{"id":"https://openalex.org/W2907148443","doi":null,"title":"Development of New Antibody Based Theranostic Agents Targeting the Receptor for Advanced Glycation End-Product (Rage)","display_name":"Development of New Antibody Based Theranostic Agents Targeting the Receptor for Advanced Glycation End-Product (Rage)","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2907148443","mag":"2907148443"},"language":"en","primary_location":{"id":"pmh:oai:library.ndsu.edu:10365/26866","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10365/26866","pdf_url":"https://hdl.handle.net/10365/26866","source":{"id":"https://openalex.org/S4306401374","display_name":"NDSU Repository (North Dakota State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I57328836","host_organization_name":"North Dakota State University","host_organization_lineage":["https://openalex.org/I57328836"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/10365/26866","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jyoti, Faidat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jyoti, Faidat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/receptor-for-advanced-glycation-end-products","display_name":"receptor for advanced glycation end products","score":0.8610000014305115},{"id":"https://openalex.org/keywords/rage","display_name":"RAGE","score":0.9700000286102295},{"id":"https://openalex.org/keywords/theranostic-agents","display_name":"theranostic agents","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hybridoma-cells","display_name":"hybridoma","score":0.6330000162124634},{"id":"https://openalex.org/keywords/soluble-rage","display_name":"soluble RAGE","score":0.8450000286102295},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7049999833106995},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9399999976158142},{"id":"https://openalex.org/keywords/antibody-affinity","display_name":"antibody affinity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/melanoma-xenografts","display_name":"melanoma xenografts","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7519999742507935},{"id":"https://openalex.org/keywords/rage-ligands","display_name":"RAGE ligands","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.8603688478469849},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.7803653478622437},{"id":"https://openalex.org/C2776997535","wikidata":"https://www.wikidata.org/wiki/Q2556837","display_name":"Advanced glycation end-product","level":4,"score":0.7597852945327759},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5225186347961426},{"id":"https://openalex.org/C2776904630","wikidata":"https://www.wikidata.org/wiki/Q356336","display_name":"Adept","level":3,"score":0.47088131308555603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42099010944366455},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.41694340109825134},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3406807780265808},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30868780612945557},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2789648473262787},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.22758617997169495},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1936512589454651},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15064695477485657},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:library.ndsu.edu:10365/26866","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10365/26866","pdf_url":"https://hdl.handle.net/10365/26866","source":{"id":"https://openalex.org/S4306401374","display_name":"NDSU Repository (North Dakota State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I57328836","host_organization_name":"North Dakota State University","host_organization_lineage":["https://openalex.org/I57328836"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"}],"best_oa_location":{"id":"pmh:oai:library.ndsu.edu:10365/26866","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10365/26866","pdf_url":"https://hdl.handle.net/10365/26866","source":{"id":"https://openalex.org/S4306401374","display_name":"NDSU Repository (North Dakota State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I57328836","host_organization_name":"North Dakota State University","host_organization_lineage":["https://openalex.org/I57328836"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2907148443.pdf","grobid_xml":"https://content.openalex.org/works/W2907148443.grobid-xml"},"referenced_works_count":242,"referenced_works":["https://openalex.org/W21964878","https://openalex.org/W81571208","https://openalex.org/W105279024","https://openalex.org/W131033830","https://openalex.org/W152234727","https://openalex.org/W161424134","https://openalex.org/W173643440","https://openalex.org/W184793376","https://openalex.org/W188303386","https://openalex.org/W195584866","https://openalex.org/W280875868","https://openalex.org/W1483703465","https://openalex.org/W1502047387","https://openalex.org/W1503491996","https://openalex.org/W1512232428","https://openalex.org/W1512294608","https://openalex.org/W1522849511","https://openalex.org/W1525114741","https://openalex.org/W1532102099","https://openalex.org/W1541130784","https://openalex.org/W1542950394","https://openalex.org/W1553198783","https://openalex.org/W1555875393","https://openalex.org/W1556333628","https://openalex.org/W1564886800","https://openalex.org/W1586099293","https://openalex.org/W1588038083","https://openalex.org/W1590156932","https://openalex.org/W1594856996","https://openalex.org/W1760240044","https://openalex.org/W1786523947","https://openalex.org/W1797343225","https://openalex.org/W1903181228","https://openalex.org/W1963522035","https://openalex.org/W1964558419","https://openalex.org/W1965497701","https://openalex.org/W1966234811","https://openalex.org/W1967060390","https://openalex.org/W1967303459","https://openalex.org/W1967784783","https://openalex.org/W1968044233","https://openalex.org/W1969488647","https://openalex.org/W1969826234","https://openalex.org/W1970936597","https://openalex.org/W1971177781","https://openalex.org/W1972816014","https://openalex.org/W1973852753","https://openalex.org/W1974292788","https://openalex.org/W1978205735","https://openalex.org/W1978611180","https://openalex.org/W1980827023","https://openalex.org/W1981209372","https://openalex.org/W1982597283","https://openalex.org/W1984193914","https://openalex.org/W1984830754","https://openalex.org/W1985009522","https://openalex.org/W1985200042","https://openalex.org/W1986130562","https://openalex.org/W1986575743","https://openalex.org/W1986884483","https://openalex.org/W1987063486","https://openalex.org/W1987321956","https://openalex.org/W1987703665","https://openalex.org/W1987796811","https://openalex.org/W1989656651","https://openalex.org/W1990596307","https://openalex.org/W1991158686","https://openalex.org/W1991180616","https://openalex.org/W1991338634","https://openalex.org/W1991544402","https://openalex.org/W1992082488","https://openalex.org/W1992624486","https://openalex.org/W1993290440","https://openalex.org/W1996479665","https://openalex.org/W1997054462","https://openalex.org/W1998919525","https://openalex.org/W1999498968","https://openalex.org/W2000636586","https://openalex.org/W2001927093","https://openalex.org/W2002351008","https://openalex.org/W2003531380","https://openalex.org/W2003813921","https://openalex.org/W2004326038","https://openalex.org/W2004437604","https://openalex.org/W2005640704","https://openalex.org/W2005869447","https://openalex.org/W2006847107","https://openalex.org/W2007281508","https://openalex.org/W2007434486","https://openalex.org/W2007500163","https://openalex.org/W2008721781","https://openalex.org/W2009744617","https://openalex.org/W2010097555","https://openalex.org/W2011205190","https://openalex.org/W2011261569","https://openalex.org/W2011776951","https://openalex.org/W2013730613","https://openalex.org/W2014684213","https://openalex.org/W2014878209","https://openalex.org/W2016184962","https://openalex.org/W2018478612","https://openalex.org/W2018620079","https://openalex.org/W2018653121","https://openalex.org/W2019558153","https://openalex.org/W2022798707","https://openalex.org/W2023985105","https://openalex.org/W2026885016","https://openalex.org/W2027868871","https://openalex.org/W2028202722","https://openalex.org/W2028227522","https://openalex.org/W2029070304","https://openalex.org/W2029231027","https://openalex.org/W2030452894","https://openalex.org/W2030937776","https://openalex.org/W2035127805","https://openalex.org/W2036355459","https://openalex.org/W2036664753","https://openalex.org/W2038048085","https://openalex.org/W2038528673","https://openalex.org/W2038792388","https://openalex.org/W2039780464","https://openalex.org/W2040766716","https://openalex.org/W2042735193","https://openalex.org/W2043786454","https://openalex.org/W2044514535","https://openalex.org/W2046871297","https://openalex.org/W2047286107","https://openalex.org/W2047887335","https://openalex.org/W2047964022","https://openalex.org/W2048569323","https://openalex.org/W2049167261","https://openalex.org/W2049815086","https://openalex.org/W2051862080","https://openalex.org/W2053969514","https://openalex.org/W2054503476","https://openalex.org/W2056059892","https://openalex.org/W2056248104","https://openalex.org/W2057630668","https://openalex.org/W2061689566","https://openalex.org/W2063840206","https://openalex.org/W2063899343","https://openalex.org/W2064532629","https://openalex.org/W2066149280","https://openalex.org/W2067832234","https://openalex.org/W2068540171","https://openalex.org/W2068817764","https://openalex.org/W2069225827","https://openalex.org/W2069610017","https://openalex.org/W2070943527","https://openalex.org/W2071301668","https://openalex.org/W2071378581","https://openalex.org/W2071675524","https://openalex.org/W2073714833","https://openalex.org/W2074465835","https://openalex.org/W2074534136","https://openalex.org/W2075817717","https://openalex.org/W2076632992","https://openalex.org/W2077080996","https://openalex.org/W2077133844","https://openalex.org/W2077865453","https://openalex.org/W2080904568","https://openalex.org/W2081080245","https://openalex.org/W2081568961","https://openalex.org/W2085128107","https://openalex.org/W2085688929","https://openalex.org/W2087638630","https://openalex.org/W2087690555","https://openalex.org/W2087737282","https://openalex.org/W2089276240","https://openalex.org/W2089685830","https://openalex.org/W2092392512","https://openalex.org/W2093161217","https://openalex.org/W2093715230","https://openalex.org/W2094005944","https://openalex.org/W2098098743","https://openalex.org/W2102565163","https://openalex.org/W2103413641","https://openalex.org/W2103484879","https://openalex.org/W2104938297","https://openalex.org/W2106889822","https://openalex.org/W2107045256","https://openalex.org/W2108690001","https://openalex.org/W2109334664","https://openalex.org/W2109590683","https://openalex.org/W2111811354","https://openalex.org/W2111839663","https://openalex.org/W2111867309","https://openalex.org/W2114081875","https://openalex.org/W2115293825","https://openalex.org/W2116784956","https://openalex.org/W2116794323","https://openalex.org/W2120357935","https://openalex.org/W2121323998","https://openalex.org/W2121527030","https://openalex.org/W2124008135","https://openalex.org/W2124136509","https://openalex.org/W2126160998","https://openalex.org/W2132793463","https://openalex.org/W2133019124","https://openalex.org/W2135388445","https://openalex.org/W2136294641","https://openalex.org/W2137603130","https://openalex.org/W2138928713","https://openalex.org/W2140409748","https://openalex.org/W2140491925","https://openalex.org/W2140971946","https://openalex.org/W2141595429","https://openalex.org/W2142130201","https://openalex.org/W2142280711","https://openalex.org/W2144474538","https://openalex.org/W2146666237","https://openalex.org/W2147993424","https://openalex.org/W2149342137","https://openalex.org/W2153618109","https://openalex.org/W2154385453","https://openalex.org/W2155987479","https://openalex.org/W2160339712","https://openalex.org/W2160496529","https://openalex.org/W2162815565","https://openalex.org/W2163351331","https://openalex.org/W2165094792","https://openalex.org/W2165537206","https://openalex.org/W2167435033","https://openalex.org/W2170646719","https://openalex.org/W2170682202","https://openalex.org/W2173998026","https://openalex.org/W2291640051","https://openalex.org/W2298763573","https://openalex.org/W2313527545","https://openalex.org/W2334100537","https://openalex.org/W2344427819","https://openalex.org/W2395038505","https://openalex.org/W2398849845","https://openalex.org/W2399625966","https://openalex.org/W2404028691","https://openalex.org/W2416465887","https://openalex.org/W2474064497","https://openalex.org/W2506859114","https://openalex.org/W2769264260","https://openalex.org/W2810374733","https://openalex.org/W4405180831","https://openalex.org/W7095734969"],"related_works":["https://openalex.org/W2793670361","https://openalex.org/W2382572597","https://openalex.org/W3087584517","https://openalex.org/W4283791224","https://openalex.org/W2391528519","https://openalex.org/W4289519993","https://openalex.org/W2754746665","https://openalex.org/W2403259545","https://openalex.org/W2076603448","https://openalex.org/W2396414156"],"abstract_inverted_index":{"The":[0,16,122,172,186],"Receptor":[1],"for":[2,239],"Advanced":[3],"Glycation":[4],"End":[5],"products":[6],"(RAGE)":[7],"interacts":[8],"with":[9,70],"several":[10,29],"classes":[11],"of":[12,18,28,44,76,131,134,142,150,157,169,180,192,216,235,256,258,272],"structurally":[13],"unrelated":[14],"ligands.":[15],"activation":[17,27],"RAGE":[19,82,91,107,119,158,225],"by":[20,262],"its":[21,160],"ligands":[22],"results":[23],"in":[24,50,56,118,124,199,200,211,282,284],"the":[25,132,167,170,176,190,193,204,208,214,219,233,253,259,273],"cellular":[26],"kinases":[30,38],"and":[31,40,66,147,152,154,159,178,203,243],"transcription":[32],"factors":[33],"including":[34],"mitogen":[35],"activated":[36,45],"protein":[37],"(MAPKs)":[39],"nuclear":[41],"factor":[42],"kappa-light-chain-enhancer":[43],"B":[46],"cells":[47,198],"(NF-\u03baB)":[48],"resulting":[49],"sustained":[51],"inflammation,":[52],"which":[53,144,229],"is":[54,261],"involved":[55],"pathologies":[57],"such":[58],"as":[59,96,111,113,115],"diabetes,":[60],"cancer,":[61],"Alzheimer's":[62],"disease,":[63],"multiple":[64],"sclerosis":[65],"other":[67],"diseases":[68],"associated":[69],"chronic":[71],"inflammation.":[72],"Current":[73],"mouse":[74,288],"models":[75],"human":[77],"disease":[78],"have":[79],"shown":[80],"that":[81,108,252,270],"activity":[83],"can":[84,109],"be":[85],"efficiently":[86],"suppressed":[87],"using":[88],"either":[89],"soluble":[90],"(sRAGE)":[92],"or":[93],"anti-RAGE":[94,136,181],"antibodies":[95,105,151,182,195,210,220,237,260,275],"inhibitors.":[97],"Our":[98],"goal":[99],"was":[100,276],"to":[101,165,196,224,232,250,265,278],"generate":[102],"new":[103],"monoclonal":[104],"against":[106],"serve":[110],"diagnostic":[112,242],"wells":[114],"therapeutic":[116,240],"tools":[117],"related":[120],"pathologies.":[121],"chapters":[123],"this":[125,217],"dissertation":[126],"are":[127,230],"a":[128,285],"complete":[129],"documentation":[130],"development":[133,177],"these":[135],"antibodies.":[137],"Additionally,":[138],"an":[139],"introductory":[140],"review":[141],"antibodies,":[143],"includes":[145],"structure":[146],"function,":[148],"types":[149],"production":[153],"basic":[155],"understanding":[156,168],"ligands,":[161],"has":[162],"been":[163],"provided":[164],"facilitate":[166],"chapters.":[171],"first":[173],"chapter":[174,188,206],"details":[175],"characterization":[179],"produced":[183],"from":[184],"hybridoma.":[185],"next":[187],"explores":[189],"effects":[191],"generated":[194,209,274],"mammalian":[197],"vitro":[201],"settings":[202],"final":[205],"applies":[207],"vivo.":[212],"During":[213],"course":[215],"work,":[218],"developed":[221],"showed":[222],"binding":[223,264],"at":[226],"nano-molar":[227],"affinities":[228,234],"comparable":[231],"current":[236],"used":[238],"purposes,":[241],"research":[244],"purposes.":[245],"We":[246],"were":[247],"also":[248],"able":[249,277],"delineate":[251],"possible":[254],"mechanism":[255],"action":[257],"preventing":[263],"RAGE.":[266],"Lastly,":[267],"we":[268],"observed":[269],"one":[271],"reduce":[279],"tumor":[280],"growth":[281],"vivo":[283],"melanoma":[286],"xenograft":[287],"model.":[289]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
