{"id":"https://openalex.org/W2907849545","doi":"https://doi.org/10.1039/c8tb03084g","title":"Hybrid lipid\u2013nanoparticle complexes for biomedical applications","display_name":"Hybrid lipid\u2013nanoparticle complexes for biomedical applications","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2907849545","doi":"https://doi.org/10.1039/c8tb03084g","mag":"2907849545","pmid":"https://pubmed.ncbi.nlm.nih.gov/30740226","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6363351"},"language":"en","primary_location":{"id":"doi:10.1039/c8tb03084g","doi":"https://doi.org/10.1039/c8tb03084g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8tb03084g","pdf_url":null,"source":{"id":"https://openalex.org/S2479884170","display_name":"Journal of Materials Chemistry B","issn_l":"2050-750X","issn":["2050-750X","2050-7518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Materials Chemistry B","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6363351","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002668451","display_name":"Kevin M. Vargas","orcid":"https://orcid.org/0000-0003-3442-9959","observed_orcids":["https://orcid.org/0000-0003-3442-9959"]},"institutions":[{"id":"https://openalex.org/I127339247","display_name":"California State University System","ror":"https://ror.org/020qm1538","country_code":"US","type":"education","lineage":["https://openalex.org/I127339247"]},{"id":"https://openalex.org/I59897056","display_name":"California State University, Long Beach","ror":"https://ror.org/0080fxk18","country_code":"US","type":"education","lineage":["https://openalex.org/I59897056"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin M. Vargas","raw_affiliation_strings":["California State University Long Beach","Department of Chemistry & Biochemistry","Long Beach","USA","Department of Chemistry & Biochemistry, California State University Long Beach, Long Beach, California 90840-9507, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California State University Long Beach","institution_ids":["https://openalex.org/I59897056"]},{"raw_affiliation_string":"Department of Chemistry & Biochemistry","institution_ids":[]},{"raw_affiliation_string":"Long Beach","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry & Biochemistry, California State University Long Beach, Long Beach, California 90840-9507, USA","institution_ids":["https://openalex.org/I127339247","https://openalex.org/I59897056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028203041","display_name":"Young\u2010Seok Shon","orcid":"https://orcid.org/0000-0003-4765-6130","observed_orcids":["https://orcid.org/0000-0003-4765-6130"]},"institutions":[{"id":"https://openalex.org/I127339247","display_name":"California State University System","ror":"https://ror.org/020qm1538","country_code":"US","type":"education","lineage":["https://openalex.org/I127339247"]},{"id":"https://openalex.org/I59897056","display_name":"California State University, Long Beach","ror":"https://ror.org/0080fxk18","country_code":"US","type":"education","lineage":["https://openalex.org/I59897056"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Young-Seok Shon","raw_affiliation_strings":["California State University Long Beach","Department of Chemistry & Biochemistry","Long Beach","USA","Department of Chemistry & Biochemistry, California State University Long Beach, Long Beach, California 90840-9507, USA"],"raw_orcid":"https://orcid.org/0000-0003-4765-6130","affiliations":[{"raw_affiliation_string":"California State University Long Beach","institution_ids":["https://openalex.org/I59897056"]},{"raw_affiliation_string":"Department of Chemistry & Biochemistry","institution_ids":[]},{"raw_affiliation_string":"Long Beach","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry & Biochemistry, California State University Long Beach, Long Beach, California 90840-9507, USA","institution_ids":["https://openalex.org/I127339247","https://openalex.org/I59897056"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028203041"],"corresponding_institution_ids":["https://openalex.org/I127339247","https://openalex.org/I59897056"],"apc_list":null,"apc_paid":null,"fwci":0.7183,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.55092593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"7","issue":"5","first_page":"695","last_page":"708"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.777999997138977},{"id":"https://openalex.org/keywords/solid-lipid-nanoparticles","display_name":"solid lipid nanoparticles","score":0.9089999794960022},{"id":"https://openalex.org/keywords/nanoemulsions","display_name":"nanoemulsions","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipoproteins","display_name":"lipoproteins","score":0.9649999737739563},{"id":"https://openalex.org/keywords/photothermal-therapy","display_name":"photothermal therapy","score":1.0},{"id":"https://openalex.org/keywords/bioimaging","display_name":"bioimaging","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.7453265190124512},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.7089667320251465},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6453709602355957}],"mesh":[{"descriptor_ui":"D004318","descriptor_name":"Doxycycline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004318","descriptor_name":"Doxycycline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D032701","descriptor_name":"Biomimetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1039/c8tb03084g","doi":"https://doi.org/10.1039/c8tb03084g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8tb03084g","pdf_url":null,"source":{"id":"https://openalex.org/S2479884170","display_name":"Journal of Materials Chemistry B","issn_l":"2050-750X","issn":["2050-750X","2050-7518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Materials Chemistry B","raw_type":"journal-article"},{"id":"pmid:30740226","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30740226","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of materials chemistry. B","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6363351","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6363351","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Mater Chem B","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6363351","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6363351","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Mater Chem B","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2379226604","display_name":"Metalloenzyme Mimics with Unsupported Metal Nanoparticle Catalysts","funder_award_id":"SC3GM089562","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W1553686307","https://openalex.org/W1757744616","https://openalex.org/W1858762448","https://openalex.org/W1881312648","https://openalex.org/W1922758105","https://openalex.org/W1967080357","https://openalex.org/W1975319981","https://openalex.org/W1980288318","https://openalex.org/W1983651709","https://openalex.org/W1983942269","https://openalex.org/W1985485491","https://openalex.org/W1988329232","https://openalex.org/W1989130768","https://openalex.org/W1989144616","https://openalex.org/W1993331221","https://openalex.org/W1993875111","https://openalex.org/W2001399280","https://openalex.org/W2002661845","https://openalex.org/W2002862770","https://openalex.org/W2003333558","https://openalex.org/W2003837630","https://openalex.org/W2005082260","https://openalex.org/W2016363934","https://openalex.org/W2022486613","https://openalex.org/W2029524441","https://openalex.org/W2038620116","https://openalex.org/W2038729386","https://openalex.org/W2044211491","https://openalex.org/W2047494164","https://openalex.org/W2048927441","https://openalex.org/W2049169201","https://openalex.org/W2049543990","https://openalex.org/W2051434186","https://openalex.org/W2051962704","https://openalex.org/W2055457307","https://openalex.org/W2057774884","https://openalex.org/W2061855669","https://openalex.org/W2062784942","https://openalex.org/W2065388970","https://openalex.org/W2068747446","https://openalex.org/W2072878440","https://openalex.org/W2076226743","https://openalex.org/W2077228161","https://openalex.org/W2079659964","https://openalex.org/W2080430067","https://openalex.org/W2082174664","https://openalex.org/W2082691117","https://openalex.org/W2087997669","https://openalex.org/W2088652149","https://openalex.org/W2089257121","https://openalex.org/W2092605333","https://openalex.org/W2093311681","https://openalex.org/W2094102413","https://openalex.org/W2094756975","https://openalex.org/W2099007176","https://openalex.org/W2100271967","https://openalex.org/W2103194980","https://openalex.org/W2106374956","https://openalex.org/W2107102561","https://openalex.org/W2108439421","https://openalex.org/W2110382462","https://openalex.org/W2113214821","https://openalex.org/W2116944245","https://openalex.org/W2117702111","https://openalex.org/W2122428913","https://openalex.org/W2125389909","https://openalex.org/W2141214816","https://openalex.org/W2142574938","https://openalex.org/W2146378598","https://openalex.org/W2148924929","https://openalex.org/W2160347422","https://openalex.org/W2161793265","https://openalex.org/W2171792381","https://openalex.org/W2176475325","https://openalex.org/W2188654150","https://openalex.org/W2238193673","https://openalex.org/W2292725232","https://openalex.org/W2319002382","https://openalex.org/W2319942179","https://openalex.org/W2330681932","https://openalex.org/W2336979913","https://openalex.org/W2343296710","https://openalex.org/W2408130038","https://openalex.org/W2468997949","https://openalex.org/W2485044017","https://openalex.org/W2521173037","https://openalex.org/W2554523550","https://openalex.org/W2559191665","https://openalex.org/W2564947465","https://openalex.org/W2565908100","https://openalex.org/W2566442566","https://openalex.org/W2571465655","https://openalex.org/W2584852739","https://openalex.org/W2594416178","https://openalex.org/W2609353882","https://openalex.org/W2612980345","https://openalex.org/W2625306848","https://openalex.org/W2751377163","https://openalex.org/W2752327745","https://openalex.org/W2755553492","https://openalex.org/W2770640289","https://openalex.org/W2786097821","https://openalex.org/W2804358033","https://openalex.org/W2895686848"],"related_works":["https://openalex.org/W4200339964","https://openalex.org/W3010950425","https://openalex.org/W4416459332","https://openalex.org/W2920971859","https://openalex.org/W2622683633","https://openalex.org/W2922097899","https://openalex.org/W2070803838","https://openalex.org/W2034711204","https://openalex.org/W2769441541","https://openalex.org/W4386134570"],"abstract_inverted_index":{"Biomolecule-nanoparticle":[0],"hybrids":[1],"have":[2],"proven":[3],"to":[4],"be":[5],"one":[6],"of":[7,26,35,57,83,95,136,143,161],"most":[8],"promising":[9],"frontiers":[10],"in":[11,155],"biomedical":[12,71,146],"research.":[13],"In":[14,55],"recent":[15,151],"years,":[16],"there":[17],"has":[18],"been":[19],"an":[20],"increased":[21],"focus":[22],"on":[23],"the":[24,37,41,86,91,96,134,140,159],"development":[25],"hybrid":[27,97,138],"lipid-nanoparticle":[28],"complexes":[29,98],"(HLNCs)":[30],"which":[31,66],"inherit":[32],"unique":[33],"properties":[34,135],"both":[36],"inorganic":[38],"nanoparticles":[39,84],"and":[40,50,79,93,99,126,139,157],"lipid":[42,48,87,120,128],"assemblies":[43,88,121],"(i.e.":[44,73],"liposomes,":[45],"lipoproteins,":[46],"solid":[47],"nanoparticles,":[49,108,113,118,125],"nanoemulsions)":[51],"that":[52],"comprise":[53],"them.":[54],"combination":[56],"their":[58],"component":[59],"parts,":[60],"HLNCs":[61,144,162],"also":[62,164],"gain":[63],"new":[64],"functionalities":[65,94],"are":[67,100,163],"utilized":[68],"for":[69,145],"numerous":[70],"applications":[72,147],"stimuli-triggered":[74],"drug":[75],"release,":[76],"photothermal":[77],"therapy,":[78],"bioimaging).":[80],"The":[81],"localization":[82],"within":[85],"largely":[89],"dictates":[90],"attributes":[92],"classified":[101],"as":[102,148],"such:":[103],"(i)":[104],"liposomes":[105,110,115],"with":[106,111,116,122],"surface-bound":[107],"(ii)":[109],"bilayer-embedded":[112],"(iii)":[114],"core-encapsulated":[117,124],"(iv)":[119],"hydrophobic":[123],"(v)":[127],"bilayer-coated":[129],"nanoparticles.":[130],"Herein,":[131],"we":[132],"review":[133],"each":[137],"rational":[141],"design":[142],"reported":[149],"by":[150],"investigations.":[152],"Future":[153],"directions":[154],"advancing":[156],"expanding":[158],"scope":[160],"proposed.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-01-11T00:00:00"}