{"id":"https://openalex.org/W2907183897","doi":"https://doi.org/10.1182/blood-2018-99-110811","title":"1,123 Consecutive Adults with Non-APL Acute Myeloid Leukemia: The Mayo Clinic Experience","display_name":"1,123 Consecutive Adults with Non-APL Acute Myeloid Leukemia: The Mayo Clinic Experience","publication_year":2018,"publication_date":"2018-11-29","ids":{"openalex":"https://openalex.org/W2907183897","doi":"https://doi.org/10.1182/blood-2018-99-110811","mag":"2907183897"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2018-99-110811","doi":"https://doi.org/10.1182/blood-2018-99-110811","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-110811","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080965667","display_name":"Kebede H. Begna","orcid":"https://orcid.org/0000-0003-2730-8593","observed_orcids":["https://orcid.org/0000-0003-2730-8593"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kebede H. Begna","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110626880","display_name":"Walid Reda Ali","orcid":"https://orcid.org/0000-0002-8805-2205","observed_orcids":["https://orcid.org/0000-0002-8805-2205"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Walid Ali","raw_affiliation_strings":["Mayo Clinic, ROCHESTER, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, ROCHESTER, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002643270","display_name":"Naseema Gangat","orcid":"https://orcid.org/0000-0002-9104-6172","observed_orcids":["https://orcid.org/0000-0002-9104-6172"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naseema Gangat","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064374340","display_name":"Michelle Ann Elliott","orcid":"https://orcid.org/0000-0002-7366-9886","observed_orcids":["https://orcid.org/0000-0002-7366-9886"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle A. Elliott","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008422091","display_name":"Aref Al\u2010Kali","orcid":"https://orcid.org/0000-0002-0824-3715","observed_orcids":["https://orcid.org/0000-0002-0824-3715"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aref Al-Kali","raw_affiliation_strings":["Division of Hematology and Medical Oncology, Department of Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Medical Oncology, Department of Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085360755","display_name":"Mark Robert Litzow","orcid":"https://orcid.org/0000-0002-9816-6302","observed_orcids":["https://orcid.org/0000-0002-9816-6302"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R. Litzow","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013866554","display_name":"C. Christopher Hook","orcid":"https://orcid.org/0000-0002-3971-6183","observed_orcids":["https://orcid.org/0000-0002-3971-6183"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Christopher Hook","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014945673","display_name":"Alexandra P. Wolanskyj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexandra Wolanskyj","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084606047","display_name":"William J. Hogan","orcid":"https://orcid.org/0000-0002-5841-4105","observed_orcids":["https://orcid.org/0000-0002-5841-4105"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. Hogan","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Department of Internal Medicine, Division of Hematology, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Department of Internal Medicine, Division of Hematology, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072463255","display_name":"Mrinal M. Patnaik","orcid":"https://orcid.org/0000-0001-6998-662X","observed_orcids":["https://orcid.org/0000-0001-6998-662X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mrinal M. Patnaik","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024612499","display_name":"Animesh Dev Pardanani","orcid":"https://orcid.org/0000-0002-9084-4148","observed_orcids":["https://orcid.org/0000-0002-9084-4148"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Animesh Pardanani","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032947311","display_name":"Darci Zblewski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Darci Zblewski","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100319444","display_name":"Dong Chen","orcid":"https://orcid.org/0000-0001-7627-9560","observed_orcids":["https://orcid.org/0000-0001-7627-9560"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Chen","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079731167","display_name":"Rong Lucy He","orcid":"https://orcid.org/0000-0001-6116-8163","observed_orcids":["https://orcid.org/0000-0001-6116-8163","https://orcid.org/0000-0002-6011-5964"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong He","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112698052","display_name":"David S. Viswanatha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David S Viswanatha","raw_affiliation_strings":["Laboratory Medicine and Pathology, Mayo Clinic, Rochester,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Medicine and Pathology, Mayo Clinic, Rochester,","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102758437","display_name":"Curtis A. Hanson","orcid":"https://orcid.org/0000-0003-1333-5355","observed_orcids":["https://orcid.org/0000-0003-1333-5355"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curtis A. Hanson","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079007941","display_name":"Rhett P. Ketterling","orcid":"https://orcid.org/0000-0001-6479-7897","observed_orcids":["https://orcid.org/0000-0001-6479-7897"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rhett P. Ketterling","raw_affiliation_strings":["Division of Laboratory Genetics and Genomics, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Laboratory Genetics and Genomics, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016216479","display_name":"Ayalew Tefferi","orcid":"https://orcid.org/0000-0003-4605-3821","observed_orcids":["https://orcid.org/0000-0003-4605-3821"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayalew Tefferi","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014945673","https://openalex.org/A5032947311","https://openalex.org/A5079007941","https://openalex.org/A5110626880","https://openalex.org/A5112698052"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"132","issue":"Supplement 1","first_page":"2689","last_page":"2689"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adult-aml","display_name":"adult AML","score":0.8429999947547913},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7580000162124634},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6579999923706055},{"id":"https://openalex.org/keywords/flt3-mutation","display_name":"FLT3 mutation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/npm1-mutation","display_name":"NPM1 mutation","score":0.996999979019165},{"id":"https://openalex.org/keywords/cebpa-mutation","display_name":"CEBPA mutation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/therapy-related-aml","display_name":"therapy-related AML","score":0.8550000190734863},{"id":"https://openalex.org/keywords/allogeneic-stem-cell-transplantation","display_name":"allogeneic stem cell transplantation","score":0.699999988079071},{"id":"https://openalex.org/keywords/long-term-survival","display_name":"long-term survival","score":0.45100000500679016},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8112398982048035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5616243481636047},{"id":"https://openalex.org/C2483381","wikidata":"https://www.wikidata.org/wiki/Q18030194","display_name":"NPM1","level":5,"score":0.48615404963493347},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.46764087677001953},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43598923087120056},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.41126441955566406},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.1552443504333496},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2018-99-110811","doi":"https://doi.org/10.1182/blood-2018-99-110811","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-110811","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3133563886","https://openalex.org/W1975345177","https://openalex.org/W2431757360","https://openalex.org/W2578433870","https://openalex.org/W2983461972","https://openalex.org/W3135915974","https://openalex.org/W2202480744","https://openalex.org/W1993631490","https://openalex.org/W3008046548","https://openalex.org/W7056489047"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],":":[2],"Pre-treatment":[3],"determinants":[4],"of":[5,52,73,80,122,142,150,154,170,172,176,315,375,394,418,469,475,523,536,579,632,647],"survival":[6,68,173,403,416,431,574],"in":[7,163,167,265,269,275,287,305,318,325,332,354,365,378,430,434,479,520,527,592,639],"adult":[8,54,200],"acute":[9],"myeloid":[10],"leukemia":[11],"(AML)":[12],"include":[13],"performance":[14],"status,":[15,638],"age,":[16,633],"karyotype,":[17,467],"the":[18,49,58,97,112,120,147,164,168,259,313,362,518,521,532,603,628,652],"distinction":[19],"between":[20,61,225,232],"primary":[21,239,629],"and":[22,25,35,63,82,109,166,227,229,234,251,272,281,294,321,345,357,370,414,421,443,453,461,471,505,559,564,587,623,635,651],"non-primary":[23],"AML":[24,32,81,100,151,212,236,449,501,508,549,555,621],"FLT3-ITD/NPM1":[26],"mutational":[27,525,637],"status.":[28],"Current":[29],"literature":[30],"on":[31,41,620],"natural":[33],"history":[34],"risk":[36,76,255,274,513],"factors":[37,514],"is":[38,589],"often":[39],"based":[40],"information":[42,284,613],"derived":[43],"from":[44,96,146,187,606],"stringent":[45],"protocol":[46],"studies.":[47],"In":[48],"current":[50,601],"series":[51],"1,123":[53,199,406,481],"patients":[55,201,222,367,407,482],"seen":[56,224],"at":[57,174,577],"Mayo":[59,98],"Clinic":[60,99],"2004":[62,226],"2017,":[64],"we":[65],"examined":[66],"long-term":[67],"specified":[69],"by":[70,448,466],"a":[71,391,424,607],"number":[72],"primarily":[74],"established":[75],"factors.":[77],"Methods:":[78],"Diagnosis":[79],"its":[83],"sub-classification":[84],"was":[85,193,263,285,330,408,432,575],"according":[86,257],"to":[87,152,258,596],"World":[88],"Health":[89],"Organization":[90],"criteria.":[91],"Study":[92],"subjects":[93],"were":[94,105,138,160,213,216,223,238,352,368,384,400,571],"recruited":[95],"database.":[101],"Conventional":[102],"response":[103,454],"criteria":[104,116],"used":[106,139,194],"for":[107,117,140,195,386,404,515],"CR":[108,118,346,650],"CRi":[110,648],"assignment;":[111],"latter":[113],"met":[114],"all":[115,196,337,373,405,480],"with":[119,210,347,411,584,617,657],"exception":[121],"platelet":[123],"count":[124,349],"<100":[125],"x":[126,133],"109/l":[127],"or":[128,156],"absolute":[129],"neutrophil":[130],"cunt":[131],"<1":[132],"109/l.":[134],"Standard":[135],"statistical":[136],"methods":[137],"analysis":[141,446,464,474],"overall":[143],"survival,":[144],"calculated":[145],"initial":[148],"diagnosis":[149],"date":[153],"death":[155],"last":[157],"follow-up;":[158],"analyses":[159],"performed":[161,338],"both":[162],"absence":[165],"presence":[169],"censoring":[171],"time":[175,578],"allogenic":[177],"stem":[178],"cell":[179],"transplant":[180],"(ASCT).":[181],"The":[182,600,625],"JMP\u00ae":[183],"Pro":[184],"13.0.0":[185],"software":[186],"SAS":[188],"Institute,":[189],"Cary,":[190],"NC,":[191],"USA,":[192],"calculations.":[197],"Results:":[198],"(median":[202],"age":[203,217,484,537],"65":[204],"years,":[205],"range":[206],"18-94;":[207],"61%":[208,215],"males)":[209],"non-APL":[211],"considered;":[214],">60":[218,485,538],"years.":[219],"351":[220],"(31%)":[221],"2009":[228],"772":[230],"(69%)":[231],"2010":[233],"2017.":[235],"subcategories":[237],"(56%),":[240],"post-myelodysplastic":[241],"syndromes":[242],"(post-MDS;":[243],"24%),":[244],"therapy-related":[245],"(10%),":[246],"post-myeloproliferative":[247],"neoplasm":[248],"(post-MPN;":[249],"8%)":[250],"post-MDS/MPN":[252],"(3%).":[253],"Cytogenetic":[254],"distribution,":[256],"European":[260],"LeukemiaNet":[261],"classification,":[262],"favorable":[264],"47":[266],"(4%),":[267],"intermediate":[268],"650":[270],"(58%)":[271],"adverse":[273,490,533,543],"426":[276],"(38%)":[277],"patients.":[278,328],"FLT3,":[279],"NPM1":[280],"CEBPA":[282],"mutation":[283],"available":[286],"462":[288],"(24%":[289],"mutated),":[290],"393":[291],"(27%":[292],"mutated)":[293,297],"228":[295],"(11%":[296],"patients,":[298,308,360],"respectively.":[299,456],"Treatment":[300],"included":[301,644],"intensive":[302],"chemotherapy":[303],"(IC)":[304],"766":[306],"(68%)":[307],"less":[309,387],"aggressive":[310,388],"chemotherapy,":[311],"including":[312],"use":[314,468],"hypomethylating":[316],"agents":[317],"144":[319],"(13%)":[320],"supportive":[322],"care":[323],"alone":[324],"213":[326],"(19%)":[327],"ASCT":[329,470,588],"utilized":[331],"258":[333],"(23%)":[334],"cases,":[335],"almost":[336],"after":[339],"achieving":[340],"CR/CRi.":[341],"Complete":[342],"remission":[343],"(CR)":[344],"incomplete":[348],"recovery":[350],"(CRi)":[351],"listed":[353,385],"333":[355],"(30%)":[356],"248":[358],"(22%)":[359],"respectively;":[361,423],"corresponding":[363],"rates":[364,417],"IC-treated":[366,379],"43%":[369],"32%.":[371],"Almost":[372],"cases":[374,530],"CR/CRi":[376],"occurred":[377],"patients;":[380],"2":[381],"(1.4%)":[382],"CRs":[383],"chemotherapy.":[389],"After":[390],"median":[392],"follow-up":[393],"11":[395],"months,":[396],"798":[397],"(71%)":[398],"deaths":[399],"recorded.":[401],"Median":[402],"14":[409],"months":[410],"1-,":[412],"3-":[413],"5-year":[415],"54%,":[419],"29%":[420],"23%,":[422],"slight":[425],"but":[426],"significant":[427],"(p=0.01)":[428],"improvement":[429],"apparent":[433],"more":[435],"recent":[436],"years":[437,486,539],"(Figure":[438],"1a).":[439],"Figures":[440],"1b,":[441],"1c":[442],"1d":[444],"depict":[445,463],"stratified":[447,465],"subcategories,":[450],"treatment":[451,585],"received":[452],"obtained,":[455],"Similarly,":[457],"figures":[458],"2a,":[459],"2b":[460],"2c":[462],"age.":[472],"Multivariable":[473],"pre-treatment":[476],"parameters":[477],"evaluable":[478],"identified":[483],"(HR":[487,492,497,502,509,540,545,550,556,561,566],"2.2,":[488],"1.9-2.6),":[489],"karyotype":[491,496,544,634],"2.9,":[493],"1.9-4.9),":[494],"intermediate-risk":[495],"1.6,":[498],"1.02-2.6),":[499],"post-MPN":[500,548,658],"1.9,":[503],"1.5-2.4)":[504],"other":[506,553],"secondary":[507,554],"1.3":[510],"(1.1-1.6),":[511],"as":[512],"shortened":[516],"survival;":[517],"inclusion":[519],"model":[522],"FLT3/NPM1":[524,636],"status":[526],"392":[528],"informative":[529],"confirmed":[531],"prognostic":[534,582,630],"effect":[535],"1.8,":[541],"1.4-2.5),":[542],"3.7,":[546],"1.4-15.3),":[547],"2.8,":[551,562],"1.6-4.6),":[552],"1.4,":[557],"1.0-1.9)":[558],"FLT3+NPM1-":[560],"1.6-4.9)":[563],"FLT3-NPM1-":[565],"1.7,":[567],"1.2-2.7)":[568],"profile.":[569],"Results":[570],"unchanged":[572],"when":[573],"censored":[576],"ASCT.":[580],"Additional":[581],"interaction":[583],"strategy":[586],"further":[590],"elaborated":[591],"an":[593],"accompanying":[594],"abstract":[595],"be":[597],"presented.":[598],"Conclusions:":[599],"study,":[602],"largest":[604],"coming":[605],"single":[608],"institution,":[609],"provides":[610],"practically":[611],"useful":[612],"that":[614],"should":[615],"assist":[616],"patient":[618],"consultation":[619],"prognosis":[622,655],"treatment.":[624],"study":[626],"confirms":[627],"importance":[631],"real-life":[640],"practice.":[641],"Novel":[642],"observations":[643],"comparable":[645],"value":[646],"vs":[649],"particularly":[653],"worse":[654],"associated":[656],"AML.":[659],"Disclosures":[660],"Al-Kali:":[661],"Novartis:":[662],"Research":[663],"Funding.":[664]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-01-11T00:00:00"}
