication_date":"2019-01-15","ids":{"openalex":"https://openalex.org/W2909209010","doi":"https://doi.org/10.1016/j.ehpc.2019.01.001","mag":"2909209010"},"language":"en","primary_location":{"id":"doi:10.1016/j.ehpc.2019.01.001","doi":"https://doi.org/10.1016/j.ehpc.2019.01.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ehpc.2019.01.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2214330018301263/pdf","source":{"id":"https://openalex.org/S2898162792","display_name":"Human Pathology Case Reports","issn_l":"2214-3300","issn":["2214-3300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Pathology: Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2214330018301263/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061796597","display_name":"Masanori Sudo","orcid":"https://orcid.org/0000-0002-6767-6895","observed_orcids":["https://orcid.org/0000-0002-6767-6895"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masanori Sudo","raw_affiliation_strings":["Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062887735","display_name":"Takuya Wakamatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Wakamatsu","raw_affiliation_strings":["Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101573741","display_name":"Tomomi Ishikawa","orcid":"https://orcid.org/0009-0009-5045-3570","observed_orcids":["https://orcid.org/0009-0009-5045-3570"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomomi Ishikawa","raw_affiliation_strings":["Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074767587","display_name":"Masato Habuka","orcid":"https://orcid.org/0000-0002-5798-1730","observed_orcids":["https://orcid.org/0000-0002-5798-1730"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Habuka","raw_affiliation_strings":["Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002881989","display_name":"Michihiro Hosojima","orcid":"https://orcid.org/0000-0002-2750-735X","observed_orcids":["https://orcid.org/0000-0002-2750-735X"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michihiro Hosojima","raw_affiliation_strings":["Department of Clinical Nutrition Science, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Nutrition Science, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101583718","display_name":"Suguru Yamamoto","orcid":"https://orcid.org/0000-0002-8279-2966","observed_orcids":["https://orcid.org/0000-0002-8279-2966"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Suguru Yamamoto","raw_affiliation_strings":["Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101962551","display_name":"Yumi Ito","orcid":"https://orcid.org/0000-0001-8189-105X","observed_orcids":["https://orcid.org/0000-0001-8189-105X"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yumi Ito","raw_affiliation_strings":["Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091641974","display_name":"Naofumi Imai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naofumi Imai","raw_affiliation_strings":["Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021747614","display_name":"Yoshikatsu Kaneko","orcid":"https://orcid.org/0000-0002-6396-0055","observed_orcids":["https://orcid.org/0000-0002-6396-0055"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshikatsu Kaneko","raw_affiliation_strings":["Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034292099","display_name":"Akira Shimizu","orcid":"https://orcid.org/0000-0002-4364-9251","observed_orcids":["https://orcid.org/0000-0002-4364-9251"]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Shimizu","raw_affiliation_strings":["Department of Analytic Human Pathology, Nippon Medical School, Tokyo 113-8602, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytic Human Pathology, Nippon Medical School, Tokyo 113-8602, Japan","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042533774","display_name":"Ichiei Narita","orcid":"https://orcid.org/0000-0001-7692-3096","observed_orcids":["https://orcid.org/0000-0001-7692-3096"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ichiei Narita","raw_affiliation_strings":["Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061796597"],"corresponding_institution_ids":["https://openalex.org/I71395657"],"apc_list":{"value":950,"currency":"USD","value_usd":950},"apc_paid":{"value":950,"currency":"USD","value_usd":950},"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00445075,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"15","issue":null,"first_page":"99","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.03420000150799751,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9760000109672546},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.6700000166893005},{"id":"https://openalex.org/keywords/glomerular-disease","display_name":"glomerular disease","score":0.7710000276565552},{"id":"https://openalex.org/keywords/complement-c3-deposition","display_name":"C3 deposition","score":0.7009999752044678},{"id":"https://openalex.org/keywords/plasma-cell-dyscrasia","display_name":"plasma cell dyscrasia","score":0.8140000104904175},{"id":"https://openalex.org/keywords/kappa-lambda-ratio","display_name":"kappa/lambda ratio","score":0.675000011920929},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.6259999871253967},{"id":"https://openalex.org/keywords/hypocomplementemia","display_name":"hypocomplementemia","score":0.6809999942779541},{"id":"https://openalex.org/keywords/hypogammaglobulinemia","display_name":"hypogammaglobulinemia","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C2780199430","wikidata":"https://www.wikidata.org/wiki/Q3347169","display_name":"Glomerulopathy","level":4,"score":0.7537295818328857},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7053142786026001},{"id":"https://openalex.org/C2781087799","wikidata":"https://www.wikidata.org/wiki/Q7312483","display_name":"Renal biopsy","level":3,"score":0.6864819526672363},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.6403036117553711},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6154003143310547},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5726352334022522},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.550668478012085},{"id":"https://openalex.org/C2778709411","wikidata":"https://www.wikidata.org/wiki/Q7201798","display_name":"Plasmacytosis","level":3,"score":0.449869841337204},{"id":"https://openalex.org/C52697466","wikidata":"https://www.wikidata.org/wiki/Q424176","display_name":"Bence Jones protein","level":4,"score":0.4383021891117096},{"id":"https://openalex.org/C2776396001","wikidata":"https://www.wikidata.org/wiki/Q250694","display_name":"Plasma cell","level":3,"score":0.42748144268989563},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.3689866065979004},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.35672956705093384},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.33081144094467163},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3055607080459595},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2533735930919647},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.22082990407943726},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.21462678909301758},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13695257902145386}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ehpc.2019.01.001","doi":"https://doi.org/10.1016/j.ehpc.2019.01.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ehpc.2019.01.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2214330018301263/pdf","source":{"id":"https://openalex.org/S2898162792","display_name":"Human Pathology Case Reports","issn_l":"2214-3300","issn":["2214-3300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Pathology: Case Reports","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:2f26174e64494d469b1a164bbe277214","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2f26174e64494d469b1a164bbe277214","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Pathology: Case Reports, Vol 15, Iss , Pp 99-104 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ehpc.2019.01.001","doi":"https://doi.org/10.1016/j.ehpc.2019.01.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ehpc.2019.01.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2214330018301263/pdf","source":{"id":"https://openalex.org/S2898162792","display_name":"Human Pathology Case Reports","issn_l":"2214-3300","issn":["2214-3300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Pathology: Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2909209010.pdf","grobid_xml":"https://content.openalex.org/works/W2909209010.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W50654167","https://openalex.org/W1486630464","https://openalex.org/W1567835982","https://openalex.org/W1963505205","https://openalex.org/W1969401741","https://openalex.org/W1970284005","https://openalex.org/W1971828262","https://openalex.org/W1990146530","https://openalex.org/W1991868707","https://openalex.org/W2016945369","https://openalex.org/W2027076242","https://openalex.org/W2042588760","https://openalex.org/W2049365670","https://openalex.org/W2058789242","https://openalex.org/W2070335603","https://openalex.org/W2070619194","https://openalex.org/W2072071303","https://openalex.org/W2073764721","https://openalex.org/W2075174733","https://openalex.org/W2077918440","https://openalex.org/W2093410231","https://openalex.org/W2096207943","https://openalex.org/W2109651910","https://openalex.org/W2119071301","https://openalex.org/W2124473981","https://openalex.org/W2140256318","https://openalex.org/W2142701069","https://openalex.org/W2148443098","https://openalex.org/W2153182756","https://openalex.org/W2206365453","https://openalex.org/W2509655866","https://openalex.org/W2533811048","https://openalex.org/W2788405474","https://openalex.org/W4247144259"],"related_works":["https://openalex.org/W1970284005","https://openalex.org/W2533811048","https://openalex.org/W2061350215","https://openalex.org/W4400293460","https://openalex.org/W1969401741","https://openalex.org/W2155472361","https://openalex.org/W4221126173","https://openalex.org/W2074144682","https://openalex.org/W2099141862","https://openalex.org/W1991868707"],"abstract_inverted_index":{"Heavy":[0],"chain":[1,107],"deposition":[2,76],"disease":[3],"(HCDD)":[4],"is":[5],"a":[6,31],"rare":[7],"complication":[8],"of":[9,18,30,55,77,103,111,121,126,145,151,163,166,170],"plasma":[10],"cell":[11],"dyscrasias,":[12],"characterized":[13],"by":[14,49],"nonamyloid":[15],"tissue":[16],"deposits":[17,169],"incomplete":[19],"monoclonal":[20],"heavy":[21,106],"chains":[22,94],"in":[23,81],"renal":[24,60],"tissues.":[25],"We":[26],"report":[27],"the":[28,75,82,86,100,104,109,112,135,146],"case":[29],"78-year-old":[32],"female":[33],"with":[34,40,59,74,119,134],"HCDD":[35],"who":[36],"was":[37],"successfully":[38],"treated":[39],"bortezomib":[41],"and":[42,65,79,84,91,149,168,172],"dexamethasone":[43],"(BD);":[44],"histopathological":[45],"improvements":[46],"were":[47,95,132,155],"confirmed":[48],"kidney":[50],"biopsy":[51,68,159],"after":[52,140],"2":[53],"years":[54,139],"chemotherapy.":[56],"She":[57],"presented":[58],"insufficiency,":[61],"proteinuria,":[62],"hematuria,":[63],"hypogammaglobulinemia,":[64],"hypocomplementemia.":[66],"Renal":[67],"showed":[69,160],"diffuse":[70],"global":[71],"nodular":[72,164],"glomerulopathy":[73],"IgG1":[78],"C3":[80],"glomeruli":[83,167],"on":[85],"tubular":[87],"basement":[88],"membrane.":[89],"Kappa":[90],"lambda":[92],"light":[93],"not":[96],"detected.":[97],"Staining":[98],"for":[99],"constant":[101],"regions":[102],"gamma":[105,122],"revealed":[108],"absence":[110],"CH1":[113],"domain.":[114],"These":[115],"findings":[116],"are":[117],"consistent":[118,133],"those":[120],"1":[123],"HCDD.":[124],"Results":[125],"liquid":[127],"chromatography-tandem":[128],"mass":[129],"spectrometric":[130],"analysis":[131],"immunohistochemical":[136],"results.":[137],"Two":[138],"weekly":[141],"BD":[142],"therapy,":[143],"normalization":[144],"kappa/lambda":[147],"ratio":[148],"reduction":[150],"urinary":[152],"protein":[153],"excretion":[154],"achieved.":[156],"A":[157],"follow-up":[158],"remarkable":[161],"diminution":[162],"lesions":[165],"IgG":[171],"C3.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-01-25T00:00:00"}