{"id":"https://openalex.org/W2907400445","doi":"https://doi.org/10.36290/lek.2018.012","title":"Therapeutic drug monitoring in clinical practice","display_name":"Therapeutic drug monitoring in clinical practice","publication_year":2018,"publication_date":"2018-06-20","ids":{"openalex":"https://openalex.org/W2907400445","doi":"https://doi.org/10.36290/lek.2018.012","mag":"2907400445"},"language":"cs","primary_location":{"id":"doi:10.36290/lek.2018.012","doi":"https://doi.org/10.36290/lek.2018.012","is_oa":true,"landing_page_url":"https://doi.org/10.36290/lek.2018.012","pdf_url":"http://solen.cz/doi/10.36290/lek.2018.012.pdf","source":{"id":"https://openalex.org/S4306523043","display_name":"Praktick\u00e9 l\u00e9k\u00e1renstv\u00ed","issn_l":"1801-2434","issn":["1801-2434","1803-5329"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314174","host_organization_name":"Solen","host_organization_lineage":["https://openalex.org/P4310314174"],"host_organization_lineage_names":["Solen"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Praktick\u00e9 l\u00e9k\u00e1renstv\u00ed","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://solen.cz/doi/10.36290/lek.2018.012.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048367376","display_name":"Hana Such\u00e1nkov\u00e1","orcid":"https://orcid.org/0000-0001-7663-1552","observed_orcids":["https://orcid.org/0000-0001-7663-1552"]},"institutions":[{"id":"https://openalex.org/I4210107161","display_name":"University Hospital Olomouc","ror":"https://ror.org/01jxtne23","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210107161"]},{"id":"https://openalex.org/I70703428","display_name":"Palack\u00fd University Olomouc","ror":"https://ror.org/04qxnmv42","country_code":"CZ","type":"education","lineage":["https://openalex.org/I70703428"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Hana Such\u00e1nkov\u00e1","raw_affiliation_strings":["Odd\u011blen\u00ed geriatrie, Fakultn\u00ed nemocnice Olomouc","\u00dastav farmakologie , L\u00e9ka\u0159sk\u00e1 fakulta , Univerzita Palack\u00e9ho","\u00dastav farmakologie, L\u00e9ka\u0159sk\u00e1 fakulta, Univerzita Palack\u00e9ho v Olomouci"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Odd\u011blen\u00ed geriatrie, Fakultn\u00ed nemocnice Olomouc","institution_ids":["https://openalex.org/I4210107161"]},{"raw_affiliation_string":"\u00dastav farmakologie , L\u00e9ka\u0159sk\u00e1 fakulta , Univerzita Palack\u00e9ho","institution_ids":["https://openalex.org/I70703428"]},{"raw_affiliation_string":"\u00dastav farmakologie, L\u00e9ka\u0159sk\u00e1 fakulta, Univerzita Palack\u00e9ho v Olomouci","institution_ids":["https://openalex.org/I70703428"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048367376"],"corresponding_institution_ids":["https://openalex.org/I4210107161","https://openalex.org/I70703428"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17103305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"2","first_page":"67","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":1.0},{"id":"https://openalex.org/keywords/individualized-dosing","display_name":"individualized dosing","score":0.7680000066757202},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8539999723434448},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/therapeutic-window","display_name":"therapeutic window","score":0.5839999914169312},{"id":"https://openalex.org/keywords/antibiotics","display_name":"antibiotics","score":0.9599999785423279},{"id":"https://openalex.org/keywords/drug-concentration-measurement","display_name":"drug concentration measurement","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cost-of-healthcare","display_name":"cost of healthcare","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.38646650314331055},{"id":"https://openalex.org/C27206212","wikidata":"https://www.wikidata.org/wiki/Q34178","display_name":"Theology","level":1,"score":0.35696136951446533},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.24107682704925537}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.36290/lek.2018.012","doi":"https://doi.org/10.36290/lek.2018.012","is_oa":true,"landing_page_url":"https://doi.org/10.36290/lek.2018.012","pdf_url":"http://solen.cz/doi/10.36290/lek.2018.012.pdf","source":{"id":"https://openalex.org/S4306523043","display_name":"Praktick\u00e9 l\u00e9k\u00e1renstv\u00ed","issn_l":"1801-2434","issn":["1801-2434","1803-5329"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314174","host_organization_name":"Solen","host_organization_lineage":["https://openalex.org/P4310314174"],"host_organization_lineage_names":["Solen"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Praktick\u00e9 l\u00e9k\u00e1renstv\u00ed","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.36290/lek.2018.012","doi":"https://doi.org/10.36290/lek.2018.012","is_oa":true,"landing_page_url":"https://doi.org/10.36290/lek.2018.012","pdf_url":"http://solen.cz/doi/10.36290/lek.2018.012.pdf","source":{"id":"https://openalex.org/S4306523043","display_name":"Praktick\u00e9 l\u00e9k\u00e1renstv\u00ed","issn_l":"1801-2434","issn":["1801-2434","1803-5329"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314174","host_organization_name":"Solen","host_organization_lineage":["https://openalex.org/P4310314174"],"host_organization_lineage_names":["Solen"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Praktick\u00e9 l\u00e9k\u00e1renstv\u00ed","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2907400445.pdf","grobid_xml":"https://content.openalex.org/works/W2907400445.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1561900493","https://openalex.org/W1899209738","https://openalex.org/W1993133629","https://openalex.org/W2010066166","https://openalex.org/W2057605178","https://openalex.org/W2067912729","https://openalex.org/W2068628074","https://openalex.org/W2080334693","https://openalex.org/W2083732042","https://openalex.org/W2101785863","https://openalex.org/W2133120422","https://openalex.org/W2144045506","https://openalex.org/W2416696399","https://openalex.org/W2466473043","https://openalex.org/W2521474688","https://openalex.org/W2523115952","https://openalex.org/W2587790829","https://openalex.org/W3161771266"],"related_works":["https://openalex.org/W2930083544","https://openalex.org/W3090093120","https://openalex.org/W4411738543","https://openalex.org/W2581736211","https://openalex.org/W7099905729","https://openalex.org/W2551764373","https://openalex.org/W1565503809","https://openalex.org/W4402514584","https://openalex.org/W2601463690","https://openalex.org/W2529612714"],"abstract_inverted_index":{"Abychom":[0],"co":[1],"nejl\u00e9pe":[2],"vyu\u017eili":[3],"terapeutick\u00fd":[4],"potenci\u00e1l":[5],"l\u00e9\u010div,":[6,87],"je":[7,21,48,71],"pot\u0159eba":[8],"se":[9,59],"soust\u0159edit":[10],"na":[11,40],"mo\u017enosti":[12],"optimalizace":[13],"jejich":[14,31],"d\u00e1vkov\u00e1n\u00ed.":[15],"Terapeutick\u00e9":[16],"monitorov\u00e1n\u00ed":[17],"(koncentrac\u00ed)":[18],"l\u00e9\u010div":[19,27],"(TDM)":[20],"metodou":[22],"slou\u017e\u00edc\u00ed":[23],"k":[24,84],"individualizaci":[25],"d\u00e1vkov\u00e1n\u00ed":[26,46,91],"s":[28],"c\u00edlem":[29],"minimalizovat":[30],"toxicitu":[32],"a":[33,37,53,62,65,92],"z\u00e1rove\u0148":[34],"maximalizovat":[35],"\u00fa\u010dinnost":[36],"sni\u017eovat":[38],"n\u00e1klady":[39],"l\u00e9\u010debnou":[41],"p\u00e9\u010di.":[42],"Pro":[43],"volbu":[44],"optim\u00e1ln\u00edho":[45],"l\u00e9\u010diva":[47],"nutn\u00e9":[49],"zn\u00e1t":[50],"jeho":[51],"farmakokinetick\u00e9":[52],"farmakodynamick\u00e9":[54],"charakteristiky.":[55],"Tato":[56],"p\u0159ehledov\u00e1":[57],"pr\u00e1ce":[58],"zab\u00fdv\u00e1":[60],"postaven\u00edm":[61],"v\u00fdznamem":[63],"TDM":[64,77],"jednotliv\u00fdmi":[66],"aspekty":[67],"samotn\u00e9ho":[68],"monitorov\u00e1n\u00ed,":[69],"jako":[70],"identifikace":[72],"pacient\u016f,":[73],"u":[74],"kter\u00fdch":[75],"m\u00e1":[76],"nejv\u011bt\u0161\u00ed":[78],"v\u00fdznam,":[79],"p\u0159\u00edpadn\u00e9":[80],"limitace":[81],"metod":[82],"u\u017e\u00edvan\u00fdch":[83],"m\u011b\u0159en\u00ed":[85],"koncentrac\u00ed":[86],"strategie":[88],"samotn\u00e9":[89],"individualizace":[90],"nakonec":[93],"diskutuje":[94],"terapeutick\u00e1":[95],"rozmez\u00ed":[96],"antibiotik.":[97]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-01-11T00:00:00"}