{"id":"https://openalex.org/W2909106973","doi":"https://doi.org/10.1093/ijnp/pyz001","title":"LiCl Pretreatment Ameliorates Adolescent Methamphetamine Exposure-Induced Long-Term Alterations in Behavior and Hippocampal Ultrastructure in Adulthood in Mice","display_name":"LiCl Pretreatment Ameliorates Adolescent Methamphetamine Exposure-Induced Long-Term Alterations in Behavior and Hippocampal Ultrastructure in Adulthood in Mice","publication_year":2019,"publication_date":"2019-01-08","ids":{"openalex":"https://openalex.org/W2909106973","doi":"https://doi.org/10.1093/ijnp/pyz001","mag":"2909106973","pmid":"https://pubmed.ncbi.nlm.nih.gov/30649326"},"language":"en","primary_location":{"id":"doi:10.1093/ijnp/pyz001","doi":"https://doi.org/10.1093/ijnp/pyz001","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ijnp/pyz001","pdf_url":null,"source":{"id":"https://openalex.org/S199972112","display_name":"The International Journal of Neuropsychopharmacology","issn_l":"1461-1457","issn":["1461-1457","1469-5111"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neuropsychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/ijnp/pyz001","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103163315","display_name":"Peng Yan","orcid":"https://orcid.org/0009-0002-5978-0382","observed_orcids":["https://orcid.org/0009-0002-5978-0382"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Yan","raw_affiliation_strings":["College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090046867","display_name":"Dan Xu","orcid":"https://orcid.org/0000-0003-0548-3833","observed_orcids":["https://orcid.org/0000-0003-0548-3833"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Xu","raw_affiliation_strings":["Traditional Chinese Medicine Department, Shenyang Pharmaceutical University, Shenyang, Liaoning, People\u2019s Republic of China","Traditional Chinese Medicine Department, Shenyang Pharmaceutical University, Shenyang, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Traditional Chinese Medicine Department, Shenyang Pharmaceutical University, Shenyang, Liaoning, People\u2019s Republic of China","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"Traditional Chinese Medicine Department, Shenyang Pharmaceutical University, Shenyang, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029594423","display_name":"Yuanyuan Ji","orcid":"https://orcid.org/0000-0001-5591-000X","observed_orcids":["https://orcid.org/0000-0001-5591-000X"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Ji","raw_affiliation_strings":["College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006002051","display_name":"Fangyuan Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangyuan Yin","raw_affiliation_strings":["College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063295839","display_name":"Jingjing Cui","orcid":"https://orcid.org/0000-0001-6849-1780","observed_orcids":["https://orcid.org/0000-0001-6849-1780"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjing Cui","raw_affiliation_strings":["College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066704289","display_name":"Rui Su","orcid":"https://orcid.org/0000-0003-1486-0418","observed_orcids":["https://orcid.org/0000-0003-1486-0418","https://orcid.org/0009-0004-2730-751X"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Su","raw_affiliation_strings":["College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103046912","display_name":"Yunpeng Wang","orcid":"https://orcid.org/0000-0003-4291-4487","observed_orcids":["https://orcid.org/0000-0003-4291-4487"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunpeng Wang","raw_affiliation_strings":["College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100732893","display_name":"Yongsheng Zhu","orcid":"https://orcid.org/0000-0002-9256-2427","observed_orcids":["https://orcid.org/0000-0002-9256-2427"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongsheng Zhu","raw_affiliation_strings":["College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102736404","display_name":"Shuguang Wei","orcid":"https://orcid.org/0000-0003-2954-344X","observed_orcids":["https://orcid.org/0000-0003-2954-344X"]},"institutions":[{"id":"https://openalex.org/I271893122","display_name":"National Health and Family Planning Commission","ror":"https://ror.org/052eegr76","country_code":"CN","type":"government","lineage":["https://openalex.org/I271893122","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuguang Wei","raw_affiliation_strings":["College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","Key Laboratory of Forensic Science, National Health and Family Planning Commission, Xi\u2019an, Shaanxi, People\u2019s Republic of China","College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China","Key Laboratory of Forensic Science, National Health and Family Planning Commission, Xi'an, Shaanxi, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"Key Laboratory of Forensic Science, National Health and Family Planning Commission, Xi\u2019an, Shaanxi, People\u2019s Republic of China","institution_ids":["https://openalex.org/I271893122"]},{"raw_affiliation_string":"College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"Key Laboratory of Forensic Science, National Health and Family Planning Commission, Xi'an, Shaanxi, People's Republic of China","institution_ids":["https://openalex.org/I271893122"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101934665","display_name":"Jianghua Lai","orcid":"https://orcid.org/0000-0003-0851-4412","observed_orcids":["https://orcid.org/0000-0003-0851-4412"]},"institutions":[{"id":"https://openalex.org/I271893122","display_name":"National Health and Family Planning Commission","ror":"https://ror.org/052eegr76","country_code":"CN","type":"government","lineage":["https://openalex.org/I271893122","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianghua Lai","raw_affiliation_strings":["College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","Key Laboratory of Forensic Science, National Health and Family Planning Commission, Xi\u2019an, Shaanxi, People\u2019s Republic of China","College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China","Key Laboratory of Forensic Science, National Health and Family Planning Commission, Xi'an, Shaanxi, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Forensic Science, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"Key Laboratory of Forensic Science, National Health and Family Planning Commission, Xi\u2019an, Shaanxi, People\u2019s Republic of China","institution_ids":["https://openalex.org/I271893122"]},{"raw_affiliation_string":"College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"Key Laboratory of Forensic Science, National Health and Family Planning Commission, Xi'an, Shaanxi, People's Republic of China","institution_ids":["https://openalex.org/I271893122"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101934665","https://openalex.org/A5102736404"],"corresponding_institution_ids":["https://openalex.org/I271893122","https://openalex.org/I87445476"],"apc_list":{"value":2042,"currency":"GBP","value_usd":2693},"apc_paid":{"value":2042,"currency":"GBP","value_usd":2693},"fwci":1.4612,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.78753583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"22","issue":"4","first_page":"303","last_page":"316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8628000020980835,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8628000020980835,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.05490000173449516,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.050200000405311584,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lithium-chloride","display_name":"lithium chloride","score":0.9610000252723694},{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3beta","display_name":"glycogen synthase kinase-3\u03b2","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hippocampal-ultrastructure","display_name":"hippocampal ultrastructure","score":0.8320000171661377},{"id":"https://openalex.org/keywords/synaptic-density","display_name":"synaptic density","score":0.6449999809265137},{"id":"https://openalex.org/keywords/postsynaptic-density","display_name":"postsynaptic density","score":0.7559999823570251},{"id":"https://openalex.org/keywords/working-memory-deficits","display_name":"working memory deficits","score":0.6499999761581421},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.984000027179718},{"id":"https://openalex.org/keywords/locomotor-sensitization","display_name":"locomotor sensitization","score":0.8899999856948853},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.8270000219345093},{"id":"https://openalex.org/keywords/dorsal-hippocampus","display_name":"dorsal hippocampus","score":0.8069999814033508},{"id":"https://openalex.org/keywords/ca1","display_name":"CA1","score":0.5080000162124634},{"id":"https://openalex.org/keywords/social-recognition-memory","display_name":"social recognition memory","score":0.6510000228881836},{"id":"https://openalex.org/keywords/novel-object-recognition","display_name":"novel object recognition","score":0.42399999499320984},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2780376393","wikidata":"https://www.wikidata.org/wiki/Q191924","display_name":"Methamphetamine","level":2,"score":0.8454128503799438},{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.6361061334609985},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6299882531166077},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5992962121963501},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.45809441804885864},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.4518624246120453},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4510077238082886},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.43553057312965393},{"id":"https://openalex.org/C187541742","wikidata":"https://www.wikidata.org/wiki/Q4374336","display_name":"Postsynaptic density","level":4,"score":0.425345778465271},{"id":"https://openalex.org/C104629339","wikidata":"https://www.wikidata.org/wiki/Q18258585","display_name":"GSK3B","level":4,"score":0.422573059797287},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40204015374183655},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39203721284866333},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30894389748573303},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26672494411468506},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.2243765890598297},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.21626761555671692},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13561081886291504},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.09423941373825073},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.0725381076335907}],"mesh":[{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008570","descriptor_name":"Memory, Short-Term","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008570","descriptor_name":"Memory, Short-Term","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008570","descriptor_name":"Memory, Short-Term","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008694","descriptor_name":"Methamphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008694","descriptor_name":"Methamphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008694","descriptor_name":"Methamphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018021","descriptor_name":"Lithium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018021","descriptor_name":"Lithium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018021","descriptor_name":"Lithium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/ijnp/pyz001","doi":"https://doi.org/10.1093/ijnp/pyz001","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ijnp/pyz001","pdf_url":null,"source":{"id":"https://openalex.org/S199972112","display_name":"The International Journal of Neuropsychopharmacology","issn_l":"1461-1457","issn":["1461-1457","1469-5111"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neuropsychopharmacology","raw_type":"journal-article"},{"id":"pmid:30649326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30649326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of neuropsychopharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5433783","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6441133","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6441133","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6441133","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Neuropsychopharmacol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/ijnp/pyz001","doi":"https://doi.org/10.1093/ijnp/pyz001","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ijnp/pyz001","pdf_url":null,"source":{"id":"https://openalex.org/S199972112","display_name":"The International Journal of Neuropsychopharmacology","issn_l":"1461-1457","issn":["1461-1457","1469-5111"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neuropsychopharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6299999952316284,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3683512865","display_name":null,"funder_award_id":"81571856","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G682713153","display_name":"\u591a\u5df4\u80fa\u53d7\u4f53\u5bb6\u65cf\u4ecb\u5bfc\u5b89\u975e\u4ed6\u660e\u6210\u763e\u673a\u5236\u7814\u7a76","funder_award_id":"31271340","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W406003202","https://openalex.org/W628958324","https://openalex.org/W1173809700","https://openalex.org/W1488072553","https://openalex.org/W1495904497","https://openalex.org/W1568632097","https://openalex.org/W1577040063","https://openalex.org/W1847306847","https://openalex.org/W1965569460","https://openalex.org/W1983334283","https://openalex.org/W1985912815","https://openalex.org/W1998006367","https://openalex.org/W2001331834","https://openalex.org/W2011995255","https://openalex.org/W2012332769","https://openalex.org/W2013661385","https://openalex.org/W2014526361","https://openalex.org/W2018667935","https://openalex.org/W2021534324","https://openalex.org/W2024612251","https://openalex.org/W2028988505","https://openalex.org/W2030030436","https://openalex.org/W2043095760","https://openalex.org/W2050441318","https://openalex.org/W2051301373","https://openalex.org/W2051788298","https://openalex.org/W2067592930","https://openalex.org/W2076508109","https://openalex.org/W2083759504","https://openalex.org/W2087607255","https://openalex.org/W2090814246","https://openalex.org/W2115898064","https://openalex.org/W2118740391","https://openalex.org/W2123437610","https://openalex.org/W2132442335","https://openalex.org/W2280426197","https://openalex.org/W2426168356","https://openalex.org/W2464748047","https://openalex.org/W2505731718","https://openalex.org/W2539328597","https://openalex.org/W2579780502","https://openalex.org/W2593829744","https://openalex.org/W2606136976","https://openalex.org/W2622379656","https://openalex.org/W2665329839","https://openalex.org/W2767397051"],"related_works":["https://openalex.org/W4237696989","https://openalex.org/W4256141538","https://openalex.org/W2168096237","https://openalex.org/W4231088204","https://openalex.org/W4285094880","https://openalex.org/W1988836147","https://openalex.org/W4248586904","https://openalex.org/W3120693685","https://openalex.org/W4245479516","https://openalex.org/W1990285976"],"abstract_inverted_index":{"BACKGROUND:":[0],"Adolescent":[1,140,185],"methamphetamine":[2,26,46,78,127,137,141,186,207,217,228,257],"exposure":[3,142],"causes":[4],"a":[5,126,244],"broad":[6],"range":[7],"of":[8,36,73,250],"neurobiological":[9],"deficits":[10,190,251],"in":[11,18,50,59,86,101,116,119,146,157,162,167,175,191,199,234,252],"adulthood.":[12,60,235],"Glycogen":[13],"synthase":[14,39,97,159,222,240],"kinase-3\u03b2":[15,40,98,160,223,241],"is":[16],"involved":[17],"various":[19],"cognitive":[20],"and":[21,54,56,83,90,106,152,165,171,196,231],"behavioral":[22,63,84,230],"processes":[23],"associated":[24,254],"with":[25,125,255],"exposure.":[27,138],"This":[28],"study":[29],"aims":[30],"to":[31,68,94,113,225],"investigate":[32,69],"the":[33,37,70,102,120,248],"protective":[34,71],"effects":[35,72],"glycogen":[38,96,158,221,239],"inhibitor":[41],"lithium":[42,74,182],"chloride":[43,75,183],"on":[44,76],"adolescent":[45,77,136,226,256],"exposure-induced":[47,79,187,229],"long-term":[48,80,144,206,216],"alterations":[49,145],"emotion,":[51],"cognition,":[52],"behavior,":[53],"molecule":[55],"hippocampal":[57,232],"ultrastructure":[58,118],"METHODS:":[61],"A":[62],"test":[64,195,202],"battery":[65],"was":[66,111,131,213],"used":[67,93,112],"emotional,":[81],"cognitive,":[82],"impairments":[85,233],"mice.":[87],"Western":[88],"blotting":[89],"immunohistochemistry":[91],"were":[92,179],"detect":[95],"activity":[99,161],"levels":[100],"medial":[103],"prefrontal":[104],"cortex":[105],"dorsal":[107,121,163],"hippocampus.":[108,122],"Electron":[109],"microscopy":[110],"analyze":[114],"changes":[115,178],"synaptic":[117],"Locomotor":[123],"sensitization":[124,212],"(1":[128],"mg/kg)":[129],"challenge":[130],"examined":[132],"80":[133],"days":[134],"after":[135,205,215],"RESULTS:":[139],"induced":[143],"locomotor":[147,211],"activity,":[148],"novel":[149],"spatial":[150],"exploration,":[151],"social":[153],"recognition":[154],"memory;":[155],"increases":[156],"hippocampus;":[164],"decreases":[166],"excitatory":[168],"synapse":[169],"density":[170,173],"postsynaptic":[172],"thickness":[174],"CA1.":[176],"These":[177],"ameliorated":[180],"by":[181],"pretreatment.":[184],"working":[188],"memory":[189],"Y-maze":[192],"spontaneous":[193],"alternation":[194],"anxiety-like":[197],"behavior":[198],"elevated-plus":[200],"maze":[201],"spontaneously":[203],"recovered":[204],"abstinence.":[208,218],"No":[209],"significant":[210],"observed":[214],"CONCLUSIONS:":[219],"Hyperactive":[220],"contributes":[224],"chronic":[227],"Our":[236],"results":[237],"suggest":[238],"may":[242],"be":[243],"potential":[245],"target":[246],"for":[247],"treatment":[249],"adulthood":[253],"abuse.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}