{"id":"https://openalex.org/W2908885437","doi":"https://doi.org/10.1016/j.ebiom.2019.01.019","title":"Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance","display_name":"Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance","publication_year":2019,"publication_date":"2019-01-18","ids":{"openalex":"https://openalex.org/W2908885437","doi":"https://doi.org/10.1016/j.ebiom.2019.01.019","mag":"2908885437","pmid":"https://pubmed.ncbi.nlm.nih.gov/30662002","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6441848"},"language":"en","primary_location":{"id":"doi:10.1016/j.ebiom.2019.01.019","doi":"https://doi.org/10.1016/j.ebiom.2019.01.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2019.01.019","pdf_url":"http://www.thelancet.com/article/S2352396419300246/pdf","source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.thelancet.com/article/S2352396419300246/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109602287","display_name":"Koutaroh Okada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koutaroh Okada","raw_affiliation_strings":["Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan","Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan","Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023816779","display_name":"Mitsugu Araki","orcid":"https://orcid.org/0000-0002-7810-4905","observed_orcids":["https://orcid.org/0000-0002-7810-4905"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210129730","display_name":"RIKEN Center for Computational Science","ror":"https://ror.org/03r519674","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210129730"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsugu Araki","raw_affiliation_strings":["RIKEN Advanced Institute for Computational Science, 7-1-26 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan","Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan","RIKEN Advanced Institute for Computational Science, 7-1-26 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Advanced Institute for Computational Science, 7-1-26 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4210110652","https://openalex.org/I4210129730"]},{"raw_affiliation_string":"Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"RIKEN Advanced Institute for Computational Science, 7-1-26 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan","institution_ids":["https://openalex.org/I4210129730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016837626","display_name":"Takuya Sakashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Sakashita","raw_affiliation_strings":["Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021610515","display_name":"Biao Ma","orcid":"https://orcid.org/0000-0003-0410-4408","observed_orcids":["https://orcid.org/0000-0003-0410-4408"]},"institutions":[{"id":"https://openalex.org/I4210167395","display_name":"Foundation for Biomedical Research and Innovation","ror":"https://ror.org/05xe40a72","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210167395"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Biao Ma","raw_affiliation_strings":["Research and Development Group for In Silico Drug Discovery, Pro-Cluster Kobe, Foundation for Biomedical Research and Innovation (FBRI), 6-3-5, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Group for In Silico Drug Discovery, Pro-Cluster Kobe, Foundation for Biomedical Research and Innovation (FBRI), 6-3-5, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan","institution_ids":["https://openalex.org/I4210167395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005844348","display_name":"Ryo Kanada","orcid":"https://orcid.org/0000-0003-1168-0606","observed_orcids":["https://orcid.org/0000-0003-1168-0606"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Kanada","raw_affiliation_strings":["RIKEN Compass to Healthy Life Research Complex Program, 6-3-5, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Compass to Healthy Life Research Complex Program, 6-3-5, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014758837","display_name":"Noriko Yanagitani","orcid":"https://orcid.org/0009-0000-9922-1214","observed_orcids":["https://orcid.org/0009-0000-9922-1214"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriko Yanagitani","raw_affiliation_strings":["Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045832805","display_name":"Atsushi Horiike","orcid":"https://orcid.org/0000-0002-1632-3125","observed_orcids":["https://orcid.org/0000-0002-1632-3125"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Horiike","raw_affiliation_strings":["Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112366993","display_name":"Sumie Koike","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sumie Koike","raw_affiliation_strings":["Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039203827","display_name":"Tomoko Oh\u2010hara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Oh-hara","raw_affiliation_strings":["Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113793905","display_name":"Kana Watanabe","orcid":"https://orcid.org/0000-0001-5139-5901","observed_orcids":["https://orcid.org/0000-0001-5139-5901"]},"institutions":[{"id":"https://openalex.org/I4210107389","display_name":"Miyagi Prefectural Hospital Organization","ror":"https://ror.org/01qt7mp11","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210107389"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kana Watanabe","raw_affiliation_strings":["Department of Respiratory Medicine, Miyagi Cancer Center, Miyagi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Miyagi Cancer Center, Miyagi, Japan","institution_ids":["https://openalex.org/I4210107389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016185391","display_name":"Keiichi Tamai","orcid":"https://orcid.org/0000-0003-0813-5885","observed_orcids":["https://orcid.org/0000-0003-0813-5885"]},"institutions":[{"id":"https://openalex.org/I4210107389","display_name":"Miyagi Prefectural Hospital Organization","ror":"https://ror.org/01qt7mp11","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210107389"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiichi Tamai","raw_affiliation_strings":["Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Miyagi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Miyagi, Japan","institution_ids":["https://openalex.org/I4210107389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007143858","display_name":"Makoto Maemondo","orcid":"https://orcid.org/0000-0002-1950-1943","observed_orcids":["https://orcid.org/0000-0002-1950-1943"]},"institutions":[{"id":"https://openalex.org/I4210107389","display_name":"Miyagi Prefectural Hospital Organization","ror":"https://ror.org/01qt7mp11","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210107389"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Maemondo","raw_affiliation_strings":["Department of Respiratory Medicine, Miyagi Cancer Center, Miyagi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Miyagi Cancer Center, Miyagi, Japan","institution_ids":["https://openalex.org/I4210107389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078287634","display_name":"Makoto Nishio","orcid":"https://orcid.org/0000-0003-4969-4165","observed_orcids":["https://orcid.org/0000-0003-4969-4165"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Nishio","raw_affiliation_strings":["Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085354248","display_name":"Takeshi Ishikawa","orcid":"https://orcid.org/0000-0002-3187-1381","observed_orcids":["https://orcid.org/0000-0002-3187-1381"]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Ishikawa","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3187-1381","affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046211758","display_name":"Yasushi Okuno","orcid":"https://orcid.org/0000-0003-3596-4208","observed_orcids":["https://orcid.org/0000-0003-3596-4208"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210129730","display_name":"RIKEN Center for Computational Science","ror":"https://ror.org/03r519674","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210129730"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Okuno","raw_affiliation_strings":["RIKEN Advanced Institute for Computational Science, 7-1-26 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan","Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan","RIKEN Advanced Institute for Computational Science, 7-1-26 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Advanced Institute for Computational Science, 7-1-26 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4210110652","https://openalex.org/I4210129730"]},{"raw_affiliation_string":"Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"RIKEN Advanced Institute for Computational Science, 7-1-26 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan","institution_ids":["https://openalex.org/I4210129730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000523070","display_name":"Naoya Fujita","orcid":"https://orcid.org/0000-0002-9631-9264","observed_orcids":["https://orcid.org/0000-0002-9631-9264"]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoya Fujita","raw_affiliation_strings":["Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan","Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan","Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011207225","display_name":"Ryohei Katayama","orcid":"https://orcid.org/0000-0001-7394-895X","observed_orcids":["https://orcid.org/0000-0001-7394-895X"]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ryohei Katayama","raw_affiliation_strings":["Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan. Electronic address: ryohei.katayama@jfcr.or.jp","Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7394-895X","affiliations":[{"raw_affiliation_string":"Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan. Electronic address: ryohei.katayama@jfcr.or.jp","institution_ids":["https://openalex.org/I42570316"]},{"raw_affiliation_string":"Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5011207225"],"corresponding_institution_ids":["https://openalex.org/I42570316"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":13.252,"has_fulltext":true,"cited_by_count":132,"citation_normalized_percentile":{"value":0.99301212,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"41","issue":null,"first_page":"105","last_page":"119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alk-rearrangement","display_name":"ALK rearrangement","score":0.8840000033378601},{"id":"https://openalex.org/keywords/alk-inhibitors","display_name":"ALK inhibitors","score":0.8240000009536743},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8610000014305115},{"id":"https://openalex.org/keywords/lorlatinib-resistance","display_name":"lorlatinib resistance","score":0.9020000100135803},{"id":"https://openalex.org/keywords/compound-mutations","display_name":"compound mutations","score":0.7110000252723694},{"id":"https://openalex.org/keywords/alectinib","display_name":"alectinib","score":0.8510000109672546},{"id":"https://openalex.org/keywords/bcr-abl-tyrosine-kinase-inhibitors","display_name":"BCR-ABL tyrosine kinase inhibitors","score":0.859000027179718},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.8560000061988831},{"id":"https://openalex.org/keywords/enu-mutagenesis","display_name":"ENU mutagenesis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/binding-free-energy","display_name":"binding free energy","score":0.824999988079071},{"id":"https://openalex.org/keywords/eml4-alk-fusion","display_name":"EML4-ALK fusion","score":0.8330000042915344},{"id":"https://openalex.org/keywords/ba-f3-cells","display_name":"Ba/F3 cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8420000076293945},{"id":"https://openalex.org/keywords/resistance-prediction","display_name":"resistance prediction","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2779220645","wikidata":"https://www.wikidata.org/wiki/Q21099132","display_name":"Alectinib","level":5,"score":0.8617112636566162},{"id":"https://openalex.org/C2779750558","wikidata":"https://www.wikidata.org/wiki/Q21011233","display_name":"Ceritinib","level":5,"score":0.7507117986679077},{"id":"https://openalex.org/C2779422266","wikidata":"https://www.wikidata.org/wiki/Q5186964","display_name":"Crizotinib","level":4,"score":0.6941109299659729},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6523947715759277},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.607771635055542},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5896806120872498},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5583018064498901},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5049958825111389},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49381503462791443},{"id":"https://openalex.org/C2778347629","wikidata":"https://www.wikidata.org/wiki/Q4652380","display_name":"ALK inhibitor","level":5,"score":0.46738114953041077},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32139846682548523},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26045578718185425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16534239053726196},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1296449899673462},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07797378301620483},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.07328727841377258},{"id":"https://openalex.org/C2776232967","wikidata":"https://www.wikidata.org/wiki/Q6743514","display_name":"Malignant pleural effusion","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077548","descriptor_name":"Anaplastic Lymphoma Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000077548","descriptor_name":"Anaplastic Lymphoma Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077548","descriptor_name":"Anaplastic Lymphoma Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000077548","descriptor_name":"Anaplastic Lymphoma Kinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000631","descriptor_name":"Aminopyridines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007769","descriptor_name":"Lactams","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047029","descriptor_name":"Lactams, Macrocyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047029","descriptor_name":"Lactams, Macrocyclic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1016/j.ebiom.2019.01.019","doi":"https://doi.org/10.1016/j.ebiom.2019.01.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2019.01.019","pdf_url":"http://www.thelancet.com/article/S2352396419300246/pdf","source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.3228884","doi":"https://doi.org/10.2139/ssrn.3228884","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.3228884","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:30662002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30662002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6441848","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6441848/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:01221:0004598141","doi":null,"is_oa":true,"landing_page_url":"https://repository.kulib.kyoto-u.ac.jp/bitstreams/cd5e0a53-91a3-4d28-bb0e-e1a81ae04521/download","pdf_url":"https://repository.kulib.kyoto-u.ac.jp/bitstreams/cd5e0a53-91a3-4d28-bb0e-e1a81ae04521/download","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EBioMedicine","raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:3388d031dc2d42b8a7c61b1d850adc34","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3388d031dc2d42b8a7c61b1d850adc34","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EBioMedicine, Vol 41, Iss , Pp 105-119 (2019)","raw_type":"article"},{"id":"pmh:oai:irdb.nii.ac.jp:01337:0006489792","doi":null,"is_oa":false,"landing_page_url":"https://iwatemed.repo.nii.ac.jp/records/2000769","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EBioMedicine","raw_type":"journal article"},{"id":"pmh:oai:iwatemed.repo.nii.ac.jp:02000769","doi":null,"is_oa":true,"landing_page_url":"https://iwatemed.repo.nii.ac.jp/records/2000769","pdf_url":null,"source":{"id":"https://openalex.org/S4306400948","display_name":"Iwate Medical University Repository (Iwate Medical University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I180680657","host_organization_name":"Iwate Medical University","host_organization_lineage":["https://openalex.org/I180680657"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"NA"},{"id":"pmh:oai:repository.kulib.kyoto-u.ac.jp:2433/255588","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2433/255588","pdf_url":null,"source":{"id":"https://openalex.org/S4306401454","display_name":"Kyoto University Research Information Repository (Kyoto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I22299242","host_organization_name":"Kyoto University","host_organization_lineage":["https://openalex.org/I22299242"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1016/j.ebiom.2019.01.019","doi":"https://doi.org/10.1016/j.ebiom.2019.01.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2019.01.019","pdf_url":"http://www.thelancet.com/article/S2352396419300246/pdf","source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1179016931","display_name":"Development of comprehensive calculation method of HLA-peptide affinity and application to elucidation of the pathogenesis of Behcet's disease","funder_award_id":"16K00397","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G1705227743","display_name":null,"funder_award_id":"JP15H02368","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G2461657676","display_name":null,"funder_award_id":"hp150272","funder_id":"https://openalex.org/F4320335125","funder_display_name":"RIKEN"},{"id":"https://openalex.org/G2505086439","display_name":"Drug sensitivity prediction for anaplastic lymphoma kinase mutants using molecular dynamics simulation and its informatics analysis","funder_award_id":"18K06594","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G292258429","display_name":null,"funder_award_id":"JP17H06327","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3080054588","display_name":null,"funder_award_id":"hp170275","funder_id":"https://openalex.org/F4320335125","funder_display_name":"RIKEN"},{"id":"https://openalex.org/G3301973260","display_name":"Susceptibility HLA alleles and the biological contribution of HLA for the pathogenesis of Behcet's disease or Scleroderma in East Asia","funder_award_id":"16H05840","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G365416419","display_name":null,"funder_award_id":"hp160213","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G4880067104","display_name":null,"funder_award_id":"JP16H04715","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G4942754464","display_name":null,"funder_award_id":"JP17H06327","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G5332735229","display_name":"\u304c\u3093\u30ea\u30f3\u9178\u5316\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u56e0\u5b50\u306e\u6d3b\u6027\u5b9a\u91cf\u306b\u57fa\u3065\u304f\u65b0\u6b21\u5143\u85ac\u52b9\u4e88\u6e2c\u8a3a\u65ad\u30b7\u30b9\u30c6\u30e0\u306e\u958b\u767a","funder_award_id":"18ck0106231h0003","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G5488337805","display_name":null,"funder_award_id":"hp160213","funder_id":"https://openalex.org/F4320335125","funder_display_name":"RIKEN"},{"id":"https://openalex.org/G6018864816","display_name":null,"funder_award_id":"hp180186","funder_id":"https://openalex.org/F4320335125","funder_display_name":"RIKEN"},{"id":"https://openalex.org/G6259499347","display_name":null,"funder_award_id":"18cm0106203h0003","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G6452549759","display_name":null,"funder_award_id":"ra000018","funder_id":"https://openalex.org/F4320335125","funder_display_name":"RIKEN"},{"id":"https://openalex.org/G6983888849","display_name":"Molecular Recognition Mechanism of RNA aptamer","funder_award_id":"18K11536","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7108588028","display_name":"Molecular analysis of acquired resistance to targeted therapies and search for overcoming drugs","funder_award_id":"15H02368","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7359349745","display_name":"Drug resistance mechanisms and therapeutic strategies in rare driver oncogene positive cancers","funder_award_id":"16H04715","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7882366961","display_name":null,"funder_award_id":"17H06327","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G848843139","display_name":"Advanced Animal Model Support","funder_award_id":"16H06276","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320310465","display_name":"Takeda Pharmaceutical Company","ror":"https://ror.org/04hjbmv12"},{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320311435","display_name":"Vehicle Racing Commemorative Foundation","ror":"https://ror.org/03y44ky43"},{"id":"https://openalex.org/F4320311653","display_name":"Taiho Pharmaceutical","ror":"https://ror.org/02v50dx14"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320321177","display_name":"Fujifilm Corporation","ror":"https://ror.org/0493bmq37"},{"id":"https://openalex.org/F4320321945","display_name":"Ministry of Health, Labour and Welfare","ror":"https://ror.org/03mwa7s65"},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320324401","display_name":"Nippon Foundation","ror":"https://ror.org/05wszs827"},{"id":"https://openalex.org/F4320327845","display_name":"Ono Pharmaceutical","ror":"https://ror.org/022jefx64"},{"id":"https://openalex.org/F4320333003","display_name":"Chugai Pharmaceutical","ror":"https://ror.org/01vepzj85"},{"id":"https://openalex.org/F4320333376","display_name":"MSD K.K.","ror":"https://ror.org/01kaqxm37"},{"id":"https://openalex.org/F4320334037","display_name":"Loxo Oncology","ror":"https://ror.org/03abe5304"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2908885437.pdf","grobid_xml":"https://content.openalex.org/works/W2908885437.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1505421350","https://openalex.org/W1841532172","https://openalex.org/W1966078827","https://openalex.org/W1975723203","https://openalex.org/W1976161355","https://openalex.org/W1976499671","https://openalex.org/W1980989103","https://openalex.org/W2000545640","https://openalex.org/W2012064062","https://openalex.org/W2021876472","https://openalex.org/W2022950330","https://openalex.org/W2042695020","https://openalex.org/W2043225209","https://openalex.org/W2050249255","https://openalex.org/W2055402151","https://openalex.org/W2055454070","https://openalex.org/W2067633683","https://openalex.org/W2069006374","https://openalex.org/W2099530756","https://openalex.org/W2131260498","https://openalex.org/W2131288855","https://openalex.org/W2145540054","https://openalex.org/W2147993766","https://openalex.org/W2153387139","https://openalex.org/W2157687487","https://openalex.org/W2163523622","https://openalex.org/W2170144893","https://openalex.org/W2205667543","https://openalex.org/W2299266038","https://openalex.org/W2329989100","https://openalex.org/W2345320779","https://openalex.org/W2482427906","https://openalex.org/W2533300620","https://openalex.org/W2536458995","https://openalex.org/W2560807575","https://openalex.org/W2570230847","https://openalex.org/W2591299832","https://openalex.org/W2613260339","https://openalex.org/W2624310346","https://openalex.org/W2797685139","https://openalex.org/W4317523379","https://openalex.org/W6683994117"],"related_works":["https://openalex.org/W2994602463","https://openalex.org/W4389410626","https://openalex.org/W7135068785","https://openalex.org/W2133422931","https://openalex.org/W4283168725","https://openalex.org/W2739890533","https://openalex.org/W2267327639","https://openalex.org/W2132840470","https://openalex.org/W7213947248","https://openalex.org/W4200419232"],"abstract_inverted_index":{"Background":[0],"Alectinib":[1],"has":[2,71],"shown":[3,39],"a":[4,118,169],"greater":[5],"efficacy":[6],"to":[7,21,40,43,52,103,149,152,187,221,227,256],"ALK":[8,29,250],"-rearranged":[9],"non-small-cell":[10],"lung":[11],"cancers":[12],"in":[13,28,55,95,113,139,167,178,196,209,273],"first-line":[14],"setting;":[15],"however,":[16],"most":[17],"patients":[18,57],"relapse":[19,56],"due":[20,51],"acquired":[22],"resistance,":[23],"such":[24],"as":[25,241,243],"secondary":[26],"mutations":[27,54,86,207,235,267],"including":[30,132],"I1171N":[31],"and":[32,156,177,195,236,268,285],"G1202R.":[33],"Although":[34],"ceritinib":[35,62],"or":[36,63,83,92,189],"lorlatinib":[37,222],"was":[38,278],"be":[41,150,262],"effective":[42],"these":[44,111,144,249],"resistant":[45,266],"mutants,":[46,131],"further":[47],"resistance":[48,70,220,272],"often":[49],"emerges":[50],"ALK-compound":[53,107,130,234],"following":[58],"the":[59,66,105,198,201,225,244,258],"use":[60],"of":[61,143,184,200],"lorlatinib.":[64],"However,":[65],"drug":[67,101,271],"for":[68,248,264,269],"overcoming":[69,270],"not":[72],"been":[73],"established":[74,78],"yet.":[75],"Methods":[76],"We":[77,99,126,230],"lorlatinib-resistant":[79,106,129,140,232],"cells":[80,194],"harboring":[81],"ALK-I1171N":[82],"-G1202R":[84],"compound":[85,145],"by":[87,205,281],"performing":[88],"ENU":[89],"mutagenesis":[90],"screening":[91,102],"using":[93],"an":[94,237],"vivo":[96],"mouse":[97],"model.":[98],"performed":[100],"overcome":[104],"mutations.":[108,251],"To":[109],"evaluate":[110],"resistances":[112],"silico":[114],",":[115],"we":[116,165],"developed":[117],"modified":[119],"computational":[120,163,254],"molecular":[121],"dynamic":[122],"simulation":[123,213,255],"(MP-CAFEE).":[124],"Findings":[125],"identified":[127],"14":[128],"several":[133,157,185],"mutants":[134,146],"that":[135,215],"were":[136,147],"recently":[137],"discovered":[138,231],"patients.":[141],"Some":[142],"found":[148,208],"sensitive":[151],"early":[153],"generation":[154],"ALK-TKIs":[155,186],"BCR-ABL":[158],"inhibitors.":[159],"Using":[160],"our":[161],"original":[162,253],"simulation,":[164],"succeeded":[166],"demonstrating":[168],"clear":[170],"linear":[171],"correlation":[172],"between":[173],"binding":[174,202,259],"free":[175],"energy":[176],"vitro":[179],"experimental":[180],"IC":[181],"50":[182],"value":[183],"single-":[188],"compound-mutated":[190],"EML4-ALK":[191],"expressing":[192],"Ba/F3":[193],"recapitulating":[197],"tendency":[199],"affinity":[203,260],"reduction":[204],"double":[206],"this":[210],"study.":[211],"Computational":[212],"revealed":[214],"ALK-L1256F":[216],"single":[217,239],"mutant":[218],"conferred":[219],"but":[223],"increased":[224],"sensitivity":[226],"alectinib.":[228],"Interpretation":[229],"multiple":[233],"L1256F":[238],"mutation":[240],"well":[242],"potential":[245],"therapeutic":[246],"strategies":[247],"Our":[252],"calculate":[257],"may":[261],"applicable":[263],"predicting":[265],"silico.":[274],"Fund":[275],"This":[276],"work":[277],"mainly":[279],"supported":[280],"MEXT/JSPS":[282],"KAKENHI":[283],"Grants":[284],"AMED":[286],"Grants.":[287]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":28},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-01-25T00:00:00"}