{"id":"https://openalex.org/W2907383716","doi":"https://doi.org/10.1182/blood-2018-06-857714","title":"Durable remissions with obinutuzumab-based chemoimmunotherapy: long-term follow-up of the phase 1b GALTON trial in CLL","display_name":"Durable remissions with obinutuzumab-based chemoimmunotherapy: long-term follow-up of the phase 1b GALTON trial in CLL","publication_year":2018,"publication_date":"2018-12-28","ids":{"openalex":"https://openalex.org/W2907383716","doi":"https://doi.org/10.1182/blood-2018-06-857714","mag":"2907383716","pmid":"https://pubmed.ncbi.nlm.nih.gov/30593446"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2018-06-857714","doi":"https://doi.org/10.1182/blood-2018-06-857714","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-06-857714","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016570475","display_name":"Jennifer R. Brown","orcid":"https://orcid.org/0000-0003-2040-4961","observed_orcids":["https://orcid.org/0000-0003-2040-4961"]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer R. Brown","raw_affiliation_strings":["CLL Research Consortium, Moores Cancer Center, UC San Diego Health, La Jolla, CA;","Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CLL Research Consortium, Moores Cancer Center, UC San Diego Health, La Jolla, CA;","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I4390039236"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006104041","display_name":"Susan Mary O'Brien","orcid":"https://orcid.org/0000-0002-2481-7504","observed_orcids":["https://orcid.org/0000-0002-2481-7504"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan O\u2019Brien","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030858806","display_name":"C. Daniel Kingsley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118515","display_name":"Clearview Cancer Institute","ror":"https://ror.org/020cs7q41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210118515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Daniel Kingsley","raw_affiliation_strings":["Clearview Cancer Institute, Huntsville, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clearview Cancer Institute, Huntsville, AL;","institution_ids":["https://openalex.org/I4210118515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070465562","display_name":"Herbert Aaron Eradat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert Eradat","raw_affiliation_strings":["David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA;","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040412322","display_name":"John M. Pagel","orcid":"https://orcid.org/0000-0001-5745-8125","observed_orcids":["https://orcid.org/0000-0001-5745-8125","https://orcid.org/0000-0003-2875-4878"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Pagel","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, WA;","Fred Hutchinson Cancer Research Center, Seattle, WA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA;","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA;","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061466414","display_name":"Jamie H. Hirata","orcid":"https://orcid.org/0009-0002-7373-362X","observed_orcids":["https://orcid.org/0009-0002-7373-362X"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie Hirata","raw_affiliation_strings":["Genentech, Inc, South San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc, South San Francisco, CA;","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006699282","display_name":"Tammy McIver","orcid":"https://orcid.org/0009-0002-9766-1245","observed_orcids":["https://orcid.org/0009-0002-9766-1245"]},"institutions":[{"id":"https://openalex.org/I4210113058","display_name":"Roche (United Kingdom)","ror":"https://ror.org/024tgbv41","country_code":"GB","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4210113058"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tammy McIver","raw_affiliation_strings":["Roche Products Ltd, Welwyn, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Products Ltd, Welwyn, United Kingdom;","institution_ids":["https://openalex.org/I4210113058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011456970","display_name":"Rodica Morariu-Zamfir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Rodica Morariu-Zamfir","raw_affiliation_strings":["F. Hoffmann-La Roche Ltd, Basel, Switzerland; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffmann-La Roche Ltd, Basel, Switzerland; and","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036828560","display_name":"Thomas J. Kipps","orcid":"https://orcid.org/0000-0002-0064-4549","observed_orcids":["https://orcid.org/0000-0002-0064-4549"]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Kipps","raw_affiliation_strings":["CLL Research Consortium, Moores Cancer Center, UC San Diego Health, La Jolla, CA;","Department of Medicine, Moores Cancer Center, UC San Diego Health, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CLL Research Consortium, Moores Cancer Center, UC San Diego Health, La Jolla, CA;","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I4390039236"]},{"raw_affiliation_string":"Department of Medicine, Moores Cancer Center, UC San Diego Health, La Jolla, CA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I4390039236"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"133","issue":"9","first_page":"990","last_page":"992"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obinutuzumab","display_name":"obinutuzumab","score":0.9549999833106995},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chemoimmunotherapy","display_name":"chemoimmunotherapy","score":0.9269999861717224},{"id":"https://openalex.org/keywords/fludarabine-and-cyclophosphamide","display_name":"fludarabine and cyclophosphamide","score":0.9419999718666077},{"id":"https://openalex.org/keywords/bendamustine","display_name":"bendamustine","score":1.0},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.6309999823570251},{"id":"https://openalex.org/keywords/sustained-remission","display_name":"sustained remission","score":0.7599999904632568},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C2777607594","wikidata":"https://www.wikidata.org/wiki/Q389496","display_name":"Obinutuzumab","level":4,"score":0.9712609648704529},{"id":"https://openalex.org/C2780790343","wikidata":"https://www.wikidata.org/wiki/Q5090610","display_name":"Chemoimmunotherapy","level":4,"score":0.8968700170516968},{"id":"https://openalex.org/C2781442060","wikidata":"https://www.wikidata.org/wiki/Q425745","display_name":"Bendamustine","level":4,"score":0.7370930910110474},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7241713404655457},{"id":"https://openalex.org/C2779263901","wikidata":"https://www.wikidata.org/wiki/Q185916","display_name":"Fludarabine","level":4,"score":0.6419312953948975},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.5021345615386963},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45443740487098694},{"id":"https://openalex.org/C2777866208","wikidata":"https://www.wikidata.org/wiki/Q415939","display_name":"Chlorambucil","level":4,"score":0.4458007216453552},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4267629384994507},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.27700328826904297},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.23261576890945435},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.1904931664466858}],"mesh":[{"descriptor_ui":"D000069461","descriptor_name":"Bendamustine Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014740","descriptor_name":"Vidarabine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood-2018-06-857714","doi":"https://doi.org/10.1182/blood-2018-06-857714","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-06-857714","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:30593446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30593446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1981177563","https://openalex.org/W2001850157","https://openalex.org/W2057432590","https://openalex.org/W2140606816","https://openalex.org/W2149515595","https://openalex.org/W2159853837","https://openalex.org/W2168109746","https://openalex.org/W2169269721","https://openalex.org/W2171240476","https://openalex.org/W2193060933","https://openalex.org/W2330280277","https://openalex.org/W2396328865","https://openalex.org/W2768100418","https://openalex.org/W2790385276","https://openalex.org/W2977195355"],"related_works":["https://openalex.org/W1981177563","https://openalex.org/W2979726693","https://openalex.org/W4293181985","https://openalex.org/W4309920827","https://openalex.org/W2909550069","https://openalex.org/W2989071867","https://openalex.org/W2983329540","https://openalex.org/W2979462529","https://openalex.org/W2098294384","https://openalex.org/W4382751474"],"abstract_inverted_index":{"TO":[0],"THE":[1],"EDITOR:\n\nGALTON":[2],"was":[3],"an":[4],"open-label,":[5],"parallel-arm,":[6],"nonrandomized,":[7],"multicenter,":[8],"phase":[9],"1b":[10],"study":[11],"to":[12],"investigate":[13],"the":[14],"safety":[15],"and":[16],"preliminary":[17],"efficacy":[18],"of":[19],"either":[20],"obinutuzumab":[21,28],"(G)":[22],"plus":[23,29],"fludarabine/cyclophosphamide":[24],"(FC;":[25],"G-FC)":[26],"or":[27],"bendamustine":[30],"(B;":[31],"G-B)":[32],"as":[33],"frontline":[34],"therapy":[35],"in":[36],"chronic":[37]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-01-11T00:00:00"}
