{"id":"https://openalex.org/W2908006163","doi":"https://doi.org/10.1002/cam4.1878","title":"Oxaliplatin regulates myeloid\u2010derived suppressor cell\u2010mediated immunosuppression via downregulation of nuclear factor\u2010\u03baB signaling","display_name":"Oxaliplatin regulates myeloid\u2010derived suppressor cell\u2010mediated immunosuppression via downregulation of nuclear factor\u2010\u03baB signaling","publication_year":2018,"publication_date":"2018-12-27","ids":{"openalex":"https://openalex.org/W2908006163","doi":"https://doi.org/10.1002/cam4.1878","mag":"2908006163","pmid":"https://pubmed.ncbi.nlm.nih.gov/30592157","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6346236"},"language":"en","primary_location":{"id":"doi:10.1002/cam4.1878","doi":"https://doi.org/10.1002/cam4.1878","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.1878","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.1878","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2908006163"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.1878","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063532984","display_name":"Narae Kim","orcid":"https://orcid.org/0000-0002-9255-4144","observed_orcids":["https://orcid.org/0000-0002-9255-4144"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Na\u2010Rae Kim","raw_affiliation_strings":["Laboratory of Microbiology and Immunology, College of Pharmacy, Inje University, Gimhae, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Microbiology and Immunology, College of Pharmacy, Inje University, Gimhae, Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101466740","display_name":"Yeon\u2010Jeong Kim","orcid":"https://orcid.org/0000-0002-5159-828X","observed_orcids":["https://orcid.org/0000-0002-5159-828X"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yeon\u2010Jeong Kim","raw_affiliation_strings":["Inje Institute of Pharmaceutical Science and Research, Inje University, Gimhae, Korea","Laboratory of Microbiology and Immunology, College of Pharmacy, Inje University, Gimhae, Korea"],"raw_orcid":"https://orcid.org/0000-0002-5159-828X","affiliations":[{"raw_affiliation_string":"Inje Institute of Pharmaceutical Science and Research, Inje University, Gimhae, Korea","institution_ids":["https://openalex.org/I104338594"]},{"raw_affiliation_string":"Laboratory of Microbiology and Immunology, College of Pharmacy, Inje University, Gimhae, Korea","institution_ids":["https://openalex.org/I104338594"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101466740"],"corresponding_institution_ids":["https://openalex.org/I104338594"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":{"value":4700,"currency":"USD","value_usd":4700},"fwci":1.6594,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.82125074,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"276","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":1.0},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":1.0},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8130000233650208},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/polymorphonuclear-mdscs","display_name":"polymorphonuclear MDSCs","score":0.9380000233650208},{"id":"https://openalex.org/keywords/arginase-1","display_name":"arginase-1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/nadph-oxidase-2","display_name":"NADPH oxidase 2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mdsc-differentiation","display_name":"MDSC differentiation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6710000038146973},{"id":"https://openalex.org/keywords/platinum-based-anticancer-drugs","display_name":"platinum anticancer drugs","score":0.5950000286102295},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.8144031763076782},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.754310667514801},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5637192726135254},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.563494086265564},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.48412808775901794},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.46279239654541016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39115381240844727},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29004955291748047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.254682719707489},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19802433252334595},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.09321674704551697},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08846932649612427},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07822877168655396},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000072737","descriptor_name":"Myeloid-Derived Suppressor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000072737","descriptor_name":"Myeloid-Derived Suppressor Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/cam4.1878","doi":"https://doi.org/10.1002/cam4.1878","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.1878","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.1878","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5330431","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6346236","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30592157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30592157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6346236","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6346236/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/cam4.1878","doi":"https://doi.org/10.1002/cam4.1878","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.1878","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.1878","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4051796581","display_name":null,"funder_award_id":"NRF\u20102017R1D1A3B03029445","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321292","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2908006163.pdf","grobid_xml":"https://content.openalex.org/works/W2908006163.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1536324162","https://openalex.org/W1893184572","https://openalex.org/W1903844621","https://openalex.org/W1925817305","https://openalex.org/W1974800193","https://openalex.org/W1987564738","https://openalex.org/W1993442154","https://openalex.org/W1995684282","https://openalex.org/W1998074965","https://openalex.org/W2004150448","https://openalex.org/W2004445332","https://openalex.org/W2016317534","https://openalex.org/W2017357456","https://openalex.org/W2018820040","https://openalex.org/W2020074441","https://openalex.org/W2020106261","https://openalex.org/W2026881684","https://openalex.org/W2030733204","https://openalex.org/W2033708244","https://openalex.org/W2040986265","https://openalex.org/W2056608844","https://openalex.org/W2059409197","https://openalex.org/W2064084286","https://openalex.org/W2075496837","https://openalex.org/W2079068389","https://openalex.org/W2081498322","https://openalex.org/W2091394940","https://openalex.org/W2101490383","https://openalex.org/W2109069850","https://openalex.org/W2111415894","https://openalex.org/W2111504178","https://openalex.org/W2116127788","https://openalex.org/W2120539661","https://openalex.org/W2122731269","https://openalex.org/W2123900004","https://openalex.org/W2124185479","https://openalex.org/W2134724142","https://openalex.org/W2135079975","https://openalex.org/W2142851096","https://openalex.org/W2143994426","https://openalex.org/W2148803730","https://openalex.org/W2160229573","https://openalex.org/W2280777602","https://openalex.org/W2294393151","https://openalex.org/W2509089285","https://openalex.org/W2625023228","https://openalex.org/W2754823888","https://openalex.org/W2793959072"],"related_works":["https://openalex.org/W3177466467","https://openalex.org/W4388048394","https://openalex.org/W2981211513","https://openalex.org/W2810710338","https://openalex.org/W7118093017","https://openalex.org/W2586476117","https://openalex.org/W2109069850","https://openalex.org/W2401267803","https://openalex.org/W2912766931","https://openalex.org/W4392236196"],"abstract_inverted_index":{"Myeloid-derived":[0],"suppressor":[1],"cells":[2,12,20],"(MDSCs)":[3],"represent":[4],"one":[5],"of":[6,10,44,62,128,134,140,150],"the":[7,60,103,131,138,148,151,188,197],"major":[8],"types":[9],"immunoregulatory":[11,204],"present":[13],"under":[14],"abnormal":[15],"conditions,":[16],"including":[17],"cancer.":[18,110],"These":[19],"are":[21,40],"characterized":[22],"by":[23,84],"their":[24],"immature":[25],"phenotype":[26],"and":[27,37,48,89,93,136,158],"suppressive":[28],"effect":[29],"on":[30],"various":[31],"immune":[32,64],"effectors.":[33],"In":[34,95,124,184],"both":[35],"human":[36],"mouse,":[38],"there":[39],"two":[41],"main":[42],"subsets":[43],"MDSCs:":[45],"polymorphonuclear":[46],"(PMN)-MDSCs":[47],"mononuclear":[49],"(Mo)-MDSCs.":[50],"Thus,":[51,194],"strategies":[52],"to":[53,80,105,199],"regulate":[54,106],"MDSC-mediated":[55,107],"immunosuppression":[56,108],"could":[57],"result":[58],"in":[59,74,109,163,182,192,212],"enhancement":[61],"anticancer":[63,69],"responses.":[65],"Oxaliplatin,":[66],"a":[67,209],"platinum-based":[68],"agent,":[70,168],"is":[71,78],"widely":[72],"used":[73,201],"clinical":[75],"settings.":[76],"It":[77],"known":[79],"induce":[81],"cell":[82],"death":[83],"interfering":[85],"with":[86],"double-stranded":[87],"DNA":[88],"interrupting":[90],"its":[91],"replication":[92],"transcription.":[94],"this":[96],"study,":[97],"we":[98],"found":[99],"that":[100],"oxaliplatin":[101,112,129,186,195],"has":[102,196],"potential":[104,198],"First,":[111],"selectively":[113],"depleted":[114],"MDSCs,":[115,164],"especially":[116],"Mo-MDSCs,":[117],"but":[118],"only":[119],"minimally":[120],"affected":[121],"T":[122],"cells.":[123,144],"addition,":[125,185],"sublethal":[126],"doses":[127],"eliminated":[130],"immunosuppressive":[132,152],"capacity":[133],"MDSCs":[135,141,177],"induced":[137],"differentiation":[139],"into":[142],"mature":[143],"Oxaliplatin":[145],"treatment":[146],"diminished":[147],"expression":[149],"functional":[153],"mediators":[154],"arginase":[155],"1":[156],"(ARG1)":[157],"NADPH":[159],"oxidase":[160],"2":[161],"(NOX2)":[162],"while":[165],"an":[166,203],"MDSC-depleting":[167],"gemcitabine,":[169],"did":[170],"not":[171],"downregulate":[172],"these":[173],"factors":[174],"significantly.":[175],"Oxaliplatin-conditioned":[176],"had":[178],"no":[179],"tumor-promoting":[180],"activity":[181],"vivo.":[183],"modulated":[187],"intracellular":[189],"NF-\u03baB":[190],"signaling":[191],"MDSCs.":[193],"be":[200],"as":[202,206,208],"agent":[205],"well":[207],"cytotoxic":[210],"drug":[211],"cancer":[213],"treatment.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2019-01-11T00:00:00"}
