{"id":"https://openalex.org/W2909093063","doi":"https://doi.org/10.1289/isee.2011.01621","title":"DELIVERY TYPE NOT ASSOCIATED WITH DIFFERENTIAL METHYLATION AT BIRTH","display_name":"DELIVERY TYPE NOT ASSOCIATED WITH DIFFERENTIAL METHYLATION AT BIRTH","publication_year":2011,"publication_date":"2011-09-13","ids":{"openalex":"https://openalex.org/W2909093063","doi":"https://doi.org/10.1289/isee.2011.01621","mag":"2909093063"},"language":"en","primary_location":{"id":"doi:10.1289/isee.2011.01621","doi":"https://doi.org/10.1289/isee.2011.01621","is_oa":false,"landing_page_url":"https://doi.org/10.1289/isee.2011.01621","pdf_url":null,"source":{"id":"https://openalex.org/S4210195765","display_name":"ISEE Conference Abstracts","issn_l":"1078-0475","issn":["1078-0475","2169-2181"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISEE Conference Abstracts","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046275543","display_name":"Shama Virani","orcid":"https://orcid.org/0000-0002-1163-432X","observed_orcids":["https://orcid.org/0000-0002-1163-432X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Virani","raw_affiliation_strings":["Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036276243","display_name":"Sindhu Halubai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Halubai","raw_affiliation_strings":["Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078933280","display_name":"Muna S. Nahar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.S. Nahar","raw_affiliation_strings":["Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073554595","display_name":"Dana C. Dolinoy","orcid":"https://orcid.org/0000-0002-3304-2456","observed_orcids":["https://orcid.org/0000-0002-3304-2456"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.C. Dolinoy","raw_affiliation_strings":["Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019021883","display_name":"Steven E. Domino","orcid":"https://orcid.org/0000-0002-5712-0535","observed_orcids":["https://orcid.org/0000-0002-5712-0535"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.E Domino","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087457107","display_name":"Laura S. Rozek","orcid":"https://orcid.org/0000-0001-6731-7000","observed_orcids":["https://orcid.org/0000-0001-6731-7000","https://orcid.org/0009-0008-1136-8667"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.S. Rozek","raw_affiliation_strings":["Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029119143","display_name":"Vasantha Padmanabhan","orcid":"https://orcid.org/0000-0002-8443-7212","observed_orcids":["https://orcid.org/0000-0002-8443-7212"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Padmanabhan","raw_affiliation_strings":["Department of Pediatrics - Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor,Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics - Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor,Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2011","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.048500001430511475,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mode-of-delivery","display_name":"mode of delivery","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cesarean-section","display_name":"cesarean section","score":0.9769999980926514},{"id":"https://openalex.org/keywords/vaginal-delivery","display_name":"vaginal delivery","score":0.984000027179718},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/global-dna-methylation","display_name":"global DNA methylation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/line-1-methylation","display_name":"LINE-1 methylation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.7200000286102295},{"id":"https://openalex.org/keywords/early-life-exposure","display_name":"early life exposure","score":0.7059999704360962},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.925000011920929},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5350000262260437},{"id":"https://openalex.org/keywords/birth-cohort","display_name":"birth cohort","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.7537455558776855},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7149791121482849},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6159637570381165},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.6069706082344055},{"id":"https://openalex.org/C66322754","wikidata":"https://www.wikidata.org/wiki/Q4128476","display_name":"Birth weight","level":3,"score":0.5841975212097168},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5121092796325684},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5059522986412048},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.43742144107818604},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4277237355709076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3065483570098877},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19980430603027344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07186552882194519},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1289/isee.2011.01621","doi":"https://doi.org/10.1289/isee.2011.01621","is_oa":false,"landing_page_url":"https://doi.org/10.1289/isee.2011.01621","pdf_url":null,"source":{"id":"https://openalex.org/S4210195765","display_name":"ISEE Conference Abstracts","issn_l":"1078-0475","issn":["1078-0475","2169-2181"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISEE Conference Abstracts","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2159655984","https://openalex.org/W4376868137","https://openalex.org/W4404789459","https://openalex.org/W2014479870","https://openalex.org/W4390982358","https://openalex.org/W7155176506","https://openalex.org/W2055266987","https://openalex.org/W3028203807","https://openalex.org/W2131052141","https://openalex.org/W2080559877"],"abstract_inverted_index":{"Background:":[0],"Birth":[1],"by":[2,35,207,220,234,254],"Cesarean":[3,145],"section":[4,146],"is":[5],"associated":[6,214,262,279],"with":[7,182,215,263,280],"adverse":[8],"health":[9,29,282],"outcomes":[10],"later":[11,28,70,281],"in":[12,32,53,69,114,126,266,295],"life,":[13],"including":[14],"diabetes":[15],"and":[16,107,128,149,166,185,187],"allergies.":[17],"Epigenetic":[18],"mechanisms":[19],"are":[20],"one":[21],"way":[22],"early":[23],"life":[24,71],"exposures":[25],"can":[26],"affect":[27],"outcomes.":[30],"Differences":[31],"global":[33,51,152,216,264,296],"methylation":[34,52,97,109,168,201,217,265],"type":[36,138,274],"of":[37,92,139,151,210,258,270,275],"birth":[38,57,211,276],"have":[39,46],"been":[40,47],"described,":[41],"but":[42],"the":[43,90,102,135,188],"sample":[44],"sizes":[45],"small.":[48],"We":[49],"measured":[50,219],"a":[54],"large,":[55],"ongoing":[56],"cohort":[58],"to":[59,67,73],"identify":[60],"epigenetic":[61],"changes":[62,294],"that":[63,287],"may":[64,277],"cause":[65],"predisposition":[66],"disease":[68],"due":[72],"delivery":[74,142,259],"type.":[75],"Methods:":[76],"DNA":[77,108],"was":[78,118,169,212,260],"obtained":[79],"from":[80,89,159],"umbilical":[81],"cord":[82],"blood":[83],"collected":[84],"immediately":[85],"after":[86],"term":[87],"deliveries":[88],"University":[91],"Michigan":[93],"Hospital":[94],"(n=417).":[95],"Global":[96,200],"levels":[98],"were":[99,124,157,179,190,203],"assessed":[100,119],"via":[101,120],"Luminometric":[103],"Methylation":[104],"Assay":[105],"(LUMA),":[106],"at":[110],"four":[111],"CpG":[112],"sites":[113],"LINE-1":[115,167,235],"repetitive":[116],"elements":[117],"bisulfite":[121],"pyrosequencing.":[122],"Samples":[123],"run":[125],"duplicate":[127],"averaged":[129],"for":[130,171],"analyses.":[131],"Nonparametric":[132],"analyses":[133],"tested":[134],"association":[136],"between":[137],"birth,":[140],"vaginal":[141],"(VD)":[143],"or":[144,233],"(CS),":[147],"gender":[148],"measures":[150],"methylation.":[153,298],"Results:":[154],"LUMA":[155,184,221],"data":[156,285],"available":[158,170],"301":[160],"births":[161,173],"(53%":[162],"male;":[163,175],"61%":[164],"CS)":[165],"212":[172],"(50%":[174],"67%":[176],"CS).":[177],"There":[178],"154":[180],"samples":[181],"both":[183],"LINE-1,":[186],"measurements":[189],"negatively":[191],"correlated":[192],"(Spearman\u2019s":[193],"r":[194],"=":[195,198,224,228,231,238,242,245],"-0.22,":[196],"p":[197],"0.006).":[199],"values":[202],"not":[204,213,250,261,290],"significantly":[205],"different":[206],"gender.":[208,255,272],"Type":[209,257],"as":[218],"(mean":[222,236],"CS":[223,237],"73.66,":[225],"mean":[226,240],"VD":[227,241],"74.98,":[229],"p-value":[230,244],"0.12)":[232],"81.19,":[239],"81.05,":[243],"0.31).":[246],"These":[247],"results":[248],"did":[249],"change":[251],"when":[252],"stratifying":[253],"Conclusion:":[256],"our":[267,284],"population":[268],"regardless":[269],"infant":[271],"While":[273],"be":[278],"outcomes,":[283],"suggest":[286],"it":[288],"does":[289],"do":[291],"so":[292],"through":[293],"genomic":[297]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2019-01-25T00:00:00"}