{"id":"https://openalex.org/W2908427159","doi":"https://doi.org/10.1200/jco.2018.36.4_suppl.828","title":"Clinical outcome and prognosis of metastatic colorectal cancer (mCRC) patients (pts) on phase 1 trials: A single institution experience from 1999 to 2016.","display_name":"Clinical outcome and prognosis of metastatic colorectal cancer (mCRC) patients (pts) on phase 1 trials: A single institution experience from 1999 to 2016.","publication_year":2018,"publication_date":"2018-02-01","ids":{"openalex":"https://openalex.org/W2908427159","doi":"https://doi.org/10.1200/jco.2018.36.4_suppl.828","mag":"2908427159"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2018.36.4_suppl.828","doi":"https://doi.org/10.1200/jco.2018.36.4_suppl.828","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.4_suppl.828","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019790700","display_name":"Audrey E. Kam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Audrey E. Kam","raw_affiliation_strings":["Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040390329","display_name":"Gopichand Pendurti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gopichand Pendurti","raw_affiliation_strings":["Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Umang H. Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Umang H. Shah","raw_affiliation_strings":["Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111845710","display_name":"Mohammad Haroon Ghalib","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Haroon Ghalib","raw_affiliation_strings":["Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073337703","display_name":"Imran Chaudhary","orcid":"https://orcid.org/0000-0003-0234-1602","observed_orcids":["https://orcid.org/0000-0003-0234-1602"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Imran Chaudhary","raw_affiliation_strings":["Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071784908","display_name":"Sengottuvel Viswanathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sengottuvel Viswanathan","raw_affiliation_strings":["Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027641455","display_name":"Ioannis Mantzaris","orcid":"https://orcid.org/0000-0001-8346-5767","observed_orcids":["https://orcid.org/0000-0001-8346-5767"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ioannis Mantzaris","raw_affiliation_strings":["Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY;","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029455802","display_name":"Sanjay Goel","orcid":"https://orcid.org/0000-0002-2798-7568","observed_orcids":["https://orcid.org/0000-0002-2798-7568"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjay Goel","raw_affiliation_strings":["Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY;","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"4_suppl","first_page":"828","last_page":"828"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7760000228881836},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9980000257492065},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.6269999742507935},{"id":"https://openalex.org/keywords/treatment-related-mortality","display_name":"non-relapse mortality","score":0.6690000295639038},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.5339999794960022},{"id":"https://openalex.org/keywords/conjugated-bilirubin","display_name":"direct bilirubin","score":0.8759999871253967},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.878000020980835},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.5339999794960022},{"id":"https://openalex.org/keywords/performance-status","display_name":"performance status","score":0.5070000290870667},{"id":"https://openalex.org/keywords/clinical-benefit-rate","display_name":"clinical benefit rate","score":0.5130000114440918},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8840000033378601},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.40299999713897705},{"id":"https://openalex.org/keywords/patient-selection-for-clinical-trials","display_name":"patient selection for clinical trials","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9500945806503296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7379693984985352},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6032150983810425},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.5976016521453857},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.557799220085144},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.486405611038208},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4717232584953308},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.43443411588668823},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3659154772758484},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34575629234313965},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.34265661239624023},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33318087458610535}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2018.36.4_suppl.828","doi":"https://doi.org/10.1200/jco.2018.36.4_suppl.828","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.4_suppl.828","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2896909095","https://openalex.org/W4281844401","https://openalex.org/W2955450919","https://openalex.org/W4410805476","https://openalex.org/W2598940302","https://openalex.org/W4318904030","https://openalex.org/W7148924862","https://openalex.org/W2088286383","https://openalex.org/W4394903835","https://openalex.org/W2599655299"],"abstract_inverted_index":{"828":[0],"Background:":[1],"Pts":[2],"with":[3,47,92,278,307,364],"mCRC":[4,35,48,308],"who":[5],"progress":[6],"on":[7,50,97,273,310,358],"all":[8],"standard":[9],"therapies":[10,114,329],"have":[11],"a":[12,23,173,279,290,315,365,369],"poor":[13],"prognosis":[14],"and":[15,32,66,81,109,133,141,148,162,249,267,298,319,332,350],"limited":[16],"therapy":[17],"options.":[18],"Phase":[19],"1":[20,182,312,382],"trials":[21,53,313],"represent":[22],"valuable":[24],"treatment":[25],"option.":[26],"Herein":[27],"we":[28],"report":[29],"the":[30,134,169],"characteristics":[31],"outcomes":[33],"of":[34,45,112,150,187,281,292,317,322],"patients":[36,95,120,277,363,379],"treated":[37],"at":[38,54],"our":[39,55],"institution.":[40],"Methods:":[41],"We":[42,88],"reviewed":[43],"records":[44],"pts":[46],"enrolled":[49,309],"phase":[51,99,311,381],"I":[52,100],"institution":[56],"from":[57],"January":[58],"1999":[59],"to":[60,289],"December":[61],"2016.":[62],"Treatment-related":[63,153],"response,":[64],"toxicity,":[65],"deaths":[67],"were":[68,76,121,144,258],"recorded.":[69],"Prognostic":[70],"factors":[71,261,336],"for":[72,123,262,265,337,380],"overall":[73],"survival":[74],"(OS)":[75],"calculated":[77],"using":[78],"univariate":[79],"(UVA)":[80],"multivariable":[82],"Cox":[83],"PH":[84],"analysis":[85],"(MVA).":[86],"Results:":[87],"observed":[89],"187":[90],"enrollments":[91],"152":[93],"unique":[94],"accrued":[96],"37":[98],"trials.":[101,383],"Median":[102,157],"age":[103,176,225,340],"was":[104,115,131,136,155,159,164],"59":[105],"years":[106],"(range":[107,117],"29-83)":[108],"median":[110,320],"number":[111],"prior":[113],"3":[116,299],"0-8).":[118],"144":[119],"evaluable":[122],"response.":[124],"The":[125],"clinical":[126],"benefit":[127],"rate":[128],"(SD+response,":[129],"CBR)":[130],"33.2%":[132,318],"ORR":[135],"4.3%.":[137],"Grade":[138],"3/4":[139],"non-hematological":[140],"hematological":[142],"AE":[143],"seen":[145],"in":[146,377],"25.5%":[147],"17.3%":[149],"patients,":[151],"respectively.":[152],"mortality":[154],"0.5%.":[156],"PFS":[158],"1.7":[160],"mos":[161],"OS":[163,286,321,338],"8.2":[165,323],"mos.":[166],"In":[167,223],"UVA,":[168],"following":[170],"variables":[171],"predicted":[172],"shorter":[174,371],"OS:":[175],"(p":[177,183,191,197,203,210,216,220],"=":[178,192,211,217,221],"0.049);":[179],"PS":[180],">":[181,189,195,208,214,226,243,251,341,348,352],"<":[184,198,201,204,231,234,239,247,256,296,303,344],"0.01);":[185],"sites":[186],"metastases":[188],"2":[190,293],"0.04);":[193],"LDH":[194],"ULN":[196,209,244],"0.001);":[199,205,218],"albumin":[200,233,343],"3.5":[202,235],"direct":[206,241,346],"bilirubin":[207,242,347],"0.02);":[212],"WBC":[213,250,351],"5.2":[215,252],"anemia":[219],"0.046).":[222],"MVA,":[224],"60":[227],"(HR":[228,236,253],"1.63,":[229],"p":[230,238,246,255],"0.004),":[232],"3.69,":[237],"0.001),":[240],"(HR1.69,":[245],"0.01),":[248],"1.97,":[254],"0.001)":[257],"negative":[259],"prognostic":[260,335],"OS,":[263,372],"adjusted":[264],"race":[266],"sex.":[268],"A":[269,354],"risk":[270,355],"score":[271,280,291,356,367],"based":[272,357],"MVA":[274],"revealed":[275],"that":[276,362],"0-1":[282],"had":[283,314,368],"an":[284],"improved":[285],"(12.5mos)":[287],"compared":[288],"(9.1mos,":[294],"p-value":[295,302],"0.005)":[297],"(3.2":[300],"mos,":[301,324],"0.001).":[304],"Conclusions:":[305],"Patients":[306],"CBR":[316],"which":[325,373],"exceeds":[326],"third":[327],"line":[328],"including":[330],"regorafenib":[331],"trifluridine/tipiracil.":[333],"Negative":[334],"were:":[339],"60,":[342],"3.5,":[345],"ULN,":[349],"5.2.":[353],"these":[359],"parameters":[360],"showed":[361],"higher":[366],"significantly":[370],"may":[374],"be":[375],"useful":[376],"selecting":[378]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2019-01-11T00:00:00"}