{"id":"https://openalex.org/W2908472980","doi":"https://doi.org/10.1021/acs.jmedchem.8b01408","title":"Triazole-Based Inhibitors of the Wnt/\u03b2-Catenin Signaling Pathway Improve Glucose and Lipid Metabolisms in Diet-Induced Obese Mice","display_name":"Triazole-Based Inhibitors of the Wnt/\u03b2-Catenin Signaling Pathway Improve Glucose and Lipid Metabolisms in Diet-Induced Obese Mice","publication_year":2019,"publication_date":"2019-01-03","ids":{"openalex":"https://openalex.org/W2908472980","doi":"https://doi.org/10.1021/acs.jmedchem.8b01408","mag":"2908472980","pmid":"https://pubmed.ncbi.nlm.nih.gov/30605343","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7187680"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.8b01408","doi":"https://doi.org/10.1021/acs.jmedchem.8b01408","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.8b01408","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7187680","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063254697","display_name":"Obinna N. Obianom","orcid":"https://orcid.org/0000-0002-2957-6615","observed_orcids":["https://orcid.org/0000-0002-2957-6615"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Obinna N. Obianom","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101955578","display_name":"Yong Ai","orcid":"https://orcid.org/0000-0002-7598-7992","observed_orcids":["https://orcid.org/0000-0002-7598-7992"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Ai","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100700498","display_name":"Yingjun Li","orcid":"https://orcid.org/0000-0002-8376-1811","observed_orcids":["https://orcid.org/0000-0002-8376-1811","https://orcid.org/0000-0002-8339-2104"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingjun Li","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100663926","display_name":"Wei Yang","orcid":"https://orcid.org/0000-0002-7083-7872","observed_orcids":["https://orcid.org/0000-0002-7083-7872"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Yang","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017542783","display_name":"Dong Guo","orcid":"https://orcid.org/0000-0002-1055-482X","observed_orcids":["https://orcid.org/0000-0002-1055-482X"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Guo","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Yang","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066699283","display_name":"Srilatha Sakamuru","orcid":"https://orcid.org/0000-0002-9693-1832","observed_orcids":["https://orcid.org/0000-0002-9693-1832"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srilatha Sakamuru","raw_affiliation_strings":["National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892-3375, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892-3375, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038035464","display_name":"Menghang Xia","orcid":"https://orcid.org/0000-0001-7285-8469","observed_orcids":["https://orcid.org/0000-0001-7285-8469"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Menghang Xia","raw_affiliation_strings":["National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892-3375, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892-3375, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071398691","display_name":"Fengtian Xue","orcid":"https://orcid.org/0000-0002-4132-9887","observed_orcids":["https://orcid.org/0000-0002-4132-9887"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fengtian Xue","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States"],"raw_orcid":"https://orcid.org/0000-0002-4132-9887","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065113416","display_name":"Yan Shu","orcid":"https://orcid.org/0000-0001-8492-1437","observed_orcids":["https://orcid.org/0000-0001-8492-1437"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Yan Shu","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States","School and Hospital of Stomatology, Guangzhou Medical University, Guangzhou 510140, China"],"raw_orcid":"https://orcid.org/0000-0001-8492-1437","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"School and Hospital of Stomatology, Guangzhou Medical University, Guangzhou 510140, China","institution_ids":["https://openalex.org/I92039509"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5065113416","https://openalex.org/A5071398691"],"corresponding_institution_ids":["https://openalex.org/I126744593","https://openalex.org/I92039509"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.0656,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.73695943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"62","issue":"2","first_page":"727","last_page":"741"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.925000011920929},{"id":"https://openalex.org/keywords/beta-catenin-degradation","display_name":"\u03b2-catenin degradation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hepatic-lipid-accumulation","display_name":"hepatic lipid accumulation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.925000011920929},{"id":"https://openalex.org/keywords/high-fat-diet-induced-obesity","display_name":"high-fat diet-induced obesity","score":0.8119999766349792},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.6179999709129333},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":0.8709999918937683},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.6909999847412109},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.6200000047683716},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.9118034839630127},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6109724044799805},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.5761262774467468},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5662696361541748},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.5457469820976257},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.45969951152801514},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43239808082580566},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4267916679382324},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4266129434108734},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.41323620080947876},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38426411151885986},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35701656341552734},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3516419231891632},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20970743894577026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12154623866081238}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018021","descriptor_name":"Lithium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jmedchem.8b01408","doi":"https://doi.org/10.1021/acs.jmedchem.8b01408","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.8b01408","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:30605343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30605343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7187680","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7187680","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Med Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7187680","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7187680","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Med Chem","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3338188491","display_name":"Xenobiotic Transporter Regulation and IRIP Function","funder_award_id":"R01GM099742","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3494643047","display_name":null,"funder_award_id":"Z99 TR999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5406285613","display_name":null,"funder_award_id":"21702073","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6458222290","display_name":null,"funder_award_id":"HAC201706","funder_id":"https://openalex.org/F4320327495","funder_display_name":"Huai\u2019an Science and Technology Bureau"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327495","display_name":"Huai\u2019an Science and Technology Bureau","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1525802878","https://openalex.org/W1900557155","https://openalex.org/W1965141016","https://openalex.org/W1966650637","https://openalex.org/W1969717239","https://openalex.org/W1978139115","https://openalex.org/W1990563353","https://openalex.org/W1993600822","https://openalex.org/W1994029539","https://openalex.org/W1994928797","https://openalex.org/W2004170013","https://openalex.org/W2006419043","https://openalex.org/W2007145040","https://openalex.org/W2013810503","https://openalex.org/W2026742412","https://openalex.org/W2030451770","https://openalex.org/W2034373020","https://openalex.org/W2035192365","https://openalex.org/W2043509228","https://openalex.org/W2044531485","https://openalex.org/W2057257265","https://openalex.org/W2057488198","https://openalex.org/W2057507857","https://openalex.org/W2058043554","https://openalex.org/W2067387842","https://openalex.org/W2082514180","https://openalex.org/W2082793267","https://openalex.org/W2083981646","https://openalex.org/W2087104293","https://openalex.org/W2094999489","https://openalex.org/W2095365870","https://openalex.org/W2120955230","https://openalex.org/W2124135976","https://openalex.org/W2129854864","https://openalex.org/W2137666062","https://openalex.org/W2139970987","https://openalex.org/W2141664611","https://openalex.org/W2144796426","https://openalex.org/W2145297900","https://openalex.org/W2156172510","https://openalex.org/W2165061154","https://openalex.org/W2177609936","https://openalex.org/W2184961837","https://openalex.org/W2194842760","https://openalex.org/W2289501098","https://openalex.org/W2313662343","https://openalex.org/W2324486771","https://openalex.org/W2342039626","https://openalex.org/W2421886702","https://openalex.org/W2746886892","https://openalex.org/W2797339699"],"related_works":["https://openalex.org/W3177340538","https://openalex.org/W2766989115","https://openalex.org/W3016104452","https://openalex.org/W4389026433","https://openalex.org/W3015049651","https://openalex.org/W2194842760","https://openalex.org/W7014649738","https://openalex.org/W4408800879","https://openalex.org/W4391160448","https://openalex.org/W2051647616"],"abstract_inverted_index":{"Wnt/\u03b2-catenin":[0,52,85],"signaling":[1,53,86],"pathway":[2,23],"is":[3],"implicated":[4],"in":[5,27,87,101,126],"the":[6,38,64,75,84,123,127,143],"etiology":[7],"and":[8,45,55,80,92,129],"progression":[9],"of":[10,15,21,50,63,78,83,90,113,145],"metabolic":[11,146],"disorders.":[12,147],"Although":[13],"lines":[14],"genetic":[16,40],"evidence":[17],"suggest":[18],"that":[19],"blockage":[20],"this":[22],"yields":[24],"favorable":[25],"outcomes":[26],"treating":[28],"such":[29],"ailments,":[30],"few":[31],"inhibitors":[32,54,135],"have":[33],"been":[34],"used":[35],"to":[36,74,138],"validate":[37],"promising":[39],"findings.":[41],"Here,":[42],"we":[43],"synthesized":[44],"characterized":[46],"a":[47],"novel":[48],"class":[49],"triazole-based":[51],"assessed":[56],"their":[57],"effects":[58],"on":[59],"energy":[60],"metabolism.":[61],"One":[62],"top":[65],"inhibitors,":[66],"compound":[67,98,108],"3a,":[68],"promoted":[69],"Axin":[70],"stabilization,":[71],"which":[72],"led":[73],"proteasome":[76],"degradation":[77],"\u03b2-catenin":[79],"subsequent":[81],"inhibition":[82],"cells.":[88],"Treatment":[89],"hepatocytes":[91],"high":[93,114],"fat":[94,115],"diet-fed":[95,116],"mice":[96,117],"with":[97],"3a":[99,109],"resulted":[100],"significantly":[102],"decreased":[103],"hepatic":[104],"lipid":[105],"accumulation.":[106],"Moreover,":[107],"improved":[110],"glucose":[111,128],"tolerance":[112],"without":[118],"noticeable":[119],"toxicity,":[120],"while":[121],"downregulating":[122],"genes":[124],"involved":[125],"fatty":[130],"acid":[131],"anabolisms.":[132],"The":[133],"new":[134],"are":[136],"expected":[137],"be":[139],"further":[140],"developed":[141],"for":[142],"treatment":[144]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-01-11T00:00:00"}
