{"id":"https://openalex.org/W2908070528","doi":"https://doi.org/10.1039/c8an02253d","title":"A cascade amplification platform assisted with DNAzyme for activity analysis, kinetic study and effector screening of Fpg in vitro","display_name":"A cascade amplification platform assisted with DNAzyme for activity analysis, kinetic study and effector screening of Fpg in vitro","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2908070528","doi":"https://doi.org/10.1039/c8an02253d","mag":"2908070528","pmid":"https://pubmed.ncbi.nlm.nih.gov/30663736"},"language":"en","primary_location":{"id":"doi:10.1039/c8an02253d","doi":"https://doi.org/10.1039/c8an02253d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8an02253d","pdf_url":null,"source":{"id":"https://openalex.org/S105746325","display_name":"The Analyst","issn_l":"0003-2654","issn":["0003-2654","1364-5528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Analyst","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043032942","display_name":"Wenya Dang","orcid":"https://orcid.org/0009-0005-4479-6295","observed_orcids":["https://orcid.org/0009-0005-4479-6295"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenya Dang","raw_affiliation_strings":["Changsha","China","College of Biology","Hunan University","College of Biology, Hunan University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changsha","institution_ids":[]},{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"College of Biology","institution_ids":[]},{"raw_affiliation_string":"Hunan University","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"College of Biology, Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032243659","display_name":"Chunyi Tong","orcid":"https://orcid.org/0000-0003-1153-5791","observed_orcids":["https://orcid.org/0000-0003-1153-5791"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunyi Tong","raw_affiliation_strings":["Changsha","China","College of Biology","Hunan University","College of Biology, Hunan University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0003-1153-5791","affiliations":[{"raw_affiliation_string":"Changsha","institution_ids":[]},{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"College of Biology","institution_ids":[]},{"raw_affiliation_string":"Hunan University","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"College of Biology, Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101601058","display_name":"Yupei Yang","orcid":"https://orcid.org/0000-0002-8452-8616","observed_orcids":["https://orcid.org/0000-0002-8452-8616","https://orcid.org/0000-0002-1436-4775"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yupei Yang","raw_affiliation_strings":["Changsha","Hunan University of Chinese Medicine","Innovative Material Medical Research Institute","School of Pharmacy","TCM and Ethnomedicine Innovation & Development International Laboratory","TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Material Medical Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changsha","institution_ids":[]},{"raw_affiliation_string":"Hunan University of Chinese Medicine","institution_ids":[]},{"raw_affiliation_string":"Innovative Material Medical Research Institute","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"TCM and Ethnomedicine Innovation & Development International Laboratory","institution_ids":[]},{"raw_affiliation_string":"TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Material Medical Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025864622","display_name":"Yongbei Liu","orcid":"https://orcid.org/0000-0002-7255-8543","observed_orcids":["https://orcid.org/0000-0002-7255-8543"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongbei Liu","raw_affiliation_strings":["Changsha","Hunan University of Chinese Medicine","Innovative Material Medical Research Institute","School of Pharmacy","TCM and Ethnomedicine Innovation & Development International Laboratory","TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Material Medical Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changsha","institution_ids":[]},{"raw_affiliation_string":"Hunan University of Chinese Medicine","institution_ids":[]},{"raw_affiliation_string":"Innovative Material Medical Research Institute","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"TCM and Ethnomedicine Innovation & Development International Laboratory","institution_ids":[]},{"raw_affiliation_string":"TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Material Medical Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100395415","display_name":"Bin Liu","orcid":"https://orcid.org/0000-0001-5574-3547","observed_orcids":["https://orcid.org/0000-0001-5574-3547","https://orcid.org/0009-0003-0761-622X"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bin Liu","raw_affiliation_strings":["Changsha","China","College of Biology","Hunan University","College of Biology, Hunan University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0001-5574-3547","affiliations":[{"raw_affiliation_string":"Changsha","institution_ids":[]},{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"College of Biology","institution_ids":[]},{"raw_affiliation_string":"Hunan University","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"College of Biology, Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020551774","display_name":"Hongyan Zhou","orcid":"https://orcid.org/0000-0002-9878-2519","observed_orcids":["https://orcid.org/0000-0002-9878-2519"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyan Zhou","raw_affiliation_strings":["Changsha","China","College of Biology","Hunan University","College of Biology, Hunan University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changsha","institution_ids":[]},{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"College of Biology","institution_ids":[]},{"raw_affiliation_string":"Hunan University","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"College of Biology, Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100392171","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0003-0876-2205","observed_orcids":["https://orcid.org/0000-0003-0876-2205"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Changsha","Hunan University of Chinese Medicine","Innovative Material Medical Research Institute","School of Pharmacy","TCM and Ethnomedicine Innovation & Development International Laboratory","TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Material Medical Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0003-0876-2205","affiliations":[{"raw_affiliation_string":"Changsha","institution_ids":[]},{"raw_affiliation_string":"Hunan University of Chinese Medicine","institution_ids":[]},{"raw_affiliation_string":"Innovative Material Medical Research Institute","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"TCM and Ethnomedicine Innovation & Development International Laboratory","institution_ids":[]},{"raw_affiliation_string":"TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Material Medical Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China","institution_ids":["https://openalex.org/I14992734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100392171","https://openalex.org/A5100395415"],"corresponding_institution_ids":["https://openalex.org/I14992734","https://openalex.org/I16609230"],"apc_list":null,"apc_paid":null,"fwci":0.7325,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.64287908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"144","issue":"5","first_page":"1731","last_page":"1740"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.8309999704360962},{"id":"https://openalex.org/keywords/dnazyme","display_name":"DNAzyme","score":0.9539999961853027},{"id":"https://openalex.org/keywords/8-oxoguanine","display_name":"8-oxoguanine","score":0.9150000214576721},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.5839999914169312},{"id":"https://openalex.org/keywords/turn-on-fluorescence-sensing","display_name":"turn-on fluorescence sensing","score":0.6119999885559082},{"id":"https://openalex.org/keywords/enzyme-activity-assay","display_name":"enzyme activity assay","score":0.875},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.847000002861023},{"id":"https://openalex.org/keywords/natural-compounds","display_name":"natural compounds","score":0.5960000157356262},{"id":"https://openalex.org/keywords/antibiotics","display_name":"antibiotics","score":0.9010000228881836},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.921999990940094}],"concepts":[{"id":"https://openalex.org/C84211826","wikidata":"https://www.wikidata.org/wiki/Q5260078","display_name":"Deoxyribozyme","level":3,"score":0.7302534580230713},{"id":"https://openalex.org/C34146451","wikidata":"https://www.wikidata.org/wiki/Q5048094","display_name":"Cascade","level":2,"score":0.7041323184967041},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6767413020133972},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6735817790031433},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5821908712387085},{"id":"https://openalex.org/C135889238","wikidata":"https://www.wikidata.org/wiki/Q46276","display_name":"Kinetic energy","level":2,"score":0.45075908303260803},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3293300271034241},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3219877779483795},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2919934093952179},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2687819004058838},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21562564373016357},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.13617175817489624},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0803307592868805},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021141","descriptor_name":"Nucleic Acid Amplification Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D021881","descriptor_name":"DNA, Catalytic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D021881","descriptor_name":"DNA, Catalytic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043382","descriptor_name":"DNA-Formamidopyrimidine Glycosylase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D043382","descriptor_name":"DNA-Formamidopyrimidine Glycosylase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/c8an02253d","doi":"https://doi.org/10.1039/c8an02253d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8an02253d","pdf_url":null,"source":{"id":"https://openalex.org/S105746325","display_name":"The Analyst","issn_l":"0003-2654","issn":["0003-2654","1364-5528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Analyst","raw_type":"journal-article"},{"id":"pmid:30663736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30663736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Analyst","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G538763904","display_name":null,"funder_award_id":"31672457]","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6849258833","display_name":null,"funder_award_id":"81673579","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W756257249","https://openalex.org/W1966268604","https://openalex.org/W1967839472","https://openalex.org/W1968523828","https://openalex.org/W1974423992","https://openalex.org/W1976385056","https://openalex.org/W1992726876","https://openalex.org/W2001797502","https://openalex.org/W2005948571","https://openalex.org/W2012342785","https://openalex.org/W2025810782","https://openalex.org/W2033256459","https://openalex.org/W2036094361","https://openalex.org/W2039827463","https://openalex.org/W2042937673","https://openalex.org/W2047155236","https://openalex.org/W2053976068","https://openalex.org/W2058259339","https://openalex.org/W2070233466","https://openalex.org/W2080490029","https://openalex.org/W2080688269","https://openalex.org/W2093863716","https://openalex.org/W2097774527","https://openalex.org/W2104403287","https://openalex.org/W2118499190","https://openalex.org/W2123847150","https://openalex.org/W2128173045","https://openalex.org/W2142827760","https://openalex.org/W2159876240","https://openalex.org/W2208770207","https://openalex.org/W2275290421","https://openalex.org/W2549534074","https://openalex.org/W2553169723","https://openalex.org/W2589014390","https://openalex.org/W2611492763","https://openalex.org/W2615642857","https://openalex.org/W2692689761","https://openalex.org/W2736255620","https://openalex.org/W2755230241","https://openalex.org/W2766252413","https://openalex.org/W2788805903","https://openalex.org/W4251393168"],"related_works":["https://openalex.org/W3024082011","https://openalex.org/W4403885936","https://openalex.org/W2692689761","https://openalex.org/W4390859605","https://openalex.org/W3036835313","https://openalex.org/W2788805903","https://openalex.org/W3162723099","https://openalex.org/W2045741139","https://openalex.org/W4406938677","https://openalex.org/W4385923954"],"abstract_inverted_index":{"As":[0],"a":[1,15,21,40,48,76],"highly":[2,41],"conserved":[3],"damage":[4],"repair":[5],"protein,":[6],"Fpg":[7,45,68,101,119,146,164],"can":[8,27],"specifically":[9],"recognize":[10],"and":[11,123,135],"digest":[12],"8-oxoG":[13],"from":[14,79,120],"damaged":[16],"DNA":[17,23],"backbone.":[18],"Meanwhile,":[19],"DNAzyme,":[20],"single-stranded":[22],"with":[24,75,102],"enzymatic":[25],"activity,":[26],"cleave":[28],"RNA":[29],"in":[30,147,174],"the":[31,56,61,97,108,116,131,155,175],"presence":[32],"of":[33,60,100,104,118,130,138],"cofactors.":[34],"In":[35,88,149],"this":[36,90],"study,":[37],"we":[38,64],"established":[39],"sensitive":[42],"method":[43,156],"for":[44,162,171],"assay":[46],"using":[47],"DNAzyme-mediated":[49],"signal":[50],"cascade":[51],"amplification":[52],"strategy.":[53],"Based":[54],"on":[55,145],"Fpg-dependent":[57],"fluorescence":[58],"response":[59,78],"\"turn-on\"":[62],"manner,":[63],"could":[65],"reliably":[66],"determine":[67],"activity":[69,165],"down":[70],"to":[71,81,95,114],"0.14":[72],"U":[73,83],"mL-1":[74,84],"linear":[77],"0.10":[80],"40":[82],"under":[85],"optimal":[86],"conditions.":[87],"addition,":[89],"strategy":[91],"was":[92,112],"successfully":[93],"applied":[94],"analyze":[96],"kinetic":[98],"parameter":[99],"Km":[103],"0.061":[105],"\u03bcM.":[106],"Furthermore,":[107],"developed":[109],"sensing":[110],"system":[111],"used":[113],"screen":[115],"regulators":[117],"natural":[121,133],"compounds":[122,134],"antibiotics.":[124],"These":[125],"results":[126,152],"indicated":[127],"that":[128,154],"all":[129],"14":[132],"6":[136],"kinds":[137],"antibiotics":[139],"deferentially":[140],"showed":[141],"an":[142,160],"active":[143],"effect":[144],"vitro.":[148],"summary,":[150],"these":[151],"show":[153],"not":[157],"only":[158],"provides":[159],"alternative":[161],"monitoring":[163],"but":[166],"also":[167],"shows":[168],"great":[169],"potential":[170],"drug":[172],"screening":[173],"future.":[176]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-01-11T00:00:00"}